pioglitazone has been researched along with Cardiomyopathies, Primary in 4 studies
Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Further application of PPAR-γ agonist (pioglitazone) and antagonist (GW9662) in H9C2 cells revealed that the up-regulation of PPAR-γ expression induced by T-2 toxin is a self-preservation phenomenon, and increasing exogenous PPAR-γ can alleviate the increase in TGF-β1 caused by T-2 toxin, thereby playing a role in relieving cardiac fibrosis." | 8.02 | PPAR-γ with its anti-fibrotic action could serve as an effective therapeutic target in T-2 toxin-induced cardiac fibrosis of rats. ( Guo, P; Hu, S; Lu, Q; Ren, Z; Wang, X; Wu, Q; Zhu, X, 2021) |
| " Further application of PPAR-γ agonist (pioglitazone) and antagonist (GW9662) in H9C2 cells revealed that the up-regulation of PPAR-γ expression induced by T-2 toxin is a self-preservation phenomenon, and increasing exogenous PPAR-γ can alleviate the increase in TGF-β1 caused by T-2 toxin, thereby playing a role in relieving cardiac fibrosis." | 4.02 | PPAR-γ with its anti-fibrotic action could serve as an effective therapeutic target in T-2 toxin-induced cardiac fibrosis of rats. ( Guo, P; Hu, S; Lu, Q; Ren, Z; Wang, X; Wu, Q; Zhu, X, 2021) |
| " Diabetic nephropathic rats were orally given vehicle, pioglitazone, aliskiren, or combined pioglitazone and aliskiren for four weeks to compare their effects on cardiovascular injury, particularly myocardial fibrosis." | 3.78 | Beneficial effects of pioglitazone against cardiovascular injury are enhanced by combination with aliskiren in a rat model of diabetic nephropathy. ( Asker, ME; Elrashidy, RA; Mohamed, HE, 2012) |
| "Pioglitazone-treated mice showed improvement in insulin resistance, adipokine, and lipid profile." | 1.35 | The peroxisome proliferator-activated receptor gamma agonist pioglitazone improves cardiometabolic risk and renal inflammation in murine lupus. ( Brosius, FC; Hodgin, JB; Kaplan, MJ; Kretzler, M; Park, JL; Pennathur, S; Randolph, A; Somers, EC; Thacker, SG; Wang, JH; Zhang, H; Zhao, W, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lu, Q | 1 |
| Hu, S | 1 |
| Guo, P | 1 |
| Zhu, X | 1 |
| Ren, Z | 1 |
| Wu, Q | 1 |
| Wang, X | 1 |
| Mori, D | 1 |
| Miyagawa, S | 1 |
| Matsuura, R | 1 |
| Sougawa, N | 1 |
| Fukushima, S | 1 |
| Ueno, T | 1 |
| Toda, K | 1 |
| Kuratani, T | 1 |
| Tomita, K | 1 |
| Maeda, N | 1 |
| Shimomura, I | 1 |
| Sawa, Y | 1 |
| Zhao, W | 1 |
| Thacker, SG | 1 |
| Hodgin, JB | 1 |
| Zhang, H | 1 |
| Wang, JH | 1 |
| Park, JL | 1 |
| Randolph, A | 1 |
| Somers, EC | 1 |
| Pennathur, S | 1 |
| Kretzler, M | 1 |
| Brosius, FC | 1 |
| Kaplan, MJ | 1 |
| Elrashidy, RA | 1 |
| Asker, ME | 1 |
| Mohamed, HE | 1 |
4 other studies available for pioglitazone and Cardiomyopathies, Primary
| Article | Year |
|---|---|
PPAR-γ with its anti-fibrotic action could serve as an effective therapeutic target in T-2 toxin-induced cardiac fibrosis of rats.
Topics: Anilides; Animals; Cardiomyopathies; Cell Line; Collagen; Fibrosis; Male; Myocardium; Pioglitazone; | 2021 |
Pioglitazone strengthen therapeutic effect of adipose-derived regenerative cells against ischemic cardiomyopathy through enhanced expression of adiponectin and modulation of macrophage phenotype.
Topics: Adiponectin; Adipose Tissue; Animals; Cadherins; Cardiomyopathies; Cell Transplantation; Cells, Cult | 2019 |
The peroxisome proliferator-activated receptor gamma agonist pioglitazone improves cardiometabolic risk and renal inflammation in murine lupus.
Topics: Animals; Cardiomyopathies; Disease Models, Animal; Endothelium, Vascular; Female; Inflammation Media | 2009 |
Beneficial effects of pioglitazone against cardiovascular injury are enhanced by combination with aliskiren in a rat model of diabetic nephropathy.
Topics: Amides; Animals; Antihypertensive Agents; Cardiomyopathies; Diabetic Nephropathies; Disease Models, | 2012 |