Page last updated: 2024-11-02

pioglitazone and Carcinogenesis

pioglitazone has been researched along with Carcinogenesis in 3 studies

Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.

Carcinogenesis: The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.

Research Excerpts

ExcerptRelevanceReference
"In LNCaP, a human androgen-dependent prostate cancer cell line, PGZ also inhibited cyclin D1 expression and the activation of both p38 MAPK and NFκB."5.43Pioglitazone, a Peroxisome Proliferator-Activated Receptor γ Agonist, Suppresses Rat Prostate Carcinogenesis. ( Kato, H; Kobayashi, M; Kuno, T; Mori, Y; Nagano, A; Nagayasu, Y; Naiki-Ito, A; Suzuki, S; Takahashi, S, 2016)
"Furthermore, treating breast cancer cells with pioglitazone that stabilizes the 3Cys-1His cluster of NAF-1 results in a similar effect on mitochondrial iron and reactive oxygen species accumulation."1.43Breast cancer tumorigenicity is dependent on high expression levels of NAF-1 and the lability of its Fe-S clusters. ( Bai, F; Darash-Yahana, M; Geiger, T; Jennings, PA; Karmi, O; Lu, M; Mittler, R; Nechushtai, R; Onuchic, JN; Pikarsky, E; Pozniak, Y; Sohn, YS; Song, L; Tamir, S, 2016)
"In LNCaP, a human androgen-dependent prostate cancer cell line, PGZ also inhibited cyclin D1 expression and the activation of both p38 MAPK and NFκB."1.43Pioglitazone, a Peroxisome Proliferator-Activated Receptor γ Agonist, Suppresses Rat Prostate Carcinogenesis. ( Kato, H; Kobayashi, M; Kuno, T; Mori, Y; Nagano, A; Nagayasu, Y; Naiki-Ito, A; Suzuki, S; Takahashi, S, 2016)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sohn, YS2
Tamir, S2
Song, L2
Michaeli, D1
Matouk, I1
Conlan, AR1
Harir, Y1
Holt, SH1
Shulaev, V1
Paddock, ML1
Hochberg, A1
Cabanchick, IZ1
Onuchic, JN2
Jennings, PA2
Nechushtai, R2
Mittler, R2
Darash-Yahana, M1
Pozniak, Y1
Lu, M1
Karmi, O1
Bai, F1
Pikarsky, E1
Geiger, T1
Suzuki, S1
Mori, Y1
Nagano, A1
Naiki-Ito, A1
Kato, H1
Nagayasu, Y1
Kobayashi, M1
Kuno, T1
Takahashi, S1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Treatment of Wolfram Syndrome Type 2 With the Chelator Deferiprone, and Incretin Based Therapy[NCT02882477]Phase 2/Phase 320 participants (Anticipated)Interventional2016-12-31Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

3 other studies available for pioglitazone and Carcinogenesis

ArticleYear
NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth.
    Proceedings of the National Academy of Sciences of the United States of America, 2013, Sep-03, Volume: 110, Issue:36

    Topics: Animals; Breast Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Fema

2013
Breast cancer tumorigenicity is dependent on high expression levels of NAF-1 and the lability of its Fe-S clusters.
    Proceedings of the National Academy of Sciences of the United States of America, 2016, 09-27, Volume: 113, Issue:39

    Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Proliferation;

2016
Pioglitazone, a Peroxisome Proliferator-Activated Receptor γ Agonist, Suppresses Rat Prostate Carcinogenesis.
    International journal of molecular sciences, 2016, Dec-10, Volume: 17, Issue:12

    Topics: Adenocarcinoma; Animals; Body Weight; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Disease

2016