pioglitazone has been researched along with Brain Injuries in 7 studies
Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pioglitazone was administered in a dose of 1mg/kg at 10min after the brain trauma." | 1.42 | A single dose of PPARγ agonist pioglitazone reduces cortical oxidative damage and microglial reaction following lateral fluid percussion brain injury in rats. ( Dolenec, P; Mršić-Pelčić, J; Pilipović, K; Župan, G; Župan, Ž, 2015) |
| "Treatment with Pioglitazone prevented the increase in the number of activated microglia and no difference was observed between sham and Pioglitazone-treated animals." | 1.37 | Pioglitazone attenuates mitochondrial dysfunction, cognitive impairment, cortical tissue loss, and inflammation following traumatic brain injury. ( Bing, G; Gao, J; Liu, M; Pauly, JR; Readnower, R; Sauerbeck, A; Sullivan, PG, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yonutas, HM | 1 |
| Sullivan, PG | 2 |
| Thal, SC | 2 |
| Neuhaus, W | 1 |
| Pilipović, K | 1 |
| Župan, Ž | 1 |
| Dolenec, P | 1 |
| Mršić-Pelčić, J | 1 |
| Župan, G | 1 |
| Qiu, L | 1 |
| Jiang, X | 1 |
| Wen, L | 1 |
| Hu, Q | 1 |
| Deng, Y | 1 |
| Sauerbeck, A | 1 |
| Gao, J | 1 |
| Readnower, R | 1 |
| Liu, M | 1 |
| Pauly, JR | 1 |
| Bing, G | 1 |
| Semple, BD | 1 |
| Noble-Haeusslein, LJ | 1 |
| Heinemann, M | 1 |
| Luh, C | 1 |
| Pieter, D | 1 |
| Werner, C | 1 |
| Engelhard, K | 1 |
2 reviews available for pioglitazone and Brain Injuries
| Article | Year |
|---|---|
Targeting PPAR isoforms following CNS injury.
Topics: Animals; Brain Injuries; Drug Design; Humans; Mitochondrial Proteins; Molecular Targeted Therapy; Ne | 2013 |
The blood-brain barrier as a target in traumatic brain injury treatment.
Topics: Blood-Brain Barrier; Brain Edema; Brain Injuries; Cell Hypoxia; Humans; Hypoglycemic Agents; Inflamm | 2014 |
5 other studies available for pioglitazone and Brain Injuries
| Article | Year |
|---|---|
A single dose of PPARγ agonist pioglitazone reduces cortical oxidative damage and microglial reaction following lateral fluid percussion brain injury in rats.
Topics: Animals; Brain Edema; Brain Injuries; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Dose-Resp | 2015 |
[Pioglitazone decreases the levels of inflammatory cytokines in SD rats with traumatic brain injury via up-regulating PPARγ].
Topics: Animals; Brain Injuries; Dose-Response Relationship, Drug; Gene Expression; Hypoglycemic Agents; Int | 2016 |
Pioglitazone attenuates mitochondrial dysfunction, cognitive impairment, cortical tissue loss, and inflammation following traumatic brain injury.
Topics: Analysis of Variance; Animals; Brain Injuries; CD11b Antigen; Cerebral Cortex; Cognition Disorders; | 2011 |
Broad-spectrum neuroprotection against traumatic brain injury by agonism of peroxisome proliferator-activated receptors.
Topics: Animals; Brain Injuries; Cerebral Cortex; Cognition Disorders; Disease Models, Animal; Encephalitis; | 2011 |
Pioglitazone reduces secondary brain damage after experimental brain trauma by PPAR-γ-independent mechanisms.
Topics: Animals; Brain Damage, Chronic; Brain Injuries; Disease Models, Animal; Hypoglycemic Agents; Male; M | 2011 |