Page last updated: 2024-11-02

pioglitazone and Brain Injuries, Traumatic

pioglitazone has been researched along with Brain Injuries, Traumatic in 5 studies

Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.

Brain Injuries, Traumatic: A form of acquired brain injury which occurs when a sudden trauma causes damage to the brain.

Research Excerpts

ExcerptRelevanceReference
" We then hypothesize that optimal pioglitazone dosing will lead to ongoing neuroprotection and cognitive benefits that are dependent on pioglitazone-mitoNEET signalling pathways."1.62Clinically relevant mitochondrial-targeted therapy improves chronic outcomes after traumatic brain injury. ( Berkowitz, BA; Burden, S; Cloud, AL; Geldenhuys, WJ; Gooch, JL; Harris, NG; Hubbard, WB; Powell, DK; Spry, ML; Sullivan, PG; Vekaria, HJ, 2021)
"Pioglitazone treated TBI rats performed significantly better in the RAM test than untreated TBI rats, and similarly to control animals."1.51Pioglitazone improves working memory performance when administered in chronic TBI. ( Anwar, FN; Correll, EA; Lowery, AC; McCullumsmith, RE; McGuire, JL; Ngwenya, LB; Rhame, K, 2019)
"Traumatic brain injury is a leading cause of death and disability around the world."1.51Pioglitazone treatment prior to transplantation improves the efficacy of human mesenchymal stem cells after traumatic brain injury in rats. ( Das, M; Foran, E; Han, JY; Mayilsamy, K; Mohapatra, S; Mohapatra, SS; Tang, X; Willing, AE, 2019)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (40.00)24.3611
2020's3 (60.00)2.80

Authors

AuthorsStudies
Hubbard, WB2
Spry, ML1
Gooch, JL1
Cloud, AL1
Vekaria, HJ2
Burden, S1
Powell, DK1
Berkowitz, BA1
Geldenhuys, WJ2
Harris, NG1
Sullivan, PG2
Zamanian, MY1
Taheri, N1
Opulencia, MJC1
Bokov, DO1
Abdullaev, SY1
Gholamrezapour, M1
Heidari, M1
Bazmandegan, G1
McGuire, JL1
Correll, EA1
Lowery, AC1
Rhame, K1
Anwar, FN1
McCullumsmith, RE1
Ngwenya, LB1
Das, M1
Mayilsamy, K1
Tang, X1
Han, JY1
Foran, E1
Willing, AE1
Mohapatra, SS1
Mohapatra, S1
Yonutas, HM1
Pandya, JD1

Reviews

1 review available for pioglitazone and Brain Injuries, Traumatic

ArticleYear
Neuroprotective and Anti-inflammatory Effects of Pioglitazone on Traumatic Brain Injury.
    Mediators of inflammation, 2022, Volume: 2022

    Topics: Animals; Anti-Inflammatory Agents; Brain Injuries, Traumatic; Disease Models, Animal; Humans; Microg

2022

Other Studies

4 other studies available for pioglitazone and Brain Injuries, Traumatic

ArticleYear
Clinically relevant mitochondrial-targeted therapy improves chronic outcomes after traumatic brain injury.
    Brain : a journal of neurology, 2021, 12-31, Volume: 144, Issue:12

    Topics: Animals; Brain Injuries, Traumatic; Iron-Binding Proteins; Membrane Proteins; Mice; Mice, Inbred C57

2021
Pioglitazone improves working memory performance when administered in chronic TBI.
    Neurobiology of disease, 2019, Volume: 132

    Topics: Animals; Brain; Brain Injuries, Traumatic; Chronic Disease; Male; Maze Learning; Memory, Short-Term;

2019
Pioglitazone treatment prior to transplantation improves the efficacy of human mesenchymal stem cells after traumatic brain injury in rats.
    Scientific reports, 2019, 09-20, Volume: 9, Issue:1

    Topics: Administration, Intranasal; Animals; Anti-Inflammatory Agents; Brain Injuries, Traumatic; Brain-Deri

2019
Bioenergetic restoration and neuroprotection after therapeutic targeting of mitoNEET: New mechanism of pioglitazone following traumatic brain injury.
    Experimental neurology, 2020, Volume: 327

    Topics: Animals; Brain Injuries, Traumatic; Disease Models, Animal; Energy Metabolism; Iron-Binding Proteins

2020