pioglitazone has been researched along with Brain Edema in 4 studies
Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Present study was carried out to investigate the possible neuroprotective effect of pioglitazone, an antidiabetic agent, peroxisome proliferator-activated receptor gamma (PPARgamma) agonist on acute phase changes in mice model of cerebral ischemia induced by Bilateral Common Carotid artery Occlusion (BCCAO)." | 7.76 | Neuroprotective effect of pioglitazone on acute phase changes induced by partial global cerebral ischemia in mice. ( Aggarwal, R; Chakrabarti, A; Medhi, B, 2010) |
| "Present study was carried out to investigate the possible neuroprotective effect of pioglitazone, an antidiabetic agent, peroxisome proliferator-activated receptor gamma (PPARgamma) agonist on acute phase changes in mice model of cerebral ischemia induced by Bilateral Common Carotid artery Occlusion (BCCAO)." | 3.76 | Neuroprotective effect of pioglitazone on acute phase changes induced by partial global cerebral ischemia in mice. ( Aggarwal, R; Chakrabarti, A; Medhi, B, 2010) |
| "Pioglitazone was administered in a dose of 1mg/kg at 10min after the brain trauma." | 1.42 | A single dose of PPARγ agonist pioglitazone reduces cortical oxidative damage and microglial reaction following lateral fluid percussion brain injury in rats. ( Dolenec, P; Mršić-Pelčić, J; Pilipović, K; Župan, G; Župan, Ž, 2015) |
| "Pioglitazone or vehicle were i." | 1.33 | The intracerebral application of the PPARgamma-ligand pioglitazone confers neuroprotection against focal ischaemia in the rat brain. ( Culman, J; Gohlke, P; Herdegen, T; Patzer, A; Zhao, Y, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thal, SC | 1 |
| Neuhaus, W | 1 |
| Pilipović, K | 1 |
| Župan, Ž | 1 |
| Dolenec, P | 1 |
| Mršić-Pelčić, J | 1 |
| Župan, G | 1 |
| Medhi, B | 1 |
| Aggarwal, R | 1 |
| Chakrabarti, A | 1 |
| Zhao, Y | 1 |
| Patzer, A | 1 |
| Gohlke, P | 1 |
| Herdegen, T | 1 |
| Culman, J | 1 |
1 review available for pioglitazone and Brain Edema
| Article | Year |
|---|---|
The blood-brain barrier as a target in traumatic brain injury treatment.
Topics: Blood-Brain Barrier; Brain Edema; Brain Injuries; Cell Hypoxia; Humans; Hypoglycemic Agents; Inflamm | 2014 |
3 other studies available for pioglitazone and Brain Edema
| Article | Year |
|---|---|
A single dose of PPARγ agonist pioglitazone reduces cortical oxidative damage and microglial reaction following lateral fluid percussion brain injury in rats.
Topics: Animals; Brain Edema; Brain Injuries; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Dose-Resp | 2015 |
Neuroprotective effect of pioglitazone on acute phase changes induced by partial global cerebral ischemia in mice.
Topics: Acute-Phase Reaction; Animals; Antioxidants; Brain Edema; Brain Ischemia; Carotid Artery, Common; Ce | 2010 |
The intracerebral application of the PPARgamma-ligand pioglitazone confers neuroprotection against focal ischaemia in the rat brain.
Topics: Animals; Brain; Brain Edema; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Encephalit | 2005 |