Page last updated: 2024-11-02

pioglitazone and Autism

pioglitazone has been researched along with Autism in 3 studies

Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.

Research Excerpts

ExcerptRelevanceReference
"To assess the safety and efficacy of pioglitazone added to risperidone in the treatment of irritability in autistic disorder (AD), we conducted this study."9.20A pilot double-blind placebo-controlled trial of pioglitazone as adjunctive treatment to risperidone: Effects on aberrant behavior in children with autism. ( Akhondzadeh, S; Farokhnia, M; Ghaleiha, A; Mohammadi, MR; Nikoo, M; Rasa, SM, 2015)
"To assess the safety and efficacy of pioglitazone added to risperidone in the treatment of irritability in autistic disorder (AD), we conducted this study."5.20A pilot double-blind placebo-controlled trial of pioglitazone as adjunctive treatment to risperidone: Effects on aberrant behavior in children with autism. ( Akhondzadeh, S; Farokhnia, M; Ghaleiha, A; Mohammadi, MR; Nikoo, M; Rasa, SM, 2015)
"No effective treatment yet exists for autism."1.48Pioglitazone abolishes autistic-like behaviors via the IL-6 pathway. ( Bernardi, MM; Casarin, RC; Felicio, LF; Kirsten, TB, 2018)
"The exact causes for autism are largely unknown, but is has been speculated that immune and inflammatory responses, particularly those of Th2 type, may be involved."1.34Effect of pioglitazone treatment on behavioral symptoms in autistic children. ( Adams, JB; Boris, M; Edelson, SM; Elice, MW; Feinstein, DL; Goldblatt, A; Kaiser, CC, 2007)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kirsten, TB1
Casarin, RC1
Bernardi, MM1
Felicio, LF1
Ghaleiha, A1
Rasa, SM1
Nikoo, M1
Farokhnia, M1
Mohammadi, MR1
Akhondzadeh, S1
Boris, M1
Kaiser, CC1
Goldblatt, A1
Elice, MW1
Edelson, SM1
Adams, JB1
Feinstein, DL1

Trials

1 trial available for pioglitazone and Autism

ArticleYear
A pilot double-blind placebo-controlled trial of pioglitazone as adjunctive treatment to risperidone: Effects on aberrant behavior in children with autism.
    Psychiatry research, 2015, Sep-30, Volume: 229, Issue:1-2

    Topics: Antipsychotic Agents; Autistic Disorder; Child; Child Behavior Disorders; Child, Preschool; Double-B

2015

Other Studies

2 other studies available for pioglitazone and Autism

ArticleYear
Pioglitazone abolishes autistic-like behaviors via the IL-6 pathway.
    PloS one, 2018, Volume: 13, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Autistic Disorder; Drug Evaluation, Preclinical; Female; Interleu

2018
Effect of pioglitazone treatment on behavioral symptoms in autistic children.
    Journal of neuroinflammation, 2007, Jan-05, Volume: 4

    Topics: Adolescent; Autistic Disorder; Behavioral Symptoms; Child; Child, Preschool; Cohort Studies; Female;

2007