pioglitazone has been researched along with Astrocytoma, Grade IV in 6 studies
Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A phase II trial was initiated to analyze the activity of continuously administered pioglitazone and rofecoxib combined with low-dose chemotherapy (capecitabine or temozolomide) in patients with high-grade gliomas (glioblastoma or anaplastic glioma)." | 5.12 | Low-dose chemotherapy in combination with COX-2 inhibitors and PPAR-gamma agonists in recurrent high-grade gliomas - a phase II study. ( Baumgart, U; Bogdahn, U; Hau, P; Hirschmann, B; Kunz-Schughart, L; Muhleisen, H; Reichle, A; Ruemmele, P; Steinbrecher, A; Weimann, E, 2007) |
| "Furthermore, treatment of fresh glioblastoma tissue from patients with PGZ, either alone or in combination with ATRA, induced a significant level of tumor cell apoptosis together with a downregulation of bcl-2 protein level as compared with untreated control brain tissue." | 1.32 | Ligands for PPARgamma and RAR cause induction of growth inhibition and apoptosis in human glioblastomas. ( Black, KL; Elstner, E; Fenner, MH; Koeffler, HP; Liu, H; Posch, MG; Possinger, K; Stadelmann, C; von Deimling, A; Wächter, M; Zang, C, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Szoka, L | 1 |
| Palka, J | 1 |
| Ching, J | 1 |
| Amiridis, S | 1 |
| Stylli, SS | 1 |
| Bjorksten, AR | 1 |
| Kountouri, N | 1 |
| Zheng, T | 1 |
| Paradiso, L | 1 |
| Luwor, RB | 1 |
| Morokoff, AP | 1 |
| O'Brien, TJ | 1 |
| Kaye, AH | 1 |
| Elmaci, İ | 1 |
| Altinoz, MA | 1 |
| Javadi, S | 1 |
| Ejtemaeimehr, S | 1 |
| Keyvanfar, HR | 1 |
| Moghaddas, P | 1 |
| Aminian, A | 1 |
| Rajabzadeh, A | 1 |
| Mani, AR | 1 |
| Dehpour, AR | 1 |
| Zang, C | 1 |
| Wächter, M | 1 |
| Liu, H | 1 |
| Posch, MG | 1 |
| Fenner, MH | 1 |
| Stadelmann, C | 1 |
| von Deimling, A | 1 |
| Possinger, K | 1 |
| Black, KL | 1 |
| Koeffler, HP | 1 |
| Elstner, E | 1 |
| Hau, P | 1 |
| Kunz-Schughart, L | 1 |
| Bogdahn, U | 1 |
| Baumgart, U | 1 |
| Hirschmann, B | 1 |
| Weimann, E | 1 |
| Muhleisen, H | 1 |
| Ruemmele, P | 1 |
| Steinbrecher, A | 1 |
| Reichle, A | 1 |
1 review available for pioglitazone and Astrocytoma, Grade IV
| Article | Year |
|---|---|
A Metabolic Inhibitory Cocktail for Grave Cancers: Metformin, Pioglitazone and Lithium Combination in Treatment of Pancreatic Cancer and Glioblastoma Multiforme.
Topics: Brain Neoplasms; Cell Proliferation; Drug Therapy, Combination; Gene Expression Regulation, Neoplast | 2016 |
1 trial available for pioglitazone and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Low-dose chemotherapy in combination with COX-2 inhibitors and PPAR-gamma agonists in recurrent high-grade gliomas - a phase II study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Capecitabin | 2007 |
4 other studies available for pioglitazone and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Capsaicin up-regulates pro-apoptotic activity of thiazolidinediones in glioblastoma cell line.
Topics: Apoptosis; Brain Neoplasms; Capsaicin; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Syne | 2020 |
The peroxisome proliferator activated receptor gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino acid transporter 2 (EAAT2) in human glioblastoma cells.
Topics: Anilides; Animals; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dose-Response Relationsh | 2015 |
Pioglitazone potentiates development of morphine-dependence in mice: possible role of NO/cGMP pathway.
Topics: Animals; Cell Line, Tumor; Cyclic AMP; Cyclic GMP; Disease Models, Animal; Enzyme Inhibitors; Gliobl | 2013 |
Ligands for PPARgamma and RAR cause induction of growth inhibition and apoptosis in human glioblastomas.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Brain Neoplasms; Cell Cycle; Cell Divi | 2003 |