pioglitazone has been researched along with Arthritis, Degenerative in 7 studies
Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aims of this study were to assess the anti-degenerative effects of pioglitazone and to compare these effects with those of methylprednisolone and hyaluronic acid on drug-induced osteoarthritis in rabbits' temporomandibular joint cartilage." | 7.83 | Effect of methylprednisolone, hyaluronic acid and pioglitazone on histological remodeling of temporomandibular joint cartilage in rabbits affected by drug-induced osteoarthritis. ( Kałużyński, K; Masiuk, M; Myśliwiec, L; Smektała, T; Sporniak-Tutak, K; Trybek, G, 2016) |
| "To evaluate the in vivo therapeutic effect of pioglitazone, a peroxisome proliferator-activated receptor gamma (PPARgamma) agonist, on the development of lesions in a guinea pig model of osteoarthritis (OA), and to determine the influence of pioglitazone on the synthesis of matrix metalloproteinase 13 (MMP-13) and interleukin-1beta (IL-1beta) in articular cartilage." | 7.73 | Pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, reduces the progression of experimental osteoarthritis in guinea pigs. ( Kobayashi, T; Martel-Pelletier, J; Naito, T; Nakamura, A; Notoya, K; Pelletier, JP; Unno, S, 2005) |
| "Pioglitazone reduced the development of cartilage lesions in a dose-dependent manner, with the highest dosage producing a statistically significant change (P < 0." | 5.34 | The peroxisome proliferator-activated receptor gamma agonist pioglitazone reduces the development of cartilage lesions in an experimental dog model of osteoarthritis: in vivo protective effects mediated through the inhibition of key signaling and cataboli ( Boileau, C; Boily, M; Fahmi, H; Martel-Pelletier, J; Mineau, F; Pelletier, JP, 2007) |
| "The aims of this study were to assess the anti-degenerative effects of pioglitazone and to compare these effects with those of methylprednisolone and hyaluronic acid on drug-induced osteoarthritis in rabbits' temporomandibular joint cartilage." | 3.83 | Effect of methylprednisolone, hyaluronic acid and pioglitazone on histological remodeling of temporomandibular joint cartilage in rabbits affected by drug-induced osteoarthritis. ( Kałużyński, K; Masiuk, M; Myśliwiec, L; Smektała, T; Sporniak-Tutak, K; Trybek, G, 2016) |
| "To evaluate the in vivo therapeutic effect of pioglitazone, a peroxisome proliferator-activated receptor gamma (PPARgamma) agonist, on the development of lesions in a guinea pig model of osteoarthritis (OA), and to determine the influence of pioglitazone on the synthesis of matrix metalloproteinase 13 (MMP-13) and interleukin-1beta (IL-1beta) in articular cartilage." | 3.73 | Pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, reduces the progression of experimental osteoarthritis in guinea pigs. ( Kobayashi, T; Martel-Pelletier, J; Naito, T; Nakamura, A; Notoya, K; Pelletier, JP; Unno, S, 2005) |
| "Pioglitazone reduced the development of cartilage lesions in a dose-dependent manner, with the highest dosage producing a statistically significant change (P < 0." | 1.34 | The peroxisome proliferator-activated receptor gamma agonist pioglitazone reduces the development of cartilage lesions in an experimental dog model of osteoarthritis: in vivo protective effects mediated through the inhibition of key signaling and cataboli ( Boileau, C; Boily, M; Fahmi, H; Martel-Pelletier, J; Mineau, F; Pelletier, JP, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, J | 1 |
| Xu, W | 1 |
| Dai, T | 1 |
| Jiao, S | 1 |
| Xue, X | 1 |
| Jiang, J | 1 |
| Li, S | 1 |
| Meng, Q | 1 |
| Ding, LB | 1 |
| Li, Y | 1 |
| Liu, GY | 1 |
| Li, TH | 1 |
| Li, F | 1 |
| Guan, J | 1 |
| Wang, HJ | 1 |
| Kałużyński, K | 1 |
| Trybek, G | 1 |
| Smektała, T | 1 |
| Masiuk, M | 1 |
| Myśliwiec, L | 1 |
| Sporniak-Tutak, K | 1 |
| Zhang, HB | 1 |
| Zhang, Y | 2 |
| Chen, C | 2 |
| Li, YQ | 1 |
| Ma, C | 1 |
| Wang, ZJ | 1 |
| Yang, Q | 1 |
| Wu, S | 1 |
| Mao, X | 1 |
| Wang, W | 1 |
| Kobayashi, T | 1 |
| Notoya, K | 1 |
| Naito, T | 1 |
| Unno, S | 1 |
| Nakamura, A | 1 |
| Martel-Pelletier, J | 2 |
| Pelletier, JP | 2 |
| Boileau, C | 1 |
| Fahmi, H | 1 |
| Mineau, F | 1 |
| Boily, M | 1 |
7 other studies available for pioglitazone and Arthritis, Degenerative
| Article | Year |
|---|---|
Pioglitazone-Loaded Cartilage-Targeted Nanomicelles (Pio@C-HA-DOs) for Osteoarthritis Treatment.
Topics: Animals; Cartilage, Articular; Chondrocytes; Hyaluronic Acid; Hydrogen Peroxide; Osteoarthritis; Pio | 2023 |
Long non-coding RNA PVT1, a molecular sponge of miR-26b, is involved in the progression of hyperglycemia-induced collagen degradation in human chondrocytes by targeting CTGF/TGF-
Topics: Aged; Cartilage; Chondrocytes; Collagen; Connective Tissue Growth Factor; Diabetes Mellitus; Female; | 2020 |
Effect of methylprednisolone, hyaluronic acid and pioglitazone on histological remodeling of temporomandibular joint cartilage in rabbits affected by drug-induced osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents; Cartilage, Articular; Hyaluronic Acid; Injections, Intra-Articula | 2016 |
Pioglitazone inhibits advanced glycation end product-induced matrix metalloproteinases and apoptosis by suppressing the activation of MAPK and NF-κB.
Topics: Animals; Apoptosis; Caspase 3; Chondrocytes; Glycation End Products, Advanced; Humans; Male; MAP Kin | 2016 |
Advanced glycation end products downregulates peroxisome proliferator-activated receptor γ expression in cultured rabbit chondrocyte through MAPK pathway.
Topics: Animals; Cartilage, Articular; Cells, Cultured; Chondrocytes; Enzyme Activation; Gene Expression Reg | 2010 |
Pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, reduces the progression of experimental osteoarthritis in guinea pigs.
Topics: Administration, Oral; Animals; Cartilage, Articular; Collagenases; Disease Models, Animal; Disease P | 2005 |
The peroxisome proliferator-activated receptor gamma agonist pioglitazone reduces the development of cartilage lesions in an experimental dog model of osteoarthritis: in vivo protective effects mediated through the inhibition of key signaling and cataboli
Topics: Animals; Cartilage; Disease Models, Animal; Dogs; Femur; Hypoglycemic Agents; Osteoarthritis; Piogli | 2007 |