Page last updated: 2024-11-02

pioglitazone and Aortic Incompetence

pioglitazone has been researched along with Aortic Incompetence in 2 studies

Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.

Research Excerpts

ExcerptRelevanceReference
"Treatment with pioglitazone prevented abnormal valve calcification, but did not protect valve function."1.42Spontaneous Aortic Regurgitation and Valvular Cardiomyopathy in Mice. ( Baumbach, GL; Brooks, RM; Chen, B; Chu, Y; Davis, MK; Doshi, H; El Accaoui, RN; Funk, ND; Hajj, GP; Hameed, T; Heistad, DD; Leinwand, LA; Lund, DD; Magida, JA; Song, LS; Weiss, RM; Zimmerman, KA, 2015)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (50.00)24.3611
2020's1 (50.00)2.80

Authors

AuthorsStudies
Assmann, AK1
Goschmer, D1
Sugimura, Y1
Chekhoeva, A1
Barth, M1
Assmann, A1
Lichtenberg, A1
Akhyari, P1
Hajj, GP1
Chu, Y1
Lund, DD1
Magida, JA1
Funk, ND1
Brooks, RM1
Baumbach, GL1
Zimmerman, KA1
Davis, MK1
El Accaoui, RN1
Hameed, T1
Doshi, H1
Chen, B1
Leinwand, LA1
Song, LS1
Heistad, DD1
Weiss, RM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Pioglitazone Treatment in Patient's Calcific Aortic Valve Disease With Mild Aortic Valve Stenosis[NCT05875675]Phase 2100 participants (Anticipated)Interventional2023-07-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

2 other studies available for pioglitazone and Aortic Incompetence

ArticleYear
A Role for Peroxisome Proliferator-Activated Receptor Gamma Agonists in Counteracting the Degeneration of Cardiovascular Grafts.
    Journal of cardiovascular pharmacology, 2021, 10-15, Volume: 79, Issue:1

    Topics: Animals; Aortic Valve; Aortic Valve Insufficiency; Bioprosthesis; Calcinosis; Chondrogenesis; Cryopr

2021
Spontaneous Aortic Regurgitation and Valvular Cardiomyopathy in Mice.
    Arteriosclerosis, thrombosis, and vascular biology, 2015, Volume: 35, Issue:7

    Topics: Actins; Animals; Aortic Valve; Aortic Valve Insufficiency; Calcinosis; Cell Death; Disease Progressi

2015