pioglitazone has been researched along with Alcohol Drinking in 8 studies
Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
Alcohol Drinking: Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We showed that activation of PPARγ receptors by pioglitazone (0, 10, and 30 mg/kg) and rosiglitazone (0, 10 and 30 mg/kg) given orally selectively reduced alcohol drinking." | 7.77 | Activation of nuclear PPARγ receptors by the antidiabetic agent pioglitazone suppresses alcohol drinking and relapse to alcohol seeking. ( Braconi, S; Cannella, N; Ciccocioppo, R; Cippitelli, A; Demopulos, G; Gaitanaris, G; Heilig, M; Kallupi, M; Massi, M; Ruggeri, B; Somaini, L; Stopponi, S, 2011) |
| "Pioglitazone is a selective peroxisome proliferator-activated receptor γ (PPARγ) agonist used for the treatment of insulin resistance and type 2 diabetes." | 5.39 | Activation of PPARγ by pioglitazone potentiates the effects of naltrexone on alcohol drinking and relapse in msP rats. ( Cannella, N; Ciccocioppo, R; Cippitelli, A; de Guglielmo, G; Demopulos, G; Gaitanaris, G; Heilig, M; Kallupi, M; Somaini, L; Stopponi, S; Ubaldi, M, 2013) |
| "Peroxisome proliferator-activated receptor γ (PPARγ) is an intracellular transcription factor whose signaling activation by the selective agonist pioglitazone reduces alcohol drinking and alcohol-seeking behavior in rats." | 4.02 | Activation of peroxisome proliferator-activated receptor γ reduces alcohol drinking and seeking by modulating multiple mesocorticolimbic regions in rats. ( Benvenuti, F; Borruto, AM; Ciccocioppo, R; Demopulos, G; Fotio, Y; Gaitanaris, G; Roberto, M, 2021) |
| " Recent studies support a role of PPARs in alcoholism and pioglitazone: a PPARγ agonist used for treatment of type 2 diabetes showed efficacy in reducing alcohol drinking, stress-induced relapse, and alcohol withdrawal syndrome in rats." | 3.96 | Further evidence for the involvement of the PPARγ system on alcohol intake and sensitivity in rodents. ( Ciccocioppo, R; Demopulos, G; Domi, A; Domi, E; Gaitanaris, G; Somaini, L; Ubaldi, M, 2020) |
| "We showed that activation of PPARγ receptors by pioglitazone (0, 10, and 30 mg/kg) and rosiglitazone (0, 10 and 30 mg/kg) given orally selectively reduced alcohol drinking." | 3.77 | Activation of nuclear PPARγ receptors by the antidiabetic agent pioglitazone suppresses alcohol drinking and relapse to alcohol seeking. ( Braconi, S; Cannella, N; Ciccocioppo, R; Cippitelli, A; Demopulos, G; Gaitanaris, G; Heilig, M; Kallupi, M; Massi, M; Ruggeri, B; Somaini, L; Stopponi, S, 2011) |
| " This study aimed to examine if pioglitazone, an antidiabetic reagent serving as a ligand of peroxisome proliferator-activated receptor gamma (PPAR gamma), could prevent alcoholic fatty liver." | 3.72 | Pioglitazone prevents alcohol-induced fatty liver in rats through up-regulation of c-Met. ( Azuma, T; Inokuchi, S; Ishii, H; Kitamura, N; Nishida, J; Nishimura, T; Oka, A; Suematsu, M; Tamiya, G; Tomita, K, 2004) |
| "Pioglitazone is a selective peroxisome proliferator-activated receptor γ (PPARγ) agonist used for the treatment of insulin resistance and type 2 diabetes." | 1.39 | Activation of PPARγ by pioglitazone potentiates the effects of naltrexone on alcohol drinking and relapse in msP rats. ( Cannella, N; Ciccocioppo, R; Cippitelli, A; de Guglielmo, G; Demopulos, G; Gaitanaris, G; Heilig, M; Kallupi, M; Somaini, L; Stopponi, S; Ubaldi, M, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 3 (37.50) | 2.80 |
| Authors | Studies |
|---|---|
| Fotio, Y | 1 |
| Borruto, AM | 1 |
| Benvenuti, F | 1 |
| Demopulos, G | 4 |
| Gaitanaris, G | 4 |
| Roberto, M | 1 |
| Ciccocioppo, R | 4 |
| Domi, E | 1 |
| Domi, A | 1 |
| Ubaldi, M | 2 |
| Somaini, L | 3 |
| Dieperink, E | 1 |
| Hauser, P | 1 |
| Dockter, K | 1 |
| Miranda, J | 1 |
| Evenson, M | 1 |
| Thuras, P | 1 |
| Banini, BA | 1 |
| Sanyal, AJ | 1 |
| Stopponi, S | 2 |
| de Guglielmo, G | 1 |
| Cippitelli, A | 2 |
| Cannella, N | 2 |
| Kallupi, M | 2 |
| Heilig, M | 2 |
| Blednov, YA | 1 |
| Benavidez, JM | 1 |
| Black, M | 1 |
| Ferguson, LB | 1 |
| Schoenhard, GL | 1 |
| Goate, AM | 1 |
| Edenberg, HJ | 1 |
| Wetherill, L | 1 |
| Hesselbrock, V | 1 |
| Foroud, T | 1 |
| Harris, RA | 1 |
| Braconi, S | 1 |
| Ruggeri, B | 1 |
| Massi, M | 1 |
| Tomita, K | 1 |
| Azuma, T | 1 |
| Kitamura, N | 1 |
| Nishida, J | 1 |
| Tamiya, G | 1 |
| Oka, A | 1 |
| Inokuchi, S | 1 |
| Nishimura, T | 1 |
| Suematsu, M | 1 |
| Ishii, H | 1 |
8 other studies available for pioglitazone and Alcohol Drinking
| Article | Year |
|---|---|
Activation of peroxisome proliferator-activated receptor γ reduces alcohol drinking and seeking by modulating multiple mesocorticolimbic regions in rats.
Topics: Alcohol Drinking; Animals; Nucleus Accumbens; Pioglitazone; PPAR gamma; Rats; Self Administration; V | 2021 |
Further evidence for the involvement of the PPARγ system on alcohol intake and sensitivity in rodents.
Topics: Alcohol Drinking; Anilides; Animals; Dose-Response Relationship, Drug; Ethanol; Male; Mice; Mice, In | 2020 |
Reduced alcohol use in patients prescribed pioglitazone.
Topics: Alcohol Drinking; Alcoholism; Humans; Pioglitazone; Veterans | 2021 |
Treatment of NASH: What Helps Beyond Weight Loss?
Topics: Alcohol Drinking; Comorbidity; Diagnosis, Differential; Diagnostic Imaging; Disease Progression; Hum | 2017 |
Activation of PPARγ by pioglitazone potentiates the effects of naltrexone on alcohol drinking and relapse in msP rats.
Topics: Alcohol Drinking; Animals; Cues; Drug Evaluation, Preclinical; Drug Therapy, Combination; Hypoglycem | 2013 |
Peroxisome proliferator-activated receptors α and γ are linked with alcohol consumption in mice and withdrawal and dependence in humans.
Topics: Adult; Alcohol Drinking; Alcoholism; Alkanesulfonates; Animals; Bezafibrate; Brain; Female; Fenofibr | 2015 |
Activation of nuclear PPARγ receptors by the antidiabetic agent pioglitazone suppresses alcohol drinking and relapse to alcohol seeking.
Topics: Adrenergic alpha-2 Receptor Antagonists; Alcohol Drinking; Alcohols; Analysis of Variance; Anilides; | 2011 |
Pioglitazone prevents alcohol-induced fatty liver in rats through up-regulation of c-Met.
Topics: Alcohol Drinking; Animals; Apolipoproteins B; CCAAT-Enhancer-Binding Proteins; Cells, Cultured; DNA; | 2004 |