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pioglitazone and Age-Related Memory Disorders

pioglitazone has been researched along with Age-Related Memory Disorders in 22 studies

Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.

Research Excerpts

ExcerptRelevanceReference
"The present study was undertaken to investigate possible mechanism of pioglitazone-induced beneficial effect in memory deficits associated with experimental dementia."7.75Exploring mechanism of pioglitazone-induced memory restorative effect in experimental dementia. ( Jaggi, AS; Kaur, B; Singh, N, 2009)
"Pioglitazone is a peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist and is widely used to treat type 2 diabetes."5.51Low-dose pioglitazone can ameliorate learning and memory impairment in a mouse model of dementia by increasing LRP1 expression in the hippocampus. ( Cha, BS; Kang, ES; Kim, E; Lee, BW; Lee, HC; Lee, M; Lee, PH; Lee, YH; Moon, JH; Seok, H; Shin, E; Yun, MR, 2019)
"Pioglitazone was given at the dose of 10mg/kgd by gavage for the last 12weeks of the 16-week period."5.36Effect of pioglitazone on insulin resistance in fructose-drinking rats correlates with AGEs/RAGE inhibition and block of NADPH oxidase and NF kappa B activation. ( Hao, Y; Hou, L; Liu, X; Luo, D; Zhang, S; Zheng, M, 2010)
"Accumulating evidence indicates that elevated levels of methionine are associated with cognitive decline, including loss of memory."4.12The Protective Effects of Pioglitazone Against Cognitive Impairment Caused by L-methionine Administration in a Rat Model. ( Al-Azzam, SI; Alfaqih, M; Alrabadi, N; Alzoubi, KH; Khabour, OF; Mhaidat, NM; Tashtoush, M, 2022)
"The present study was undertaken to investigate possible mechanism of pioglitazone-induced beneficial effect in memory deficits associated with experimental dementia."3.75Exploring mechanism of pioglitazone-induced memory restorative effect in experimental dementia. ( Jaggi, AS; Kaur, B; Singh, N, 2009)
"Patients diagnosed with fetal alcohol spectrum disorder (FASD) show persistent cognitive disabilities, including memory deficits."1.91The role of PPAR-γ in memory deficits induced by prenatal and lactation alcohol exposure in mice. ( de la Torre, R; Gallego-Landin, I; Garcia-Baos, A; Pastor, A; Sanz, F; Valverde, O, 2023)
"Treatment with fenofibrate, pioglitazone and their combination resulted in a significant improvement in the behavioural and neurochemical changes induced by βA injection."1.56Neuroprotective effect of PPAR alpha and gamma agonists in a mouse model of amyloidogenesis through modulation of the Wnt/beta catenin pathway via targeting alpha- and beta-secretases. ( Assaf, N; El Sayed, NS; El-Shamarka, ME; Khadrawy, YA; Salem, NA, 2020)
"Pioglitazone is a peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist and is widely used to treat type 2 diabetes."1.51Low-dose pioglitazone can ameliorate learning and memory impairment in a mouse model of dementia by increasing LRP1 expression in the hippocampus. ( Cha, BS; Kang, ES; Kim, E; Lee, BW; Lee, HC; Lee, M; Lee, PH; Lee, YH; Moon, JH; Seok, H; Shin, E; Yun, MR, 2019)
"Insulin resistance is known to be a risk factor for cognitive impairment, most likely linked to insulin signaling, microglia overactivation, and beta amyloid (Aβ) deposition in the brain."1.43Pioglitazone and exenatide enhance cognition and downregulate hippocampal beta amyloid oligomer and microglia expression in insulin-resistant rats. ( Gad, ES; Moustafa, YM; Zaitone, SA, 2016)
" The current study was carried out to investigate the effects of chronic administration of pioglitazone, a PPAR-γ agonist, on cognitive impairment in an animal model of Alzheimer's disease induced by β-amyloid."1.40Role of nuclear receptor on regulation of BDNF and neuroinflammation in hippocampus of β-amyloid animal model of Alzheimer's disease. ( Kumar, A; Prakash, A, 2014)
"Pioglitazone ameliorates memory deficits in STZ-induced diabetic mice by reducing brain Aβ level via activation of PPARγ, which is independent of its effects on blood glucose and insulin levels."1.39Pioglitazone ameliorates memory deficits in streptozotocin-induced diabetic mice by reducing brain β-amyloid through PPARγ activation. ( Hong, H; Hu, M; Hu, W; Jiang, LY; Li, YQ; Liu, LP; Long, Y; Wang, C; Wang, JQ; Yan, TH; Zhang, Q, 2013)
"Pioglitazone was also investigated for its effects on parameters of oxidative stress by measuring malondialdehyde (MDA) and reduced glutathione (GSH) levels in the brain."1.38Improvement in long term and visuo-spatial memory following chronic pioglitazone in mouse model of Alzheimer's disease. ( Gupta, LK; Gupta, R, 2012)
"2) Treatment with pioglitazone significantly improved the memory performance in morphine-treated mice in both tests."1.38Involvement of nitric oxide in pioglitazone memory improvement in morphine-induced memory impaired mice. ( Almasi-Nasrabadi, M; Babaei, R; Dehpour, AR; Javadi-Paydar, M; Mahdavian, S; Norouzi, A; Sharifian, M, 2012)
"Pioglitazone was given at the dose of 10mg/kgd by gavage for the last 12weeks of the 16-week period."1.36Effect of pioglitazone on insulin resistance in fructose-drinking rats correlates with AGEs/RAGE inhibition and block of NADPH oxidase and NF kappa B activation. ( Hao, Y; Hou, L; Liu, X; Luo, D; Zhang, S; Zheng, M, 2010)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (9.09)29.6817
2010's17 (77.27)24.3611
2020's3 (13.64)2.80

Authors

AuthorsStudies
Garcia-Baos, A1
Pastor, A1
Gallego-Landin, I1
de la Torre, R1
Sanz, F1
Valverde, O1
Assaf, N1
El-Shamarka, ME1
Salem, NA1
Khadrawy, YA1
El Sayed, NS1
Alzoubi, KH1
Khabour, OF1
Alfaqih, M1
Tashtoush, M1
Al-Azzam, SI1
Mhaidat, NM1
Alrabadi, N1
Silva-Abreu, M1
Calpena, AC1
Andrés-Benito, P1
Aso, E1
Romero, IA1
Roig-Carles, D1
Gromnicova, R1
Espina, M1
Ferrer, I1
García, ML1
Male, D1
Seok, H1
Lee, M1
Shin, E1
Yun, MR1
Lee, YH1
Moon, JH1
Kim, E1
Lee, PH1
Lee, BW1
Kang, ES1
Lee, HC1
Cha, BS1
Liu, LP2
Yan, TH1
Jiang, LY3
Hu, W2
Hu, M3
Wang, C2
Zhang, Q1
Long, Y2
Wang, JQ1
Li, YQ1
Hong, H3
Prakash, A3
Kumar, A3
Ming, LC1
Mani, V1
Majeed, AB1
Gad, ES1
Zaitone, SA1
Moustafa, YM1
Kaur, B1
Singh, N1
Jaggi, AS1
Liu, X1
Luo, D1
Zheng, M1
Hao, Y1
Hou, L1
Zhang, S1
Allami, N1
Javadi-Paydar, M3
Rayatnia, F1
Sehhat, K1
Rahimian, R1
Norouzi, A3
Dehpour, AR3
Ponce-Lopez, T1
Liy-Salmeron, G1
Hong, E1
Meneses, A1
Xiang, GQ1
Tang, SS2
Li, Q1
Wang, XY2
Zhang, TT1
Yin, L1
Almasi-Nasrabadi, M2
Mahdavian, S2
Babaei, R2
Sharifian, M2
Gupta, R1
Gupta, LK1
Liao, MX1
Ding, QL1
Li, JC1
Suge, R1
Shimazu, T1
Hasegawa, H1
Inoue, I1
Hayashibe, H1
Nagasaka, H1
Araki, N1
Katayama, S1
Nomura, M1
Watanabe, S1
Rahigude, A1
Bhutada, P1
Kaulaskar, S1
Aswar, M1
Otari, K1
Pathan, AR1
Viswanad, B1
Sonkusare, SK1
Ramarao, P1

Other Studies

22 other studies available for pioglitazone and Age-Related Memory Disorders

ArticleYear
The role of PPAR-γ in memory deficits induced by prenatal and lactation alcohol exposure in mice.
    Molecular psychiatry, 2023, Volume: 28, Issue:8

    Topics: Animals; Child; Female; Fetal Alcohol Spectrum Disorders; Humans; Lactation; Memory Disorders; Mice;

2023
Neuroprotective effect of PPAR alpha and gamma agonists in a mouse model of amyloidogenesis through modulation of the Wnt/beta catenin pathway via targeting alpha- and beta-secretases.
    Progress in neuro-psychopharmacology & biological psychiatry, 2020, 03-08, Volume: 97

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Cognitive D

2020
The Protective Effects of Pioglitazone Against Cognitive Impairment Caused by L-methionine Administration in a Rat Model.
    CNS & neurological disorders drug targets, 2022, Volume: 21, Issue:1

    Topics: Animals; Antioxidants; Cognitive Dysfunction; Hippocampus; Hypoglycemic Agents; Male; Maze Learning;

2022
PPARγ agonist-loaded PLGA-PEG nanocarriers as a potential treatment for Alzheimer's disease: in vitro and in vivo studies.
    International journal of nanomedicine, 2018, Volume: 13

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Blood-Brain Barrier; Cells, Cultured; Di

2018
Low-dose pioglitazone can ameliorate learning and memory impairment in a mouse model of dementia by increasing LRP1 expression in the hippocampus.
    Scientific reports, 2019, 03-13, Volume: 9, Issue:1

    Topics: Amyloid beta-Peptides; Animals; Dementia; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay;

2019
Pioglitazone ameliorates memory deficits in streptozotocin-induced diabetic mice by reducing brain β-amyloid through PPARγ activation.
    Acta pharmacologica Sinica, 2013, Volume: 34, Issue:4

    Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals

2013
Pioglitazone alleviates the mitochondrial apoptotic pathway and mito-oxidative damage in the d-galactose-induced mouse model.
    Clinical and experimental pharmacology & physiology, 2013, Volume: 40, Issue:9

    Topics: Acetylcholinesterase; Aging; Animals; Antioxidants; Apoptosis; Behavior, Animal; Brain; Caspase 3; C

2013
Role of nuclear receptor on regulation of BDNF and neuroinflammation in hippocampus of β-amyloid animal model of Alzheimer's disease.
    Neurotoxicity research, 2014, Volume: 25, Issue:4

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain-Derived Neurotrophic Factor; Cognition Diso

2014
Modulation of the Nitrergic Pathway via Activation of PPAR-γ Contributes to the Neuroprotective Effect of Pioglitazone Against Streptozotocin-Induced Memory Dysfunction.
    Journal of molecular neuroscience : MN, 2015, Volume: 56, Issue:3

    Topics: Animals; Antioxidants; Apoptosis; Caspase 3; Interleukin-6; Male; Memory Disorders; Neuroprotective

2015
Pioglitazone and exenatide enhance cognition and downregulate hippocampal beta amyloid oligomer and microglia expression in insulin-resistant rats.
    Canadian journal of physiology and pharmacology, 2016, Volume: 94, Issue:8

    Topics: Amyloid beta-Peptides; Animals; Cognition; Down-Regulation; Drug Therapy, Combination; Exenatide; Fr

2016
Exploring mechanism of pioglitazone-induced memory restorative effect in experimental dementia.
    Fundamental & clinical pharmacology, 2009, Volume: 23, Issue:5

    Topics: Acetylcholinesterase; Animals; Blood Glucose; Brain; Dementia; Disease Models, Animal; Glutathione;

2009
Effect of pioglitazone on insulin resistance in fructose-drinking rats correlates with AGEs/RAGE inhibition and block of NADPH oxidase and NF kappa B activation.
    European journal of pharmacology, 2010, Mar-10, Volume: 629, Issue:1-3

    Topics: Animals; Brain; Drinking; Fructose; Gene Expression Regulation, Enzymologic; Glycation End Products,

2010
Suppression of nitric oxide synthesis by L-NAME reverses the beneficial effects of pioglitazone on scopolamine-induced memory impairment in mice.
    European journal of pharmacology, 2011, Jan-10, Volume: 650, Issue:1

    Topics: Animals; Drug Interactions; Maze Learning; Memory Disorders; Memory, Short-Term; Mice; Motor Activit

2011
Lithium, phenserine, memantine and pioglitazone reverse memory deficit and restore phospho-GSK3β decreased in hippocampus in intracerebroventricular streptozotocin induced memory deficit model.
    Brain research, 2011, Dec-02, Volume: 1426

    Topics: Animals; Conditioning, Classical; Disease Models, Animal; Enzyme Inhibitors; Glycogen Synthase Kinas

2011
PPARγ agonist pioglitazone improves scopolamine-induced memory impairment in mice.
    The Journal of pharmacy and pharmacology, 2012, Volume: 64, Issue:4

    Topics: Administration, Oral; Alzheimer Disease; Animals; Avoidance Learning; Cerebral Cortex; Disease Model

2012
Involvement of NMDA receptors in the beneficial effects of pioglitazone on scopolamine-induced memory impairment in mice.
    Behavioural brain research, 2012, May-16, Volume: 231, Issue:1

    Topics: Animals; Avoidance Learning; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hypoglycemic Ag

2012
Improvement in long term and visuo-spatial memory following chronic pioglitazone in mouse model of Alzheimer's disease.
    Pharmacology, biochemistry, and behavior, 2012, Volume: 102, Issue:2

    Topics: Alzheimer Disease; Animals; Blood Glucose; Body Weight; Disease Models, Animal; Male; Maze Learning;

2012
PPARγ agonist pioglitazone reverses memory impairment and biochemical changes in a mouse model of type 2 diabetes mellitus.
    CNS neuroscience & therapeutics, 2012, Volume: 18, Issue:8

    Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases;

2012
Involvement of nitric oxide in pioglitazone memory improvement in morphine-induced memory impaired mice.
    Pharmacology, biochemistry, and behavior, 2012, Volume: 103, Issue:2

    Topics: Animals; Avoidance Learning; Dose-Response Relationship, Drug; Fear; Male; Maze Learning; Memory Dis

2012
Cerebral antioxidant enzyme increase associated with learning deficit in type 2 diabetes rats.
    Brain research, 2012, Oct-24, Volume: 1481

    Topics: Adiponectin; Animals; Antioxidants; Brain; Cerebral Cortex; Conditioning, Operant; Corpus Striatum;

2012
Participation of antioxidant and cholinergic system in protective effect of naringenin against type-2 diabetes-induced memory dysfunction in rats.
    Neuroscience, 2012, Dec-13, Volume: 226

    Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Cholinesterase Inhibitors; Cholinesterases; Diabe

2012
Chronic administration of pioglitazone attenuates intracerebroventricular streptozotocin induced-memory impairment in rats.
    Life sciences, 2006, Nov-02, Volume: 79, Issue:23

    Topics: Administration, Oral; Aging; Animals; Antibiotics, Antineoplastic; Brain Chemistry; Cognition; Demen

2006