pioglitazone has been researched along with Adrenal Hyperplasia, Congenital in 2 studies
Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
Adrenal Hyperplasia, Congenital: A group of inherited disorders of the ADRENAL GLANDS, caused by enzyme defects in the synthesis of cortisol (HYDROCORTISONE) and/or ALDOSTERONE leading to accumulation of precursors for ANDROGENS. Depending on the hormone imbalance, congenital adrenal hyperplasia can be classified as salt-wasting, hypertensive, virilizing, or feminizing. Defects in STEROID 21-HYDROXYLASE; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; 3-beta-hydroxysteroid dehydrogenase (3-HYDROXYSTEROID DEHYDROGENASES); TESTOSTERONE 5-ALPHA-REDUCTASE; or steroidogenic acute regulatory protein; among others, underlie these disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess insulin sensitivity in CAH patients and the effect of pioglitazone treatment on insulin sensitivity in CAH patients." | 9.14 | Pioglitazone improves insulin resistance and decreases blood pressure in adult patients with congenital adrenal hyperplasia. ( Hermus, AR; Kroese, JM; Mooij, CF; Tack, CJ; van der Graaf, M, 2009) |
| "To assess insulin sensitivity in CAH patients and the effect of pioglitazone treatment on insulin sensitivity in CAH patients." | 5.14 | Pioglitazone improves insulin resistance and decreases blood pressure in adult patients with congenital adrenal hyperplasia. ( Hermus, AR; Kroese, JM; Mooij, CF; Tack, CJ; van der Graaf, M, 2009) |
| "After both placebo and pioglitazone treatment, insulin sensitivity was determined by hyperinsulinemic euglycemic clamp and abdominal sc adipose tissue was obtained to measure adipocyte cell surface and expression of genes involved in glucose uptake and inflammation." | 5.14 | Pioglitazone treatment enlarges subcutaneous adipocytes in insulin-resistant patients. ( de Graaf, J; Hermus, AR; Koenen, TB; Kroese, JM; Stalenhoef, AF; Stienstra, R; Sweep, FC; Tack, CJ; van der Laak, J; van Tits, LJ, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kroese, JM | 2 |
| Mooij, CF | 1 |
| van der Graaf, M | 1 |
| Hermus, AR | 2 |
| Tack, CJ | 2 |
| Koenen, TB | 1 |
| Sweep, FC | 1 |
| van der Laak, J | 1 |
| Stalenhoef, AF | 1 |
| de Graaf, J | 1 |
| van Tits, LJ | 1 |
| Stienstra, R | 1 |
2 trials available for pioglitazone and Adrenal Hyperplasia, Congenital
| Article | Year |
|---|---|
Pioglitazone improves insulin resistance and decreases blood pressure in adult patients with congenital adrenal hyperplasia.
Topics: Adipose Tissue; Adrenal Hyperplasia, Congenital; Adult; Blood Pressure; Cross-Over Studies; Female; | 2009 |
Pioglitazone treatment enlarges subcutaneous adipocytes in insulin-resistant patients.
Topics: Adipocytes; Adrenal Hyperplasia, Congenital; Adult; Cross-Over Studies; Glucose Clamp Technique; Hum | 2009 |