pioglitazone has been researched along with Acute Lung Injury in 3 studies
Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
Acute Lung Injury: A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate whether the PPARgamma ligand pioglitazone (PGZ) inhibited bleomycin (BLM)-induced acute lung injury and subsequent fibrosis." | 7.75 | Pioglitazone, a peroxisome proliferator-activated receptor gamma ligand, suppresses bleomycin-induced acute lung injury and fibrosis. ( Aoki, F; Aoki, N; Aoki, Y; Aoyagi, K; Arai, M; Kurabayashi, M; Maeno, T; Nakagawa, J; Sando, Y; Shimizu, Y; Suga, T; Ueno, M, 2009) |
| "Pioglitazone treatment before or after induction of ALI significantly diminished alveolar (reduction by 73% and 67%, respectively) and interstitial neutrophil influx (reduction by 55% and 63%, respectively) and reduced lung permeability changes (reduction by 64% and 58%, respectively) indicating a protective role of pioglitazone treatment in ALI." | 5.38 | Pioglitazone attenuates endotoxin-induced acute lung injury by reducing neutrophil recruitment. ( Grommes, J; Mörgelin, M; Soehnlein, O, 2012) |
| "Pioglitazone effectively prevents lung injury caused by CLP-induced sepsis by maintaining the anti-inflammatory status of visceral adipose tissue." | 3.80 | Pioglitazone attenuates lung injury by modulating adipose inflammation. ( Kobayashi, M; Kutsukake, M; Matsuda, A; Matsutani, T; Tachikawa, E; Tamura, K; Uchida, E, 2014) |
| "To investigate whether the PPARgamma ligand pioglitazone (PGZ) inhibited bleomycin (BLM)-induced acute lung injury and subsequent fibrosis." | 3.75 | Pioglitazone, a peroxisome proliferator-activated receptor gamma ligand, suppresses bleomycin-induced acute lung injury and fibrosis. ( Aoki, F; Aoki, N; Aoki, Y; Aoyagi, K; Arai, M; Kurabayashi, M; Maeno, T; Nakagawa, J; Sando, Y; Shimizu, Y; Suga, T; Ueno, M, 2009) |
| "Pioglitazone treatment before or after induction of ALI significantly diminished alveolar (reduction by 73% and 67%, respectively) and interstitial neutrophil influx (reduction by 55% and 63%, respectively) and reduced lung permeability changes (reduction by 64% and 58%, respectively) indicating a protective role of pioglitazone treatment in ALI." | 1.38 | Pioglitazone attenuates endotoxin-induced acute lung injury by reducing neutrophil recruitment. ( Grommes, J; Mörgelin, M; Soehnlein, O, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kutsukake, M | 1 |
| Matsutani, T | 1 |
| Tamura, K | 1 |
| Matsuda, A | 1 |
| Kobayashi, M | 1 |
| Tachikawa, E | 1 |
| Uchida, E | 1 |
| Aoki, Y | 1 |
| Maeno, T | 1 |
| Aoyagi, K | 1 |
| Ueno, M | 1 |
| Aoki, F | 1 |
| Aoki, N | 1 |
| Nakagawa, J | 1 |
| Sando, Y | 1 |
| Shimizu, Y | 1 |
| Suga, T | 1 |
| Arai, M | 1 |
| Kurabayashi, M | 1 |
| Grommes, J | 1 |
| Mörgelin, M | 1 |
| Soehnlein, O | 1 |
3 other studies available for pioglitazone and Acute Lung Injury
| Article | Year |
|---|---|
Pioglitazone attenuates lung injury by modulating adipose inflammation.
Topics: Acute Lung Injury; Adipose Tissue; Animals; Apoptosis; Disease Models, Animal; Endotoxins; Hypoglyce | 2014 |
Pioglitazone, a peroxisome proliferator-activated receptor gamma ligand, suppresses bleomycin-induced acute lung injury and fibrosis.
Topics: Acute Lung Injury; Animals; Bleomycin; Cells, Cultured; Collagen Type I; Connective Tissue Growth Fa | 2009 |
Pioglitazone attenuates endotoxin-induced acute lung injury by reducing neutrophil recruitment.
Topics: Acute Lung Injury; Adult; Aerosols; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; | 2012 |