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pioglitazone and Acute Lung Injury

pioglitazone has been researched along with Acute Lung Injury in 3 studies

Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.

Acute Lung Injury: A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).

Research Excerpts

ExcerptRelevanceReference
"To investigate whether the PPARgamma ligand pioglitazone (PGZ) inhibited bleomycin (BLM)-induced acute lung injury and subsequent fibrosis."7.75Pioglitazone, a peroxisome proliferator-activated receptor gamma ligand, suppresses bleomycin-induced acute lung injury and fibrosis. ( Aoki, F; Aoki, N; Aoki, Y; Aoyagi, K; Arai, M; Kurabayashi, M; Maeno, T; Nakagawa, J; Sando, Y; Shimizu, Y; Suga, T; Ueno, M, 2009)
"Pioglitazone treatment before or after induction of ALI significantly diminished alveolar (reduction by 73% and 67%, respectively) and interstitial neutrophil influx (reduction by 55% and 63%, respectively) and reduced lung permeability changes (reduction by 64% and 58%, respectively) indicating a protective role of pioglitazone treatment in ALI."5.38Pioglitazone attenuates endotoxin-induced acute lung injury by reducing neutrophil recruitment. ( Grommes, J; Mörgelin, M; Soehnlein, O, 2012)
"Pioglitazone effectively prevents lung injury caused by CLP-induced sepsis by maintaining the anti-inflammatory status of visceral adipose tissue."3.80Pioglitazone attenuates lung injury by modulating adipose inflammation. ( Kobayashi, M; Kutsukake, M; Matsuda, A; Matsutani, T; Tachikawa, E; Tamura, K; Uchida, E, 2014)
"To investigate whether the PPARgamma ligand pioglitazone (PGZ) inhibited bleomycin (BLM)-induced acute lung injury and subsequent fibrosis."3.75Pioglitazone, a peroxisome proliferator-activated receptor gamma ligand, suppresses bleomycin-induced acute lung injury and fibrosis. ( Aoki, F; Aoki, N; Aoki, Y; Aoyagi, K; Arai, M; Kurabayashi, M; Maeno, T; Nakagawa, J; Sando, Y; Shimizu, Y; Suga, T; Ueno, M, 2009)
"Pioglitazone treatment before or after induction of ALI significantly diminished alveolar (reduction by 73% and 67%, respectively) and interstitial neutrophil influx (reduction by 55% and 63%, respectively) and reduced lung permeability changes (reduction by 64% and 58%, respectively) indicating a protective role of pioglitazone treatment in ALI."1.38Pioglitazone attenuates endotoxin-induced acute lung injury by reducing neutrophil recruitment. ( Grommes, J; Mörgelin, M; Soehnlein, O, 2012)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kutsukake, M1
Matsutani, T1
Tamura, K1
Matsuda, A1
Kobayashi, M1
Tachikawa, E1
Uchida, E1
Aoki, Y1
Maeno, T1
Aoyagi, K1
Ueno, M1
Aoki, F1
Aoki, N1
Nakagawa, J1
Sando, Y1
Shimizu, Y1
Suga, T1
Arai, M1
Kurabayashi, M1
Grommes, J1
Mörgelin, M1
Soehnlein, O1

Other Studies

3 other studies available for pioglitazone and Acute Lung Injury

ArticleYear
Pioglitazone attenuates lung injury by modulating adipose inflammation.
    The Journal of surgical research, 2014, Jun-15, Volume: 189, Issue:2

    Topics: Acute Lung Injury; Adipose Tissue; Animals; Apoptosis; Disease Models, Animal; Endotoxins; Hypoglyce

2014
Pioglitazone, a peroxisome proliferator-activated receptor gamma ligand, suppresses bleomycin-induced acute lung injury and fibrosis.
    Respiration; international review of thoracic diseases, 2009, Volume: 77, Issue:3

    Topics: Acute Lung Injury; Animals; Bleomycin; Cells, Cultured; Collagen Type I; Connective Tissue Growth Fa

2009
Pioglitazone attenuates endotoxin-induced acute lung injury by reducing neutrophil recruitment.
    The European respiratory journal, 2012, Volume: 40, Issue:2

    Topics: Acute Lung Injury; Adult; Aerosols; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid;

2012