Page last updated: 2024-11-02

pioglitazone and Acute Kidney Injury

pioglitazone has been researched along with Acute Kidney Injury in 6 studies

Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.

Acute Kidney Injury: Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.

Research Excerpts

ExcerptRelevanceReference
"Pioglitazone is a novel class of oral antidiabetic agents currently used to treat type 2 diabetes mellitus."5.38Protective effects of pioglitazone on renal ischemia-reperfusion injury in mice. ( Hu, H; Huang, X; Shi, Z; Wang, G; Xi, X; Zou, C, 2012)
"Pretreatment with cilostazol or pioglitazone provided significant protection against the I/R-induced renal injury as manifested by the attenuated serum levels of creatinine, blood urea nitrogen and cystatin C."1.40Cilostazol renoprotective effect: modulation of PPAR-γ, NGAL, KIM-1 and IL-18 underlies its novel effect in a model of ischemia-reperfusion. ( Abdallah, DM; El-Abhar, HS; Ragab, D, 2014)
"Pioglitazone was administered for six consecutive days in doses of 15 or 30 mg kg(-1)  day(-1), per os (p."1.40The peroxisome proliferator-activated receptor-γ agonist pioglitazone protects against cisplatin-induced renal damage in mice. ( Bortolatto, CF; Jesse, CR; Nogueira, CW; Prigol, M; Roman, SS; Wilhelm, EA, 2014)
"Pioglitazone is a novel class of oral antidiabetic agents currently used to treat type 2 diabetes mellitus."1.38Protective effects of pioglitazone on renal ischemia-reperfusion injury in mice. ( Hu, H; Huang, X; Shi, Z; Wang, G; Xi, X; Zou, C, 2012)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Elshazly, S1
Soliman, E1
Ragab, D1
Abdallah, DM1
El-Abhar, HS1
Abdel-Rahman, EM1
Okusa, MD1
Zhang, J1
Zhang, Y1
Xiao, F1
Liu, Y1
Wang, J1
Gao, H1
Rong, S1
Yao, Y1
Li, J1
Xu, G1
Hu, H1
Zou, C1
Xi, X1
Shi, Z1
Wang, G1
Huang, X1
Jesse, CR1
Bortolatto, CF1
Wilhelm, EA1
Roman, SS1
Prigol, M1
Nogueira, CW1

Reviews

1 review available for pioglitazone and Acute Kidney Injury

ArticleYear
Effects of aging on renal function and regenerative capacity.
    Nephron. Clinical practice, 2014, Volume: 127, Issue:1-4

    Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Aging; Animals; Cellular Senescence; Disease Models, A

2014

Other Studies

5 other studies available for pioglitazone and Acute Kidney Injury

ArticleYear
PPAR gamma agonist, pioglitazone, rescues liver damage induced by renal ischemia/reperfusion injury.
    Toxicology and applied pharmacology, 2019, 01-01, Volume: 362

    Topics: Acute Kidney Injury; Animals; Caspase 3; Kidney; Liver; Liver Diseases; Male; Pioglitazone; PPAR gam

2019
Cilostazol renoprotective effect: modulation of PPAR-γ, NGAL, KIM-1 and IL-18 underlies its novel effect in a model of ischemia-reperfusion.
    PloS one, 2014, Volume: 9, Issue:5

    Topics: Acute Kidney Injury; Acute-Phase Proteins; Animals; Blood Urea Nitrogen; Caspase 1; Cell Adhesion Mo

2014
The peroxisome proliferator-activated receptor γ agonist pioglitazone prevents NF-κB activation in cisplatin nephrotoxicity through the reduction of p65 acetylation via the AMPK-SIRT1/p300 pathway.
    Biochemical pharmacology, 2016, Feb-01, Volume: 101

    Topics: Acetylation; Acute Kidney Injury; AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Cis

2016
Protective effects of pioglitazone on renal ischemia-reperfusion injury in mice.
    The Journal of surgical research, 2012, Volume: 178, Issue:1

    Topics: Acute Kidney Injury; Animals; Apoptosis; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Hy

2012
The peroxisome proliferator-activated receptor-γ agonist pioglitazone protects against cisplatin-induced renal damage in mice.
    Journal of applied toxicology : JAT, 2014, Volume: 34, Issue:1

    Topics: Acute Kidney Injury; Animals; Ascorbic Acid; Catalase; Cisplatin; Creatinine; Glutathione; Glutathio

2014