pioglitazone has been researched along with Acute Brain Injuries in 7 studies
Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pioglitazone was administered in a dose of 1mg/kg at 10min after the brain trauma." | 1.42 | A single dose of PPARγ agonist pioglitazone reduces cortical oxidative damage and microglial reaction following lateral fluid percussion brain injury in rats. ( Dolenec, P; Mršić-Pelčić, J; Pilipović, K; Župan, G; Župan, Ž, 2015) |
| "Treatment with Pioglitazone prevented the increase in the number of activated microglia and no difference was observed between sham and Pioglitazone-treated animals." | 1.37 | Pioglitazone attenuates mitochondrial dysfunction, cognitive impairment, cortical tissue loss, and inflammation following traumatic brain injury. ( Bing, G; Gao, J; Liu, M; Pauly, JR; Readnower, R; Sauerbeck, A; Sullivan, PG, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yonutas, HM | 1 |
| Sullivan, PG | 2 |
| Thal, SC | 2 |
| Neuhaus, W | 1 |
| Pilipović, K | 1 |
| Župan, Ž | 1 |
| Dolenec, P | 1 |
| Mršić-Pelčić, J | 1 |
| Župan, G | 1 |
| Qiu, L | 1 |
| Jiang, X | 1 |
| Wen, L | 1 |
| Hu, Q | 1 |
| Deng, Y | 1 |
| Sauerbeck, A | 1 |
| Gao, J | 1 |
| Readnower, R | 1 |
| Liu, M | 1 |
| Pauly, JR | 1 |
| Bing, G | 1 |
| Semple, BD | 1 |
| Noble-Haeusslein, LJ | 1 |
| Heinemann, M | 1 |
| Luh, C | 1 |
| Pieter, D | 1 |
| Werner, C | 1 |
| Engelhard, K | 1 |
2 reviews available for pioglitazone and Acute Brain Injuries
| Article | Year |
|---|---|
Targeting PPAR isoforms following CNS injury.
Topics: Animals; Brain Injuries; Drug Design; Humans; Mitochondrial Proteins; Molecular Targeted Therapy; Ne | 2013 |
The blood-brain barrier as a target in traumatic brain injury treatment.
Topics: Blood-Brain Barrier; Brain Edema; Brain Injuries; Cell Hypoxia; Humans; Hypoglycemic Agents; Inflamm | 2014 |
5 other studies available for pioglitazone and Acute Brain Injuries
| Article | Year |
|---|---|
A single dose of PPARγ agonist pioglitazone reduces cortical oxidative damage and microglial reaction following lateral fluid percussion brain injury in rats.
Topics: Animals; Brain Edema; Brain Injuries; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Dose-Resp | 2015 |
[Pioglitazone decreases the levels of inflammatory cytokines in SD rats with traumatic brain injury via up-regulating PPARγ].
Topics: Animals; Brain Injuries; Dose-Response Relationship, Drug; Gene Expression; Hypoglycemic Agents; Int | 2016 |
Pioglitazone attenuates mitochondrial dysfunction, cognitive impairment, cortical tissue loss, and inflammation following traumatic brain injury.
Topics: Analysis of Variance; Animals; Brain Injuries; CD11b Antigen; Cerebral Cortex; Cognition Disorders; | 2011 |
Broad-spectrum neuroprotection against traumatic brain injury by agonism of peroxisome proliferator-activated receptors.
Topics: Animals; Brain Injuries; Cerebral Cortex; Cognition Disorders; Disease Models, Animal; Encephalitis; | 2011 |
Pioglitazone reduces secondary brain damage after experimental brain trauma by PPAR-γ-independent mechanisms.
Topics: Animals; Brain Damage, Chronic; Brain Injuries; Disease Models, Animal; Hypoglycemic Agents; Male; M | 2011 |