pindolol has been researched along with Neuroblastoma in 3 studies
Pindolol: A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)
pindolol : A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In SK-N-MC human neuroblastoma cells, the cAMP response to 10 nM isoproterenol (ISO) is mediated primarily by beta 1-adrenergic receptors." | 3.68 | Coexisting beta 1- and atypical beta-adrenergic receptors cause redundant increases in cyclic AMP in human neuroblastoma cells. ( Esbenshade, TA; Granneman, JG; Han, C; Minneman, KP; Theroux, TL, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Whitsett, JA | 1 |
| Noguchi, A | 1 |
| Neely, JE | 1 |
| Johnson, CL | 1 |
| Moore, JJ | 1 |
| Ammer, H | 1 |
| Schulz, R | 1 |
| Esbenshade, TA | 1 |
| Han, C | 1 |
| Theroux, TL | 1 |
| Granneman, JG | 1 |
| Minneman, KP | 1 |
3 other studies available for pindolol and Neuroblastoma
| Article | Year |
|---|---|
beta 1-adrenergic receptors in human neuroblastoma.
Topics: Adenylyl Cyclases; Animals; Binding, Competitive; Cell Line; Dihydroalprenolol; Humans; Mice; Mice, | 1981 |
Opioid tolerance/dependence in neuroblastoma x glioma (NG108-15) hybrid cells is associated with a reduction in spontaneous stimulatory receptor activity.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Binding, Competitive; COS Cells; Drug Toler | 2000 |
Coexisting beta 1- and atypical beta-adrenergic receptors cause redundant increases in cyclic AMP in human neuroblastoma cells.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Cyclic AMP; Ethanolamines; Humans; Imidazoles | 1992 |