Compounds > pindolol
Page last updated: 2024-11-02

pindolol and Muscle Relaxation

pindolol has been researched along with Muscle Relaxation in 40 studies

Pindolol: A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)
pindolol : A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.

Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.

Research Excerpts

ExcerptRelevanceReference
"The molecular pharmacology of a new putative long-acting bronchodilator TA 2005 (8-hydroxy-5-[(1R)-1-hydroxy-2-[N-[(1R)-2-(p-methoxy-phenyl)- 1-methylethyl]amino]ethyl]carbostyril hydrochloride) has been compared with that of the reference compounds isoprenaline and salbutamol in both methacholine (3 x 10(-6) M) precontracted guinea pig tracheal smooth muscle relaxation and in bovine trapezium muscle binding experiments."3.68Atypical molecular pharmacology of a new long-acting beta 2-adrenoceptor agonist, TA 2005. ( Bast, A; Donnell, D; Voss, HP, 1992)
" The autoradiographic distribution of alpha 1-adrenoceptors was investigated in non-diseased and asthmatic human lung by use of [3H]-prazosin (H-PZ)."3.67Alpha 1-adrenoceptor function and autoradiographic distribution in human asthmatic lung. ( Goldie, RG; Paterson, JW; Rigby, PJ; Spina, D, 1989)
"Ulcerative colitis is characterized by dysfunctional motility."1.31Studies on the expression and function of beta-3-adrenoceptors in the colon of rats with acetic acid-induced colitis. ( Hussein, SM; Khan, I; Oriowo, M, 2002)
"Pretreatment with BRL 37344 induced a marked desensitization of the distal colon and fundic strips but not the aorta and carotid artery to isoprenaline."1.29Different atypical beta-adrenoceptors mediate isoprenaline-induced relaxation in vascular and non-vascular smooth muscles. ( Oriowo, MA, 1995)
"Cyanopindolol (CYP) is a potent antagonist at the beta 3-adrenoceptor in rat ileum."1.29Characteristics of cyanopindolol analogues active at the beta 3-adrenoceptor in rat ileum. ( Hoey, AJ; Jackson, CM; Pegg, GG; Sillence, MN, 1996)
"(+)-Pindolol was less potent as antagonist of the relaxant effects of (-)-noradrenaline on trachea than against those of (-)-adrenaline, (-)-isoprenaline and (+/-)-salbutamol."1.27Stimulant and blocking effects of optical isomers of pindolol on the sinoatrial node and trachea of guinea pig. Role of beta-adrenoceptor subtypes in the dissociation between blockade and stimulation. ( Kaumann, AJ; Lemoine, H; Walter, M, 1984)
" The dose-response curves of dilevalol and labetalol were shifted to the right with propranolol pretreatment."1.27Intrinsic beta-sympathomimetic activity of dilevalol, R, R-isomer of labetalol. ( Matsunaga, K; Nakamura, K; Ueda, M, 1985)

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-199016 (40.00)18.7374
1990's15 (37.50)18.2507
2000's9 (22.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mallem, MY2
Toumaniantz, G1
Serpillon, S1
Gautier, F1
Gogny, M3
Desfontis, JC3
Gauthier, C1
Khan, I2
Omu, AE1
Fatinikun, T1
Chandrasekhar, B1
Kadavil, EA1
Oriowo, MA3
Mallem, Y1
Holopherne, D1
Reculeau, O2
Le Coz, O2
Walter, M1
Lemoine, H1
Kaumann, AJ1
Thulesius, O1
Gjöres, JE1
Berlin, E1
Duncan, PG1
Brink, C1
Douglas, JS1
Minneman, KP1
Puckett, AM1
Jensen, AD1
Rinard, GA1
Carswell, H1
Nahorski, SR1
Cohen, ML1
Granneman, JG1
Chaudhry, A1
Schenck, KW1
Cushing, DJ1
Palkowitz, AD1
Tamaoki, J2
Yamauchi, F1
Chiyotani, A1
Yamawaki, I1
Takeuchi, S1
Konno, K1
Hoey, A1
Jackson, C1
Pegg, G1
Sillence, M1
Lezama, EJ1
Konkar, AA1
Salazar-Bookaman, MM1
Miller, DD1
Feller, DR1
Hoey, AJ1
Jackson, CM1
Pegg, GG1
Sillence, MN1
Kelly, J1
Houston, G1
Tagaya, E1
Isono, K1
Nagai, A1
Hayes, ES1
Adaikan, PG1
Ratnam, SS1
Ng, SC1
Mustafa, SM1
Yousif, M1
Cherian, A1
Brawley, L1
Shaw, AM1
MacDonald, A2
Hutchinson, DS1
Evans, BA1
Summers, RJ1
Horinouchi, T2
Koike, K2
Hussein, SM1
Oriowo, M1
Ozawa, H1
Matsubara, T1
Chen, CS1
Zaagsma, J1
Meems, L1
Boorsma, M1
Brodde, OE1
Schemuth, W1
Voss, HP1
Donnell, D1
Bast, A2
McLaughlin, DP1
Kikkawa, H1
Naito, K1
Ikezawa, K1
van der Vliet, A1
Rademaker, B1
Doggrell, SA1
Tsujimoto, G2
Lee, CH1
Hoffman, BB2
Spina, D1
Rigby, PJ1
Paterson, JW1
Goldie, RG1
Humphrey, PP1
Feniuk, W1
Perren, MJ1
Connor, HE1
Oxford, AW1
Coates, LH1
Butina, D1
Matsunaga, K1
Nakamura, K1
Ueda, M1
Beckmann, R1
Müller, B1
Schröder, G1
Stock, G1
Murakami, H1
Sano, M1
Tsukimura, T1
Yamazaki, A1
van Koppen, CJ1
Hermanussen, MW1
Verrijp, KN1
Rodrigues de Miranda, JF1
Beld, AJ1
Lammers, JW1
van Ginneken, CA1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Controlled,14-Treatment Day, Multicenter Study to Determine the Optimal Efficacious and Safe Dose of CHF 4226 in a Metered Dose Inhaler in Treating Patients With Chronic Obstructive Pulmonary Disease[NCT00605891]Phase 2278 participants (Actual)Interventional2006-10-31Completed
Evaluation of the Effect of 2 Weeks Treatment With CHF 4226 pMDI 2µg and 4µg, Given Once Daily in the Morning, on 24-Hour FEV1 in Patients With COPD[NCT00640484]Phase 257 participants (Actual)Interventional2008-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

40 other studies available for pindolol and Muscle Relaxation

ArticleYear
Impairment of the low-affinity state beta1-adrenoceptor-induced relaxation in spontaneously hypertensive rats.
    British journal of pharmacology, 2004, Volume: 143, Issue:5

    Topics: Adrenergic beta-Antagonists; Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Enzyme Inhi

2004
Evidence for the presence of beta-3-adrenoceptors mediating relaxation in the human oviduct.
    Pharmacology, 2005, Volume: 74, Issue:3

    Topics: Adrenergic beta-3 Receptor Agonists; Adrenergic beta-3 Receptor Antagonists; Adult; Dose-Response Re

2005
Beta-adrenoceptor-mediated vascular relaxation in spontaneously hypertensive rats.
    Autonomic neuroscience : basic & clinical, 2005, Mar-31, Volume: 118, Issue:1-2

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Aorta, Thoracic; Dose-Response Relat

2005
Low-affinity state beta1-adrenoceptor-induced vasodilation in SHR.
    Peptides, 2005, Volume: 26, Issue:8

    Topics: Adrenergic beta-1 Receptor Agonists; Alprenolol; Animals; Aorta; Blood Pressure; Dose-Response Relat

2005
Stimulant and blocking effects of optical isomers of pindolol on the sinoatrial node and trachea of guinea pig. Role of beta-adrenoceptor subtypes in the dissociation between blockade and stimulation.
    Naunyn-Schmiedeberg's archives of pharmacology, 1984, Volume: 327, Issue:2

    Topics: Animals; Bupranolol; Cimetidine; Female; Guinea Pigs; Heart Rate; In Vitro Techniques; Isoproterenol

1984
Vasodilating properties of beta-adrenoceptor blockers with intrinsic sympathomimetic activity.
    British journal of clinical pharmacology, 1982, Volume: 13, Issue:Suppl 2

    Topics: Adrenergic beta-Antagonists; Celiprolol; Humans; In Vitro Techniques; Muscle Contraction; Muscle Rel

1982
Beta-receptors during aging in respiratory tissues.
    European journal of pharmacology, 1982, Feb-19, Volume: 78, Issue:1

    Topics: Aging; Animals; Benzyl Alcohols; Bronchi; Female; Guinea Pigs; Histamine; Isoproterenol; Muscle Rela

1982
Regional variation in beta adrenergic receptors in dog trachea: correlation of receptor density and in vitro relaxation.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 226, Issue:1

    Topics: Animals; Dinoprostone; Dogs; Iodocyanopindolol; Isoproterenol; Kinetics; Muscle Contraction; Muscle

1983
Beta-adrenoceptor heterogeneity in guinea-pig airways: comparison of functional and receptor labelling studies.
    British journal of pharmacology, 1983, Volume: 79, Issue:4

    Topics: Animals; Binding, Competitive; Bronchi; Dihydroalprenolol; Guinea Pigs; In Vitro Techniques; Iodocya

1983
Is the "atypical" beta-receptor in the rat stomach fundus the rat beta 3 receptor?
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:1

    Topics: Adenylyl Cyclases; Animals; CHO Cells; Cricetinae; Dioxoles; Enzyme Activation; Gene Expression; In

1995
Atypical beta-adrenoceptor- (beta 3-adrenoceptor) mediated relaxation of canine isolated bronchial smooth muscle.
    Journal of applied physiology (Bethesda, Md. : 1985), 1993, Volume: 74, Issue:1

    Topics: Acetylcholine; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Albuterol; Animals; Bronchi; C

1993
Different atypical beta-adrenoceptors mediate isoprenaline-induced relaxation in vascular and non-vascular smooth muscles.
    Life sciences, 1995, Mar-03, Volume: 56, Issue:15

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Ethanolamines; Female; In Vitro Tech

1995
Atypical responses of rat ileum to pindolol, cyanopindolol and iodocyanopindolol.
    British journal of pharmacology, 1996, Volume: 117, Issue:4

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Female; Ileum; In Vitro Techniques;

1996
Pharmacological study of atypical beta-adrenoceptors in rat esophageal smooth muscle.
    European journal of pharmacology, 1996, Jul-11, Volume: 308, Issue:1

    Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-Anta

1996
Characteristics of cyanopindolol analogues active at the beta 3-adrenoceptor in rat ileum.
    British journal of pharmacology, 1996, Volume: 119, Issue:3

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Dose-Response Relationship, Drug; Et

1996
Beta 3-adrenoceptors mediating relaxation of the oesophageal tunica muscularis mucosae and distal colon in the rat: comparative pharmacology and their desensitization by BRL 37344.
    Journal of autonomic pharmacology, 1996, Volume: 16, Issue:4

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Colon; Dose-Response Relationship, D

1996
Atypical adrenoceptor-mediated relaxation of canine pulmonary artery through a cAMP-dependent pathway.
    Biochemical and biophysical research communications, 1998, Jul-30, Volume: 248, Issue:3

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Albuterol; Animals; Cyclic AMP; Dioxoles; Dog

1998
5-HT4 receptors in isolated human corpus cavernosum?
    International journal of impotence research, 1999, Volume: 11, Issue:4

    Topics: 4-Aminobenzoic Acid; Adrenergic beta-Antagonists; Benzamides; Humans; Male; Methysergide; Muscle Rel

1999
Beta1- and beta3-adrenoceptors mediate relaxation in ovine trachealis smooth muscle.
    Journal of autonomic pharmacology, 1999, Volume: 19, Issue:4

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Atenolol; Ethanolamines; In Vitro Te

1999
Beta 1-, beta 2- and atypical beta-adrenoceptor-mediated relaxation in rat isolated aorta.
    British journal of pharmacology, 2000, Volume: 129, Issue:4

    Topics: Acetylcholine; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Ani

2000
beta(1)-Adrenoceptors compensate for beta(3)-adrenoceptors in ileum from beta(3)-adrenoceptor knock-out mice.
    British journal of pharmacology, 2001, Volume: 132, Issue:2

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Dioxoles; Genotype; Ileum; In Vitro

2001
(+/-)-Pindolol acts as a partial agonist at atypical beta-adrenoceptors in the guinea pig duodenum.
    Japanese journal of pharmacology, 2001, Volume: 85, Issue:1

    Topics: Adrenergic beta-1 Receptor Agonists; Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-2 Recep

2001
Functional properties of atypical beta-adrenoceptors on the guinea pig duodenum.
    European journal of pharmacology, 2001, Mar-23, Volume: 416, Issue:1-2

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Albuterol; Alprenolol; Animals; Bupranolol; C

2001
Studies on the expression and function of beta-3-adrenoceptors in the colon of rats with acetic acid-induced colitis.
    Pharmacology, 2002, Volume: 64, Issue:2

    Topics: Acetic Acid; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Colitis, Ulcerative; Co

2002
Analysis of hypotensive mechanisms of pindolol, a beta-adrenoceptor blocking drugs in rats.
    Japanese journal of pharmacology, 1977, Volume: 27, Issue:2

    Topics: Adrenergic beta-Antagonists; Anesthesia, Intravenous; Animals; Antihypertensive Agents; Blood Pressu

1977
Beta-Adrenoceptor studies. 4. Influence of albumin on in vitro beta-adrenoceptor blocking and antiarrhythmic properties of propranolol, pindolol, practolol and metoprolol.
    Naunyn-Schmiedeberg's archives of pharmacology, 1977, Volume: 298, Issue:1

    Topics: Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Guinea Pigs; Heart

1977
Specific antagonism by metoclopramide of dopamine-induced relaxation on isolated rabbit mesenteric arteries contracted with prostaglandin F2alpha.
    Life sciences, 1979, Jul-02, Volume: 25, Issue:1

    Topics: Animals; Dopamine; Dopamine Antagonists; Female; In Vitro Techniques; Isoproterenol; Male; Mesenteri

1979
Atypical molecular pharmacology of a new long-acting beta 2-adrenoceptor agonist, TA 2005.
    European journal of pharmacology, 1992, Dec-01, Volume: 227, Issue:4

    Topics: Adrenergic beta-Agonists; Amphetamines; Animals; Binding, Competitive; Bronchodilator Agents; Cattle

1992
Atypical molecular pharmacology of a new long-acting beta 2-adrenoceptor agonist, TA 2005.
    European journal of pharmacology, 1992, Dec-01, Volume: 227, Issue:4

    Topics: Adrenergic beta-Agonists; Amphetamines; Animals; Binding, Competitive; Bronchodilator Agents; Cattle

1992
Atypical molecular pharmacology of a new long-acting beta 2-adrenoceptor agonist, TA 2005.
    European journal of pharmacology, 1992, Dec-01, Volume: 227, Issue:4

    Topics: Adrenergic beta-Agonists; Amphetamines; Animals; Binding, Competitive; Bronchodilator Agents; Cattle

1992
Atypical molecular pharmacology of a new long-acting beta 2-adrenoceptor agonist, TA 2005.
    European journal of pharmacology, 1992, Dec-01, Volume: 227, Issue:4

    Topics: Adrenergic beta-Agonists; Amphetamines; Animals; Binding, Competitive; Bronchodilator Agents; Cattle

1992
Characterization of catecholamine-mediated relaxations in rat isolated gastric fundus: evidence for an atypical beta-adrenoceptor.
    British journal of pharmacology, 1991, Volume: 103, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Catecholamines; Ethanolamines; Gastric

1991
Tracheal relaxing effects and beta 2-selectivity of TA-2005, a newly developed bronchodilating agent, in isolated guinea pig tissues.
    Japanese journal of pharmacology, 1991, Volume: 57, Issue:2

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Albuterol; Amphetamines; Animals; Bronchodila

1991
Tracheal relaxing effects and beta 2-selectivity of TA-2005, a newly developed bronchodilating agent, in isolated guinea pig tissues.
    Japanese journal of pharmacology, 1991, Volume: 57, Issue:2

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Albuterol; Amphetamines; Animals; Bronchodila

1991
Tracheal relaxing effects and beta 2-selectivity of TA-2005, a newly developed bronchodilating agent, in isolated guinea pig tissues.
    Japanese journal of pharmacology, 1991, Volume: 57, Issue:2

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Albuterol; Amphetamines; Animals; Bronchodila

1991
Tracheal relaxing effects and beta 2-selectivity of TA-2005, a newly developed bronchodilating agent, in isolated guinea pig tissues.
    Japanese journal of pharmacology, 1991, Volume: 57, Issue:2

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Albuterol; Amphetamines; Animals; Bronchodila

1991
A beta adrenoceptor with atypical characteristics is involved in the relaxation of the rat small intestine.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:1

    Topics: Adipose Tissue; Adrenergic beta-Antagonists; Animals; Ethanolamines; In Vitro Techniques; Intestine,

1990
Relaxant and beta 2-adrenoceptor blocking activities of (+/- )-, (+)- and (-)-pindolol on the rat isolated aorta.
    The Journal of pharmacy and pharmacology, 1990, Volume: 42, Issue:6

    Topics: Adrenergic beta-Antagonists; Animals; Aorta, Thoracic; Ethanolamines; In Vitro Techniques; Male; Mus

1990
Age-related decrease in beta adrenergic receptor-mediated vascular smooth muscle relaxation.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 239, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Acetylcholine; Aging; B

1986
Alpha 1-adrenoceptor function and autoradiographic distribution in human asthmatic lung.
    British journal of pharmacology, 1989, Volume: 97, Issue:3

    Topics: Adult; Asthma; Autoradiography; Bronchi; Carbachol; Humans; In Vitro Techniques; Iodine Radioisotope

1989
Desensitization of beta-adrenergic receptor-mediated vascular smooth muscle relaxation.
    Molecular pharmacology, 1985, Volume: 27, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Catecholamines; Cyclic AMP; Epinephrine; In Vitro Techniques;

1985
GR43175, a selective agonist for the 5-HT1-like receptor in dog isolated saphenous vein.
    British journal of pharmacology, 1988, Volume: 94, Issue:4

    Topics: Animals; Cats; Dogs; Female; In Vitro Techniques; Indoles; Male; Methiothepin; Muscle Contraction; M

1988
Intrinsic beta-sympathomimetic activity of dilevalol, R, R-isomer of labetalol.
    Journal of pharmacobio-dynamics, 1985, Volume: 8, Issue:9

    Topics: Adrenergic beta-Agonists; Animals; Blood Pressure; Guinea Pigs; Heart Rate; In Vitro Techniques; Lab

1985
Pharmacological studies on the intrinsic sympathomimetic activity of the beta-adrenoceptor antagonist mepindolol.
    Arzneimittel-Forschung, 1986, Volume: 36, Issue:5

    Topics: Adrenergic beta-Antagonists; Anesthesia; Animals; Heart; Hemodynamics; In Vitro Techniques; Isoprote

1986
The relaxation induced by indole and nonindole 5-HT agonists in the molluscan smooth muscle.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1988, Volume: 90, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Bivalvia; Cyclic AMP; In Vitro Techniques; Indoles;

1988
Beta-adrenoceptors in human tracheal smooth muscle: characteristics of binding and relaxation.
    Life sciences, 1987, Jun-29, Volume: 40, Issue:26

    Topics: Atenolol; Binding, Competitive; Humans; In Vitro Techniques; Muscle Contraction; Muscle Relaxation;

1987