pindolol has been researched along with Muscle Contraction in 50 studies
Pindolol: A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)
pindolol : A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
Excerpt | Relevance | Reference |
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" There was a decrease in sensitivity to isoproterenol in spontaneously beating right atria, electrically driven left atria and field-stimulated vas deferens associated with hypothyroidism, with no change in maximum response." | 3.67 | Thyroid status and adrenergic receptor subtypes in the rat: comparison of receptor density and responsiveness. ( Abel, PW; Fox, AW; Johnson, RD; Juberg, EN; May, JM; Minneman, KP, 1985) |
"The effects of pindolol and sotalol on neuromusclar transmission were tested using intracellular microelectrode recording of resting membrane potentials, miniature end-plate potentials and end-plate potentials, and recording of muscle contractions upon nerve stimulation of rat phrenic nerve-hemidaphragm preparations." | 3.66 | On the neuromuscular effects of pindolol and sotalol in the rat. ( Larsen, A, 1978) |
"6." | 2.67 | Selective beta-adrenoceptor partial agonist effects of pindolol and xamoterol on skeletal muscle assessed by plasma creatine kinase changes in healthy subjects. ( Cruickshank, JM; Graham, BR; Hayes, Y; Jones, A; Lewis, AD; Lui, JB; Prichard, BN; Renondin, JC; Tomlinson, B, 1990) |
"2 Pindolol displays a striking diversity of agonist activities in isolated tissues." | 2.36 | Pindolol--the pharmacology of a partial agonist. ( Bertholet, A; Clark, BJ; Menninger, K, 1982) |
"Pretreatment with ketanserin (10 microM), a 5-HT2 antagonist, tropisetron (1 microM), a 5-HT3/4 antagonist, SDZ 216-525 (1 to 10 microM) and pindobind (10 microM), both selective 5-HT1A antagonists, or capsaicin (10 microM), which depletes sensory nerves from neuropeptides, had no effect on the inhibition of the cholinergic contraction by 8-OH-DPAT (10 to 30 microM)." | 1.30 | The effects of 8-hydroxy-2-(di-n-propylamino)tetralin on the cholinergic contraction in guinea pig and human airways in vitro. ( De Leyn, P; Demedts, MG; Deneffe, G; Dupont, LJ; Pype, JL; Verleden, GM, 1998) |
"125I-pindolol binding was inhibited by the three agonists, with relative potencies (IC50S) of ISO (0." | 1.28 | Characterization of beta-adrenoreceptors on smooth muscle cells from guinea pig stomach. ( Jensen, RT; Maton, PN; Zhang, L, 1990) |
"(+)-pindolol was about 200 times less potent in this respect." | 1.27 | Steric aspects of agonism and antagonism at beta-adrenoceptors: experiments with the enantiomers of terbutaline and pindolol. ( Jeppsson, AB; Johansson, U; Waldeck, B, 1984) |
"Pindolol is a non-selective beta-adrenoceptor blocking agent with relatively marked intrinsic sympathomimetic activity." | 1.27 | Effects of pindolol on vascular smooth muscle. ( Bertholet, A; Clark, BJ, 1983) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 37 (74.00) | 18.7374 |
1990's | 13 (26.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Hedberg, A | 1 |
Mattsson, H | 1 |
O'Donnell, SR | 1 |
Wanstall, JC | 1 |
Thulesius, O | 1 |
Gjöres, JE | 1 |
Berlin, E | 1 |
Bonelli, J | 1 |
Minneman, KP | 2 |
Puckett, AM | 1 |
Jensen, AD | 1 |
Rinard, GA | 1 |
Jeppsson, AB | 1 |
Johansson, U | 1 |
Waldeck, B | 1 |
Clark, BJ | 2 |
Bertholet, A | 2 |
Menninger, K | 1 |
Hosohata, Y | 2 |
Sasaki, K | 1 |
Suzuki, M | 1 |
Karakisawa, Y | 1 |
Maruyama, K | 1 |
Tsuchihashi, H | 2 |
Nagatomo, T | 2 |
Bax, WA | 1 |
Renzenbrink, GJ | 1 |
Van Heuven-Nolsen, D | 1 |
Thijssen, EJ | 1 |
Bos, E | 1 |
Saxena, PR | 1 |
Fraundorfer, PF | 2 |
Lezama, EJ | 1 |
Salazar-Bookaman, MM | 1 |
Fertel, RH | 2 |
Miller, DD | 2 |
Feller, DR | 2 |
Craig, DA | 1 |
Martin, GR | 1 |
Konkar, AA | 1 |
Burkman, AM | 1 |
Dupont, LJ | 1 |
Pype, JL | 1 |
Demedts, MG | 1 |
De Leyn, P | 1 |
Deneffe, G | 1 |
Verleden, GM | 1 |
Salimi, M | 1 |
Weinstock, M | 1 |
Weiss, C | 1 |
Gitter, S | 1 |
Zaagsma, J | 1 |
Meems, L | 1 |
Boorsma, M | 1 |
Roberts, JM | 1 |
Insel, PA | 1 |
Goldfien, RD | 1 |
Goldfien, A | 1 |
Jindal, MN | 1 |
Shah, UH | 1 |
Patel, VK | 1 |
Kelkar, VV | 1 |
Nirmala, G | 1 |
Brahmayya Sastry, P | 1 |
Larsen, A | 1 |
Rumboldt, Z | 1 |
Henry, PJ | 1 |
Rigby, PJ | 2 |
Mackenzie, JS | 1 |
Goldie, RG | 2 |
Sakuma, N | 1 |
Akashi, H | 1 |
Kinami, J | 1 |
Kikkawa, H | 1 |
Naito, K | 1 |
Ikezawa, K | 1 |
Zhang, L | 1 |
Jensen, RT | 1 |
Maton, PN | 1 |
Sakai, Y | 1 |
Inazu, M | 1 |
Aihara, K | 1 |
Inoue, K | 1 |
Homma, I | 1 |
Tomlinson, B | 1 |
Cruickshank, JM | 1 |
Hayes, Y | 1 |
Renondin, JC | 1 |
Lui, JB | 1 |
Graham, BR | 1 |
Jones, A | 1 |
Lewis, AD | 1 |
Prichard, BN | 1 |
Daffonchio, L | 1 |
Abbracchio, MP | 1 |
Di Luca, M | 1 |
Hernandez, A | 1 |
Amadeo, L | 1 |
Cattabeni, F | 1 |
Omini, C | 1 |
Tsujimoto, G | 2 |
Lee, CH | 1 |
Hoffman, BB | 2 |
Humphrey, PP | 1 |
Feniuk, W | 1 |
Perren, MJ | 1 |
Connor, HE | 1 |
Oxford, AW | 1 |
Coates, LH | 1 |
Butina, D | 1 |
Amlaiky, N | 1 |
Leclerc, G | 1 |
Fagher, B | 1 |
Liedholm, H | 1 |
Monti, M | 1 |
Moritz, U | 1 |
Abrahamsson, T | 1 |
Nerme, V | 1 |
Pennefather, JN | 1 |
Hartley, ML | 1 |
Leedham, JA | 1 |
Murakami, H | 1 |
Sano, M | 1 |
Tsukimura, T | 1 |
Yamazaki, A | 1 |
Mian, MA | 1 |
Malta, E | 1 |
Fox, AW | 1 |
Juberg, EN | 1 |
May, JM | 1 |
Johnson, RD | 1 |
Abel, PW | 1 |
Papadimitriou, JM | 1 |
Paterson, JW | 1 |
Self, HM | 1 |
Spina, D | 1 |
van Koppen, CJ | 1 |
Hermanussen, MW | 1 |
Verrijp, KN | 1 |
Rodrigues de Miranda, JF | 1 |
Beld, AJ | 1 |
Lammers, JW | 1 |
van Ginneken, CA | 1 |
Holt, SE | 1 |
Cooper, M | 1 |
Wyllie, JH | 1 |
Bosisio, E | 1 |
Colombo, F | 1 |
Sega, R | 1 |
Sergi, M | 1 |
Libretti, A | 1 |
Horii, D | 1 |
Kawada, T | 1 |
Takeda, K | 1 |
Imai, S | 1 |
Grün, G | 1 |
Byon, KY | 1 |
Kaufmann, R | 1 |
Fleckenstein, A | 1 |
Reinhardt, D | 1 |
Wagner, J | 1 |
Schümann, HJ | 1 |
Limbourg, P | 2 |
Just, H | 2 |
Roskamm, H | 1 |
Skinner, J | 1 |
Lesch, A | 1 |
Wink, K | 1 |
Schnellbacher, K | 1 |
Schwendel, V | 1 |
Reindell, H | 1 |
Lang, KF | 1 |
Endoh, M | 1 |
Hashimoto, K | 1 |
Kimura, T | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Frequency and Risk Factors of Portal Vein Thrombosis in Neonate With Umbilical Catheter[NCT06150807] | 45 participants (Anticipated) | Observational | 2023-12-20 | Not yet recruiting | |||
A Randomized, Controlled,14-Treatment Day, Multicenter Study to Determine the Optimal Efficacious and Safe Dose of CHF 4226 in a Metered Dose Inhaler in Treating Patients With Chronic Obstructive Pulmonary Disease[NCT00605891] | Phase 2 | 278 participants (Actual) | Interventional | 2006-10-31 | Completed | ||
Evaluation of the Effect of 2 Weeks Treatment With CHF 4226 pMDI 2µg and 4µg, Given Once Daily in the Morning, on 24-Hour FEV1 in Patients With COPD[NCT00640484] | Phase 2 | 57 participants (Actual) | Interventional | 2008-04-30 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
1 review available for pindolol and Muscle Contraction
Article | Year |
---|---|
Pindolol--the pharmacology of a partial agonist.
Topics: Animals; Bronchi; Heart; Hemodynamics; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smoo | 1982 |
4 trials available for pindolol and Muscle Contraction
Article | Year |
---|---|
Isometric exercise before and after beta-receptor blockade with propranolol and mepindolol sulfate.
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Cardiac Output; Heart Rate; Hemodynamics; Humans | 1984 |
Selective beta-adrenoceptor partial agonist effects of pindolol and xamoterol on skeletal muscle assessed by plasma creatine kinase changes in healthy subjects.
Topics: Adrenergic beta-Agonists; Adult; Aged; Blood Pressure; Creatine Kinase; Double-Blind Method; Heart R | 1990 |
Thermogenesis in human skeletal muscle as measured by direct microcalorimetry and muscle contractile performance during beta-adrenoceptor blockade.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Atenolol; Blood Pressure; Body Temperature Regulatio | 1986 |
Ventilatory response to carbon dioxide and to isometric muscle contraction after administration of placebo, propranolol, mepindolol and salbutamol.
Topics: Adult; Albuterol; Carbon Dioxide; Humans; Isometric Contraction; Male; Muscle Contraction; Pindolol; | 1985 |
45 other studies available for pindolol and Muscle Contraction
Article | Year |
---|---|
Beta adrenoceptor interaction of full and partial agonists in the cat heart and soleus muscle.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Binding, Competitive; Cats; Female; Guanosine | 1981 |
Pharmacological approaches to the characterization of beta-adrenoreceptor populations in tissues.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Cats; Female; Fenoterol; Guinea Pigs; Male; Muscle C | 1981 |
Vasodilating properties of beta-adrenoceptor blockers with intrinsic sympathomimetic activity.
Topics: Adrenergic beta-Antagonists; Celiprolol; Humans; In Vitro Techniques; Muscle Contraction; Muscle Rel | 1982 |
Regional variation in beta adrenergic receptors in dog trachea: correlation of receptor density and in vitro relaxation.
Topics: Animals; Dinoprostone; Dogs; Iodocyanopindolol; Isoproterenol; Kinetics; Muscle Contraction; Muscle | 1983 |
Steric aspects of agonism and antagonism at beta-adrenoceptors: experiments with the enantiomers of terbutaline and pindolol.
Topics: Animals; Carbachol; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscl | 1984 |
Effects of pindolol on vascular smooth muscle.
Topics: Animals; Blood Pressure; Cats; Dogs; Guinea Pigs; In Vitro Techniques; Isoproterenol; Muscle Contrac | 1983 |
Alpha-1 and beta-adrenergic receptor blocking potencies of bopindolol and its two metabolites (18-502 and 20-785) as assessed by radioligand binding assay methods.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Cattle; Dogs; Heart; | 1995 |
5-HT receptors mediating contractions of the isolated human coronary artery.
Topics: Adolescent; Adult; Arteries; Blood Platelets; Child; Child, Preschool; Coronary Vessels; Dose-Respon | 1993 |
Isomeric-activity ratios of trimetoquinol enantiomers on beta-adrenergic receptor subtypes: functional and biochemical studies.
Topics: Adrenergic beta-Agonists; Animals; CHO Cells; Cricetinae; Cyclic AMP; Escherichia coli; Guinea Pigs; | 1994 |
5-HT1B receptors mediate potent contractile responses to 5-HT in rat caudal artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arteries; Ergolines; In | 1993 |
Pharmacological activities of trimetoquinol and 1-benzyl halogen-substituted analogues on rat beta-adrenoceptor subtypes.
Topics: Adipose Tissue, Brown; Adrenergic beta-Agonists; Animals; Binding, Competitive; CHO Cells; Colon; Cr | 1996 |
The effects of 8-hydroxy-2-(di-n-propylamino)tetralin on the cholinergic contraction in guinea pig and human airways in vitro.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Animals; Bronchi; Bronchoconstriction; Capsai | 1998 |
Comparison of beta-adrenoceptor blocking properties of sotalol, oxprenolol, propranolol and pindolol on rabbit intestinal smooth muscle.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-A | 1975 |
Blockade of 5-hydroxytryptamine receptors in the central nervous system by beta-adrenoceptor antagonists.
Topics: Adrenergic beta-Antagonists; Animals; Brain; Chickens; Male; Methysergide; Mice; Motor Activity; Mus | 1977 |
Beta-Adrenoceptor studies. 4. Influence of albumin on in vitro beta-adrenoceptor blocking and antiarrhythmic properties of propranolol, pindolol, practolol and metoprolol.
Topics: Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Guinea Pigs; Heart | 1977 |
Identification of beta-adrenergic binding sites in rabbit myometrium.
Topics: Adenylyl Cyclases; Animals; Binding, Competitive; Estradiol; Female; Guanylyl Imidodiphosphate; Isop | 1977 |
A study of some beta-adrenoceptor blocking agents on skeletal muscle.
Topics: Acetylcholine; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Anura; Cats; Diaphragm; Ele | 1975 |
Neuro-muscular depressant action of pindolol in comparison with propranolol and procaine.
Topics: Acetylcholine; Animals; Anura; Drug Interactions; Female; In Vitro Techniques; Male; Muscle Contract | 1979 |
On the neuromuscular effects of pindolol and sotalol in the rat.
Topics: Action Potentials; Animals; Membrane Potentials; Motor Endplate; Muscle Contraction; Neuromuscular J | 1978 |
[The venomotor effects of some adrenergic mediators evaluated by the venoconstriction test (author's transl)].
Topics: Adolescent; Adult; Aged; Epinephrine; Female; Humans; Isoproterenol; Male; Middle Aged; Muscle Contr | 1977 |
Effect of respiratory tract viral infection on murine airway beta-adrenoceptor function, distribution and density.
Topics: Animals; Autoradiography; Carbachol; Chick Embryo; In Vitro Techniques; Influenza A virus; Iodine Ra | 1991 |
Beta-blocking potency and selectivity of bopindolol and its two metabolites for beta 1- and beta 2-adrenergic receptors as assessed by radioligand binding assay.
Topics: Adrenergic beta-Antagonists; Animals; Binding, Competitive; Brain; Guinea Pigs; Heart Rate; In Vitro | 1991 |
Tracheal relaxing effects and beta 2-selectivity of TA-2005, a newly developed bronchodilating agent, in isolated guinea pig tissues.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Albuterol; Amphetamines; Animals; Bronchodila | 1991 |
Tracheal relaxing effects and beta 2-selectivity of TA-2005, a newly developed bronchodilating agent, in isolated guinea pig tissues.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Albuterol; Amphetamines; Animals; Bronchodila | 1991 |
Tracheal relaxing effects and beta 2-selectivity of TA-2005, a newly developed bronchodilating agent, in isolated guinea pig tissues.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Albuterol; Amphetamines; Animals; Bronchodila | 1991 |
Tracheal relaxing effects and beta 2-selectivity of TA-2005, a newly developed bronchodilating agent, in isolated guinea pig tissues.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Albuterol; Amphetamines; Animals; Bronchodila | 1991 |
Characterization of beta-adrenoreceptors on smooth muscle cells from guinea pig stomach.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Binding, Competitive; Carbachol; Cyclic AMP; Epinephrine; Guin | 1990 |
Relations between contractile responses and beta-adrenoceptors in gastric fundus of diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smo | 1991 |
Beta-adrenoceptor desensitization induced by antigen challenge in guinea-pig trachea.
Topics: Animals; Antigens; Arachidonic Acid; Arachidonic Acids; Eicosanoids; Epinephrine; Guinea Pigs; Hydro | 1990 |
Age-related decrease in beta adrenergic receptor-mediated vascular smooth muscle relaxation.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Acetylcholine; Aging; B | 1986 |
Desensitization of beta-adrenergic receptor-mediated vascular smooth muscle relaxation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Catecholamines; Cyclic AMP; Epinephrine; In Vitro Techniques; | 1985 |
GR43175, a selective agonist for the 5-HT1-like receptor in dog isolated saphenous vein.
Topics: Animals; Cats; Dogs; Female; In Vitro Techniques; Indoles; Male; Methiothepin; Muscle Contraction; M | 1988 |
Synthesis and irreversible beta-adrenergic blockade with a bromoacetamido derivative of betaxolol.
Topics: Adrenergic beta-Antagonists; Animals; Betaxolol; Binding, Competitive; Cerebral Cortex; Chemical Phe | 1985 |
Beta 1- and beta 2-adrenoceptor affinity and stimulatory effects of (S)-pindolol and iodinated (S)-pindolol.
Topics: Adrenergic beta-Antagonists; Animals; Female; Heart Atria; Heart Rate; In Vitro Techniques; Male; Me | 1987 |
(+/-)-Pindolol has beta 2-adrenoceptor antagonist but not agonist action on the costo-uterine muscle of the rat.
Topics: Adrenergic beta-Antagonists; Animals; Carbachol; Electric Stimulation; Female; In Vitro Techniques; | 1987 |
The relaxation induced by indole and nonindole 5-HT agonists in the molluscan smooth muscle.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Bivalvia; Cyclic AMP; In Vitro Techniques; Indoles; | 1988 |
The sympathomimetic activity of (+/-)-pindolol at beta 1- and beta 2-adrenoceptor sites.
Topics: Anesthesia; Animals; Blood Pressure; Cats; Female; Guinea Pigs; Heart Rate; In Vitro Techniques; Iso | 1985 |
Thyroid status and adrenergic receptor subtypes in the rat: comparison of receptor density and responsiveness.
Topics: Animals; Cerebral Cortex; Ethanolamines; Heart; Heart Rate; Hyperthyroidism; Hypothyroidism; In Vitr | 1985 |
Influence of the epithelium on responsiveness of guinea-pig isolated trachea to contractile and relaxant agonists.
Topics: Acetylcholine; Animals; Asthma; Autoradiography; Carbachol; Cimetidine; Colforsin; Dose-Response Rel | 1986 |
Beta-adrenoceptors in human tracheal smooth muscle: characteristics of binding and relaxation.
Topics: Atenolol; Binding, Competitive; Humans; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; | 1987 |
On the nature of the receptor mediating the action of 5-hydroxytryptamine in potentiating responses of the mouse urinary bladder strip to electrical stimulation.
Topics: Animals; Catecholamines; Electric Stimulation; In Vitro Techniques; Male; Mice; Muscle Contraction; | 1986 |
Comparison of beta-adrenergic blocking activities of propranolol, isopropylmethoxamine, sotalol, practolol, alprenolol, pindolol, oxprenolol and D-32 in the atria and trachea of the guinea-pig.
Topics: Adrenergic beta-Antagonists; Alprenolol; Animals; Butylamines; Dose-Response Relationship, Drug; Ele | 1974 |
[Differentiation between beta adrenergic and Ca 2+ antagonistic influencing components of beta receptor blockaders in the myocardium and in smooth muscles with special reference to Trasicor].
Topics: Adrenergic beta-Antagonists; Allyl Compounds; Amino Alcohols; Animals; Calcium; Cats; Chick Embryo; | 1972 |
Influence of temperature on the sensitivity of the -receptors and the contractility of guinea-pig atrium.
Topics: Acetanilides; Adrenergic beta-Antagonists; Amino Alcohols; Animals; Dose-Response Relationship, Drug | 1972 |
[Contraction and output capacity of the heart with coronary disease during beta adrenolysis using LB 46 (visken)].
Topics: Adult; Angina Pectoris; Blood Pressure; Cardiac Output; Coronary Disease; Electrocardiography; Heart | 1972 |
[Contractility reserve of the healthy left ventricle in physical strain following beta receptor blockade].
Topics: Heart; Heart Rate; Heart Ventricles; Humans; Muscle Contraction; Physical Exertion; Pindolol | 1972 |
[Comparative studies on practolol, pindolol and propranolol effect on hemodynamics and contractility of left ventricle in coronary disease patients].
Topics: Coronary Disease; Heart; Heart Ventricles; Hemodynamics; Humans; Muscle Contraction; Pindolol; Pract | 1973 |
Effects of perivascular nerve stimulation on the contraction and automaticity of the blood-perfused canine papillary muscle.
Topics: Alprenolol; Animals; Atropine; Cocaine; Dogs; Electric Stimulation; Female; Guanethidine; Hexamethon | 1972 |