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pindolol and Lymphoma

pindolol has been researched along with Lymphoma in 26 studies

Pindolol: A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)
pindolol : A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.

Lymphoma: A general term for various neoplastic diseases of the lymphoid tissue.

Research Excerpts

ExcerptRelevanceReference
"The beta-adrenergic antagonist [125I]iodoazidobenzylpindolol ( [125I]IABP) specifically photolabeled two polypeptides in membrane preparations from wild-type (WT) and coupling protein-deficient cyc- cultured lymphoma cells."7.66Photoaffinity labeling of the beta-adrenergic receptor from cultured lymphoma cells with [125I]iodoazidobenzylpindolol: loss of the label with desensitization. ( Clark, RB; Green, DA; Rashidbaigi, A; Ruoho, AE, 1983)
"Dithiothreitol (DTT) treatment of WT or cyc- lymphoma membranes resulted in the simultaneous loss of epinephrine-stimulated adenylate cyclase activity and beta-adrenergic antagonist binding."7.66Effect of dithiothreitol on the beta-adrenergic receptor of S49 wild type and cyc- lymphoma cells: decreased affinity of the ligand-receptor interaction. ( Clark, RB; Green, DA; Rashidbaigi, A; Ruoho, A, 1983)
"beta-Adrenergic receptors on membranes prepared from L6 myoblasts, wild-type S49 lymphoma cells, and an adenylate cyclase-deficient variant (cyc-) of S49 lymphoma cells bind the agonist [3H]hydroxybenzylisoproterenol ([3H]HBI) with high affinity."3.67Interaction of beta-adrenergic receptors with the inhibitory guanine nucleotide-binding protein of adenylate cyclase in membranes prepared from cyc- S49 lymphoma cells. ( Abramson, SN; Barrett, DA; Harden, TK; Hughes, AR; Martin, MW; Molinoff, PB; Neve, KA, 1988)
" The beta-adrenergic agonist activity of the derivatives was evaluated in vitro by measuring the intracellular accumulation of cyclic AMP in S49 mouse lymphoma cells and by the displacement of iodocyanopindolol (ICYP)."3.67Conjugates of catecholamines. 6. Synthesis and beta-adrenergic activity of N-(hydroxyalkyl)catecholamine derivatives. ( Akita, Y; Avery, MA; Castagnoli, N; Goodman, M; Hoffman, BB; Melmon, KL; Reitz, AB; Rosenkranz, RP; Verlander, MS, 1985)
" The beta-adrenergic activities of these new compounds were assessed through measurement of intracellular cyclic AMP accumulation in S49 mouse lymphoma cells and displacement of iodocyanopindolol (ICYP) from membrane preparations."3.67Conjugates of catecholamines. 5. Synthesis and beta-adrenergic activity of N-(aminoalkyl)norepinephrine derivatives. ( Akita, Y; Castagnoli, N; Goodman, M; Hoffman, BB; Melmon, KL; Reitz, AB; Rosenkranz, RP; Sonveaux, E; Verlander, MS, 1985)
"The ability of the atypical agonists celiprolol and pindolol to induce sequestration and down regulation of beta adrenergic receptors was investigated in S49 lymphoma cells."3.67Down regulation of beta adrenergic receptors in S49 lymphoma cells induced by atypical agonists. ( Molinoff, PB; Reynolds, EE, 1986)
" Two different cell types (human mononuclear leukocytes and S49 murine lymphoma cells) were used, and beta-adrenergic receptors were measured using either the hydrophilic ligand 3H-CGP 12177 (specific for surface receptors) or lipophilic 125I-pindolol (which measures total receptors)."3.67Certain beta-blockers can decrease beta-adrenergic receptor number: I. Acute reduction in receptor number by tertatolol and bopindolol. ( De Blasi, A; Fratelli, M; Marasco, O, 1988)
" In the current studies, we show that several beta AR antagonists with ISA (dichloroisoproterenol, pindolol, and celiprolol) stimulate cAMP accumulation five-, two-, and threefold, respectively, in S49 lymphoma cells, but only if cells are simultaneously incubated with the diterpene forskolin."3.67Molecular mechanism of beta-adrenergic receptor blockers with intrinsic sympathomimetic activity. ( Insel, PA; Jasper, JR; Michel, MC, 1988)
"Beta-adrenergic receptors on membranes prepared from rat lung, wild-type S49 lymphoma cells, and the adenylate cyclase-deficient variant of S49 lymphoma cells (cyc-) bind the agonist [3H]hydroxybenzylisoproterenol ([3H]HBI) with high affinity and this binding of [3H]HBI can be inhibited by GTP."3.67Interactions of beta-adrenergic receptors with a membrane protein other than the stimulatory guanine nucleotide-binding protein. ( Abramson, SN; Molinoff, PB; Shorr, RG, 1987)
"The beta-adrenergic antagonist [125I]iodoazidobenzylpindolol ( [125I]IABP) specifically photolabeled two polypeptides in membrane preparations from wild-type (WT) and coupling protein-deficient cyc- cultured lymphoma cells."3.66Photoaffinity labeling of the beta-adrenergic receptor from cultured lymphoma cells with [125I]iodoazidobenzylpindolol: loss of the label with desensitization. ( Clark, RB; Green, DA; Rashidbaigi, A; Ruoho, AE, 1983)
"Dithiothreitol (DTT) treatment of WT or cyc- lymphoma membranes resulted in the simultaneous loss of epinephrine-stimulated adenylate cyclase activity and beta-adrenergic antagonist binding."3.66Effect of dithiothreitol on the beta-adrenergic receptor of S49 wild type and cyc- lymphoma cells: decreased affinity of the ligand-receptor interaction. ( Clark, RB; Green, DA; Rashidbaigi, A; Ruoho, A, 1983)
"Treatment with propranolol slightly enhanced the proliferation of the RC-2A cells but did not markedly alter the growth rate of two other cell lines, regardless of their beta-adrenoceptor status."1.28Expression and function of beta-adrenergic receptors in human hematopoietic cell lines. ( Andersson, LC; Kontula, KK; Mäki, T, 1992)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-199022 (84.62)18.7374
1990's4 (15.38)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rashidbaigi, A3
Ruoho, AE2
Green, DA2
Clark, RB3
Insel, PA6
Mahan, LC3
Motulsky, HJ2
Stoolman, LM1
Koachman, AM1
Ruoho, A1
Cremaschi, GA1
Miguel, S1
Cazaux, C1
Sterin-Borda, L1
Johnson, GL1
Bourne, HR2
Gleason, MK1
Coffino, P2
Melmon, KL4
Maguire, ME2
Gilman, AG2
Ross, EM1
Sturgill, TW1
Biltonen, RL1
Gonzales, JM1
O'Donnell, JK1
Stadel, JM1
Sweet, RW1
Molinoff, PB5
Mäki, T1
Andersson, LC1
Kontula, KK1
Jasper, JR2
Feldman, RD1
Abramson, SN3
Martin, MW1
Hughes, AR1
Harden, TK1
Neve, KA1
Barrett, DA1
Reitz, AB2
Avery, MA1
Rosenkranz, RP2
Verlander, MS2
Hoffman, BB2
Akita, Y2
Castagnoli, N2
Goodman, M2
Sonveaux, E1
Reynolds, EE2
Hoyer, D1
Fabisiak, JP1
Vesell, ES1
Rannels, DE1
Marbach, I1
Shiloach, J1
Levitzki, A1
De Blasi, A1
Fratelli, M1
Marasco, O1
Michel, MC1
Shane, E1
Yeh, M1
Feigin, AS1
Owens, JM1
Bilezikian, JP1
Strasser, RH1
Sibley, DR1
Lefkowitz, RJ1
George, ST1
Malbon, CC1
Barber, R1
Shorr, RG1

Other Studies

26 other studies available for pindolol and Lymphoma

ArticleYear
Photoaffinity labeling of the beta-adrenergic receptor from cultured lymphoma cells with [125I]iodoazidobenzylpindolol: loss of the label with desensitization.
    Proceedings of the National Academy of Sciences of the United States of America, 1983, Volume: 80, Issue:10

    Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Affinity Labels; Animals; Azides; Cells, Cultured; Lymp

1983
Time-dependent decreases in binding affinity of agonists for beta-adrenergic receptors of intact S49 lymphoma cells. A mechanism of desensitization.
    The Journal of biological chemistry, 1983, Nov-25, Volume: 258, Issue:22

    Topics: Animals; Binding, Competitive; Cell Line; Cell Membrane; Cyclic AMP; Iodocyanopindolol; Isoprotereno

1983
Effect of dithiothreitol on the beta-adrenergic receptor of S49 wild type and cyc- lymphoma cells: decreased affinity of the ligand-receptor interaction.
    Journal of cyclic nucleotide and protein phosphorylation research, 1983, Volume: 9, Issue:3

    Topics: Adenylyl Cyclases; Affinity Labels; Azides; Cells, Cultured; Dithiothreitol; Epinephrine; Lymphoma;

1983
Increased proliferative activity, loss of beta-adrenergic receptor function and class I major histocompatibility complex antigen surface expression in a modified lymphoma cell line.
    Cellular signalling, 1994, Volume: 6, Issue:7

    Topics: Adrenergic beta-Antagonists; Animals; Biomarkers; Cell Division; Histocompatibility Antigens Class I

1994
Isolation and characterization of S49 lymphoma cells deficient in beta-adrenergic receptors: relation of receptor number to activation of adenylate cyclase.
    Molecular pharmacology, 1979, Volume: 15, Issue:1

    Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Clone Cells; Enzyme Activation; Isoproterenol; Lymphoma

1979
Beta adrenergic receptors and adenylate cyclase: products of separate genes?
    Molecular pharmacology, 1976, Volume: 12, Issue:6

    Topics: Adenylyl Cyclases; Animals; Binding Sites; Binding, Competitive; Cell Line; Clone Cells; Genes; Iodi

1976
Relationship between the beta-adrenergic receptor and adenylate cyclase.
    The Journal of biological chemistry, 1977, Aug-25, Volume: 252, Issue:16

    Topics: Adenylyl Cyclases; Bacterial Toxins; Cell Line; Cell Membrane; Enzyme Activation; Guanosine Triphosp

1977
Down-regulation of beta-adrenergic receptors by pindolol in Gs alpha-transfected S49 cyc- murine lymphoma cells.
    Journal of neurochemistry, 1992, Volume: 58, Issue:3

    Topics: Adenylyl Cyclases; Animals; Down-Regulation; GTP-Binding Proteins; Lymphoma; Mice; Pindolol; Recepto

1992
Expression and function of beta-adrenergic receptors in human hematopoietic cell lines.
    European journal of haematology, 1992, Volume: 49, Issue:5

    Topics: Blood Cells; Blotting, Southern; Cell Division; Cell Line; Cyclic AMP; DNA; DNA, Neoplasm; Humans; I

1992
Beta-adrenoceptor metabolism in wild-type, Gs, and protein kinase A-variant S49 cells.
    The American journal of physiology, 1990, Volume: 259, Issue:1 Pt 1

    Topics: Adrenergic beta-Antagonists; Animals; Binding, Competitive; Cell Line; Clone Cells; Cyclohexane Mono

1990
Photoaffinity labeling in the study of lymphoid cell beta-adrenergic receptors.
    Methods in enzymology, 1987, Volume: 150

    Topics: Affinity Labels; Animals; Azides; Cell Line; Cell Membrane; Electrophoresis, Polyacrylamide Gel; Hum

1987
Interaction of beta-adrenergic receptors with the inhibitory guanine nucleotide-binding protein of adenylate cyclase in membranes prepared from cyc- S49 lymphoma cells.
    Biochemical pharmacology, 1988, Nov-15, Volume: 37, Issue:22

    Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; GTP-Binding Prote

1988
Conjugates of catecholamines. 6. Synthesis and beta-adrenergic activity of N-(hydroxyalkyl)catecholamine derivatives.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:5

    Topics: Adrenergic beta-Agonists; Animals; Binding, Competitive; Catecholamines; Cyclic AMP; Hydroxylation;

1985
Conjugates of catecholamines. 5. Synthesis and beta-adrenergic activity of N-(aminoalkyl)norepinephrine derivatives.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:5

    Topics: Adrenergic beta-Agonists; Animals; Binding, Competitive; Cyclic AMP; In Vitro Techniques; Iodocyanop

1985
Interactions of agonists with beta-adrenergic receptors on S49 lymphoma cells.
    Advances in cyclic nucleotide and protein phosphorylation research, 1985, Volume: 19

    Topics: Adenosine Triphosphate; Adrenergic beta-Agonists; Albuterol; Animals; Binding, Competitive; Cell Lin

1985
Expression of beta-adrenergic receptors in synchronous and asynchronous S49 lymphoma cells. I. Receptor metabolism after irreversible blockade of receptors and in cells traversing the cell division cycle.
    Molecular pharmacology, 1986, Volume: 29, Issue:1

    Topics: Adrenergic beta-Antagonists; Alprenolol; Cell Cycle; Cell Division; Cell Line; Centrifugation; Human

1986
Down regulation of beta adrenergic receptors in S49 lymphoma cells induced by atypical agonists.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 239, Issue:3

    Topics: Adrenergic beta-Agonists; Animals; Binding Sites; Celiprolol; Cell Division; Cell Line; Isoprotereno

1986
Interactions of beta adrenergic antagonists with isolated rat alveolar type II pneumocytes. II. Receptor-independent accumulation of beta adrenergic antagonists and other cationic amphiphilic drugs in lamellar bodies.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:2

    Topics: Adrenergic beta-Antagonists; Animals; Histocytochemistry; Humans; Hydrogen-Ion Concentration; Iodocy

1987
Gi affects the agonist-binding properties of beta-adrenoceptors in the presence of Gs.
    European journal of biochemistry, 1988, Feb-15, Volume: 172, Issue:1

    Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Catalysis; Cholera To

1988
Certain beta-blockers can decrease beta-adrenergic receptor number: I. Acute reduction in receptor number by tertatolol and bopindolol.
    Circulation research, 1988, Volume: 63, Issue:2

    Topics: Adrenergic beta-Antagonists; Binding, Competitive; Humans; Leukocytes, Mononuclear; Lymphoma; Male;

1988
Molecular mechanism of beta-adrenergic receptor blockers with intrinsic sympathomimetic activity.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1988, Volume: 2, Issue:13

    Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Celiprolol; Colforsin; Cyclic AMP; Drug Synergism; I

1988
Cytosol activator protein from rat reticulocytes requires the stimulatory guanine nucleotide-binding protein for its actions on adenylate cyclase.
    Endocrinology, 1985, Volume: 117, Issue:1

    Topics: Adenylyl Cyclases; Animals; Cell Line; Cytosol; Dinoprostone; Enzyme Activation; Erythrocyte Membran

1985
A novel catecholamine-activated adenosine cyclic 3',5'-phosphate independent pathway for beta-adrenergic receptor phosphorylation in wild-type and mutant S49 lymphoma cells: mechanism of homologous desensitization of adenylate cyclase.
    Biochemistry, 1986, Mar-25, Volume: 25, Issue:6

    Topics: Adenosine Triphosphate; Adenylyl Cyclases; Amino Acids; Animals; Cell Line; Cell Membrane; Cyclic AM

1986
Large-scale purification of beta-adrenergic receptors from mammalian cells in culture.
    Preparative biochemistry, 1985, Volume: 15, Issue:5

    Topics: Animals; Autoradiography; Cell Line; Cell Membrane; Chromatography, Affinity; Chromatography, High P

1985
Discrimination between intact cell desensitization and agonist affinity changes.
    Molecular and cellular endocrinology, 1986, Volume: 46, Issue:3

    Topics: Adenylyl Cyclases; Animals; Binding, Competitive; Cell Line; Epinephrine; Kinetics; Lymphoma; Mice;

1986
Interactions of beta-adrenergic receptors with a membrane protein other than the stimulatory guanine nucleotide-binding protein.
    Biochemical pharmacology, 1987, Jul-15, Volume: 36, Issue:14

    Topics: Adenylyl Cyclases; Animals; Cell Line; GTP-Binding Proteins; Isoproterenol; Lymphoma; Membrane Prote

1987