pindolol has been researched along with Lymphoma in 26 studies
Pindolol: A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)
pindolol : A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.
Lymphoma: A general term for various neoplastic diseases of the lymphoid tissue.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The beta-adrenergic antagonist [125I]iodoazidobenzylpindolol ( [125I]IABP) specifically photolabeled two polypeptides in membrane preparations from wild-type (WT) and coupling protein-deficient cyc- cultured lymphoma cells." | 7.66 | Photoaffinity labeling of the beta-adrenergic receptor from cultured lymphoma cells with [125I]iodoazidobenzylpindolol: loss of the label with desensitization. ( Clark, RB; Green, DA; Rashidbaigi, A; Ruoho, AE, 1983) |
| "Dithiothreitol (DTT) treatment of WT or cyc- lymphoma membranes resulted in the simultaneous loss of epinephrine-stimulated adenylate cyclase activity and beta-adrenergic antagonist binding." | 7.66 | Effect of dithiothreitol on the beta-adrenergic receptor of S49 wild type and cyc- lymphoma cells: decreased affinity of the ligand-receptor interaction. ( Clark, RB; Green, DA; Rashidbaigi, A; Ruoho, A, 1983) |
| "beta-Adrenergic receptors on membranes prepared from L6 myoblasts, wild-type S49 lymphoma cells, and an adenylate cyclase-deficient variant (cyc-) of S49 lymphoma cells bind the agonist [3H]hydroxybenzylisoproterenol ([3H]HBI) with high affinity." | 3.67 | Interaction of beta-adrenergic receptors with the inhibitory guanine nucleotide-binding protein of adenylate cyclase in membranes prepared from cyc- S49 lymphoma cells. ( Abramson, SN; Barrett, DA; Harden, TK; Hughes, AR; Martin, MW; Molinoff, PB; Neve, KA, 1988) |
| " The beta-adrenergic agonist activity of the derivatives was evaluated in vitro by measuring the intracellular accumulation of cyclic AMP in S49 mouse lymphoma cells and by the displacement of iodocyanopindolol (ICYP)." | 3.67 | Conjugates of catecholamines. 6. Synthesis and beta-adrenergic activity of N-(hydroxyalkyl)catecholamine derivatives. ( Akita, Y; Avery, MA; Castagnoli, N; Goodman, M; Hoffman, BB; Melmon, KL; Reitz, AB; Rosenkranz, RP; Verlander, MS, 1985) |
| " The beta-adrenergic activities of these new compounds were assessed through measurement of intracellular cyclic AMP accumulation in S49 mouse lymphoma cells and displacement of iodocyanopindolol (ICYP) from membrane preparations." | 3.67 | Conjugates of catecholamines. 5. Synthesis and beta-adrenergic activity of N-(aminoalkyl)norepinephrine derivatives. ( Akita, Y; Castagnoli, N; Goodman, M; Hoffman, BB; Melmon, KL; Reitz, AB; Rosenkranz, RP; Sonveaux, E; Verlander, MS, 1985) |
| "The ability of the atypical agonists celiprolol and pindolol to induce sequestration and down regulation of beta adrenergic receptors was investigated in S49 lymphoma cells." | 3.67 | Down regulation of beta adrenergic receptors in S49 lymphoma cells induced by atypical agonists. ( Molinoff, PB; Reynolds, EE, 1986) |
| " Two different cell types (human mononuclear leukocytes and S49 murine lymphoma cells) were used, and beta-adrenergic receptors were measured using either the hydrophilic ligand 3H-CGP 12177 (specific for surface receptors) or lipophilic 125I-pindolol (which measures total receptors)." | 3.67 | Certain beta-blockers can decrease beta-adrenergic receptor number: I. Acute reduction in receptor number by tertatolol and bopindolol. ( De Blasi, A; Fratelli, M; Marasco, O, 1988) |
| " In the current studies, we show that several beta AR antagonists with ISA (dichloroisoproterenol, pindolol, and celiprolol) stimulate cAMP accumulation five-, two-, and threefold, respectively, in S49 lymphoma cells, but only if cells are simultaneously incubated with the diterpene forskolin." | 3.67 | Molecular mechanism of beta-adrenergic receptor blockers with intrinsic sympathomimetic activity. ( Insel, PA; Jasper, JR; Michel, MC, 1988) |
| "Beta-adrenergic receptors on membranes prepared from rat lung, wild-type S49 lymphoma cells, and the adenylate cyclase-deficient variant of S49 lymphoma cells (cyc-) bind the agonist [3H]hydroxybenzylisoproterenol ([3H]HBI) with high affinity and this binding of [3H]HBI can be inhibited by GTP." | 3.67 | Interactions of beta-adrenergic receptors with a membrane protein other than the stimulatory guanine nucleotide-binding protein. ( Abramson, SN; Molinoff, PB; Shorr, RG, 1987) |
| "The beta-adrenergic antagonist [125I]iodoazidobenzylpindolol ( [125I]IABP) specifically photolabeled two polypeptides in membrane preparations from wild-type (WT) and coupling protein-deficient cyc- cultured lymphoma cells." | 3.66 | Photoaffinity labeling of the beta-adrenergic receptor from cultured lymphoma cells with [125I]iodoazidobenzylpindolol: loss of the label with desensitization. ( Clark, RB; Green, DA; Rashidbaigi, A; Ruoho, AE, 1983) |
| "Dithiothreitol (DTT) treatment of WT or cyc- lymphoma membranes resulted in the simultaneous loss of epinephrine-stimulated adenylate cyclase activity and beta-adrenergic antagonist binding." | 3.66 | Effect of dithiothreitol on the beta-adrenergic receptor of S49 wild type and cyc- lymphoma cells: decreased affinity of the ligand-receptor interaction. ( Clark, RB; Green, DA; Rashidbaigi, A; Ruoho, A, 1983) |
| "Treatment with propranolol slightly enhanced the proliferation of the RC-2A cells but did not markedly alter the growth rate of two other cell lines, regardless of their beta-adrenoceptor status." | 1.28 | Expression and function of beta-adrenergic receptors in human hematopoietic cell lines. ( Andersson, LC; Kontula, KK; Mäki, T, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (84.62) | 18.7374 |
| 1990's | 4 (15.38) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rashidbaigi, A | 3 |
| Ruoho, AE | 2 |
| Green, DA | 2 |
| Clark, RB | 3 |
| Insel, PA | 6 |
| Mahan, LC | 3 |
| Motulsky, HJ | 2 |
| Stoolman, LM | 1 |
| Koachman, AM | 1 |
| Ruoho, A | 1 |
| Cremaschi, GA | 1 |
| Miguel, S | 1 |
| Cazaux, C | 1 |
| Sterin-Borda, L | 1 |
| Johnson, GL | 1 |
| Bourne, HR | 2 |
| Gleason, MK | 1 |
| Coffino, P | 2 |
| Melmon, KL | 4 |
| Maguire, ME | 2 |
| Gilman, AG | 2 |
| Ross, EM | 1 |
| Sturgill, TW | 1 |
| Biltonen, RL | 1 |
| Gonzales, JM | 1 |
| O'Donnell, JK | 1 |
| Stadel, JM | 1 |
| Sweet, RW | 1 |
| Molinoff, PB | 5 |
| Mäki, T | 1 |
| Andersson, LC | 1 |
| Kontula, KK | 1 |
| Jasper, JR | 2 |
| Feldman, RD | 1 |
| Abramson, SN | 3 |
| Martin, MW | 1 |
| Hughes, AR | 1 |
| Harden, TK | 1 |
| Neve, KA | 1 |
| Barrett, DA | 1 |
| Reitz, AB | 2 |
| Avery, MA | 1 |
| Rosenkranz, RP | 2 |
| Verlander, MS | 2 |
| Hoffman, BB | 2 |
| Akita, Y | 2 |
| Castagnoli, N | 2 |
| Goodman, M | 2 |
| Sonveaux, E | 1 |
| Reynolds, EE | 2 |
| Hoyer, D | 1 |
| Fabisiak, JP | 1 |
| Vesell, ES | 1 |
| Rannels, DE | 1 |
| Marbach, I | 1 |
| Shiloach, J | 1 |
| Levitzki, A | 1 |
| De Blasi, A | 1 |
| Fratelli, M | 1 |
| Marasco, O | 1 |
| Michel, MC | 1 |
| Shane, E | 1 |
| Yeh, M | 1 |
| Feigin, AS | 1 |
| Owens, JM | 1 |
| Bilezikian, JP | 1 |
| Strasser, RH | 1 |
| Sibley, DR | 1 |
| Lefkowitz, RJ | 1 |
| George, ST | 1 |
| Malbon, CC | 1 |
| Barber, R | 1 |
| Shorr, RG | 1 |
26 other studies available for pindolol and Lymphoma
| Article | Year |
|---|---|
Photoaffinity labeling of the beta-adrenergic receptor from cultured lymphoma cells with [125I]iodoazidobenzylpindolol: loss of the label with desensitization.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Affinity Labels; Animals; Azides; Cells, Cultured; Lymp | 1983 |
Time-dependent decreases in binding affinity of agonists for beta-adrenergic receptors of intact S49 lymphoma cells. A mechanism of desensitization.
Topics: Animals; Binding, Competitive; Cell Line; Cell Membrane; Cyclic AMP; Iodocyanopindolol; Isoprotereno | 1983 |
Effect of dithiothreitol on the beta-adrenergic receptor of S49 wild type and cyc- lymphoma cells: decreased affinity of the ligand-receptor interaction.
Topics: Adenylyl Cyclases; Affinity Labels; Azides; Cells, Cultured; Dithiothreitol; Epinephrine; Lymphoma; | 1983 |
Increased proliferative activity, loss of beta-adrenergic receptor function and class I major histocompatibility complex antigen surface expression in a modified lymphoma cell line.
Topics: Adrenergic beta-Antagonists; Animals; Biomarkers; Cell Division; Histocompatibility Antigens Class I | 1994 |
Isolation and characterization of S49 lymphoma cells deficient in beta-adrenergic receptors: relation of receptor number to activation of adenylate cyclase.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Clone Cells; Enzyme Activation; Isoproterenol; Lymphoma | 1979 |
Beta adrenergic receptors and adenylate cyclase: products of separate genes?
Topics: Adenylyl Cyclases; Animals; Binding Sites; Binding, Competitive; Cell Line; Clone Cells; Genes; Iodi | 1976 |
Relationship between the beta-adrenergic receptor and adenylate cyclase.
Topics: Adenylyl Cyclases; Bacterial Toxins; Cell Line; Cell Membrane; Enzyme Activation; Guanosine Triphosp | 1977 |
Down-regulation of beta-adrenergic receptors by pindolol in Gs alpha-transfected S49 cyc- murine lymphoma cells.
Topics: Adenylyl Cyclases; Animals; Down-Regulation; GTP-Binding Proteins; Lymphoma; Mice; Pindolol; Recepto | 1992 |
Expression and function of beta-adrenergic receptors in human hematopoietic cell lines.
Topics: Blood Cells; Blotting, Southern; Cell Division; Cell Line; Cyclic AMP; DNA; DNA, Neoplasm; Humans; I | 1992 |
Beta-adrenoceptor metabolism in wild-type, Gs, and protein kinase A-variant S49 cells.
Topics: Adrenergic beta-Antagonists; Animals; Binding, Competitive; Cell Line; Clone Cells; Cyclohexane Mono | 1990 |
Photoaffinity labeling in the study of lymphoid cell beta-adrenergic receptors.
Topics: Affinity Labels; Animals; Azides; Cell Line; Cell Membrane; Electrophoresis, Polyacrylamide Gel; Hum | 1987 |
Interaction of beta-adrenergic receptors with the inhibitory guanine nucleotide-binding protein of adenylate cyclase in membranes prepared from cyc- S49 lymphoma cells.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; GTP-Binding Prote | 1988 |
Conjugates of catecholamines. 6. Synthesis and beta-adrenergic activity of N-(hydroxyalkyl)catecholamine derivatives.
Topics: Adrenergic beta-Agonists; Animals; Binding, Competitive; Catecholamines; Cyclic AMP; Hydroxylation; | 1985 |
Conjugates of catecholamines. 5. Synthesis and beta-adrenergic activity of N-(aminoalkyl)norepinephrine derivatives.
Topics: Adrenergic beta-Agonists; Animals; Binding, Competitive; Cyclic AMP; In Vitro Techniques; Iodocyanop | 1985 |
Interactions of agonists with beta-adrenergic receptors on S49 lymphoma cells.
Topics: Adenosine Triphosphate; Adrenergic beta-Agonists; Albuterol; Animals; Binding, Competitive; Cell Lin | 1985 |
Expression of beta-adrenergic receptors in synchronous and asynchronous S49 lymphoma cells. I. Receptor metabolism after irreversible blockade of receptors and in cells traversing the cell division cycle.
Topics: Adrenergic beta-Antagonists; Alprenolol; Cell Cycle; Cell Division; Cell Line; Centrifugation; Human | 1986 |
Down regulation of beta adrenergic receptors in S49 lymphoma cells induced by atypical agonists.
Topics: Adrenergic beta-Agonists; Animals; Binding Sites; Celiprolol; Cell Division; Cell Line; Isoprotereno | 1986 |
Interactions of beta adrenergic antagonists with isolated rat alveolar type II pneumocytes. II. Receptor-independent accumulation of beta adrenergic antagonists and other cationic amphiphilic drugs in lamellar bodies.
Topics: Adrenergic beta-Antagonists; Animals; Histocytochemistry; Humans; Hydrogen-Ion Concentration; Iodocy | 1987 |
Gi affects the agonist-binding properties of beta-adrenoceptors in the presence of Gs.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Catalysis; Cholera To | 1988 |
Certain beta-blockers can decrease beta-adrenergic receptor number: I. Acute reduction in receptor number by tertatolol and bopindolol.
Topics: Adrenergic beta-Antagonists; Binding, Competitive; Humans; Leukocytes, Mononuclear; Lymphoma; Male; | 1988 |
Molecular mechanism of beta-adrenergic receptor blockers with intrinsic sympathomimetic activity.
Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Celiprolol; Colforsin; Cyclic AMP; Drug Synergism; I | 1988 |
Cytosol activator protein from rat reticulocytes requires the stimulatory guanine nucleotide-binding protein for its actions on adenylate cyclase.
Topics: Adenylyl Cyclases; Animals; Cell Line; Cytosol; Dinoprostone; Enzyme Activation; Erythrocyte Membran | 1985 |
A novel catecholamine-activated adenosine cyclic 3',5'-phosphate independent pathway for beta-adrenergic receptor phosphorylation in wild-type and mutant S49 lymphoma cells: mechanism of homologous desensitization of adenylate cyclase.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Amino Acids; Animals; Cell Line; Cell Membrane; Cyclic AM | 1986 |
Large-scale purification of beta-adrenergic receptors from mammalian cells in culture.
Topics: Animals; Autoradiography; Cell Line; Cell Membrane; Chromatography, Affinity; Chromatography, High P | 1985 |
Discrimination between intact cell desensitization and agonist affinity changes.
Topics: Adenylyl Cyclases; Animals; Binding, Competitive; Cell Line; Epinephrine; Kinetics; Lymphoma; Mice; | 1986 |
Interactions of beta-adrenergic receptors with a membrane protein other than the stimulatory guanine nucleotide-binding protein.
Topics: Adenylyl Cyclases; Animals; Cell Line; GTP-Binding Proteins; Isoproterenol; Lymphoma; Membrane Prote | 1987 |