pindolol has been researched along with Hypothyroidism in 8 studies
Pindolol: A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)
pindolol : A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.
Hypothyroidism: A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| " There was a decrease in sensitivity to isoproterenol in spontaneously beating right atria, electrically driven left atria and field-stimulated vas deferens associated with hypothyroidism, with no change in maximum response." | 3.67 | Thyroid status and adrenergic receptor subtypes in the rat: comparison of receptor density and responsiveness. ( Abel, PW; Fox, AW; Johnson, RD; Juberg, EN; May, JM; Minneman, KP, 1985) |
| "In isolated sc adipocytes removed from hyperthyroid patients, the specific binding of [3H]dihydroalprenolol and [125I]iodocyanopindolol was greater than that in adipocytes from normal subjects." | 3.67 | Adrenergic regulation of lipolysis in human adipocytes: findings in hyper- and hypothyroidism. ( Arner, P; Engfeldt, P; Ostman, J; Wahrenberg, H; Wennlund, A, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (50.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ghosh, M | 1 |
| Das, S | 1 |
| Rubio, A | 1 |
| Raasmaja, A | 1 |
| Maia, AL | 1 |
| Kim, KR | 1 |
| Silva, JE | 1 |
| Medina-Martínez, O | 1 |
| García-Sáinz, JA | 1 |
| Kragie, L | 1 |
| Kwon, YW | 1 |
| Smiehorowski, R | 1 |
| Bilezikian, JP | 1 |
| Loeb, JN | 1 |
| Gammon, DE | 1 |
| Elks, ML | 1 |
| Manganiello, VC | 1 |
| Fox, AW | 1 |
| Juberg, EN | 1 |
| May, JM | 1 |
| Johnson, RD | 1 |
| Abel, PW | 1 |
| Minneman, KP | 1 |
| Wahrenberg, H | 1 |
| Engfeldt, P | 1 |
| Arner, P | 1 |
| Wennlund, A | 1 |
| Ostman, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Thyroid Hormone-Induced Lipolysis: An In Vivo Microdialysis Study[NCT00312715] | 41 participants (Actual) | Observational | 2006-04-03 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 other studies available for pindolol and Hypothyroidism
| Article | Year |
|---|---|
Increased beta(2)-adrenergic receptor activity by thyroid hormone possibly leads to differentiation and maturation of astrocytes in culture.
Topics: Adrenergic beta-2 Receptor Antagonists; Animals; Animals, Newborn; Astrocytes; Cell Differentiation; | 2007 |
Effects of thyroid hormone on norepinephrine signaling in brown adipose tissue. I. Beta 1- and beta 2-adrenergic receptors and cyclic adenosine 3',5'-monophosphate generation.
Topics: Adipose Tissue, Brown; Adrenergic Agents; Adrenergic beta-Antagonists; Animals; Cyclic AMP; Hypothyr | 1995 |
Hepatocyte homologous beta 2-adrenergic desensitization is associated with a decrease in number of plasma membrane beta 2-adrenoceptors.
Topics: Adenosine Diphosphate Ribose; Adenylyl Cyclases; Alkaline Phosphatase; Animals; Autoradiography; Bin | 1993 |
Rat cardiac calcium channels and their relationships with beta-adrenergic and muscarinic receptors in hypothyroidism.
Topics: Animals; Calcium; Calcium Channels; Carbachol; Dose-Response Relationship, Drug; Heart Rate; Hypothy | 1993 |
The influence of hyperthyroidism and hypothyroidism on the beta-adrenergic responsiveness of the turkey erythrocyte.
Topics: Adenylyl Cyclases; Animals; Catecholamines; Cyclic AMP; Erythrocytes; Hyperthyroidism; Hypothyroidis | 1979 |
Effects of thyroid hormone on regulation of lipolysis and adenosine 3',5'-monophosphate metabolism in 3T3-L1 adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Adipose Tissue; | 1985 |
Thyroid status and adrenergic receptor subtypes in the rat: comparison of receptor density and responsiveness.
Topics: Animals; Cerebral Cortex; Ethanolamines; Heart; Heart Rate; Hyperthyroidism; Hypothyroidism; In Vitr | 1985 |
Adrenergic regulation of lipolysis in human adipocytes: findings in hyper- and hypothyroidism.
Topics: Adipose Tissue; Adult; Catecholamines; Dihydroalprenolol; Female; Humans; Hyperthyroidism; Hypothyro | 1986 |