pindolol has been researched along with Heart Failure in 29 studies
Pindolol: A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)
pindolol : A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study investigated the effects of myocardial infarction (MI)-induced cardiac failure and treatment with an angiotensin-converting enzyme (ACE) inhibitor perindopril (2 mg/kg/day) on rat beta-adrenoceptor (beta-ar) subtypes in anatomically defined regions of infarcted left ventricular (LV) free wall and noninfarcted tissue from right ventricle (RV) by using autoradiography." | 7.70 | Regulation of beta-adrenoceptors in a rat model of cardiac failure: effect of perindopril. ( Gu, XH; Kompa, AR; Summers, RJ, 1998) |
| "Dose- and time-dependent pharmacokinetics and plasma protein binding of pindolol were studied in patients with idiopathic cardiomyopathy who had mild to moderate congestive heart failure." | 7.67 | Dose- and time-dependent binding and kinetics of pindolol in patients with congestive heart failure. ( Binkley, PF; Johnson, J; Leier, CV; Lima, JJ, 1986) |
| " These results indicate that the slope of the left ventricular ESP/ESD relation is not altered following repeated dosing with pindolol in subjects with congestive heart failure." | 5.27 | Preservation of the end-systolic pressure/end-systolic dimension relation following pindolol in congestive heart failure. ( Binkley, PF; Leier, CV; Lewe, RF; Unverferth, DV, 1988) |
| "1 This study was designed to compare in a randomized cross-over trial pindolol, a beta-adrenoceptor blocking agent with intrinsic sympathomimetic activity and metoprolol, a cardioselective beta-adrenoceptor blocker lacking sympathomimetic activity in hypertensives with incipient heart failure." | 5.05 | The influence of beta-adrenoceptor blockade on left ventricular function. ( Hahn, B; Strauer, BE, 1982) |
| "This study investigated the effects of myocardial infarction (MI)-induced cardiac failure and treatment with an angiotensin-converting enzyme (ACE) inhibitor perindopril (2 mg/kg/day) on rat beta-adrenoceptor (beta-ar) subtypes in anatomically defined regions of infarcted left ventricular (LV) free wall and noninfarcted tissue from right ventricle (RV) by using autoradiography." | 3.70 | Regulation of beta-adrenoceptors in a rat model of cardiac failure: effect of perindopril. ( Gu, XH; Kompa, AR; Summers, RJ, 1998) |
| "Dose- and time-dependent pharmacokinetics and plasma protein binding of pindolol were studied in patients with idiopathic cardiomyopathy who had mild to moderate congestive heart failure." | 3.67 | Dose- and time-dependent binding and kinetics of pindolol in patients with congestive heart failure. ( Binkley, PF; Johnson, J; Leier, CV; Lima, JJ, 1986) |
| "Three patients with ischaemic heart disease developed profound cardiac failure, hypotension and bradycardia during combined therapy with verapamil and beta-adrenergic blocking drugs." | 3.66 | Adverse interaction between beta-adrenergic blocking drugs and verapamil--report of three cases. ( Anderson, ST; Federman, J; Harper, RW; Laufer, E; Pitt, A; Wayne, VS, 1982) |
| "The authors report a case of syncopal ventricular tachycardia in a patient with a respiratory-dependent rate responsive pacemaker, followed-up for valvular heart disease with severe left ventricular dysfunction and sustained atrial and ventricular arrhythmias." | 1.28 | [Ventricular tachycardia in a patient with rate-responsive cardiac pacemaker]. ( Busquet, P; Coutte, R; Frank, R; Grosgogeat, Y; Himbert, C; Lascault, G; Tonet, J, 1992) |
| " Increases in norepinephrine, dopamine, and epinephrine concentrations after dosing were noted, with the most marked increase in norepinephrine concentration being coincident with a significant decline in stroke volume index." | 1.27 | Neurohumoral profile in congestive heart failure: response to beta-blockade. ( Binkley, PF; Leier, CV; Lewe, R; Lima, J; Unverferth, DV, 1988) |
| " These results indicate that the slope of the left ventricular ESP/ESD relation is not altered following repeated dosing with pindolol in subjects with congestive heart failure." | 1.27 | Preservation of the end-systolic pressure/end-systolic dimension relation following pindolol in congestive heart failure. ( Binkley, PF; Leier, CV; Lewe, RF; Unverferth, DV, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (65.52) | 18.7374 |
| 1990's | 9 (31.03) | 18.2507 |
| 2000's | 1 (3.45) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sal'nikov, EV | 1 |
| Moses, JW | 1 |
| Borer, JS | 1 |
| Davies, B | 1 |
| Bannister, R | 1 |
| Mathias, C | 1 |
| Sever, P | 1 |
| Hahn, B | 1 |
| Strauer, BE | 1 |
| Wayne, VS | 1 |
| Harper, RW | 1 |
| Laufer, E | 1 |
| Federman, J | 1 |
| Anderson, ST | 1 |
| Pitt, A | 1 |
| McDevitt, DG | 1 |
| Tkaczewski, W | 1 |
| Goch, JH | 1 |
| Wichan, P | 1 |
| Kowalski, J | 1 |
| Steinfath, M | 1 |
| Lavicky, J | 1 |
| Schmitz, W | 1 |
| Scholz, H | 1 |
| Döring, V | 1 |
| Kalmár, P | 1 |
| Gu, XH | 1 |
| Kompa, AR | 1 |
| Summers, RJ | 1 |
| Zilcher, H | 1 |
| Glogar, D | 1 |
| Ponsonnaille, J | 1 |
| Pailloncy, M | 1 |
| Goujon, B | 1 |
| Marcheix, JC | 1 |
| Gras, H | 1 |
| Himbert, C | 1 |
| Lascault, G | 1 |
| Tonet, J | 1 |
| Coutte, R | 1 |
| Busquet, P | 1 |
| Frank, R | 1 |
| Grosgogeat, Y | 1 |
| Bristow, MR | 3 |
| Minobe, W | 3 |
| Rasmussen, R | 2 |
| Larrabee, P | 2 |
| Skerl, L | 2 |
| Klein, JW | 1 |
| Anderson, FL | 1 |
| Murray, J | 1 |
| Mestroni, L | 1 |
| Karwande, SV | 1 |
| Takahashi, M | 1 |
| Shichiri, G | 1 |
| Amano, M | 1 |
| Kanamori, T | 1 |
| Kinoshita, M | 1 |
| Müller-Beckmann, B | 1 |
| Roden, R | 1 |
| Klein, J | 1 |
| Handwerger, D | 1 |
| Port, JD | 1 |
| Kozlik, R | 1 |
| Kramer, HH | 1 |
| Wicht, H | 1 |
| Bircks, W | 1 |
| Reinhardt, D | 1 |
| Sullebarger, JT | 1 |
| Fan, TH | 1 |
| Torres, F | 1 |
| Liang, CS | 1 |
| Böhm, M | 1 |
| Mittmann, C | 1 |
| Schwinger, RH | 1 |
| Erdmann, E | 1 |
| Denniss, AR | 1 |
| Colucci, WS | 1 |
| Allen, PD | 1 |
| Marsh, JD | 1 |
| Murphree, SS | 1 |
| Saffitz, JE | 1 |
| Hershberger, RE | 1 |
| Hoffman, BB | 1 |
| Binkley, PF | 3 |
| Lewe, R | 1 |
| Lima, J | 1 |
| Unverferth, DV | 2 |
| Leier, CV | 3 |
| Weber, S | 1 |
| Cabanes, L | 1 |
| Lanouar, K | 1 |
| Degeorges, M | 1 |
| Lewe, RF | 1 |
| Lima, JJ | 1 |
| Johnson, J | 1 |
| Ohly, A | 1 |
| König, E | 1 |
| Nachreiner, K | 1 |
| Schmidt, F | 1 |
| Singh, BN | 1 |
| Simpson, FO | 1 |
| Scebat, L | 1 |
| Rocha, P | 1 |
| Ourbak, P | 1 |
| Renais, J | 1 |
| Lenègre, J | 1 |
3 reviews available for pindolol and Heart Failure
| Article | Year |
|---|---|
Beta-adrenergic antagonists in the treatment of patients with heart disease.
Topics: Acebutolol; Adrenergic beta-Agonists; Alprenolol; Animals; Arrhythmias, Cardiac; Bronchial Spasm; Ca | 1981 |
[Heart failure: beta-stimulant or beta-blocker?].
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Adrenergic Fibers; Heart Failure; Pindolol | 1988 |
Beta-adrenergic receptor blocking drugs in hypertension.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Alprenolol; Antidepressive Agents; Antihy | 1974 |
2 trials available for pindolol and Heart Failure
| Article | Year |
|---|---|
The influence of beta-adrenoceptor blockade on left ventricular function.
Topics: Adrenergic beta-Antagonists; Cardiac Output; Heart; Heart Failure; Humans; Hypertension; Metoprolol; | 1982 |
[Ergometric test in sympatheticotonia after administration of propranolol, pindolol, verapamil and oxazepam].
Topics: Adolescent; Adrenergic Fibers; Adult; Clinical Trials as Topic; Exercise Test; Heart; Heart Failure; | 1980 |
24 other studies available for pindolol and Heart Failure
| Article | Year |
|---|---|
Heart rate variability in rats with experimental chronic heart failure and long-term exposure to beta-adrenoblockers.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Benzopyrans; Bisoprolol; Ethanolamines; Heart Failur | 2009 |
Pindolol in postural hypotension: the case for caution.
Topics: Aged; Female; Heart Failure; Humans; Hypotension, Orthostatic; Male; Middle Aged; Pindolol | 1981 |
Adverse interaction between beta-adrenergic blocking drugs and verapamil--report of three cases.
Topics: Adrenergic beta-Antagonists; Aged; Bradycardia; Coronary Disease; Drug Interactions; Drug Therapy, C | 1982 |
Beta-adrenoceptor blocking drugs and partial agonist activity. Is it clinically relevant?
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Asthma; Bradycardia; Cardiac Output; Heart Fa | 1983 |
Changes in cardiac beta-adrenoceptors in human heart diseases: relationship to the degree of heart failure and further evidence for etiology-related regulation of beta 1 and beta 2 subtypes.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aortic Valve; Cardiomyopathy, Hypertrophic; Down-Reg | 1993 |
Regulation of beta-adrenoceptors in a rat model of cardiac failure: effect of perindopril.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Autoradiography; Blood Pressure; Body Weight; Dow | 1998 |
[Non arrhythmogenic sudden death as complication of coronary heart disease].
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Coronary Artery Bypass; Coronary Disease; Death, | 1979 |
[Congestive-type primary myocardiopathies: treatment with beta-blocking agents].
Topics: Adult; Cardiomyopathies; Heart Failure; Humans; Middle Aged; Pindolol; Propranolol | 1978 |
[Ventricular tachycardia in a patient with rate-responsive cardiac pacemaker].
Topics: Aged; Amiodarone; Electrocardiography, Ambulatory; Heart Failure; Heart Rate; Humans; Male; Pacemake | 1992 |
Beta-adrenergic neuroeffector abnormalities in the failing human heart are produced by local rather than systemic mechanisms.
Topics: Adenylyl Cyclases; Adult; Cardiomyopathy, Dilated; Catecholamines; Female; Heart; Heart Failure; Hum | 1992 |
Increased uncoupling of beta-, beta 1- and beta 2-adrenoceptor to myocardial contraction in failing human myocardium.
Topics: Adult; Aged; Binding, Competitive; Dobutamine; Down-Regulation; Female; Heart Failure; Humans; Iodoc | 1992 |
Effects of carvedilol on adrenergic receptor pharmacology in human ventricular myocardium and lymphocytes.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Binding, Competitive; Carbazoles; Cardiomyopat | 1992 |
Beta-adrenoceptor density on mononuclear leukocytes and right atrial myocardium in infants and children with congenital heart disease.
Topics: Binding, Competitive; Child; Child, Preschool; Down-Regulation; Epinephrine; Female; Heart Atria; He | 1991 |
Both cell surface and internalized beta-adrenoceptors are reduced in the failing myocardium.
Topics: Animals; Binding Sites; Cell Membrane; Dogs; Heart Failure; Iodocyanopindolol; Ouabain; Pindolol; Re | 1991 |
Effects of xamoterol on inotropic and lusitropic properties of the human myocardium and on adenylate cyclase activity.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Dose-Response Relationship, Drug; Heart Atria; Heart Fa | 1990 |
Distribution and function of human ventricular beta adrenergic receptors in congestive heart failure.
Topics: Adenylyl Cyclases; Adolescent; Adult; Binding, Competitive; GTP-Binding Proteins; Heart Failure; Hea | 1989 |
Distribution of beta-adrenergic receptors in failing human myocardium. Implications for mechanisms of down-regulation.
Topics: Adrenergic beta-Antagonists; Adult; Autoradiography; Female; Heart Failure; Heart Transplantation; H | 1989 |
Alpha-1 adrenergic receptors in the nonfailing and failing human heart.
Topics: Carbachol; Heart Failure; Humans; Iodocyanopindolol; Myocardium; Norepinephrine; Phenethylamines; Ph | 1988 |
Neurohumoral profile in congestive heart failure: response to beta-blockade.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Heart Failure; Hemodynamics; Humans; Hypertension; Middle | 1988 |
Preservation of the end-systolic pressure/end-systolic dimension relation following pindolol in congestive heart failure.
Topics: Echocardiography; Heart; Heart Failure; Humans; Myocardial Contraction; Pindolol; Stroke Volume; Sys | 1988 |
Dose- and time-dependent binding and kinetics of pindolol in patients with congestive heart failure.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Administra | 1986 |
[Cardiodepressive side effects of beta sympatholytic therapy. Clinical tests with Visken].
Topics: Administration, Oral; Adrenergic beta-Antagonists; Adult; Aged; Coronary Disease; Dose-Response Rela | 1973 |
Clinical aspects of the anti-arrhythmic actions of beta-receptor blocking drugs. 2. Clinical pharmacology.
Topics: Adrenergic beta-Antagonists; Alprenolol; Arrhythmias, Cardiac; Drug Therapy, Combination; Heart Fail | 1973 |
[Hemodynamic effects of intravenous injection of beta-adrenergic inhibitor (Pindolol) in man].
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Female; Heart Failure; Heart Rate; Hemodynamics; Hum | 1972 |