pindolol and Glioma
pindolol has been researched along with Glioma in 24 studies
Pindolol: A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)
pindolol : A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "C6 glioma cells possess beta adrenergic receptors coupled with adenylate cyclase which can be irreversibly blocked by bromoacetylaminomethylpindolol (Br-AAM-pindolol), a beta adrenergic antagonist." | 3.67 | Beta adrenergic receptor repopulation of C6 glioma cells after irreversible blockade and down regulation. ( Bockaert, J; Gozlan, H; Homburger, V; Lucas, M; Pantaloni, C, 1984) |
| "Competition by beta-adrenergic agonists and antagonists for 125I-pindolol binding sites on intact cells (1321N1 human astrocytoma and C62B rat glioma) was measured using short time binding assays as previously described (Toews, M." | 3.67 | Agonist-induced changes in beta-adrenergic receptors on intact cells. ( Perkins, JP; Toews, ML, 1984) |
| " This compound devoid of agonist properties, competed for all (3H)-dihydroalprenolol (3H-DHA) binding sites in C6 glioma cell and rat cerebellum membranes." | 3.67 | Irreversible blockade of beta-adrenergic receptors with a bromoacetyl derivative of pindolol. ( Bockaert, J; Bouhelal, R; Gozlan, H; Homburger, V; Lucas, M, 1985) |
| " The selectivity of [125I]iodopindolol, [125I]iodocyanopindolol, [125I]iodohydroxybenzylpindolol and [3H]dihydroalprenolol for beta-1 and beta-2 adrenergic receptors was assessed by inhibiting the binding of each radioligand with the beta-1-selective unlabeled ligand ICI 89,406 at increasing concentrations of the radioligand, using membranes prepared from C6 glioma cells, which have both beta-1 and beta-2 adrenergic receptors." | 3.67 | Quantitative analysis of the selectivity of radioligands for subtypes of beta adrenergic receptors. ( McGonigle, P; Molinoff, PB; Neve, KA, 1986) |
| " Treatment of intact L6 myoblasts or C6 glioma cells with N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) inactivated beta-adrenergic receptors on membranes prepared from these cells." | 3.67 | Turnover of beta 1- and beta 2-adrenergic receptors after down-regulation or irreversible blockade. ( Molinoff, PB; Neve, KA, 1986) |
| "The interactions of agonists and antagonists with beta-adrenergic receptors on intact 1321N1 human astrocytoma and C62B rat glioma cells were studied by using the radioligand (-)-[125I]iodopindolol." | 3.66 | High-affinity binding of agonists to beta-adrenergic receptors on intact cells. ( Harden, TK; Perkins, JP; Toews, ML, 1983) |
| " The beta-adrenergic receptors of cultured rat C6 glioma cells (2B clone) as assessed by [(125)I]iodohydroxybenzylpindolol binding were decreased 50 and >95% after pretreatment with 8 nM and 1 muM aminobenzylpropranolol, respectively." | 3.66 | Quantitative relationship between beta-adrenergic receptor number and physiologic responses as studied with a long-lasting beta-adrenergic antagonist. ( Brooker, G; Linden, J; Terasaki, WL, 1979) |
| " Each antagonist alone caused smaller shifts to the right in the dose-response curve to NE and, when present simultaneously, completely abolished the NE response." | 1.29 | Inducible expression of beta 1- and beta 2-adrenergic receptors in rat C6 glioma cells: functional interactions between closely related subtypes. ( Esbenshade, TA; Guerrero, SW; Minneman, KP; Zhong, H, 1996) |
| "Phenoxybenzamine was used to irreversibly block alpha 1 adrenergic receptors both in vitro in the BC3H1 cell line and in vivo in rat submaxillary glands." | 1.27 | Turnover of adrenergic receptors under normal and desensitized conditions. ( Bockaert, J; Bouhelal, R; Gozlan, H; Homburger, V; Lucas, M; Mauger, JP; Pantaloni, C; Sladeczek, F, 1984) |
| "Brain tumors are supplied by vessels that differ from those supplying normal cerebral tissue in various structural and functional parameters." | 1.27 | Glial brain tumors lack microvascular adrenergic receptors. ( Frattola, L; Govoni, S; Kobayashi, H; Magnoni, MS; Piolti, R; Trabucchi, M, 1988) |
| " Computer-assisted analysis of dose-response curves resulting from the inhibition of the binding of [125I]iodopindolol by the beta-1 and beta-2 selective compounds ICI 89,406 and ICI 118,551 revealed that approximately one-third of the beta adrenergic receptors on these cells were beta-1 receptors." | 1.27 | Selective regulation of beta-1 and beta-2 adrenergic receptors by atypical agonists. ( Barrett, DA; Molinoff, PB; Neve, KA, 1985) |
Research
Studies (24)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (79.17) | 18.7374 |
| 1990's | 4 (16.67) | 18.2507 |
| 2000's | 1 (4.17) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Homburger, V | 4 |
| Pantaloni, C | 2 |
| Lucas, M | 3 |
| Gozlan, H | 3 |
| Bockaert, J | 4 |
| Sladeczek, F | 2 |
| Mauger, JP | 2 |
| Bouhelal, R | 3 |
| Harden, TK | 2 |
| McCarthy, KD | 1 |
| Toews, ML | 2 |
| Perkins, JP | 3 |
| Charlton, RR | 1 |
| Venter, JC | 1 |
| Hertel, C | 2 |
| Staehelin, M | 2 |
| Zhong, H | 2 |
| Minneman, KP | 2 |
| Guerrero, SW | 1 |
| Esbenshade, TA | 1 |
| Conti, P | 1 |
| Dallanoce, C | 1 |
| De Amici, M | 1 |
| De Micheli, C | 1 |
| Klotz, KN | 1 |
| Ammer, H | 1 |
| Schulz, R | 1 |
| Schmitt, H | 1 |
| Pochet, R | 1 |
| Terasaki, WL | 2 |
| Linden, J | 1 |
| Brooker, G | 2 |
| Magnusson, Y | 1 |
| Wallukat, G | 1 |
| Guillet, JG | 1 |
| Hjalmarson, A | 1 |
| Hoebeke, J | 1 |
| Magnoni, MS | 1 |
| Frattola, L | 1 |
| Piolti, R | 1 |
| Govoni, S | 1 |
| Kobayashi, H | 1 |
| Trabucchi, M | 1 |
| Affolter, H | 1 |
| Jaeggi, K | 1 |
| Portenier, M | 1 |
| Neve, KA | 4 |
| Barrett, DA | 1 |
| Molinoff, PB | 4 |
| Kassis, S | 1 |
| Lauter, CJ | 1 |
| Stojanov, M | 1 |
| Salem, N | 1 |
| McGonigle, P | 2 |
| Mermet-Bouvier, R | 1 |
Other Studies
24 other studies available for pindolol and Glioma
| Article | Year |
|---|---|
Beta adrenergic receptor repopulation of C6 glioma cells after irreversible blockade and down regulation.
Topics: Cells, Cultured; Cycloheximide; Glioma; Isoproterenol; Nerve Block; Pindolol; Receptors, Adrenergic, | 1984 |
Turnover of adrenergic receptors under normal and desensitized conditions.
Topics: Animals; Cell Line; Cycloheximide; Erythrocyte Membrane; Glioma; Kinetics; Phenoxybenzamine; Pindolo | 1984 |
Identification of the beta adrenergic receptor subtype on astroglia purified from rat brain.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Astrocytes; Astrocytoma; Cells, Cult | 1982 |
High-affinity binding of agonists to beta-adrenergic receptors on intact cells.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Astrocytoma; Binding, Competitive; C | 1983 |
Agonist-induced changes in beta-adrenergic receptors on intact cells.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Astrocytoma; Binding, Competitive; C | 1984 |
Cell cycle-specific changes in beta-adrenergic receptor concentrations in C6 glioma cells.
Topics: Animals; Cell Cycle; Cell Line; DNA, Neoplasm; Glioma; Kinetics; Mitosis; Pindolol; Rats; Receptors, | 1980 |
Evidence for intravesicular beta-adrenergic receptors in membrane fractions from desensitized cells: binding of the hydrophilic ligand CGP-12177 only in the presence of alamethicin.
Topics: Alamethicin; Animals; Anti-Bacterial Agents; Cells, Cultured; Centrifugation, Density Gradient; Glio | 1983 |
Coexisting beta-1 and beta-2-adrenergic receptors with differential receptor reserves in rat C6 glioma cells.
Topics: Animals; Cyclohexane Monoterpenes; Dexamethasone; Glioma; Guanosine Triphosphate; In Vitro Technique | 1995 |
Inducible expression of beta 1- and beta 2-adrenergic receptors in rat C6 glioma cells: functional interactions between closely related subtypes.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Colforsin; Cyclic AMP; Epinephrine; | 1996 |
Synthesis of new delta 2-isoxazoline derivatives and their pharmacological characterization as beta-adrenergic receptor antagonists.
Topics: Adenylyl Cyclases; Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-2 Receptor Antagonists; A | 1998 |
Opioid tolerance/dependence in neuroblastoma x glioma (NG108-15) hybrid cells is associated with a reduction in spontaneous stimulatory receptor activity.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Binding, Competitive; COS Cells; Drug Toler | 2000 |
In vivo labelling of beta-adrenergic receptors on rat glioma cells.
Topics: Adrenergic beta-Antagonists; Animals; Cell Line; Glioma; Isoproterenol; Kinetics; Phentolamine; Pind | 1977 |
Quantitative relationship between beta-adrenergic receptor number and physiologic responses as studied with a long-lasting beta-adrenergic antagonist.
Topics: Adrenergic beta-Antagonists; Animals; Cell Line; Cyclic AMP; Glioma; Guinea Pigs; Heart Atria; In Vi | 1979 |
[125I]Iodohydroxybenzylpindolol binding sites on intact rat glioma cells. Evidence for beta-adrenergic receptors of high coupling efficiency.
Topics: Binding, Competitive; Cell Line; Cell Membrane; Cyclic AMP; Glioma; Kinetics; Pindolol; Receptors, A | 1978 |
Functional analysis of rabbit anti-peptide antibodies which mimic autoantibodies against the beta 1-adrenergic receptor in patients with idiopathic dilated cardiomyopathy.
Topics: Amino Acid Sequence; Animals; Autoantibodies; Binding Sites; Binding, Competitive; Cardiomyopathy, H | 1991 |
Glial brain tumors lack microvascular adrenergic receptors.
Topics: Brain Neoplasms; Cerebral Arteries; Glioma; Humans; Iodocyanopindolol; Meningeal Neoplasms; Meningio | 1988 |
(-)-S-[3H]CGP-12177 and its use to determine the rate constants of unlabeled beta-adrenergic antagonists.
Topics: Adrenergic beta-Antagonists; Alprenolol; Animals; Cell Line; Computers; Glioma; Kinetics; Pindolol; | 1985 |
Irreversible blockade of beta-adrenergic receptors with a bromoacetyl derivative of pindolol.
Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Animals; Dihydroalprenolol; Erythrocytes; Glioma; In | 1985 |
Selective regulation of beta-1 and beta-2 adrenergic receptors by atypical agonists.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Celiprolol; Cells, Cultured; Glioma; Guanosine | 1985 |
Exfoliation of the beta-adrenergic receptor and the regulatory components of adenylate cyclase by cultured rat glioma C6 cells.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; A | 1986 |
A quantitative method of analyzing the interaction of slightly selective radioligands with multiple receptor subtypes.
Topics: Adrenergic beta-Antagonists; Animals; Cell Line; Cell Membrane; Glioma; Iodine Radioisotopes; Kineti | 1986 |
Quantitative analysis of the selectivity of radioligands for subtypes of beta adrenergic receptors.
Topics: Alprenolol; Animals; Cell Line; Dihydroalprenolol; Dose-Response Relationship, Drug; Glioma; Heart A | 1986 |
Turnover of beta 1- and beta 2-adrenergic receptors after down-regulation or irreversible blockade.
Topics: Animals; Cell Line; Cell Membrane; Cycloheximide; Glioma; Iodocyanopindolol; Isoproterenol; Kinetics | 1986 |
Metabolism of adrenergic receptors and adenylate cyclase.
Topics: Adenylyl Cyclases; Animals; Cell Line; Contact Inhibition; Cyclic AMP; Dihydroalprenolol; Glioma; Ha | 1987 |