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pindolol and Glioma

pindolol has been researched along with Glioma in 24 studies

Pindolol: A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)
pindolol : A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
"C6 glioma cells possess beta adrenergic receptors coupled with adenylate cyclase which can be irreversibly blocked by bromoacetylaminomethylpindolol (Br-AAM-pindolol), a beta adrenergic antagonist."3.67Beta adrenergic receptor repopulation of C6 glioma cells after irreversible blockade and down regulation. ( Bockaert, J; Gozlan, H; Homburger, V; Lucas, M; Pantaloni, C, 1984)
"Competition by beta-adrenergic agonists and antagonists for 125I-pindolol binding sites on intact cells (1321N1 human astrocytoma and C62B rat glioma) was measured using short time binding assays as previously described (Toews, M."3.67Agonist-induced changes in beta-adrenergic receptors on intact cells. ( Perkins, JP; Toews, ML, 1984)
" This compound devoid of agonist properties, competed for all (3H)-dihydroalprenolol (3H-DHA) binding sites in C6 glioma cell and rat cerebellum membranes."3.67Irreversible blockade of beta-adrenergic receptors with a bromoacetyl derivative of pindolol. ( Bockaert, J; Bouhelal, R; Gozlan, H; Homburger, V; Lucas, M, 1985)
" The selectivity of [125I]iodopindolol, [125I]iodocyanopindolol, [125I]iodohydroxybenzylpindolol and [3H]dihydroalprenolol for beta-1 and beta-2 adrenergic receptors was assessed by inhibiting the binding of each radioligand with the beta-1-selective unlabeled ligand ICI 89,406 at increasing concentrations of the radioligand, using membranes prepared from C6 glioma cells, which have both beta-1 and beta-2 adrenergic receptors."3.67Quantitative analysis of the selectivity of radioligands for subtypes of beta adrenergic receptors. ( McGonigle, P; Molinoff, PB; Neve, KA, 1986)
" Treatment of intact L6 myoblasts or C6 glioma cells with N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) inactivated beta-adrenergic receptors on membranes prepared from these cells."3.67Turnover of beta 1- and beta 2-adrenergic receptors after down-regulation or irreversible blockade. ( Molinoff, PB; Neve, KA, 1986)
"The interactions of agonists and antagonists with beta-adrenergic receptors on intact 1321N1 human astrocytoma and C62B rat glioma cells were studied by using the radioligand (-)-[125I]iodopindolol."3.66High-affinity binding of agonists to beta-adrenergic receptors on intact cells. ( Harden, TK; Perkins, JP; Toews, ML, 1983)
" The beta-adrenergic receptors of cultured rat C6 glioma cells (2B clone) as assessed by [(125)I]iodohydroxybenzylpindolol binding were decreased 50 and >95% after pretreatment with 8 nM and 1 muM aminobenzylpropranolol, respectively."3.66Quantitative relationship between beta-adrenergic receptor number and physiologic responses as studied with a long-lasting beta-adrenergic antagonist. ( Brooker, G; Linden, J; Terasaki, WL, 1979)
" Each antagonist alone caused smaller shifts to the right in the dose-response curve to NE and, when present simultaneously, completely abolished the NE response."1.29Inducible expression of beta 1- and beta 2-adrenergic receptors in rat C6 glioma cells: functional interactions between closely related subtypes. ( Esbenshade, TA; Guerrero, SW; Minneman, KP; Zhong, H, 1996)
"Phenoxybenzamine was used to irreversibly block alpha 1 adrenergic receptors both in vitro in the BC3H1 cell line and in vivo in rat submaxillary glands."1.27Turnover of adrenergic receptors under normal and desensitized conditions. ( Bockaert, J; Bouhelal, R; Gozlan, H; Homburger, V; Lucas, M; Mauger, JP; Pantaloni, C; Sladeczek, F, 1984)
"Brain tumors are supplied by vessels that differ from those supplying normal cerebral tissue in various structural and functional parameters."1.27Glial brain tumors lack microvascular adrenergic receptors. ( Frattola, L; Govoni, S; Kobayashi, H; Magnoni, MS; Piolti, R; Trabucchi, M, 1988)
" Computer-assisted analysis of dose-response curves resulting from the inhibition of the binding of [125I]iodopindolol by the beta-1 and beta-2 selective compounds ICI 89,406 and ICI 118,551 revealed that approximately one-third of the beta adrenergic receptors on these cells were beta-1 receptors."1.27Selective regulation of beta-1 and beta-2 adrenergic receptors by atypical agonists. ( Barrett, DA; Molinoff, PB; Neve, KA, 1985)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-199019 (79.17)18.7374
1990's4 (16.67)18.2507
2000's1 (4.17)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Homburger, V4
Pantaloni, C2
Lucas, M3
Gozlan, H3
Bockaert, J4
Sladeczek, F2
Mauger, JP2
Bouhelal, R3
Harden, TK2
McCarthy, KD1
Toews, ML2
Perkins, JP3
Charlton, RR1
Venter, JC1
Hertel, C2
Staehelin, M2
Zhong, H2
Minneman, KP2
Guerrero, SW1
Esbenshade, TA1
Conti, P1
Dallanoce, C1
De Amici, M1
De Micheli, C1
Klotz, KN1
Ammer, H1
Schulz, R1
Schmitt, H1
Pochet, R1
Terasaki, WL2
Linden, J1
Brooker, G2
Magnusson, Y1
Wallukat, G1
Guillet, JG1
Hjalmarson, A1
Hoebeke, J1
Magnoni, MS1
Frattola, L1
Piolti, R1
Govoni, S1
Kobayashi, H1
Trabucchi, M1
Affolter, H1
Jaeggi, K1
Portenier, M1
Neve, KA4
Barrett, DA1
Molinoff, PB4
Kassis, S1
Lauter, CJ1
Stojanov, M1
Salem, N1
McGonigle, P2
Mermet-Bouvier, R1

Other Studies

24 other studies available for pindolol and Glioma

ArticleYear
Beta adrenergic receptor repopulation of C6 glioma cells after irreversible blockade and down regulation.
    Journal of cellular physiology, 1984, Volume: 121, Issue:3

    Topics: Cells, Cultured; Cycloheximide; Glioma; Isoproterenol; Nerve Block; Pindolol; Receptors, Adrenergic,

1984
Turnover of adrenergic receptors under normal and desensitized conditions.
    Journal of receptor research, 1984, Volume: 4, Issue:1-6

    Topics: Animals; Cell Line; Cycloheximide; Erythrocyte Membrane; Glioma; Kinetics; Phenoxybenzamine; Pindolo

1984
Identification of the beta adrenergic receptor subtype on astroglia purified from rat brain.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 222, Issue:3

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Astrocytes; Astrocytoma; Cells, Cult

1982
High-affinity binding of agonists to beta-adrenergic receptors on intact cells.
    Proceedings of the National Academy of Sciences of the United States of America, 1983, Volume: 80, Issue:12

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Astrocytoma; Binding, Competitive; C

1983
Agonist-induced changes in beta-adrenergic receptors on intact cells.
    The Journal of biological chemistry, 1984, Feb-25, Volume: 259, Issue:4

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Astrocytoma; Binding, Competitive; C

1984
Cell cycle-specific changes in beta-adrenergic receptor concentrations in C6 glioma cells.
    Biochemical and biophysical research communications, 1980, Jun-30, Volume: 94, Issue:4

    Topics: Animals; Cell Cycle; Cell Line; DNA, Neoplasm; Glioma; Kinetics; Mitosis; Pindolol; Rats; Receptors,

1980
Evidence for intravesicular beta-adrenergic receptors in membrane fractions from desensitized cells: binding of the hydrophilic ligand CGP-12177 only in the presence of alamethicin.
    Journal of cyclic nucleotide and protein phosphorylation research, 1983, Volume: 9, Issue:2

    Topics: Alamethicin; Animals; Anti-Bacterial Agents; Cells, Cultured; Centrifugation, Density Gradient; Glio

1983
Coexisting beta-1 and beta-2-adrenergic receptors with differential receptor reserves in rat C6 glioma cells.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:3

    Topics: Animals; Cyclohexane Monoterpenes; Dexamethasone; Glioma; Guanosine Triphosphate; In Vitro Technique

1995
Inducible expression of beta 1- and beta 2-adrenergic receptors in rat C6 glioma cells: functional interactions between closely related subtypes.
    Molecular pharmacology, 1996, Volume: 50, Issue:1

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Colforsin; Cyclic AMP; Epinephrine;

1996
Synthesis of new delta 2-isoxazoline derivatives and their pharmacological characterization as beta-adrenergic receptor antagonists.
    Bioorganic & medicinal chemistry, 1998, Volume: 6, Issue:4

    Topics: Adenylyl Cyclases; Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-2 Receptor Antagonists; A

1998
Opioid tolerance/dependence in neuroblastoma x glioma (NG108-15) hybrid cells is associated with a reduction in spontaneous stimulatory receptor activity.
    FEBS letters, 2000, Nov-24, Volume: 485, Issue:2-3

    Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Binding, Competitive; COS Cells; Drug Toler

2000
In vivo labelling of beta-adrenergic receptors on rat glioma cells.
    FEBS letters, 1977, Apr-15, Volume: 76, Issue:2

    Topics: Adrenergic beta-Antagonists; Animals; Cell Line; Glioma; Isoproterenol; Kinetics; Phentolamine; Pind

1977
Quantitative relationship between beta-adrenergic receptor number and physiologic responses as studied with a long-lasting beta-adrenergic antagonist.
    Proceedings of the National Academy of Sciences of the United States of America, 1979, Volume: 76, Issue:12

    Topics: Adrenergic beta-Antagonists; Animals; Cell Line; Cyclic AMP; Glioma; Guinea Pigs; Heart Atria; In Vi

1979
[125I]Iodohydroxybenzylpindolol binding sites on intact rat glioma cells. Evidence for beta-adrenergic receptors of high coupling efficiency.
    The Journal of biological chemistry, 1978, Aug-10, Volume: 253, Issue:15

    Topics: Binding, Competitive; Cell Line; Cell Membrane; Cyclic AMP; Glioma; Kinetics; Pindolol; Receptors, A

1978
Functional analysis of rabbit anti-peptide antibodies which mimic autoantibodies against the beta 1-adrenergic receptor in patients with idiopathic dilated cardiomyopathy.
    Journal of autoimmunity, 1991, Volume: 4, Issue:6

    Topics: Amino Acid Sequence; Animals; Autoantibodies; Binding Sites; Binding, Competitive; Cardiomyopathy, H

1991
Glial brain tumors lack microvascular adrenergic receptors.
    European neurology, 1988, Volume: 28, Issue:1

    Topics: Brain Neoplasms; Cerebral Arteries; Glioma; Humans; Iodocyanopindolol; Meningeal Neoplasms; Meningio

1988
(-)-S-[3H]CGP-12177 and its use to determine the rate constants of unlabeled beta-adrenergic antagonists.
    Proceedings of the National Academy of Sciences of the United States of America, 1985, Volume: 82, Issue:3

    Topics: Adrenergic beta-Antagonists; Alprenolol; Animals; Cell Line; Computers; Glioma; Kinetics; Pindolol;

1985
Irreversible blockade of beta-adrenergic receptors with a bromoacetyl derivative of pindolol.
    Naunyn-Schmiedeberg's archives of pharmacology, 1985, Volume: 328, Issue:3

    Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Animals; Dihydroalprenolol; Erythrocytes; Glioma; In

1985
Selective regulation of beta-1 and beta-2 adrenergic receptors by atypical agonists.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:3

    Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Celiprolol; Cells, Cultured; Glioma; Guanosine

1985
Exfoliation of the beta-adrenergic receptor and the regulatory components of adenylate cyclase by cultured rat glioma C6 cells.
    Biochimica et biophysica acta, 1986, May-29, Volume: 886, Issue:3

    Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; A

1986
A quantitative method of analyzing the interaction of slightly selective radioligands with multiple receptor subtypes.
    Molecular pharmacology, 1986, Volume: 30, Issue:4

    Topics: Adrenergic beta-Antagonists; Animals; Cell Line; Cell Membrane; Glioma; Iodine Radioisotopes; Kineti

1986
Quantitative analysis of the selectivity of radioligands for subtypes of beta adrenergic receptors.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 238, Issue:1

    Topics: Alprenolol; Animals; Cell Line; Dihydroalprenolol; Dose-Response Relationship, Drug; Glioma; Heart A

1986
Turnover of beta 1- and beta 2-adrenergic receptors after down-regulation or irreversible blockade.
    Molecular pharmacology, 1986, Volume: 30, Issue:2

    Topics: Animals; Cell Line; Cell Membrane; Cycloheximide; Glioma; Iodocyanopindolol; Isoproterenol; Kinetics

1986
Metabolism of adrenergic receptors and adenylate cyclase.
    Journal of receptor research, 1987, Volume: 7, Issue:1-4

    Topics: Adenylyl Cyclases; Animals; Cell Line; Contact Inhibition; Cyclic AMP; Dihydroalprenolol; Glioma; Ha

1987