pindolol has been researched along with Glial Cell Tumors in 24 studies
Pindolol: A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)
pindolol : A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.
| Excerpt | Relevance | Reference |
|---|---|---|
| "C6 glioma cells possess beta adrenergic receptors coupled with adenylate cyclase which can be irreversibly blocked by bromoacetylaminomethylpindolol (Br-AAM-pindolol), a beta adrenergic antagonist." | 3.67 | Beta adrenergic receptor repopulation of C6 glioma cells after irreversible blockade and down regulation. ( Bockaert, J; Gozlan, H; Homburger, V; Lucas, M; Pantaloni, C, 1984) |
| "Competition by beta-adrenergic agonists and antagonists for 125I-pindolol binding sites on intact cells (1321N1 human astrocytoma and C62B rat glioma) was measured using short time binding assays as previously described (Toews, M." | 3.67 | Agonist-induced changes in beta-adrenergic receptors on intact cells. ( Perkins, JP; Toews, ML, 1984) |
| " This compound devoid of agonist properties, competed for all (3H)-dihydroalprenolol (3H-DHA) binding sites in C6 glioma cell and rat cerebellum membranes." | 3.67 | Irreversible blockade of beta-adrenergic receptors with a bromoacetyl derivative of pindolol. ( Bockaert, J; Bouhelal, R; Gozlan, H; Homburger, V; Lucas, M, 1985) |
| " The selectivity of [125I]iodopindolol, [125I]iodocyanopindolol, [125I]iodohydroxybenzylpindolol and [3H]dihydroalprenolol for beta-1 and beta-2 adrenergic receptors was assessed by inhibiting the binding of each radioligand with the beta-1-selective unlabeled ligand ICI 89,406 at increasing concentrations of the radioligand, using membranes prepared from C6 glioma cells, which have both beta-1 and beta-2 adrenergic receptors." | 3.67 | Quantitative analysis of the selectivity of radioligands for subtypes of beta adrenergic receptors. ( McGonigle, P; Molinoff, PB; Neve, KA, 1986) |
| " Treatment of intact L6 myoblasts or C6 glioma cells with N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) inactivated beta-adrenergic receptors on membranes prepared from these cells." | 3.67 | Turnover of beta 1- and beta 2-adrenergic receptors after down-regulation or irreversible blockade. ( Molinoff, PB; Neve, KA, 1986) |
| "The interactions of agonists and antagonists with beta-adrenergic receptors on intact 1321N1 human astrocytoma and C62B rat glioma cells were studied by using the radioligand (-)-[125I]iodopindolol." | 3.66 | High-affinity binding of agonists to beta-adrenergic receptors on intact cells. ( Harden, TK; Perkins, JP; Toews, ML, 1983) |
| " The beta-adrenergic receptors of cultured rat C6 glioma cells (2B clone) as assessed by [(125)I]iodohydroxybenzylpindolol binding were decreased 50 and >95% after pretreatment with 8 nM and 1 muM aminobenzylpropranolol, respectively." | 3.66 | Quantitative relationship between beta-adrenergic receptor number and physiologic responses as studied with a long-lasting beta-adrenergic antagonist. ( Brooker, G; Linden, J; Terasaki, WL, 1979) |
| " Each antagonist alone caused smaller shifts to the right in the dose-response curve to NE and, when present simultaneously, completely abolished the NE response." | 1.29 | Inducible expression of beta 1- and beta 2-adrenergic receptors in rat C6 glioma cells: functional interactions between closely related subtypes. ( Esbenshade, TA; Guerrero, SW; Minneman, KP; Zhong, H, 1996) |
| "Phenoxybenzamine was used to irreversibly block alpha 1 adrenergic receptors both in vitro in the BC3H1 cell line and in vivo in rat submaxillary glands." | 1.27 | Turnover of adrenergic receptors under normal and desensitized conditions. ( Bockaert, J; Bouhelal, R; Gozlan, H; Homburger, V; Lucas, M; Mauger, JP; Pantaloni, C; Sladeczek, F, 1984) |
| "Brain tumors are supplied by vessels that differ from those supplying normal cerebral tissue in various structural and functional parameters." | 1.27 | Glial brain tumors lack microvascular adrenergic receptors. ( Frattola, L; Govoni, S; Kobayashi, H; Magnoni, MS; Piolti, R; Trabucchi, M, 1988) |
| " Computer-assisted analysis of dose-response curves resulting from the inhibition of the binding of [125I]iodopindolol by the beta-1 and beta-2 selective compounds ICI 89,406 and ICI 118,551 revealed that approximately one-third of the beta adrenergic receptors on these cells were beta-1 receptors." | 1.27 | Selective regulation of beta-1 and beta-2 adrenergic receptors by atypical agonists. ( Barrett, DA; Molinoff, PB; Neve, KA, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (79.17) | 18.7374 |
| 1990's | 4 (16.67) | 18.2507 |
| 2000's | 1 (4.17) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Homburger, V | 4 |
| Pantaloni, C | 2 |
| Lucas, M | 3 |
| Gozlan, H | 3 |
| Bockaert, J | 4 |
| Sladeczek, F | 2 |
| Mauger, JP | 2 |
| Bouhelal, R | 3 |
| Harden, TK | 2 |
| McCarthy, KD | 1 |
| Toews, ML | 2 |
| Perkins, JP | 3 |
| Charlton, RR | 1 |
| Venter, JC | 1 |
| Hertel, C | 2 |
| Staehelin, M | 2 |
| Zhong, H | 2 |
| Minneman, KP | 2 |
| Guerrero, SW | 1 |
| Esbenshade, TA | 1 |
| Conti, P | 1 |
| Dallanoce, C | 1 |
| De Amici, M | 1 |
| De Micheli, C | 1 |
| Klotz, KN | 1 |
| Ammer, H | 1 |
| Schulz, R | 1 |
| Schmitt, H | 1 |
| Pochet, R | 1 |
| Terasaki, WL | 2 |
| Linden, J | 1 |
| Brooker, G | 2 |
| Magnusson, Y | 1 |
| Wallukat, G | 1 |
| Guillet, JG | 1 |
| Hjalmarson, A | 1 |
| Hoebeke, J | 1 |
| Magnoni, MS | 1 |
| Frattola, L | 1 |
| Piolti, R | 1 |
| Govoni, S | 1 |
| Kobayashi, H | 1 |
| Trabucchi, M | 1 |
| Affolter, H | 1 |
| Jaeggi, K | 1 |
| Portenier, M | 1 |
| Neve, KA | 4 |
| Barrett, DA | 1 |
| Molinoff, PB | 4 |
| Kassis, S | 1 |
| Lauter, CJ | 1 |
| Stojanov, M | 1 |
| Salem, N | 1 |
| McGonigle, P | 2 |
| Mermet-Bouvier, R | 1 |
24 other studies available for pindolol and Glial Cell Tumors
| Article | Year |
|---|---|
Beta adrenergic receptor repopulation of C6 glioma cells after irreversible blockade and down regulation.
Topics: Cells, Cultured; Cycloheximide; Glioma; Isoproterenol; Nerve Block; Pindolol; Receptors, Adrenergic, | 1984 |
Turnover of adrenergic receptors under normal and desensitized conditions.
Topics: Animals; Cell Line; Cycloheximide; Erythrocyte Membrane; Glioma; Kinetics; Phenoxybenzamine; Pindolo | 1984 |
Identification of the beta adrenergic receptor subtype on astroglia purified from rat brain.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Astrocytes; Astrocytoma; Cells, Cult | 1982 |
High-affinity binding of agonists to beta-adrenergic receptors on intact cells.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Astrocytoma; Binding, Competitive; C | 1983 |
Agonist-induced changes in beta-adrenergic receptors on intact cells.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Astrocytoma; Binding, Competitive; C | 1984 |
Cell cycle-specific changes in beta-adrenergic receptor concentrations in C6 glioma cells.
Topics: Animals; Cell Cycle; Cell Line; DNA, Neoplasm; Glioma; Kinetics; Mitosis; Pindolol; Rats; Receptors, | 1980 |
Evidence for intravesicular beta-adrenergic receptors in membrane fractions from desensitized cells: binding of the hydrophilic ligand CGP-12177 only in the presence of alamethicin.
Topics: Alamethicin; Animals; Anti-Bacterial Agents; Cells, Cultured; Centrifugation, Density Gradient; Glio | 1983 |
Coexisting beta-1 and beta-2-adrenergic receptors with differential receptor reserves in rat C6 glioma cells.
Topics: Animals; Cyclohexane Monoterpenes; Dexamethasone; Glioma; Guanosine Triphosphate; In Vitro Technique | 1995 |
Inducible expression of beta 1- and beta 2-adrenergic receptors in rat C6 glioma cells: functional interactions between closely related subtypes.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Colforsin; Cyclic AMP; Epinephrine; | 1996 |
Synthesis of new delta 2-isoxazoline derivatives and their pharmacological characterization as beta-adrenergic receptor antagonists.
Topics: Adenylyl Cyclases; Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-2 Receptor Antagonists; A | 1998 |
Opioid tolerance/dependence in neuroblastoma x glioma (NG108-15) hybrid cells is associated with a reduction in spontaneous stimulatory receptor activity.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Binding, Competitive; COS Cells; Drug Toler | 2000 |
In vivo labelling of beta-adrenergic receptors on rat glioma cells.
Topics: Adrenergic beta-Antagonists; Animals; Cell Line; Glioma; Isoproterenol; Kinetics; Phentolamine; Pind | 1977 |
Quantitative relationship between beta-adrenergic receptor number and physiologic responses as studied with a long-lasting beta-adrenergic antagonist.
Topics: Adrenergic beta-Antagonists; Animals; Cell Line; Cyclic AMP; Glioma; Guinea Pigs; Heart Atria; In Vi | 1979 |
[125I]Iodohydroxybenzylpindolol binding sites on intact rat glioma cells. Evidence for beta-adrenergic receptors of high coupling efficiency.
Topics: Binding, Competitive; Cell Line; Cell Membrane; Cyclic AMP; Glioma; Kinetics; Pindolol; Receptors, A | 1978 |
Functional analysis of rabbit anti-peptide antibodies which mimic autoantibodies against the beta 1-adrenergic receptor in patients with idiopathic dilated cardiomyopathy.
Topics: Amino Acid Sequence; Animals; Autoantibodies; Binding Sites; Binding, Competitive; Cardiomyopathy, H | 1991 |
Glial brain tumors lack microvascular adrenergic receptors.
Topics: Brain Neoplasms; Cerebral Arteries; Glioma; Humans; Iodocyanopindolol; Meningeal Neoplasms; Meningio | 1988 |
(-)-S-[3H]CGP-12177 and its use to determine the rate constants of unlabeled beta-adrenergic antagonists.
Topics: Adrenergic beta-Antagonists; Alprenolol; Animals; Cell Line; Computers; Glioma; Kinetics; Pindolol; | 1985 |
Irreversible blockade of beta-adrenergic receptors with a bromoacetyl derivative of pindolol.
Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Animals; Dihydroalprenolol; Erythrocytes; Glioma; In | 1985 |
Selective regulation of beta-1 and beta-2 adrenergic receptors by atypical agonists.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Celiprolol; Cells, Cultured; Glioma; Guanosine | 1985 |
Exfoliation of the beta-adrenergic receptor and the regulatory components of adenylate cyclase by cultured rat glioma C6 cells.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; A | 1986 |
A quantitative method of analyzing the interaction of slightly selective radioligands with multiple receptor subtypes.
Topics: Adrenergic beta-Antagonists; Animals; Cell Line; Cell Membrane; Glioma; Iodine Radioisotopes; Kineti | 1986 |
Quantitative analysis of the selectivity of radioligands for subtypes of beta adrenergic receptors.
Topics: Alprenolol; Animals; Cell Line; Dihydroalprenolol; Dose-Response Relationship, Drug; Glioma; Heart A | 1986 |
Turnover of beta 1- and beta 2-adrenergic receptors after down-regulation or irreversible blockade.
Topics: Animals; Cell Line; Cell Membrane; Cycloheximide; Glioma; Iodocyanopindolol; Isoproterenol; Kinetics | 1986 |
Metabolism of adrenergic receptors and adenylate cyclase.
Topics: Adenylyl Cyclases; Animals; Cell Line; Contact Inhibition; Cyclic AMP; Dihydroalprenolol; Glioma; Ha | 1987 |