pindolol has been researched along with Disease Models, Animal in 28 studies
Pindolol: A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)
pindolol : A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the effects of labetalol and pindolol on uterine, placental, and fetal hemodynamics following norepinephrine-induced maternal hypertension in a sheep model of increased placental vascular resistance." | 7.75 | Placental and fetal hemodynamics after labetalol or pindolol in a sheep model of increased placental vascular resistance and maternal hypertension. ( Acharya, G; Alahuhta, S; Erkinaro, T; Haapsamo, M; Kavasmaa, T; Mäkikallio, K; Ohtonen, P; Räsänen, J; Ylikauma, L, 2009) |
| "The repeated administration of nicotine at small doses, which do not produce whole body tremor or convulsion, causes tremor only in the tail (tail-tremor) of rats." | 7.69 | [Assessment of anti-tremorogenic drugs--nicotine-induced tail-tremor model]. ( Gomita, Y; Kawasaki, H; Suemaru, K, 1997) |
| "We investigated the effects of labetalol and pindolol on uterine, placental, and fetal hemodynamics following norepinephrine-induced maternal hypertension in a sheep model of increased placental vascular resistance." | 3.75 | Placental and fetal hemodynamics after labetalol or pindolol in a sheep model of increased placental vascular resistance and maternal hypertension. ( Acharya, G; Alahuhta, S; Erkinaro, T; Haapsamo, M; Kavasmaa, T; Mäkikallio, K; Ohtonen, P; Räsänen, J; Ylikauma, L, 2009) |
| "The effect of inositol as an antidepressant was previously demonstrated in both animal models of depression-like behavior and in clinical trials." | 3.71 | The antidepressant activity of inositol in the forced swim test involves 5-HT(2) receptors. ( Belmaker, RH; Bourin, M; Clenet, F; Einat, H; Shaldubina, A, 2001) |
| "The repeated administration of nicotine at small doses, which do not produce whole body tremor or convulsion, causes tremor only in the tail (tail-tremor) of rats." | 3.69 | [Assessment of anti-tremorogenic drugs--nicotine-induced tail-tremor model]. ( Gomita, Y; Kawasaki, H; Suemaru, K, 1997) |
| " However, in vitro experiments are not satisfactory to predict antiarrhythmic activity "in vivo", because: 1) they are mostly performed in preparations made from the normal myocardium; 2) "in vitro" the autonomic and hormonal effects are absent; 3) some drugs as nitroglycerin or strophanthin do not produce antiarrhythmic electrophysiological changes in "vitro" but under appropriate conditions they may have a clear-cut antiarrhythmic action "in vivo"; 4) arrhythmias mostly arise from the interaction of changes in several fundamental electrophysiological parameters which could be best studied "in vivo"." | 3.66 | [Pharmacologic evaluation of electrical processes in the myocardium]. ( Sekeresh, L, 1982) |
| " Lidocaine and pindolol pretreatment increased the survival rate and attenuated the life-threatening arrhythmias during the first 20 min, but did not influence the infarct size 16 hrs later." | 3.66 | Coronary artery ligation, early arrhythmias, and determination of the ischemic area in conscious rats. ( Koltai, M; Leprán, I; Siegmund, W; Szekeres, L, 1983) |
| "Fluoxetine treatment reverted the alterations induced by CMS." | 1.31 | Altered expression of autonomic neurotransmitter receptors and proliferative responses in lymphocytes from a chronic mild stress model of depression: effects of fluoxetine. ( Cremaschi, GA; Edgar, VA; Genaro, AM; Sterin-Borda, L, 2002) |
| " +/- Pindolol, an antagonist at 5-HT1 receptors, showed a biphasic dose-response curve with a fall in entry ratio at one high dose." | 1.27 | Effects in the X-maze anxiety model of agents acting at 5-HT1 and 5-HT2 receptors. ( Critchley, MA; Handley, SL, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (35.71) | 18.7374 |
| 1990's | 8 (28.57) | 18.2507 |
| 2000's | 6 (21.43) | 29.6817 |
| 2010's | 3 (10.71) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Patkar, OL | 1 |
| Belmer, A | 1 |
| Holgate, JY | 1 |
| Tarren, JR | 1 |
| Shariff, MR | 1 |
| Morgan, M | 1 |
| Fogarty, MJ | 1 |
| Bellingham, MC | 1 |
| Bartlett, SE | 1 |
| Klenowski, PM | 1 |
| Nautiyal, KM | 1 |
| Tritschler, L | 1 |
| Ahmari, SE | 1 |
| David, DJ | 1 |
| Gardier, AM | 1 |
| Hen, R | 1 |
| Erkinaro, T | 1 |
| Kavasmaa, T | 1 |
| Ylikauma, L | 1 |
| Mäkikallio, K | 1 |
| Haapsamo, M | 1 |
| Acharya, G | 1 |
| Ohtonen, P | 1 |
| Alahuhta, S | 1 |
| Räsänen, J | 1 |
| Yalcin, I | 1 |
| Aksu, F | 1 |
| Belzung, C | 1 |
| Sekeresh, L | 1 |
| Leprán, I | 1 |
| Koltai, M | 1 |
| Siegmund, W | 1 |
| Szekeres, L | 1 |
| Ohnaus, EE | 1 |
| Frösch, R | 1 |
| Przegaliński, E | 1 |
| Filip, M | 1 |
| Chojnacka-Wójcik, E | 1 |
| Tatarczyńska, E | 1 |
| Kobayashi, A | 2 |
| Nishiyama, T | 1 |
| Ikegaya, T | 1 |
| Kaneko, M | 1 |
| Yamazaki, N | 2 |
| Grignaschi, G | 1 |
| Mantelli, B | 1 |
| Samanin, R | 1 |
| Suemaru, K | 1 |
| Kawasaki, H | 1 |
| Gomita, Y | 1 |
| Cryan, JF | 1 |
| McGrath, C | 1 |
| Leonard, BE | 1 |
| Norman, TR | 1 |
| Griebel, G | 1 |
| Rodgers, RJ | 1 |
| Perrault, G | 1 |
| Sanger, DJ | 1 |
| Einat, H | 1 |
| Clenet, F | 1 |
| Shaldubina, A | 1 |
| Belmaker, RH | 1 |
| Bourin, M | 1 |
| Nagatomo, T | 1 |
| Hosohata, Y | 1 |
| Ohnuki, T | 1 |
| Nakamura, T | 1 |
| Hattori, K | 1 |
| Suzuki, J | 1 |
| Ishiguro, M | 1 |
| Edgar, VA | 1 |
| Cremaschi, GA | 1 |
| Sterin-Borda, L | 1 |
| Genaro, AM | 1 |
| Brusoni, B | 1 |
| Marchetti, G | 1 |
| Merlo, L | 1 |
| Samizadeh, A | 1 |
| Losse, H | 1 |
| Wessels, F | 1 |
| Giudicelli, JF | 1 |
| Berdeaux, A | 1 |
| Lossnitzer, K | 1 |
| Konrad, A | 1 |
| Heine, HW | 1 |
| Ziegler, E | 1 |
| Stauch, M | 1 |
| Stumpe, KO | 1 |
| Kolloch, RE | 1 |
| Overlack, A | 1 |
| Tawarahara, K | 1 |
| Kurata, C | 1 |
| Taguchi, T | 1 |
| Strassheim, D | 1 |
| Houslay, MD | 1 |
| Milligan, G | 1 |
| Saxena, PR | 1 |
| Heiligers, JP | 1 |
| Villalón, CM | 1 |
| Ferrari, MD | 1 |
| Chan, SC | 1 |
| Hanifin, JM | 1 |
| Holden, CA | 1 |
| Thompson, WJ | 1 |
| Hirshman, CA | 1 |
| Critchley, MA | 1 |
| Handley, SL | 1 |
1 review available for pindolol and Disease Models, Animal
| Article | Year |
|---|---|
Bopindolol: pharmacological basis and clinical implications.
Topics: Adrenergic beta-Antagonists; Animals; Cardiovascular Diseases; Disease Models, Animal; Hemodynamics; | 2001 |
27 other studies available for pindolol and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
The antihypertensive drug pindolol attenuates long-term but not short-term binge-like ethanol consumption in mice.
Topics: Animals; Antihypertensive Agents; Behavior, Animal; Binge Drinking; Disease Models, Animal; Ethanol; | 2017 |
A Lack of Serotonin 1B Autoreceptors Results in Decreased Anxiety and Depression-Related Behaviors.
Topics: Animals; Animals, Newborn; Anxiety; Autoreceptors; Depression; Disease Models, Animal; Exploratory B | 2016 |
Placental and fetal hemodynamics after labetalol or pindolol in a sheep model of increased placental vascular resistance and maternal hypertension.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Anima | 2009 |
Effects of desipramine and tramadol in a chronic mild stress model in mice are altered by yohimbine but not by pindolol.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Analgesics, Opioid; Animals; Antidepressi | 2005 |
[Pharmacologic evaluation of electrical processes in the myocardium].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Dogs; Drug Evaluation | 1982 |
Coronary artery ligation, early arrhythmias, and determination of the ischemic area in conscious rats.
Topics: Animals; Arrhythmias, Cardiac; Coronary Disease; Coronary Vessels; Disease Models, Animal; Lidocaine | 1983 |
The effect of pindolol and salmon calcitonin on experimental gastric ulcers in rats.
Topics: Animals; Calcitonin; Disease Models, Animal; Ligation; Male; Phenylbutazone; Pindolol; Pylorus; Rats | 1980 |
The role of 5-hydroxytryptamine1A (5-HT1A) receptors in the anticonflict activity of beta-adrenoceptor antagonists.
Topics: Adrenergic beta-Antagonists; Animals; Anxiety; Betaxolol; Conflict, Psychological; Disease Models, A | 1994 |
Verapamil induced reduction of the myocardial beta-adrenoceptor density in BIO 14.6 cardiomyopathic Syrian hamsters.
Topics: Animals; Binding, Competitive; Calcium Channels; Cardiomyopathies; Cricetinae; Disease Models, Anima | 1993 |
The hypophagic effect of restraint stress in rats can be mediated by 5-HT2 receptors in the paraventricular nucleus of the hypothalamus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amidines; Animals; Anorexia; Anorexia Nervosa; Disease Model | 1993 |
[Assessment of anti-tremorogenic drugs--nicotine-induced tail-tremor model].
Topics: Adrenergic beta-Antagonists; Animals; Anti-Anxiety Agents; Clonazepam; Diazepam; Disease Models, Ani | 1997 |
Combining pindolol and paroxetine in an animal model of chronic antidepressant action--can early onset of action be detected?
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Animals; Antidepressive Agents; | 1998 |
The effects of compounds varying in selectivity as 5-HT(1A) receptor antagonists in three rat models of anxiety.
Topics: Aminopyridines; Animals; Anxiety; Cyclohexane Monoterpenes; Diazepam; Disease Models, Animal; Dose-R | 2000 |
The antidepressant activity of inositol in the forced swim test involves 5-HT(2) receptors.
Topics: Animals; Antidepressive Agents; Benzylamines; Depression; Disease Models, Animal; Drug Interactions; | 2001 |
Altered expression of autonomic neurotransmitter receptors and proliferative responses in lymphocytes from a chronic mild stress model of depression: effects of fluoxetine.
Topics: Adrenergic beta-Antagonists; Animals; Antidepressive Agents, Second-Generation; Autonomic Nervous Sy | 2002 |
[Modification of isopropyl-noradrenaline-induced tachycardia through the effects of the beta blockaders: pindolol, practolol and SD/1601 in the conscious dog].
Topics: Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Dogs; Heart Rate; Norepinephrine; Pind | 1977 |
[Effects of kitchen salt and beta sympatholytics on the course of blood pressure in the hereditary, spontaneously hypertensive rat (SH rats, Münster strain)].
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Disease Models, Animal; Hypertension; Metoprol | 1977 |
[Beta-blockers: redistribution of coronary blood flow and experimental myocardial ischaemia].
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Coronary Circulation; Coronary Disease; Disease Mode | 1978 |
[Proceedings: Prevention of myocardial degeneration in a disease model of hereditary cardiomyopathy].
Topics: Animals; Calcium; Cardiomegaly; Cardiomyopathies; Cricetinae; Disease Models, Animal; Heart; Myocard | 1975 |
[Significance of renin-angiotensin system inhibitors in the diagnosis of hypertension].
Topics: Angiotensin II; Animals; Blood Pressure; Disease Models, Animal; Dogs; Enzyme Inhibitors; Humans; Hy | 1977 |
Augmentation of beta adrenergic receptors in cardiomyopathic hamsters (BIO 14.6) with heart failure.
Topics: Animals; Autoradiography; Cardiomyopathies; Cricetinae; Disease Models, Animal; Iodocyanopindolol; M | 1992 |
Regulation of cardiac adenylate cyclase activity in rodent models of obesity.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Binding, Competitive; Disease Models, Animal; | 1992 |
Effects of tertatolol, a beta-adrenoceptor antagonist with agonist affinity at 5-HT1A receptors, in an animal model of migraine: comparison with propranolol and pindolol.
Topics: Adrenergic beta-Antagonists; Animals; Carotid Arteries; Disease Models, Animal; Hemodynamics; Inject | 1992 |
Elevated leukocyte phosphodiesterase as a basis for depressed cyclic adenosine monophosphate responses in the Basenji greyhound dog model of asthma.
Topics: Adenylyl Cyclases; Animals; Asthma; Cyclic AMP; Disease Models, Animal; Dog Diseases; Dogs; Iodine R | 1985 |
Effects in the X-maze anxiety model of agents acting at 5-HT1 and 5-HT2 receptors.
Topics: Animals; Anxiety; Diazepam; Disease Models, Animal; Drug Combinations; Exploratory Behavior; Male; P | 1987 |