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pindolol and Depression

pindolol has been researched along with Depression in 21 studies

Pindolol: A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)
pindolol : A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.

Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.

Research Excerpts

ExcerptRelevanceReference
"A case is reported of a 34-year-old lady with a 2-year history of resistant depression who responded to pindolol augmentation of sertraline."7.70Pindolol augmentation of sertraline in resistant depression and its effect on sleep. ( Bell, C; Nutt, DJ; Wilson, S, 1998)
" After a 1-week placebo run-in period, 72 patients received fluvoxamine 300 mg/day in combination with placebo or pindolol 7."6.69Faster onset of action of fluvoxamine in combination with pindolol in the treatment of delusional depression: a controlled study. ( Franchini, L; Gasperini, M; Lucca, A; Perez, J; Smeraldi, E; Zanardi, R, 1998)
"Of 132 eligible patients with major depression, 111 were randomly assigned to treatment with fluoxetine (20 mg daily) and either placebo or pindolol (7."5.08Randomised, double-blind, placebo-controlled trial of pindolol in combination with fluoxetine antidepressant treatment. ( Alvarez, E; Artigas, F; Faries, D; Gilaberte, I; Pérez, V, 1997)
"The effect of inositol as an antidepressant was previously demonstrated in both animal models of depression-like behavior and in clinical trials."3.71The antidepressant activity of inositol in the forced swim test involves 5-HT(2) receptors. ( Belmaker, RH; Bourin, M; Clenet, F; Einat, H; Shaldubina, A, 2001)
"A case is reported of a 34-year-old lady with a 2-year history of resistant depression who responded to pindolol augmentation of sertraline."3.70Pindolol augmentation of sertraline in resistant depression and its effect on sleep. ( Bell, C; Nutt, DJ; Wilson, S, 1998)
"Pindolol was initially used due to its ability to block 5-HT1A receptor-mediated responses and to enhance the neurochemical effects of SSRIs."2.43Pindolol augmentation of antidepressant response. ( Adell, A; Artigas, F; Celada, P, 2006)
" In patients who have experienced only partial treatment results, the clinician should first consider optimizing antidepressant dosage or lengthening therapy."2.40Practical management of treatment-resistant depression. ( Cadieux, RJ, 1998)
" Using drugs together may increase the risk of adverse effects, through potentiation of existing adverse effects or alterations in plasma concentrations of the drug."2.40Risk of adverse events with the use of augmentation therapy for the treatment of resistant depression. ( Schweitzer, I; Tuckwell, V, 1998)
" However, the optimal dosing schedule of pindolol remains controversial."1.33A mathematical model for paroxetine antidepressant effect time course and its interaction with pindolol. ( Dauphin, A; Gruwez, B; Tod, M, 2005)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.76)18.7374
1990's11 (52.38)18.2507
2000's7 (33.33)29.6817
2010's2 (9.52)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Laver, B1
Diwan, M1
Nobrega, JN1
Hamani, C1
Nautiyal, KM1
Tritschler, L1
Ahmari, SE1
David, DJ1
Gardier, AM1
Hen, R1
Jiang, XZ1
Li, YF1
Zhang, YZ1
Chen, HX1
Li, J1
Wang, NP1
Portella, MJ1
de Diego-Adeliño, J1
Puigdemont, D1
Pérez-Egea, R1
Alvarez, E2
Artigas, F3
Pérez, V2
Gruwez, B1
Dauphin, A1
Tod, M1
Adell, A1
Celada, P1
Geretsegger, C1
Bitterlich, W1
Stelzig, R1
Stuppaeck, C1
Bondy, B1
Aichhorn, W1
Tejani-Butt, SM1
Paré, WP1
Yang, J1
Blier, P1
Bergeron, R1
Gilaberte, I1
Faries, D1
Bourin, M2
Redrobe, JP1
Baker, GB1
Bell, C1
Wilson, S1
Nutt, DJ1
Gurguis, GN1
Yonkers, KA1
Blakeley, JE1
Phan, SP1
Williams, A1
Rush, AJ1
Cryan, JF1
McGrath, C1
Leonard, BE1
Norman, TR1
Mundo, E1
Guglielmo, E1
Bellodi, L1
Cadieux, RJ1
Zanardi, R1
Franchini, L1
Gasperini, M1
Lucca, A1
Smeraldi, E1
Perez, J1
Schweitzer, I1
Tuckwell, V1
Einat, H1
Clenet, F1
Shaldubina, A1
Belmaker, RH1
Kohn, R1
Koella, WP1

Reviews

5 reviews available for pindolol and Depression

ArticleYear
Pindolol augmentation of antidepressant response.
    Current drug targets, 2006, Volume: 7, Issue:2

    Topics: Brain; Depression; Humans; Pindolol; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Tr

2006
Practical management of treatment-resistant depression.
    American family physician, 1998, Volume: 58, Issue:9

    Topics: Antidepressive Agents; Buspirone; Depression; Drug Resistance; Drug Therapy, Combination; Humans; Li

1998
Risk of adverse events with the use of augmentation therapy for the treatment of resistant depression.
    Drug safety, 1998, Volume: 19, Issue:6

    Topics: Antidepressive Agents; Antidepressive Agents, Tricyclic; Depression; Drug Resistance; Drug Therapy,

1998
Beta-blockers an important cause of depression: a medical myth without evidence.
    Medicine and health, Rhode Island, 2001, Volume: 84, Issue:3

    Topics: Adrenergic beta-Antagonists; Antidepressive Agents; Antihypertensive Agents; Controlled Clinical Tri

2001
CNS-related (side-)effects of beta-blockers with special reference to mechanisms of action.
    European journal of clinical pharmacology, 1985, Volume: 28 Suppl

    Topics: Adrenergic beta-Antagonists; Amphetamine; Animals; Anxiety; Blood-Brain Barrier; Central Nervous Sys

1985

Trials

5 trials available for pindolol and Depression

ArticleYear
Pindolol augmentation enhances response outcomes in first depressive episodes.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2009, Volume: 19, Issue:7

    Topics: Adolescent; Adult; Antidepressive Agents; Depression; Double-Blind Method; Drug Therapy, Combination

2009
Paroxetine with pindolol augmentation: a double-blind, randomized, placebo-controlled study in depressed in-patients.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2008, Volume: 18, Issue:2

    Topics: Adult; Depression; Double-Blind Method; Drug Evaluation; Drug Synergism; Female; Humans; Inpatients;

2008
Randomised, double-blind, placebo-controlled trial of pindolol in combination with fluoxetine antidepressant treatment.
    Lancet (London, England), 1997, May-31, Volume: 349, Issue:9065

    Topics: Adult; Antidepressive Agents, Second-Generation; Depression; Double-Blind Method; Drug Therapy, Comb

1997
Effect of adjuvant pindolol on the antiobsessional response to fluvoxamine: a double-blind, placebo-controlled study.
    International clinical psychopharmacology, 1998, Volume: 13, Issue:5

    Topics: Adult; Antidepressive Agents, Second-Generation; Depression; Double-Blind Method; Drug Therapy, Comb

1998
Faster onset of action of fluvoxamine in combination with pindolol in the treatment of delusional depression: a controlled study.
    Journal of clinical psychopharmacology, 1998, Volume: 18, Issue:6

    Topics: Adolescent; Adult; Aged; Antidepressive Agents, Second-Generation; Depression; Double-Blind Method;

1998

Other Studies

11 other studies available for pindolol and Depression

ArticleYear
Augmentative therapies do not potentiate the antidepressant-like effects of deep brain stimulation in rats.
    Journal of affective disorders, 2014, Volume: 161

    Topics: Animals; Behavior, Animal; Buspirone; Deep Brain Stimulation; Depression; Dopamine Antagonists; Gyru

2014
A Lack of Serotonin 1B Autoreceptors Results in Decreased Anxiety and Depression-Related Behaviors.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016, Volume: 41, Issue:12

    Topics: Animals; Animals, Newborn; Anxiety; Autoreceptors; Depression; Disease Models, Animal; Exploratory B

2016
[5-HT1A/1B receptors, alpha2-adrenoceptors and the post-receptor adenylate cyclase activation in the mice brain are involved in the antidepressant-like action of agmatine].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2008, Volume: 43, Issue:5

    Topics: Adenylyl Cyclases; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Agmatine; Animals; Ant

2008
A mathematical model for paroxetine antidepressant effect time course and its interaction with pindolol.
    Journal of pharmacokinetics and pharmacodynamics, 2005, Volume: 32, Issue:5-6

    Topics: Algorithms; Antidepressive Agents, Second-Generation; Clinical Trials as Topic; Depression; Dose-Res

2005
Effect of repeated novel stressors on depressive behavior and brain norepinephrine receptor system in Sprague-Dawley and Wistar Kyoto (WKY) rats.
    Brain research, 1994, Jun-27, Volume: 649, Issue:1-2

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Body Weight; Brain; Carrier Prot

1994
Sequential administration of augmentation strategies in treatment-resistant obsessive-compulsive disorder: preliminary findings.
    International clinical psychopharmacology, 1996, Volume: 11, Issue:1

    Topics: Adrenergic beta-Antagonists; Adult; Buspirone; Depression; Drug Resistance; Drug Therapy, Combinatio

1996
Pindolol does not act only on 5-HT1A receptors in augmenting antidepressant activity in the mouse forced swimming test.
    Psychopharmacology, 1998, Volume: 136, Issue:3

    Topics: Adrenergic beta-Antagonists; Animals; Antidepressive Agents; Depression; Dose-Response Relationship,

1998
Pindolol augmentation of sertraline in resistant depression and its effect on sleep.
    Journal of psychopharmacology (Oxford, England), 1998, Volume: 12, Issue:1

    Topics: 1-Naphthylamine; Adrenergic beta-Antagonists; Adult; Antidepressive Agents; Brain; Depression; Drug

1998
Adrenergic receptors in premenstrual dysphoric disorder. II. Neutrophil beta2-adrenergic receptors: Gs protein coupling, phase of menstrual cycle and prediction of luteal phase symptom severity.
    Psychiatry research, 1998, Jun-02, Volume: 79, Issue:1

    Topics: Adult; Anxiety; Case-Control Studies; Depression; Female; Follicular Phase; GTP-Binding Proteins; Hu

1998
Combining pindolol and paroxetine in an animal model of chronic antidepressant action--can early onset of action be detected?
    European journal of pharmacology, 1998, Jul-03, Volume: 352, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Animals; Antidepressive Agents;

1998
The antidepressant activity of inositol in the forced swim test involves 5-HT(2) receptors.
    Behavioural brain research, 2001, Jan-08, Volume: 118, Issue:1

    Topics: Animals; Antidepressive Agents; Benzylamines; Depression; Disease Models, Animal; Drug Interactions;

2001