pindolol has been researched along with Cardiomegaly in 14 studies
Pindolol: A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)
pindolol : A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Therefore, hypertension and cardiac hypertrophy were dissociable in this model when pindolol was administered from the onset of hypertension." | 5.28 | Reduction of cardiac hypertrophy in renal hypertensive rabbits with pindolol. ( Cimini, CM; Gonzalez, MA; Weiss, HR, 1991) |
| "Reversal of cardiac hypertrophy has been obtained by treatment with some antihypertensive drugs but has not been achieved consistently with beta blockers." | 5.27 | Pindolol, not propranolol, reverses cardiac hypertrophy in renal hypertensive rats. ( Almeida, JB; Amorin, MP; Bessa, AM; Cezaretti, ML; Ramos, OL; Saragoça, MA; Tavares, A, 1988) |
| "The beta-adrenergic system has been explored in cardiac hypertrophy (CH) by combining an in vitro study of the inotropic effect of isoproterenol (ISO) and of forskolin (FSK) and binding assays using radioactive pindolol." | 3.67 | Beta-adrenergic system is modified in compensatory pressure cardiac overload in rats: physiological and biochemical evidence. ( Callens-el Amrani, F; Chevalier, B; Mansier, P; Swynghedauw, B, 1989) |
| "Regression of cardiac hypertrophy occurred after treatment of aortic banded rats with a high dose of enalapril, bunazosin or propranolol, and was accompanied by a reduction in systolic blood pressure." | 1.29 | Modulation of adrenergic receptors during regression of cardiac hypertrophy. ( Hata, T; Makino, N; Matsui, H; Nakanishi, H; Yanaga, T; Yano, K, 1994) |
| "Therefore, hypertension and cardiac hypertrophy were dissociable in this model when pindolol was administered from the onset of hypertension." | 1.28 | Reduction of cardiac hypertrophy in renal hypertensive rabbits with pindolol. ( Cimini, CM; Gonzalez, MA; Weiss, HR, 1991) |
| "Treatment with propranolol + T4 blunted the coronary blood flow increase, but receptor upregulation occurred to the same extent as with either substance alone." | 1.28 | Role of beta adrenoceptors in the hypertrophic response to thyroxine. ( Eliades, D; Weiss, HR, 1989) |
| "Reversal of cardiac hypertrophy has been obtained by treatment with some antihypertensive drugs but has not been achieved consistently with beta blockers." | 1.27 | Pindolol, not propranolol, reverses cardiac hypertrophy in renal hypertensive rats. ( Almeida, JB; Amorin, MP; Bessa, AM; Cezaretti, ML; Ramos, OL; Saragoça, MA; Tavares, A, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (42.86) | 18.7374 |
| 1990's | 7 (50.00) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Matsui, H | 1 |
| Makino, N | 1 |
| Yano, K | 1 |
| Nakanishi, H | 1 |
| Hata, T | 1 |
| Yanaga, T | 1 |
| Dorn, GW | 1 |
| Tepe, NM | 1 |
| Wu, G | 1 |
| Yatani, A | 1 |
| Liggett, SB | 1 |
| Lossnitzer, K | 1 |
| Konrad, A | 1 |
| Heine, HW | 1 |
| Ziegler, E | 1 |
| Stauch, M | 1 |
| Girndt, J | 1 |
| Kramer, A | 1 |
| Scheler, F | 1 |
| Pernot, C | 1 |
| Török, E | 1 |
| Borbás, S | 1 |
| Lengyel, M | 1 |
| Zorándi, A | 1 |
| Pelá, G | 1 |
| Missale, C | 1 |
| Raddino, R | 1 |
| Condorelli, E | 1 |
| Spano, PF | 1 |
| Visioli, O | 1 |
| Cimini, CM | 1 |
| Gonzalez, MA | 1 |
| Weiss, HR | 2 |
| Widimský, J | 2 |
| Cífková, R | 1 |
| Frídl, P | 1 |
| Skibová, J | 1 |
| Niederle, P | 1 |
| Sau, F | 1 |
| Seguro, C | 1 |
| Pili, G | 1 |
| Basciu, M | 1 |
| Siddi, PP | 1 |
| Tamponi, R | 1 |
| Cherchi, A | 1 |
| Chevalier, B | 1 |
| Mansier, P | 1 |
| Callens-el Amrani, F | 1 |
| Swynghedauw, B | 1 |
| Eliades, D | 1 |
| Saragoça, MA | 1 |
| Cezaretti, ML | 1 |
| Tavares, A | 1 |
| Bessa, AM | 1 |
| Almeida, JB | 1 |
| Amorin, MP | 1 |
| Ramos, OL | 1 |
2 trials available for pindolol and Cardiomegaly
| Article | Year |
|---|---|
Regression of cardiac hypertrophy in hypertensive patients by long-term treatment with isradipine.
Topics: Adolescent; Adult; Aged; Calcium Channel Blockers; Cardiomegaly; Dihydropyridines; Drug Therapy, Com | 1992 |
[Electrocardiographic and echocardiographic changes during antihypertensive therapy].
Topics: Acebutolol; Adolescent; Adult; Aged; Antihypertensive Agents; Captopril; Cardiomegaly; Chlorthalidon | 1990 |
12 other studies available for pindolol and Cardiomegaly
| Article | Year |
|---|---|
Modulation of adrenergic receptors during regression of cardiac hypertrophy.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Cardiomegaly; Iodocyanopindolol; Male; Norepineph | 1994 |
Mechanisms of impaired beta-adrenergic receptor signaling in G(alphaq)-mediated cardiac hypertrophy and ventricular dysfunction.
Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Animals; Cardiomegaly; GTP-Binding Protein alpha Sub | 2000 |
[Proceedings: Prevention of myocardial degeneration in a disease model of hereditary cardiomyopathy].
Topics: Animals; Calcium; Cardiomegaly; Cardiomyopathies; Cricetinae; Disease Models, Animal; Heart; Myocard | 1975 |
[The influence of the beta-blocking agent pindolol on blood pressure and heart weight of rats with Goldblatt-type hypertension (author's transl)].
Topics: Animals; Blood Pressure; Cardiomegaly; Female; Hypertension, Renal; Pindolol; Rats; Renin | 1977 |
[Myocardiopathy of Friedreich's disease. Apropos of a series of 17 observations].
Topics: Adolescent; Adult; Cardiomegaly; Cardiomyopathies; Child; Child, Preschool; Echocardiography; Electr | 1979 |
Beta 1- and beta 2-receptors are differentially desensitized in an experimental model of heart failure.
Topics: Adenylyl Cyclases; Animals; Autoradiography; Cardiac Output, Low; Cardiomegaly; Cardiomyopathies; Fe | 1990 |
Reduction of cardiac hypertrophy in renal hypertensive rabbits with pindolol.
Topics: Animals; Body Weight; Cardiomegaly; Coronary Circulation; Hemodynamics; Hypertension, Renal; Nephrec | 1991 |
Patients with essential hypertension.
Topics: Blood Pressure; Cardiac Output; Cardiac Volume; Cardiomegaly; Diuretics; Drug Therapy, Combination; | 1990 |
Cardiac hypertrophy in hypertension.
Topics: Blood Pressure; Cardiac Output; Cardiac Volume; Cardiomegaly; Diuretics; Dose-Response Relationship, | 1990 |
Beta-adrenergic system is modified in compensatory pressure cardiac overload in rats: physiological and biochemical evidence.
Topics: Animals; Binding Sites; Cardiac Pacing, Artificial; Cardiomegaly; Colforsin; Coronary Circulation; I | 1989 |
Role of beta adrenoceptors in the hypertrophic response to thyroxine.
Topics: Animals; Blood Pressure; Cardiomegaly; Coronary Circulation; Heart Rate; Iodine Radioisotopes; Organ | 1989 |
Pindolol, not propranolol, reverses cardiac hypertrophy in renal hypertensive rats.
Topics: Animals; Blood Pressure; Cardiomegaly; Hypertension, Renovascular; Male; Myocardial Contraction; Pin | 1988 |