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pindolol and Cardiomegaly

pindolol has been researched along with Cardiomegaly in 14 studies

Pindolol: A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)
pindolol : A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.

Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.

Research Excerpts

ExcerptRelevanceReference
"Therefore, hypertension and cardiac hypertrophy were dissociable in this model when pindolol was administered from the onset of hypertension."5.28Reduction of cardiac hypertrophy in renal hypertensive rabbits with pindolol. ( Cimini, CM; Gonzalez, MA; Weiss, HR, 1991)
"Reversal of cardiac hypertrophy has been obtained by treatment with some antihypertensive drugs but has not been achieved consistently with beta blockers."5.27Pindolol, not propranolol, reverses cardiac hypertrophy in renal hypertensive rats. ( Almeida, JB; Amorin, MP; Bessa, AM; Cezaretti, ML; Ramos, OL; Saragoça, MA; Tavares, A, 1988)
"The beta-adrenergic system has been explored in cardiac hypertrophy (CH) by combining an in vitro study of the inotropic effect of isoproterenol (ISO) and of forskolin (FSK) and binding assays using radioactive pindolol."3.67Beta-adrenergic system is modified in compensatory pressure cardiac overload in rats: physiological and biochemical evidence. ( Callens-el Amrani, F; Chevalier, B; Mansier, P; Swynghedauw, B, 1989)
"Regression of cardiac hypertrophy occurred after treatment of aortic banded rats with a high dose of enalapril, bunazosin or propranolol, and was accompanied by a reduction in systolic blood pressure."1.29Modulation of adrenergic receptors during regression of cardiac hypertrophy. ( Hata, T; Makino, N; Matsui, H; Nakanishi, H; Yanaga, T; Yano, K, 1994)
"Therefore, hypertension and cardiac hypertrophy were dissociable in this model when pindolol was administered from the onset of hypertension."1.28Reduction of cardiac hypertrophy in renal hypertensive rabbits with pindolol. ( Cimini, CM; Gonzalez, MA; Weiss, HR, 1991)
"Treatment with propranolol + T4 blunted the coronary blood flow increase, but receptor upregulation occurred to the same extent as with either substance alone."1.28Role of beta adrenoceptors in the hypertrophic response to thyroxine. ( Eliades, D; Weiss, HR, 1989)
"Reversal of cardiac hypertrophy has been obtained by treatment with some antihypertensive drugs but has not been achieved consistently with beta blockers."1.27Pindolol, not propranolol, reverses cardiac hypertrophy in renal hypertensive rats. ( Almeida, JB; Amorin, MP; Bessa, AM; Cezaretti, ML; Ramos, OL; Saragoça, MA; Tavares, A, 1988)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19906 (42.86)18.7374
1990's7 (50.00)18.2507
2000's1 (7.14)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Matsui, H1
Makino, N1
Yano, K1
Nakanishi, H1
Hata, T1
Yanaga, T1
Dorn, GW1
Tepe, NM1
Wu, G1
Yatani, A1
Liggett, SB1
Lossnitzer, K1
Konrad, A1
Heine, HW1
Ziegler, E1
Stauch, M1
Girndt, J1
Kramer, A1
Scheler, F1
Pernot, C1
Török, E1
Borbás, S1
Lengyel, M1
Zorándi, A1
Pelá, G1
Missale, C1
Raddino, R1
Condorelli, E1
Spano, PF1
Visioli, O1
Cimini, CM1
Gonzalez, MA1
Weiss, HR2
Widimský, J2
Cífková, R1
Frídl, P1
Skibová, J1
Niederle, P1
Sau, F1
Seguro, C1
Pili, G1
Basciu, M1
Siddi, PP1
Tamponi, R1
Cherchi, A1
Chevalier, B1
Mansier, P1
Callens-el Amrani, F1
Swynghedauw, B1
Eliades, D1
Saragoça, MA1
Cezaretti, ML1
Tavares, A1
Bessa, AM1
Almeida, JB1
Amorin, MP1
Ramos, OL1

Trials

2 trials available for pindolol and Cardiomegaly

ArticleYear
Regression of cardiac hypertrophy in hypertensive patients by long-term treatment with isradipine.
    Journal of cardiovascular pharmacology, 1992, Volume: 19 Suppl 3

    Topics: Adolescent; Adult; Aged; Calcium Channel Blockers; Cardiomegaly; Dihydropyridines; Drug Therapy, Com

1992
[Electrocardiographic and echocardiographic changes during antihypertensive therapy].
    Cardiologia (Rome, Italy), 1990, Volume: 35, Issue:12

    Topics: Acebutolol; Adolescent; Adult; Aged; Antihypertensive Agents; Captopril; Cardiomegaly; Chlorthalidon

1990

Other Studies

12 other studies available for pindolol and Cardiomegaly

ArticleYear
Modulation of adrenergic receptors during regression of cardiac hypertrophy.
    Journal of hypertension, 1994, Volume: 12, Issue:12

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Cardiomegaly; Iodocyanopindolol; Male; Norepineph

1994
Mechanisms of impaired beta-adrenergic receptor signaling in G(alphaq)-mediated cardiac hypertrophy and ventricular dysfunction.
    Molecular pharmacology, 2000, Volume: 57, Issue:2

    Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Animals; Cardiomegaly; GTP-Binding Protein alpha Sub

2000
[Proceedings: Prevention of myocardial degeneration in a disease model of hereditary cardiomyopathy].
    Zeitschrift fur Kardiologie, 1975, Volume: Suppl 2

    Topics: Animals; Calcium; Cardiomegaly; Cardiomyopathies; Cricetinae; Disease Models, Animal; Heart; Myocard

1975
[The influence of the beta-blocking agent pindolol on blood pressure and heart weight of rats with Goldblatt-type hypertension (author's transl)].
    Klinische Wochenschrift, 1977, Apr-01, Volume: 55, Issue:7

    Topics: Animals; Blood Pressure; Cardiomegaly; Female; Hypertension, Renal; Pindolol; Rats; Renin

1977
[Myocardiopathy of Friedreich's disease. Apropos of a series of 17 observations].
    Archives francaises de pediatrie, 1979, Volume: 36, Issue:1

    Topics: Adolescent; Adult; Cardiomegaly; Cardiomyopathies; Child; Child, Preschool; Echocardiography; Electr

1979
Beta 1- and beta 2-receptors are differentially desensitized in an experimental model of heart failure.
    Journal of cardiovascular pharmacology, 1990, Volume: 16, Issue:5

    Topics: Adenylyl Cyclases; Animals; Autoradiography; Cardiac Output, Low; Cardiomegaly; Cardiomyopathies; Fe

1990
Reduction of cardiac hypertrophy in renal hypertensive rabbits with pindolol.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 257, Issue:2

    Topics: Animals; Body Weight; Cardiomegaly; Coronary Circulation; Hemodynamics; Hypertension, Renal; Nephrec

1991
Patients with essential hypertension.
    Cor et vasa, 1990, Volume: 32, Issue:1

    Topics: Blood Pressure; Cardiac Output; Cardiac Volume; Cardiomegaly; Diuretics; Drug Therapy, Combination;

1990
Cardiac hypertrophy in hypertension.
    Cor et vasa, 1990, Volume: 32, Issue:1

    Topics: Blood Pressure; Cardiac Output; Cardiac Volume; Cardiomegaly; Diuretics; Dose-Response Relationship,

1990
Beta-adrenergic system is modified in compensatory pressure cardiac overload in rats: physiological and biochemical evidence.
    Journal of cardiovascular pharmacology, 1989, Volume: 13, Issue:3

    Topics: Animals; Binding Sites; Cardiac Pacing, Artificial; Cardiomegaly; Colforsin; Coronary Circulation; I

1989
Role of beta adrenoceptors in the hypertrophic response to thyroxine.
    Journal of cardiovascular pharmacology, 1989, Volume: 14, Issue:1

    Topics: Animals; Blood Pressure; Cardiomegaly; Coronary Circulation; Heart Rate; Iodine Radioisotopes; Organ

1989
Pindolol, not propranolol, reverses cardiac hypertrophy in renal hypertensive rats.
    Hypertension (Dallas, Tex. : 1979), 1988, Volume: 11, Issue:2 Pt 2

    Topics: Animals; Blood Pressure; Cardiomegaly; Hypertension, Renovascular; Male; Myocardial Contraction; Pin

1988