pindolol has been researched along with Cardiac Failure in 29 studies
Pindolol: A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)
pindolol : A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study investigated the effects of myocardial infarction (MI)-induced cardiac failure and treatment with an angiotensin-converting enzyme (ACE) inhibitor perindopril (2 mg/kg/day) on rat beta-adrenoceptor (beta-ar) subtypes in anatomically defined regions of infarcted left ventricular (LV) free wall and noninfarcted tissue from right ventricle (RV) by using autoradiography." | 7.70 | Regulation of beta-adrenoceptors in a rat model of cardiac failure: effect of perindopril. ( Gu, XH; Kompa, AR; Summers, RJ, 1998) |
| "Dose- and time-dependent pharmacokinetics and plasma protein binding of pindolol were studied in patients with idiopathic cardiomyopathy who had mild to moderate congestive heart failure." | 7.67 | Dose- and time-dependent binding and kinetics of pindolol in patients with congestive heart failure. ( Binkley, PF; Johnson, J; Leier, CV; Lima, JJ, 1986) |
| " These results indicate that the slope of the left ventricular ESP/ESD relation is not altered following repeated dosing with pindolol in subjects with congestive heart failure." | 5.27 | Preservation of the end-systolic pressure/end-systolic dimension relation following pindolol in congestive heart failure. ( Binkley, PF; Leier, CV; Lewe, RF; Unverferth, DV, 1988) |
| "1 This study was designed to compare in a randomized cross-over trial pindolol, a beta-adrenoceptor blocking agent with intrinsic sympathomimetic activity and metoprolol, a cardioselective beta-adrenoceptor blocker lacking sympathomimetic activity in hypertensives with incipient heart failure." | 5.05 | The influence of beta-adrenoceptor blockade on left ventricular function. ( Hahn, B; Strauer, BE, 1982) |
| "This study investigated the effects of myocardial infarction (MI)-induced cardiac failure and treatment with an angiotensin-converting enzyme (ACE) inhibitor perindopril (2 mg/kg/day) on rat beta-adrenoceptor (beta-ar) subtypes in anatomically defined regions of infarcted left ventricular (LV) free wall and noninfarcted tissue from right ventricle (RV) by using autoradiography." | 3.70 | Regulation of beta-adrenoceptors in a rat model of cardiac failure: effect of perindopril. ( Gu, XH; Kompa, AR; Summers, RJ, 1998) |
| "Dose- and time-dependent pharmacokinetics and plasma protein binding of pindolol were studied in patients with idiopathic cardiomyopathy who had mild to moderate congestive heart failure." | 3.67 | Dose- and time-dependent binding and kinetics of pindolol in patients with congestive heart failure. ( Binkley, PF; Johnson, J; Leier, CV; Lima, JJ, 1986) |
| "Three patients with ischaemic heart disease developed profound cardiac failure, hypotension and bradycardia during combined therapy with verapamil and beta-adrenergic blocking drugs." | 3.66 | Adverse interaction between beta-adrenergic blocking drugs and verapamil--report of three cases. ( Anderson, ST; Federman, J; Harper, RW; Laufer, E; Pitt, A; Wayne, VS, 1982) |
| "The authors report a case of syncopal ventricular tachycardia in a patient with a respiratory-dependent rate responsive pacemaker, followed-up for valvular heart disease with severe left ventricular dysfunction and sustained atrial and ventricular arrhythmias." | 1.28 | [Ventricular tachycardia in a patient with rate-responsive cardiac pacemaker]. ( Busquet, P; Coutte, R; Frank, R; Grosgogeat, Y; Himbert, C; Lascault, G; Tonet, J, 1992) |
| " Increases in norepinephrine, dopamine, and epinephrine concentrations after dosing were noted, with the most marked increase in norepinephrine concentration being coincident with a significant decline in stroke volume index." | 1.27 | Neurohumoral profile in congestive heart failure: response to beta-blockade. ( Binkley, PF; Leier, CV; Lewe, R; Lima, J; Unverferth, DV, 1988) |
| " These results indicate that the slope of the left ventricular ESP/ESD relation is not altered following repeated dosing with pindolol in subjects with congestive heart failure." | 1.27 | Preservation of the end-systolic pressure/end-systolic dimension relation following pindolol in congestive heart failure. ( Binkley, PF; Leier, CV; Lewe, RF; Unverferth, DV, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (65.52) | 18.7374 |
| 1990's | 9 (31.03) | 18.2507 |
| 2000's | 1 (3.45) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sal'nikov, EV | 1 |
| Moses, JW | 1 |
| Borer, JS | 1 |
| Davies, B | 1 |
| Bannister, R | 1 |
| Mathias, C | 1 |
| Sever, P | 1 |
| Hahn, B | 1 |
| Strauer, BE | 1 |
| Wayne, VS | 1 |
| Harper, RW | 1 |
| Laufer, E | 1 |
| Federman, J | 1 |
| Anderson, ST | 1 |
| Pitt, A | 1 |
| McDevitt, DG | 1 |
| Tkaczewski, W | 1 |
| Goch, JH | 1 |
| Wichan, P | 1 |
| Kowalski, J | 1 |
| Steinfath, M | 1 |
| Lavicky, J | 1 |
| Schmitz, W | 1 |
| Scholz, H | 1 |
| Döring, V | 1 |
| Kalmár, P | 1 |
| Gu, XH | 1 |
| Kompa, AR | 1 |
| Summers, RJ | 1 |
| Zilcher, H | 1 |
| Glogar, D | 1 |
| Ponsonnaille, J | 1 |
| Pailloncy, M | 1 |
| Goujon, B | 1 |
| Marcheix, JC | 1 |
| Gras, H | 1 |
| Himbert, C | 1 |
| Lascault, G | 1 |
| Tonet, J | 1 |
| Coutte, R | 1 |
| Busquet, P | 1 |
| Frank, R | 1 |
| Grosgogeat, Y | 1 |
| Bristow, MR | 3 |
| Minobe, W | 3 |
| Rasmussen, R | 2 |
| Larrabee, P | 2 |
| Skerl, L | 2 |
| Klein, JW | 1 |
| Anderson, FL | 1 |
| Murray, J | 1 |
| Mestroni, L | 1 |
| Karwande, SV | 1 |
| Takahashi, M | 1 |
| Shichiri, G | 1 |
| Amano, M | 1 |
| Kanamori, T | 1 |
| Kinoshita, M | 1 |
| Müller-Beckmann, B | 1 |
| Roden, R | 1 |
| Klein, J | 1 |
| Handwerger, D | 1 |
| Port, JD | 1 |
| Kozlik, R | 1 |
| Kramer, HH | 1 |
| Wicht, H | 1 |
| Bircks, W | 1 |
| Reinhardt, D | 1 |
| Sullebarger, JT | 1 |
| Fan, TH | 1 |
| Torres, F | 1 |
| Liang, CS | 1 |
| Böhm, M | 1 |
| Mittmann, C | 1 |
| Schwinger, RH | 1 |
| Erdmann, E | 1 |
| Denniss, AR | 1 |
| Colucci, WS | 1 |
| Allen, PD | 1 |
| Marsh, JD | 1 |
| Murphree, SS | 1 |
| Saffitz, JE | 1 |
| Hershberger, RE | 1 |
| Hoffman, BB | 1 |
| Binkley, PF | 3 |
| Lewe, R | 1 |
| Lima, J | 1 |
| Unverferth, DV | 2 |
| Leier, CV | 3 |
| Weber, S | 1 |
| Cabanes, L | 1 |
| Lanouar, K | 1 |
| Degeorges, M | 1 |
| Lewe, RF | 1 |
| Lima, JJ | 1 |
| Johnson, J | 1 |
| Ohly, A | 1 |
| König, E | 1 |
| Nachreiner, K | 1 |
| Schmidt, F | 1 |
| Singh, BN | 1 |
| Simpson, FO | 1 |
| Scebat, L | 1 |
| Rocha, P | 1 |
| Ourbak, P | 1 |
| Renais, J | 1 |
| Lenègre, J | 1 |
3 reviews available for pindolol and Cardiac Failure
| Article | Year |
|---|---|
Beta-adrenergic antagonists in the treatment of patients with heart disease.
Topics: Acebutolol; Adrenergic beta-Agonists; Alprenolol; Animals; Arrhythmias, Cardiac; Bronchial Spasm; Ca | 1981 |
[Heart failure: beta-stimulant or beta-blocker?].
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Adrenergic Fibers; Heart Failure; Pindolol | 1988 |
Beta-adrenergic receptor blocking drugs in hypertension.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Alprenolol; Antidepressive Agents; Antihy | 1974 |
2 trials available for pindolol and Cardiac Failure
| Article | Year |
|---|---|
The influence of beta-adrenoceptor blockade on left ventricular function.
Topics: Adrenergic beta-Antagonists; Cardiac Output; Heart; Heart Failure; Humans; Hypertension; Metoprolol; | 1982 |
[Ergometric test in sympatheticotonia after administration of propranolol, pindolol, verapamil and oxazepam].
Topics: Adolescent; Adrenergic Fibers; Adult; Clinical Trials as Topic; Exercise Test; Heart; Heart Failure; | 1980 |
24 other studies available for pindolol and Cardiac Failure
| Article | Year |
|---|---|
Heart rate variability in rats with experimental chronic heart failure and long-term exposure to beta-adrenoblockers.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Benzopyrans; Bisoprolol; Ethanolamines; Heart Failur | 2009 |
Pindolol in postural hypotension: the case for caution.
Topics: Aged; Female; Heart Failure; Humans; Hypotension, Orthostatic; Male; Middle Aged; Pindolol | 1981 |
Adverse interaction between beta-adrenergic blocking drugs and verapamil--report of three cases.
Topics: Adrenergic beta-Antagonists; Aged; Bradycardia; Coronary Disease; Drug Interactions; Drug Therapy, C | 1982 |
Beta-adrenoceptor blocking drugs and partial agonist activity. Is it clinically relevant?
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Asthma; Bradycardia; Cardiac Output; Heart Fa | 1983 |
Changes in cardiac beta-adrenoceptors in human heart diseases: relationship to the degree of heart failure and further evidence for etiology-related regulation of beta 1 and beta 2 subtypes.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aortic Valve; Cardiomyopathy, Hypertrophic; Down-Reg | 1993 |
Regulation of beta-adrenoceptors in a rat model of cardiac failure: effect of perindopril.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Autoradiography; Blood Pressure; Body Weight; Dow | 1998 |
[Non arrhythmogenic sudden death as complication of coronary heart disease].
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Coronary Artery Bypass; Coronary Disease; Death, | 1979 |
[Congestive-type primary myocardiopathies: treatment with beta-blocking agents].
Topics: Adult; Cardiomyopathies; Heart Failure; Humans; Middle Aged; Pindolol; Propranolol | 1978 |
[Ventricular tachycardia in a patient with rate-responsive cardiac pacemaker].
Topics: Aged; Amiodarone; Electrocardiography, Ambulatory; Heart Failure; Heart Rate; Humans; Male; Pacemake | 1992 |
Beta-adrenergic neuroeffector abnormalities in the failing human heart are produced by local rather than systemic mechanisms.
Topics: Adenylyl Cyclases; Adult; Cardiomyopathy, Dilated; Catecholamines; Female; Heart; Heart Failure; Hum | 1992 |
Increased uncoupling of beta-, beta 1- and beta 2-adrenoceptor to myocardial contraction in failing human myocardium.
Topics: Adult; Aged; Binding, Competitive; Dobutamine; Down-Regulation; Female; Heart Failure; Humans; Iodoc | 1992 |
Effects of carvedilol on adrenergic receptor pharmacology in human ventricular myocardium and lymphocytes.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Binding, Competitive; Carbazoles; Cardiomyopat | 1992 |
Beta-adrenoceptor density on mononuclear leukocytes and right atrial myocardium in infants and children with congenital heart disease.
Topics: Binding, Competitive; Child; Child, Preschool; Down-Regulation; Epinephrine; Female; Heart Atria; He | 1991 |
Both cell surface and internalized beta-adrenoceptors are reduced in the failing myocardium.
Topics: Animals; Binding Sites; Cell Membrane; Dogs; Heart Failure; Iodocyanopindolol; Ouabain; Pindolol; Re | 1991 |
Effects of xamoterol on inotropic and lusitropic properties of the human myocardium and on adenylate cyclase activity.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Dose-Response Relationship, Drug; Heart Atria; Heart Fa | 1990 |
Distribution and function of human ventricular beta adrenergic receptors in congestive heart failure.
Topics: Adenylyl Cyclases; Adolescent; Adult; Binding, Competitive; GTP-Binding Proteins; Heart Failure; Hea | 1989 |
Distribution of beta-adrenergic receptors in failing human myocardium. Implications for mechanisms of down-regulation.
Topics: Adrenergic beta-Antagonists; Adult; Autoradiography; Female; Heart Failure; Heart Transplantation; H | 1989 |
Alpha-1 adrenergic receptors in the nonfailing and failing human heart.
Topics: Carbachol; Heart Failure; Humans; Iodocyanopindolol; Myocardium; Norepinephrine; Phenethylamines; Ph | 1988 |
Neurohumoral profile in congestive heart failure: response to beta-blockade.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Heart Failure; Hemodynamics; Humans; Hypertension; Middle | 1988 |
Preservation of the end-systolic pressure/end-systolic dimension relation following pindolol in congestive heart failure.
Topics: Echocardiography; Heart; Heart Failure; Humans; Myocardial Contraction; Pindolol; Stroke Volume; Sys | 1988 |
Dose- and time-dependent binding and kinetics of pindolol in patients with congestive heart failure.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Administra | 1986 |
[Cardiodepressive side effects of beta sympatholytic therapy. Clinical tests with Visken].
Topics: Administration, Oral; Adrenergic beta-Antagonists; Adult; Aged; Coronary Disease; Dose-Response Rela | 1973 |
Clinical aspects of the anti-arrhythmic actions of beta-receptor blocking drugs. 2. Clinical pharmacology.
Topics: Adrenergic beta-Antagonists; Alprenolol; Arrhythmias, Cardiac; Drug Therapy, Combination; Heart Fail | 1973 |
[Hemodynamic effects of intravenous injection of beta-adrenergic inhibitor (Pindolol) in man].
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Female; Heart Failure; Heart Rate; Hemodynamics; Hum | 1972 |