pindolol has been researched along with Astrocytoma in 13 studies
Pindolol: A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)
pindolol : A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.
Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The ligand-induced internalization of beta-adrenergic receptors and the receptor-mediated internalization of epidermal growth factor were blocked, under similar conditions, by phenylarsine oxide (PAO) in human astrocytoma cells (1321N1)." | 7.67 | A comparison of catecholamine-induced internalization of beta-adrenergic receptors and receptor-mediated endocytosis of epidermal growth factor in human astrocytoma cells. Inhibition by phenylarsine oxide. ( Coulter, SJ; Hertel, C; Perkins, JP, 1985) |
| "Competition by beta-adrenergic agonists and antagonists for 125I-pindolol binding sites on intact cells (1321N1 human astrocytoma and C62B rat glioma) was measured using short time binding assays as previously described (Toews, M." | 3.67 | Agonist-induced changes in beta-adrenergic receptors on intact cells. ( Perkins, JP; Toews, ML, 1984) |
| "The ligand-induced internalization of beta-adrenergic receptors and the receptor-mediated internalization of epidermal growth factor were blocked, under similar conditions, by phenylarsine oxide (PAO) in human astrocytoma cells (1321N1)." | 3.67 | A comparison of catecholamine-induced internalization of beta-adrenergic receptors and receptor-mediated endocytosis of epidermal growth factor in human astrocytoma cells. Inhibition by phenylarsine oxide. ( Coulter, SJ; Hertel, C; Perkins, JP, 1985) |
| "Binding of 125I-iodopindolol (IPIN) to intact 1321N1 human astrocytoma cell B-adrenergic receptors was measured at 37 degrees and on ice." | 3.67 | Comparison of binding of 125I-iodopindolol to control and desensitized cells at 37 degrees and on ice. ( Harden, TK; Perkins, JP; Toews, ML; Waldo, GL, 1986) |
| "The interactions of agonists and antagonists with beta-adrenergic receptors on intact 1321N1 human astrocytoma and C62B rat glioma cells were studied by using the radioligand (-)-[125I]iodopindolol." | 3.66 | High-affinity binding of agonists to beta-adrenergic receptors on intact cells. ( Harden, TK; Perkins, JP; Toews, ML, 1983) |
| "As a part of the process of agonist-induced desensitization, 1321N1 human astrocytoma cells lose up to 95% of their beta-adrenergic receptors, as detected by 125I-hydroxybenzylpindolol (125IHYP) binding, after 12-24 h of exposure to isoproterenol." | 3.66 | Recovery of beta-adrenergic receptors following long term exposure of astrocytoma cells to catecholamine. Role of protein synthesis. ( Doss, RC; Harden, TK; Perkins, JP, 1981) |
| "Incubation of 1321N1 human astrocytoma cells with 1 microM isoproterenol rapidly results in the conversion of a portion of the beta-adrenergic receptors to a membrane form that can be separated from markers for the plasma membrane by sucrose density gradient or differential centrifugation." | 3.66 | Characterization of an altered membrane form of the beta-adrenergic receptor produced during agonist-induced desensitization. ( Harden, TK; Northup, JK; Perkins, JP; Waldo, GL, 1983) |
| "Incubation of 1321N1 astrocytoma cells for 15 min with 1 microM (-)-isoproterenol resulted in a 50-65% loss of isoproterenol-stimulated adenylate cyclase activity." | 3.66 | Catecholamine-induced desensitization involves an uncoupling of beta-adrenergic receptors and adenylate cyclase. ( Harden, TK; Perkins, JP; Su, YF, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (92.31) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Toews, ML | 4 |
| Waldo, GL | 4 |
| Harden, TK | 9 |
| Perkins, JP | 11 |
| Doss, RC | 2 |
| Barovsky, K | 1 |
| Brooker, G | 1 |
| McCarthy, KD | 1 |
| Su, YF | 2 |
| Northup, JK | 1 |
| Kurz, JB | 1 |
| Hertel, C | 1 |
| Coulter, SJ | 1 |
13 other studies available for pindolol and Astrocytoma
| Article | Year |
|---|---|
Relationship between an altered membrane form and a low affinity form of the beta-adrenergic receptor occurring during catecholamine-induced desensitization. Evidence for receptor internalization.
Topics: Astrocytoma; Cell Line; Centrifugation, Density Gradient; Concanavalin A; Humans; Isoproterenol; Met | 1984 |
Use of a density shift method to assess beta-adrenergic receptor synthesis during recovery from catecholamine-induced down-regulation in human astrocytoma cells.
Topics: Ascorbic Acid; Astrocytoma; Cell Line; Humans; Iodocyanopindolol; Isoproterenol; Kinetics; Pindolol; | 1984 |
(-)-[125I]-iodopindolol, a new highly selective radioiodinated beta-adrenergic receptor antagonist: measurement of beta-receptors on intact rat astrocytoma cells.
Topics: Adrenergic beta-Antagonists; Animals; Astrocytoma; Binding Sites; Cells, Cultured; Iodine Radioisoto | 1980 |
Identification of the beta adrenergic receptor subtype on astroglia purified from rat brain.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Astrocytes; Astrocytoma; Cells, Cult | 1982 |
High-affinity binding of agonists to beta-adrenergic receptors on intact cells.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Astrocytoma; Binding, Competitive; C | 1983 |
Agonist-induced changes in beta-adrenergic receptors on intact cells.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Astrocytoma; Binding, Competitive; C | 1984 |
Catecholamine-specific desensitization of adenylate cyclase. Evidence for a multistep process.
Topics: Adenylyl Cyclases; Animals; Astrocytoma; Catecholamines; Cell Membrane; Enzyme Activation; Epinephri | 1980 |
Recovery of beta-adrenergic receptors following long term exposure of astrocytoma cells to catecholamine. Role of protein synthesis.
Topics: Astrocytoma; Cell Line; Cell Membrane; Cycloheximide; Humans; Isoproterenol; Kinetics; Neoplasm Prot | 1981 |
Characterization of an altered membrane form of the beta-adrenergic receptor produced during agonist-induced desensitization.
Topics: Adenylyl Cyclases; Astrocytoma; Cell Line; Cell Membrane; Humans; Isoproterenol; Molecular Weight; P | 1983 |
Catecholamine-induced desensitization involves an uncoupling of beta-adrenergic receptors and adenylate cyclase.
Topics: Adenylyl Cyclases; Astrocytoma; Benzyl Alcohols; Binding Sites; Cell Line; Dose-Response Relationshi | 1979 |
Isoproterenol-initiated beta-adrenergic receptor diacytosis in cultured cells.
Topics: Adrenergic beta-Antagonists; Astrocytoma; Cell Membrane; Half-Life; Humans; Iodine Radioisotopes; Is | 1992 |
A comparison of catecholamine-induced internalization of beta-adrenergic receptors and receptor-mediated endocytosis of epidermal growth factor in human astrocytoma cells. Inhibition by phenylarsine oxide.
Topics: Adenosine Triphosphate; Arsenicals; Astrocytoma; Catecholamines; Cell Line; Dithiothreitol; Endocyto | 1985 |
Comparison of binding of 125I-iodopindolol to control and desensitized cells at 37 degrees and on ice.
Topics: Astrocytoma; Cell Membrane; Cells, Cultured; Centrifugation, Density Gradient; Humans; Iodine Radioi | 1986 |