Page last updated: 2024-11-02

pindolol and Anxiety

pindolol has been researched along with Anxiety in 19 studies

Pindolol: A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)
pindolol : A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.

Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.

Research Excerpts

ExcerptRelevanceReference
"To test whether the combination of pindolol with a serotonergic antidepressant produces a synergistic increase in synaptic 5HT by examining the effects on measures of sleep, psychomotor performance and ratings of anxiety."5.10Effects on sleep architecture of pindolol, paroxetine and their combination in healthy volunteers. ( Bailey, J; Bell, C; Nutt, D; Rich, A; Wilson, S, 2003)
"Pindolol or a placebo was administered 90 min before a test flight and the flying and hovering performance of five students was assessed by qualified flying instructors."2.65Pilot study on the value of a beta-blocking drug in initial helicopter training. ( Donaldson, E; Grant-Thomson, J; Morwood, P; O'Connor, N; Tippett, R, 1980)
" +/- Pindolol, an antagonist at 5-HT1 receptors, showed a biphasic dose-response curve with a fall in entry ratio at one high dose."1.27Effects in the X-maze anxiety model of agents acting at 5-HT1 and 5-HT2 receptors. ( Critchley, MA; Handley, SL, 1987)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19909 (47.37)18.7374
1990's2 (10.53)18.2507
2000's5 (26.32)29.6817
2010's2 (10.53)24.3611
2020's1 (5.26)2.80

Authors

AuthorsStudies
Paltian, JJ1
Dos Reis, AS1
de Oliveira, RL1
da Fonseca, CAR1
Domingues, WB1
Dellagostin, EN1
Campos, VF1
Kruger, R1
Alves, D1
Luchese, C1
Wilhelm, EA1
Bernik, M1
Ramos, RT1
Hetem, LAB1
Graeff, F1
Nautiyal, KM1
Tritschler, L1
Ahmari, SE1
David, DJ1
Gardier, AM1
Hen, R1
Hasler, F1
Studerus, E1
Lindner, K1
Ludewig, S1
Vollenweider, FX1
Fleminger, S2
Greenwood, RJ2
Oliver, DL2
Bell, C1
Wilson, S1
Rich, A1
Bailey, J1
Nutt, D1
Donaldson, E1
Grant-Thomson, J1
Morwood, P1
O'Connor, N1
Tippett, R1
Krope, P1
Kohrs, A1
Ott, H1
Wagner, W1
Fichte, K1
Oswald, WD1
Przegaliński, E1
Filip, M1
Chojnacka-Wójcik, E1
Tatarczyńska, E1
Gurguis, GN1
Yonkers, KA1
Blakeley, JE1
Phan, SP1
Williams, A1
Rush, AJ1
Griebel, G1
Rodgers, RJ1
Perrault, G1
Sanger, DJ1
Scharbach, H1
Schoenen, J1
Delwaide, PJ1
Koella, WP1
Chierichetti, SM1
Moise, G1
Galeone, M1
Fiorella, G1
Lazzari, R1
Critchley, MA1
Handley, SL1
Albus, M1
Stahl, S1
Müller-Spahn, F1
Engel, RR1

Reviews

4 reviews available for pindolol and Anxiety

ArticleYear
Pharmacological management for agitation and aggression in people with acquired brain injury.
    The Cochrane database of systematic reviews, 2003, Issue:1

    Topics: Adrenergic beta-Antagonists; Aggression; Amantadine; Anxiety; Brain Injuries; Humans; Methylphenidat

2003
Pharmacological management for agitation and aggression in people with acquired brain injury.
    The Cochrane database of systematic reviews, 2006, Oct-18, Issue:4

    Topics: Adrenergic beta-Antagonists; Aggression; Amantadine; Anxiety; Brain Injuries; Humans; Methylphenidat

2006
[Beta blockers as psychotropic drugs].
    L'Encephale, 1976, Volume: 2, Issue:1

    Topics: Adjustment Disorders; Adrenergic beta-Antagonists; Alprenolol; Anxiety; Attention; Behavior Therapy;

1976
CNS-related (side-)effects of beta-blockers with special reference to mechanisms of action.
    European journal of clinical pharmacology, 1985, Volume: 28 Suppl

    Topics: Adrenergic beta-Antagonists; Amphetamine; Animals; Anxiety; Blood-Brain Barrier; Central Nervous Sys

1985

Trials

9 trials available for pindolol and Anxiety

ArticleYear
Effect of single doses of pindolol and d-fenfluramine on flumazenil-induced anxiety in panic disorder patients.
    Behavioural brain research, 2019, 01-14, Volume: 357-358

    Topics: Adult; Anxiety; Female; Fenfluramine; Flumazenil; GABA Modulators; Humans; Male; Middle Aged; Panic

2019
Investigation of serotonin-1A receptor function in the human psychopharmacology of MDMA.
    Journal of psychopharmacology (Oxford, England), 2009, Volume: 23, Issue:8

    Topics: Adult; Affect; Anxiety; Cognition; Double-Blind Method; Humans; Male; N-Methyl-3,4-methylenedioxyamp

2009
Effects on sleep architecture of pindolol, paroxetine and their combination in healthy volunteers.
    Psychopharmacology, 2003, Volume: 166, Issue:2

    Topics: Adult; Affect; Anxiety; Blood Pressure; Cross-Over Studies; Drug Therapy, Combination; Eye Movements

2003
Pilot study on the value of a beta-blocking drug in initial helicopter training.
    Aviation, space, and environmental medicine, 1980, Volume: 51, Issue:9 Pt 1

    Topics: Adrenergic beta-Antagonists; Adult; Aerospace Medicine; Anxiety; Clinical Trials as Topic; Double-Bl

1980
Evaluating mepindolol in a test model of examination anxiety in students.
    Pharmacopsychiatria, 1982, Volume: 15, Issue:2

    Topics: Adrenergic beta-Antagonists; Adult; Anxiety; Drug Evaluation; Female; Humans; Male; Motor Activity;

1982
[Anxiolysis and reduction of subjectively scaled "strain" in cognitive stress by means of pindolol].
    Fortschritte der Medizin, 1980, Feb-07, Volume: 98, Issue:5

    Topics: Adult; Anxiety; Chlordiazepoxide; Drug Evaluation; Humans; Neurotic Disorders; Pindolol; Placebos; S

1980
[Indications for beta-blockers in neurology].
    Acta clinica Belgica, 1978, Volume: 33, Issue:2

    Topics: Alcoholism; Antiparkinson Agents; Anxiety; Clinical Trials as Topic; Drug Therapy, Combination; Huma

1978
Beta-blockers and psychic stress: a double-blind, placebo-controlled study of bopindolol vs lorazepam and butalbital in surgical patients.
    International journal of clinical pharmacology, therapy, and toxicology, 1985, Volume: 23, Issue:9

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Anxiety; Barbiturates; Clinical Trials as Topic; Double-Bl

1985
Psychophysiological differentiation of two types of anxiety and its pharmacological modification by minor tranquillizer and beta-receptor-blocker.
    Biological psychology, 1986, Volume: 23, Issue:1

    Topics: Adult; Anti-Anxiety Agents; Anxiety; Autonomic Nervous System; Benzodiazepines; Benzodiazepinones; D

1986

Other Studies

6 other studies available for pindolol and Anxiety

ArticleYear
The anxiolytic effect of a promising quinoline containing selenium with the contribution of the serotonergic and GABAergic pathways: Modulation of parameters associated with anxiety in mice.
    Behavioural brain research, 2020, 09-01, Volume: 393

    Topics: Animals; Anti-Anxiety Agents; Anxiety; GABA-A Receptor Antagonists; Male; Mice; Pindolol; Quinolines

2020
A Lack of Serotonin 1B Autoreceptors Results in Decreased Anxiety and Depression-Related Behaviors.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016, Volume: 41, Issue:12

    Topics: Animals; Animals, Newborn; Anxiety; Autoreceptors; Depression; Disease Models, Animal; Exploratory B

2016
The role of 5-hydroxytryptamine1A (5-HT1A) receptors in the anticonflict activity of beta-adrenoceptor antagonists.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 47, Issue:4

    Topics: Adrenergic beta-Antagonists; Animals; Anxiety; Betaxolol; Conflict, Psychological; Disease Models, A

1994
Adrenergic receptors in premenstrual dysphoric disorder. II. Neutrophil beta2-adrenergic receptors: Gs protein coupling, phase of menstrual cycle and prediction of luteal phase symptom severity.
    Psychiatry research, 1998, Jun-02, Volume: 79, Issue:1

    Topics: Adult; Anxiety; Case-Control Studies; Depression; Female; Follicular Phase; GTP-Binding Proteins; Hu

1998
The effects of compounds varying in selectivity as 5-HT(1A) receptor antagonists in three rat models of anxiety.
    Neuropharmacology, 2000, Jul-24, Volume: 39, Issue:10

    Topics: Aminopyridines; Animals; Anxiety; Cyclohexane Monoterpenes; Diazepam; Disease Models, Animal; Dose-R

2000
Effects in the X-maze anxiety model of agents acting at 5-HT1 and 5-HT2 receptors.
    Psychopharmacology, 1987, Volume: 93, Issue:4

    Topics: Animals; Anxiety; Diazepam; Disease Models, Animal; Drug Combinations; Exploratory Behavior; Male; P

1987