pindolol has been researched along with Anaplastic Astrocytoma in 13 studies
Pindolol: A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)
pindolol : A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The ligand-induced internalization of beta-adrenergic receptors and the receptor-mediated internalization of epidermal growth factor were blocked, under similar conditions, by phenylarsine oxide (PAO) in human astrocytoma cells (1321N1)." | 7.67 | A comparison of catecholamine-induced internalization of beta-adrenergic receptors and receptor-mediated endocytosis of epidermal growth factor in human astrocytoma cells. Inhibition by phenylarsine oxide. ( Coulter, SJ; Hertel, C; Perkins, JP, 1985) |
| "Competition by beta-adrenergic agonists and antagonists for 125I-pindolol binding sites on intact cells (1321N1 human astrocytoma and C62B rat glioma) was measured using short time binding assays as previously described (Toews, M." | 3.67 | Agonist-induced changes in beta-adrenergic receptors on intact cells. ( Perkins, JP; Toews, ML, 1984) |
| "The ligand-induced internalization of beta-adrenergic receptors and the receptor-mediated internalization of epidermal growth factor were blocked, under similar conditions, by phenylarsine oxide (PAO) in human astrocytoma cells (1321N1)." | 3.67 | A comparison of catecholamine-induced internalization of beta-adrenergic receptors and receptor-mediated endocytosis of epidermal growth factor in human astrocytoma cells. Inhibition by phenylarsine oxide. ( Coulter, SJ; Hertel, C; Perkins, JP, 1985) |
| "Binding of 125I-iodopindolol (IPIN) to intact 1321N1 human astrocytoma cell B-adrenergic receptors was measured at 37 degrees and on ice." | 3.67 | Comparison of binding of 125I-iodopindolol to control and desensitized cells at 37 degrees and on ice. ( Harden, TK; Perkins, JP; Toews, ML; Waldo, GL, 1986) |
| "The interactions of agonists and antagonists with beta-adrenergic receptors on intact 1321N1 human astrocytoma and C62B rat glioma cells were studied by using the radioligand (-)-[125I]iodopindolol." | 3.66 | High-affinity binding of agonists to beta-adrenergic receptors on intact cells. ( Harden, TK; Perkins, JP; Toews, ML, 1983) |
| "As a part of the process of agonist-induced desensitization, 1321N1 human astrocytoma cells lose up to 95% of their beta-adrenergic receptors, as detected by 125I-hydroxybenzylpindolol (125IHYP) binding, after 12-24 h of exposure to isoproterenol." | 3.66 | Recovery of beta-adrenergic receptors following long term exposure of astrocytoma cells to catecholamine. Role of protein synthesis. ( Doss, RC; Harden, TK; Perkins, JP, 1981) |
| "Incubation of 1321N1 human astrocytoma cells with 1 microM isoproterenol rapidly results in the conversion of a portion of the beta-adrenergic receptors to a membrane form that can be separated from markers for the plasma membrane by sucrose density gradient or differential centrifugation." | 3.66 | Characterization of an altered membrane form of the beta-adrenergic receptor produced during agonist-induced desensitization. ( Harden, TK; Northup, JK; Perkins, JP; Waldo, GL, 1983) |
| "Incubation of 1321N1 astrocytoma cells for 15 min with 1 microM (-)-isoproterenol resulted in a 50-65% loss of isoproterenol-stimulated adenylate cyclase activity." | 3.66 | Catecholamine-induced desensitization involves an uncoupling of beta-adrenergic receptors and adenylate cyclase. ( Harden, TK; Perkins, JP; Su, YF, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (92.31) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Toews, ML | 4 |
| Waldo, GL | 4 |
| Harden, TK | 9 |
| Perkins, JP | 11 |
| Doss, RC | 2 |
| Barovsky, K | 1 |
| Brooker, G | 1 |
| McCarthy, KD | 1 |
| Su, YF | 2 |
| Northup, JK | 1 |
| Kurz, JB | 1 |
| Hertel, C | 1 |
| Coulter, SJ | 1 |
13 other studies available for pindolol and Anaplastic Astrocytoma
| Article | Year |
|---|---|
Relationship between an altered membrane form and a low affinity form of the beta-adrenergic receptor occurring during catecholamine-induced desensitization. Evidence for receptor internalization.
Topics: Astrocytoma; Cell Line; Centrifugation, Density Gradient; Concanavalin A; Humans; Isoproterenol; Met | 1984 |
Use of a density shift method to assess beta-adrenergic receptor synthesis during recovery from catecholamine-induced down-regulation in human astrocytoma cells.
Topics: Ascorbic Acid; Astrocytoma; Cell Line; Humans; Iodocyanopindolol; Isoproterenol; Kinetics; Pindolol; | 1984 |
(-)-[125I]-iodopindolol, a new highly selective radioiodinated beta-adrenergic receptor antagonist: measurement of beta-receptors on intact rat astrocytoma cells.
Topics: Adrenergic beta-Antagonists; Animals; Astrocytoma; Binding Sites; Cells, Cultured; Iodine Radioisoto | 1980 |
Identification of the beta adrenergic receptor subtype on astroglia purified from rat brain.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Astrocytes; Astrocytoma; Cells, Cult | 1982 |
High-affinity binding of agonists to beta-adrenergic receptors on intact cells.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Astrocytoma; Binding, Competitive; C | 1983 |
Agonist-induced changes in beta-adrenergic receptors on intact cells.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Astrocytoma; Binding, Competitive; C | 1984 |
Catecholamine-specific desensitization of adenylate cyclase. Evidence for a multistep process.
Topics: Adenylyl Cyclases; Animals; Astrocytoma; Catecholamines; Cell Membrane; Enzyme Activation; Epinephri | 1980 |
Recovery of beta-adrenergic receptors following long term exposure of astrocytoma cells to catecholamine. Role of protein synthesis.
Topics: Astrocytoma; Cell Line; Cell Membrane; Cycloheximide; Humans; Isoproterenol; Kinetics; Neoplasm Prot | 1981 |
Characterization of an altered membrane form of the beta-adrenergic receptor produced during agonist-induced desensitization.
Topics: Adenylyl Cyclases; Astrocytoma; Cell Line; Cell Membrane; Humans; Isoproterenol; Molecular Weight; P | 1983 |
Catecholamine-induced desensitization involves an uncoupling of beta-adrenergic receptors and adenylate cyclase.
Topics: Adenylyl Cyclases; Astrocytoma; Benzyl Alcohols; Binding Sites; Cell Line; Dose-Response Relationshi | 1979 |
Isoproterenol-initiated beta-adrenergic receptor diacytosis in cultured cells.
Topics: Adrenergic beta-Antagonists; Astrocytoma; Cell Membrane; Half-Life; Humans; Iodine Radioisotopes; Is | 1992 |
A comparison of catecholamine-induced internalization of beta-adrenergic receptors and receptor-mediated endocytosis of epidermal growth factor in human astrocytoma cells. Inhibition by phenylarsine oxide.
Topics: Adenosine Triphosphate; Arsenicals; Astrocytoma; Catecholamines; Cell Line; Dithiothreitol; Endocyto | 1985 |
Comparison of binding of 125I-iodopindolol to control and desensitized cells at 37 degrees and on ice.
Topics: Astrocytoma; Cell Membrane; Cells, Cultured; Centrifugation, Density Gradient; Humans; Iodine Radioi | 1986 |