pindolol has been researched along with Alzheimer Disease in 4 studies
Pindolol: A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)
pindolol : A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The hypothesis of this study was that central NE responsivity would predict aggression response to treatment with a NE medication, pindolol." | 5.11 | Noradrenergic activity is associated with response to pindolol in aggressive Alzheimer's disease patients. ( Eryavec, G; Herrmann, N; Khan, LR; Lanctôt, KL, 2004) |
| "These results suggest that cases of Alzheimer's disease express heterogeneities in neocortical pathology which are reflected in the laminar patterns of binding to postsynaptic receptors." | 1.28 | Laminar alterations in gamma-aminobutyric acidA, muscarinic, and beta adrenoceptors and neuron degeneration in cingulate cortex in Alzheimer's disease. ( Crino, PB; Vogt, BA; Volicer, L, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Herrmann, N | 1 |
| Lanctôt, KL | 1 |
| Eryavec, G | 1 |
| Khan, LR | 1 |
| Vogt, BA | 1 |
| Crino, PB | 1 |
| Volicer, L | 1 |
| Kalaria, RN | 1 |
| Andorn, AC | 1 |
| Tabaton, M | 1 |
| Whitehouse, PJ | 1 |
| Harik, SI | 1 |
| Unnerstall, JR | 1 |
| Jensen, CF | 1 |
1 trial available for pindolol and Alzheimer Disease
| Article | Year |
|---|---|
Noradrenergic activity is associated with response to pindolol in aggressive Alzheimer's disease patients.
Topics: Administration, Oral; Aged; Aged, 80 and over; Aggression; Alzheimer Disease; Behavioral Symptoms; C | 2004 |
3 other studies available for pindolol and Alzheimer Disease
| Article | Year |
|---|---|
Laminar alterations in gamma-aminobutyric acidA, muscarinic, and beta adrenoceptors and neuron degeneration in cingulate cortex in Alzheimer's disease.
Topics: Adrenergic beta-Antagonists; Aged; Alzheimer Disease; Gyrus Cinguli; Humans; Muscimol; Nerve Degener | 1991 |
Adrenergic receptors in aging and Alzheimer's disease: increased beta 2-receptors in prefrontal cortex and hippocampus.
Topics: Aged; Aging; Alzheimer Disease; Autoradiography; Binding, Competitive; Cerebellum; Cerebral Cortex; | 1989 |
Hypersexual agitation in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Haloperidol; Humans; Hydroxyzine; Male; Pindolol; Sex Offenses; Sexual Beha | 1989 |