pinafide has been researched along with Carcinoma--Ehrlich-Tumor* in 1 studies
1 other study(ies) available for pinafide and Carcinoma--Ehrlich-Tumor
| Article | Year |
|---|---|
Synthesis and mode(s) of action of a new series of imide derivatives of 3-nitro-1,8 naphthalic acid.
Four new imide derivatives of 3-nitro-1,8-naphthalic acid have been synthesised. The compounds show strong cytostatic activity against both HeLa and KB cells and are moderately toxic towards both mice and rats (LD50 above 4 mg/kg IP). Two of the most active compounds, M-4212 and M-12210, prevented the development of mouse Ehrlich ascites and rat Yoshida carcinoma. All these drugs block cell growth by inhibiting the synthesis of both DNA and RNA. In particular, both M-4212 and M-12210 raise the melting point of double-stranded DNA. Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Survival; DNA Replication; HeLa Cells; Humans; Imides; Isoquinolines; Lethal Dose 50; Mice; Naphthalimides; Neoplasm Proteins; Nitro Compounds; Pyrrolidines; Rats; RNA; Spectrophotometry, Infrared | 1980 |