pinacidil has been researched along with Ventricular Fibrillation in 20 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We studied the electrophysiologic and antifibrillatory effects of the class III agent MS-551 in a rabbit isolated heart model in which ventricular fibrillation (VF) occurs reproducibly under conditions of hypoxia/reoxygenation in the presence of the ATP-dependent potassium channel opener, pinacidil." | 7.69 | Antiarrhythmic agent, MS-551, protects against pinacidil + hypoxia-induced ventricular fibrillation in Langendorff-perfused rabbit isolated heart. ( Black, SC; Chi, L; Friedrichs, GS; Lucchesi, BR; Manley, PJ, 1994) |
| "Ranolazine has been reported to have an antiarrhythmic potential." | 5.43 | Ranolazine and Vernakalant Prevent Ventricular Arrhythmias in an Experimental Whole-Heart Model of Short QT Syndrome. ( Bögeholz, N; Dechering, DG; Eckardt, L; Ellermann, C; Frommeyer, G; Güner, F; Kochhäuser, S; Leitz, P; Pott, C, 2016) |
| "We assessed whether pravastatin attenuates cardiac sympathetic reinnervation after myocardial infarction through the activation of ATP-sensitive K(+) (K(ATP)) channels." | 3.74 | Effect of pravastatin on sympathetic reinnervation in postinfarcted rats. ( Chang, NC; Lee, TM; Lin, MS, 2007) |
| "We studied the electrophysiologic and antifibrillatory effects of the class III agent MS-551 in a rabbit isolated heart model in which ventricular fibrillation (VF) occurs reproducibly under conditions of hypoxia/reoxygenation in the presence of the ATP-dependent potassium channel opener, pinacidil." | 3.69 | Antiarrhythmic agent, MS-551, protects against pinacidil + hypoxia-induced ventricular fibrillation in Langendorff-perfused rabbit isolated heart. ( Black, SC; Chi, L; Friedrichs, GS; Lucchesi, BR; Manley, PJ, 1994) |
| "We investigated the effect of ATP-sensitive K+ channel (KATP) openers (pinacidil and cromakalim), and a KATP blocker (glibenclamide) on reperfusion-induced arrhythmias in pentobarbitone-anaesthetized rats." | 3.69 | KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats. ( Baczkó, I; Leprán, I; Papp, JG, 1997) |
| "This study determined if ibutilide, a drug with class III activity, exhibited antifibrillatory effects in an isolated heart model of ventricular fibrillation (VF)." | 3.68 | Antifibrillatory effects of ibutilide in the rabbit isolated heart: mediation via ATP-dependent potassium channels. ( Black, SC; Chi, L; Friedrichs, GS; Lucchesi, BR; Manley, PJ; Oh, JY, 1993) |
| "Antazoline is a first-generation antihistamine with antiarrhythmic properties." | 1.48 | Antiarrhythmic effect of antazoline in experimental models of acquired short- and long-QT-syndromes. ( Dechering, DG; Eckardt, L; Ellermann, C; Fehr, M; Frommeyer, G; Kochhäuser, S; Sterneberg, M, 2018) |
| "Ranolazine has been reported to have an antiarrhythmic potential." | 1.43 | Ranolazine and Vernakalant Prevent Ventricular Arrhythmias in an Experimental Whole-Heart Model of Short QT Syndrome. ( Bögeholz, N; Dechering, DG; Eckardt, L; Ellermann, C; Frommeyer, G; Güner, F; Kochhäuser, S; Leitz, P; Pott, C, 2016) |
| " The DFT, 90% action potential duration (APD(90)) and activation recovery interval (ARI) were evaluated before and after pinacidil administration (loading dosage 0." | 1.38 | The effect of pinacidil on postshock activation and ventricular defibrillation threshold in canine hearts. ( Gu, G; Jin, Q; Lin, CJ; Pang, Y; Shen, WF; Wu, LQ; Zhang, N; Zhou, J, 2012) |
| "The Brugada syndrome is characterized by ST-segment elevation on the ECG, especially in the right precordial leads sensitive to the right ventricular outflow tract (RVOT)." | 1.34 | Differences in arrhythmogenicity between the canine right ventricular outflow tract and anteroinferior right ventricle in a model of Brugada syndrome. ( Morita, H; Morita, ST; Wu, J; Zipes, DP, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (45.00) | 18.2507 |
| 2000's | 7 (35.00) | 29.6817 |
| 2010's | 4 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ellermann, C | 2 |
| Sterneberg, M | 1 |
| Kochhäuser, S | 2 |
| Dechering, DG | 2 |
| Fehr, M | 1 |
| Eckardt, L | 2 |
| Frommeyer, G | 2 |
| Li, L | 1 |
| Zheng, X | 2 |
| Dosdall, DJ | 1 |
| Huang, J | 1 |
| Pogwizd, SM | 1 |
| Ideker, RE | 2 |
| Bögeholz, N | 1 |
| Güner, F | 1 |
| Leitz, P | 1 |
| Pott, C | 1 |
| Jin, Q | 1 |
| Zhang, N | 1 |
| Zhou, J | 1 |
| Lin, CJ | 1 |
| Pang, Y | 1 |
| Gu, G | 1 |
| Shen, WF | 1 |
| Wu, LQ | 1 |
| Fischbach, PS | 1 |
| Barrett, TD | 1 |
| Reed, NJ | 1 |
| Lucchesi, BR | 7 |
| Wu, S | 1 |
| Weiss, JN | 1 |
| Chou, CC | 1 |
| Attin, M | 1 |
| Hayashi, H | 1 |
| Lin, SF | 1 |
| Walcott, GP | 1 |
| Smith, WM | 1 |
| Roth, BJ | 1 |
| Aiba, T | 1 |
| Shimizu, W | 1 |
| Hidaka, I | 1 |
| Uemura, K | 1 |
| Noda, T | 1 |
| Zheng, C | 1 |
| Kamiya, A | 1 |
| Inagaki, M | 1 |
| Sugimachi, M | 1 |
| Sunagawa, K | 1 |
| Morita, H | 1 |
| Zipes, DP | 1 |
| Morita, ST | 1 |
| Wu, J | 1 |
| Lee, TM | 1 |
| Lin, MS | 1 |
| Chang, NC | 1 |
| Friedrichs, GS | 4 |
| Chi, L | 6 |
| Black, SC | 4 |
| Manley, PJ | 2 |
| Kuo, PI | 1 |
| Fagbemi, SO | 2 |
| Oh, JY | 1 |
| Lawton, JS | 1 |
| Sepic, JD | 1 |
| Allen, CT | 1 |
| Hsia, PW | 1 |
| Damiano, RJ | 1 |
| Park, JL | 1 |
| Banglawala, YA | 1 |
| Perez, MA | 1 |
| Tanhehco, EJ | 1 |
| Baczkó, I | 1 |
| Leprán, I | 1 |
| Papp, JG | 1 |
| Padrini, R | 1 |
| Bova, S | 1 |
| Cargnelli, G | 1 |
| Piovan, D | 1 |
| Ferrari, M | 1 |
| Uprichard, AC | 1 |
20 other studies available for pinacidil and Ventricular Fibrillation
| Article | Year |
|---|---|
Antiarrhythmic effect of antazoline in experimental models of acquired short- and long-QT-syndromes.
Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Antazoline; Anti-Bacterial Agents; Arrhythm | 2018 |
Long-duration ventricular fibrillation exhibits 2 distinct organized states.
Topics: Animals; Calcium Channel Blockers; Death, Sudden, Cardiac; Dogs; Electrophysiologic Techniques, Card | 2013 |
Ranolazine and Vernakalant Prevent Ventricular Arrhythmias in an Experimental Whole-Heart Model of Short QT Syndrome.
Topics: Action Potentials; Animals; Anisoles; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Pacing, | 2016 |
The effect of pinacidil on postshock activation and ventricular defibrillation threshold in canine hearts.
Topics: Action Potentials; Animals; Differential Threshold; Disease Models, Animal; Dogs; Electric Countersh | 2012 |
SNC-80-induced preconditioning: selective activation of the mitochondrial adenosine triphosphate-gated potassium channel.
Topics: Adenosine Triphosphate; Animals; Benzamides; Female; Heart; In Vitro Techniques; Ion Channel Gating; | 2003 |
Dissociation of membrane potential and intracellular calcium during ventricular fibrillation.
Topics: Animals; Calcium; In Vitro Techniques; Membrane Potentials; Pinacidil; Rabbits; Vasodilator Agents; | 2005 |
Evidence that activation following failed defibrillation is not caused by triggered activity.
Topics: Analysis of Variance; Animals; Electric Countershock; Electrocardiography; Electrodes; Endocardium; | 2005 |
The puzzle of defibrillation: putting the pieces together.
Topics: Animals; Electric Countershock; Electrocardiography; Electrodes; Endocardium; Flunarizine; Pinacidil | 2005 |
Cellular basis for trigger and maintenance of ventricular fibrillation in the Brugada syndrome model: high-resolution optical mapping study.
Topics: Action Potentials; Animals; Cardiovascular Agents; Disease Models, Animal; Dogs; Electrocardiography | 2006 |
Differences in arrhythmogenicity between the canine right ventricular outflow tract and anteroinferior right ventricle in a model of Brugada syndrome.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Brugada Syndrome; Disease Models, Animal; Dogs; | 2007 |
Effect of pravastatin on sympathetic reinnervation in postinfarcted rats.
Topics: Animals; Blotting, Western; Cardiac Pacing, Artificial; Coronary Vessels; Disease Models, Animal; GA | 2007 |
Antiarrhythmic agent, MS-551, protects against pinacidil + hypoxia-induced ventricular fibrillation in Langendorff-perfused rabbit isolated heart.
Topics: Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Dogs; Guanidines; Heart; Heart Atria; Hypox | 1994 |
Actions of pinacidil at a reduced potassium concentration: a direct cardiac effect possibly involving the ATP-dependent potassium channel.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Blood Pressure; Gu | 1993 |
Phorbol ester-induced ventricular fibrillation in the Langendorff-perfused rabbit heart: antagonism by staurosporine and glibenclamide.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Diglycerides; Glyburide; Guanidin | 1993 |
Antifibrillatory effects of ibutilide in the rabbit isolated heart: mediation via ATP-dependent potassium channels.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Atrial Function; Depression, Chemical; Elec | 1993 |
Myocardial protection with potassium-channel openers is as effective as St. Thomas' solution in the rabbit heart.
Topics: Adenosine Triphosphate; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Ci | 1996 |
Effects of tedisamil (KC-8857) on cardiac electrophysiology and ventricular fibrillation in the rabbit isolated heart.
Topics: Animals; Anti-Arrhythmia Agents; Bridged Bicyclo Compounds, Heterocyclic; Cyclopropanes; Dose-Respon | 1996 |
KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats.
Topics: Action Potentials; Adenosine Triphosphate; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Ar | 1997 |
Effects of pinacidil on guinea-pig isolated perfused heart with particular reference to the proarrhythmic effect.
Topics: Animals; Arrhythmias, Cardiac; Coronary Circulation; Electric Stimulation; Electrocardiography; Fema | 1992 |
Profibrillatory actions of pinacidil in a conscious canine model of sudden coronary death.
Topics: Action Potentials; Animals; Blood Pressure; Coronary Disease; Death, Sudden; Dogs; Dose-Response Rel | 1990 |