pinacidil has been researched along with Urinary Incontinence in 1 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
Urinary Incontinence: Involuntary loss of URINE, such as leaking of urine. It is a symptom of various underlying pathological processes. Major types of incontinence include URINARY URGE INCONTINENCE and URINARY STRESS INCONTINENCE.
| Excerpt | Relevance | Reference |
|---|---|---|
| " As part of our efforts directed toward identifying novel, bladder-selective potassium channel openers (KCOs) targeted for urge urinary incontinence (UUI), we found that bioisosteric replacement of the N-cyanoguanidine moiety of pinacidil (1, Figure 1) with a diaminocyclobutenedione template afforded squaric acid analogue 2, the prototype of a novel series of K(ATP) channel openers with unique selectivity for bladder smooth muscle in vivo." | 3.70 | Design and SAR of novel potassium channel openers targeted for urge urinary incontinence. 1. N-Cyanoguanidine bioisosteres possessing in vivo bladder selectivity. ( Antane, MM; Antane, SA; Argentieri, TM; Butera, JA; Freeden, C; Graceffa, RF; Hirth, BH; Jenkins, D; Lennox, JR; Matelan, E; Norton, NW; Quagliato, D; Sheldon, JH; Spinelli, W; Warga, D; Wojdan, A; Woods, M, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Butera, JA | 1 |
| Antane, MM | 1 |
| Antane, SA | 1 |
| Argentieri, TM | 1 |
| Freeden, C | 1 |
| Graceffa, RF | 1 |
| Hirth, BH | 1 |
| Jenkins, D | 1 |
| Lennox, JR | 1 |
| Matelan, E | 1 |
| Norton, NW | 1 |
| Quagliato, D | 1 |
| Sheldon, JH | 1 |
| Spinelli, W | 1 |
| Warga, D | 1 |
| Wojdan, A | 1 |
| Woods, M | 1 |
1 other study available for pinacidil and Urinary Incontinence
| Article | Year |
|---|---|
Design and SAR of novel potassium channel openers targeted for urge urinary incontinence. 1. N-Cyanoguanidine bioisosteres possessing in vivo bladder selectivity.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Cyclobutanes; Drug Design; Drug Evaluation, Preclin | 2000 |