pinacidil has been researched along with Urethral Obstruction in 2 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
Urethral Obstruction: Partial or complete blockage in any part of the URETHRA that can lead to difficulty or inability to empty the URINARY BLADDER. It is characterized by an enlarged, often damaged, bladder with frequent urges to void.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Normal rats as well as rats with bladder hypertrophy secondary to outflow obstruction were investigated cystometrically before and after administration of the potassium channel openers pinacidil or cromakalim one mg." | 3.67 | Effects of pinacidil and cromakalim (BRL 34915) on bladder function in rats with detrusor instability. ( Andersson, KE; Andersson, PO; Malmgren, A; Sjögren, C, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pinna, C | 1 |
| Sanvito, P | 1 |
| Bolego, C | 1 |
| Cignarella, A | 1 |
| Puglisi, L | 1 |
| Malmgren, A | 1 |
| Andersson, KE | 1 |
| Sjögren, C | 1 |
| Andersson, PO | 1 |
2 other studies available for pinacidil and Urethral Obstruction
| Article | Year |
|---|---|
Effect of the ATP-sensitive potassium channel opener ZM226600 on cystometric parameters in rats with ligature-intact, partial urethral obstruction.
Topics: Adenosine Triphosphate; Amides; Animals; Benzophenones; Blood Pressure; Carbachol; Dose-Response Rel | 2005 |
Effects of pinacidil and cromakalim (BRL 34915) on bladder function in rats with detrusor instability.
Topics: Animals; Benzopyrans; Cromakalim; Female; Guanidines; Hypertrophy; Pinacidil; Pyrroles; Rats; Rats, | 1989 |