pinacidil has been researched along with Sensitivity and Specificity in 9 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hydrogen sulfide (H(2)S) is an endogenous gaseous mediator of mucosal defense with antiinflammatory effects that promote ulcer healing." | 5.35 | Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats. ( Dicay, M; Martin, GR; McKnight, W; Vong, L; Wallace, JL, 2009) |
| "Potassium channel openers with pinacidil can provide pulmonary protection against warm ischemia reperfusion injury." | 3.72 | Warm ischemia lung protection with pinacidil: an ATP regulated potassium channel opener. ( Cohen, NM; Holwitt, DM; Mouria, MM; Pavot, DR; Tang, DG, 2003) |
| "Hydrogen sulfide (H(2)S) is an endogenous gaseous mediator of mucosal defense with antiinflammatory effects that promote ulcer healing." | 1.35 | Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats. ( Dicay, M; Martin, GR; McKnight, W; Vong, L; Wallace, JL, 2009) |
| "Treatment with glyburide, pinacidil or hydralazine did not alter L-type calcium channels, assessed by [3H]PN 200 110 binding, in cardiac and brain membranes or small size Ca(2+)-activated K+ channels in brain assessed by [125I]apamin binding." | 1.28 | Regulation of ATP-sensitive K+ channels by chronic glyburide and pinacidil administration. ( Gopalakrishnan, M; Triggle, DJ, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (44.44) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Wallace, JL | 1 |
| Vong, L | 1 |
| McKnight, W | 1 |
| Dicay, M | 1 |
| Martin, GR | 1 |
| Chang, MG | 1 |
| de Lange, E | 1 |
| Calmettes, G | 1 |
| Garfinkel, A | 1 |
| Qu, Z | 1 |
| Weiss, JN | 1 |
| Tang, DG | 1 |
| Pavot, DR | 1 |
| Mouria, MM | 1 |
| Holwitt, DM | 1 |
| Cohen, NM | 1 |
| Zhang, HL | 1 |
| Bolton, TB | 1 |
| Ma, L | 1 |
| Yu, Z | 1 |
| Xiao, S | 1 |
| Thadani, U | 1 |
| Robinson, CP | 1 |
| Patterson, E | 1 |
| Fukuse, T | 1 |
| Hirata, T | 1 |
| Omasa, M | 1 |
| Wada, H | 1 |
| Holzmann, S | 1 |
| Kukovetz, WR | 1 |
| Braida, C | 1 |
| Pöch, G | 1 |
| Gopalakrishnan, M | 1 |
| Triggle, DJ | 1 |
9 other studies available for pinacidil and Sensitivity and Specificity
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats.
Topics: Analysis of Variance; Animals; Biomarkers; Biopsy, Needle; Colitis; Cyclooxygenase 1; Cyclooxygenase | 2009 |
Pro- and antiarrhythmic effects of ATP-sensitive potassium current activation on reentry during early afterdepolarization-mediated arrhythmias.
Topics: Action Potentials; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Body Sur | 2013 |
Warm ischemia lung protection with pinacidil: an ATP regulated potassium channel opener.
Topics: Animals; Disease Models, Animal; Female; Graft Rejection; Graft Survival; Lung Transplantation; Male | 2003 |
Two types of ATP-sensitive potassium channels in rat portal vein smooth muscle cells.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cells, Cultured; Cromakalim; Glyburide; Guanidines; Ma | 1996 |
Supersensitivity to serotonin- and histamine-induced arterial contraction following ovariectomy.
Topics: Acetylcholine; Adenosine; Animals; Aorta, Thoracic; Coronary Vessels; Dose-Response Relationship, Dr | 1998 |
Effect of adenosine triphosphate-sensitive potassium channel openers on lung preservation.
Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Glyburide; Hypertension, Pulmonary; Lung; P | 2002 |
Pharmacological interaction experiments differentiate between glibenclamide-sensitive K+ channels and cyclic GMP as components of vasodilation by nicorandil.
Topics: Animals; Benzopyrans; Cattle; Coronary Vessels; Cromakalim; Cyclic GMP; Drug Interactions; Glyburide | 1992 |
Regulation of ATP-sensitive K+ channels by chronic glyburide and pinacidil administration.
Topics: Adenosine Triphosphate; Animals; Apamin; Brain; Calcium; Calcium Channels; Glyburide; Guanidines; He | 1992 |