pinacidil has been researched along with Reperfusion Injury in 12 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate effect of pinacidil, an ATP sensitive potassium channel (K(ATP)) opener, on the neuronal apoptosis and its signaling transduction mechanism following focal cerebral ischemia-reperfusion in rats." | 7.74 | Pinacidil reduces neuronal apoptosis following cerebral ischemia-reperfusion in rats through both mitochondrial and death-receptor signal pathways. ( Liu, YY; Lu, YL; Ma, Y; Song, LC; Zhang, H, 2007) |
| "To investigate effect of pinacidil, an ATP sensitive potassium channel (K(ATP)) opener, on the neuronal apoptosis and its signaling transduction mechanism following focal cerebral ischemia-reperfusion in rats." | 3.74 | Pinacidil reduces neuronal apoptosis following cerebral ischemia-reperfusion in rats through both mitochondrial and death-receptor signal pathways. ( Liu, YY; Lu, YL; Ma, Y; Song, LC; Zhang, H, 2007) |
| "Potassium channel openers with pinacidil can provide pulmonary protection against warm ischemia reperfusion injury." | 3.72 | Warm ischemia lung protection with pinacidil: an ATP regulated potassium channel opener. ( Cohen, NM; Holwitt, DM; Mouria, MM; Pavot, DR; Tang, DG, 2003) |
| "In fact, severe ischemia reperfusion injury can significantly reduce graft survival, even with modern immunosuppressive agents." | 1.35 | Blockade of K(ATP) channels reduces endothelial hyperpolarization and leukocyte recruitment upon reperfusion after hypoxia. ( Chilton, L; Figura, M; Giles, WR; Knight, D; Kubes, P; Liacini, A; Millar, TM; Patel, K; Phan, V; Tibbles, LA; Viskovic, MM, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 9 (75.00) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Figura, M | 1 |
| Chilton, L | 1 |
| Liacini, A | 1 |
| Viskovic, MM | 1 |
| Phan, V | 1 |
| Knight, D | 1 |
| Millar, TM | 1 |
| Patel, K | 1 |
| Kubes, P | 1 |
| Giles, WR | 1 |
| Tibbles, LA | 1 |
| Voitychuk, OI | 1 |
| Strutynskyi, RB | 1 |
| Yagupolskii, LM | 1 |
| Tinker, A | 1 |
| Moibenko, OO | 2 |
| Shuba, YM | 1 |
| Strutyns'kyĭ, RB | 1 |
| Kotsiuruba, AV | 1 |
| Neshcheret, OP | 1 |
| Rovenets', RA | 1 |
| Zhu, HF | 1 |
| Dong, JW | 1 |
| Zhu, WZ | 1 |
| Ding, HL | 1 |
| Zhou, ZN | 1 |
| Tang, DG | 1 |
| Pavot, DR | 1 |
| Mouria, MM | 1 |
| Holwitt, DM | 1 |
| Cohen, NM | 1 |
| Zhang, H | 2 |
| Song, LC | 2 |
| Liu, YY | 1 |
| Ma, Y | 1 |
| Lu, YL | 2 |
| Jia, CH | 1 |
| McPherson, CD | 1 |
| Pierce, GN | 1 |
| Cole, WC | 1 |
| Vanden Hoek, T | 1 |
| Becker, LB | 1 |
| Shao, ZH | 1 |
| Li, CQ | 1 |
| Schumacker, PT | 1 |
| Ducko, CT | 1 |
| Stephenson, ER | 1 |
| Jayawant, AM | 1 |
| Vigilance, DW | 1 |
| Damiano, RJ | 1 |
| Matsuyama, N | 1 |
| Leavens, JE | 1 |
| McKinnon, D | 1 |
| Gaudette, GR | 1 |
| Aksehirli, TO | 1 |
| Krukenkamp, IB | 1 |
| Fukuse, T | 1 |
| Hirata, T | 1 |
| Omasa, M | 1 |
| Wada, H | 1 |
12 other studies available for pinacidil and Reperfusion Injury
| Article | Year |
|---|---|
Blockade of K(ATP) channels reduces endothelial hyperpolarization and leukocyte recruitment upon reperfusion after hypoxia.
Topics: Animals; Cats; Cell Membrane; Endothelium, Vascular; Gelatin; Glyburide; Humans; Hypoxia; KATP Chann | 2009 |
Sarcolemmal cardiac K(ATP) channels as a target for the cardioprotective effects of the fluorine-containing pinacidil analogue, flocalin.
Topics: Animals; Cardiotonic Agents; Cells, Cultured; Fluorine; Glyburide; Guinea Pigs; Heart; HEK293 Cells; | 2011 |
[The changes of metabolism in myocardium at ischemia-reperfusion and activating of the ATP-sensitive potassium channels].
Topics: Adenosine Triphosphate; Animals; Apoptosis; Arachidonic Acid; Arginase; Arginine; Dogs; Eicosanoids; | 2012 |
ATP-dependent potassium channels involved in the cardiac protection induced by intermittent hypoxia against ischemia/reperfusion injury.
Topics: Animals; Calcium; Decanoic Acids; Glyburide; Heart Ventricles; Hemodynamics; Hydroxy Acids; Hypoxia; | 2003 |
Warm ischemia lung protection with pinacidil: an ATP regulated potassium channel opener.
Topics: Animals; Disease Models, Animal; Female; Graft Rejection; Graft Survival; Lung Transplantation; Male | 2003 |
Pinacidil reduces neuronal apoptosis following cerebral ischemia-reperfusion in rats through both mitochondrial and death-receptor signal pathways.
Topics: Animals; Antihypertensive Agents; Apoptosis; Brain Ischemia; Caspases; Gene Expression Regulation; I | 2007 |
Effects of ATP sensitive potassium channel opener on the mRNA and protein expressions of caspase-12 after cerebral ischemia-reperfusion in rats.
Topics: Animals; Brain Ischemia; Caspase 12; Endoplasmic Reticulum Stress; Infarction, Middle Cerebral Arter | 2008 |
Ischemic cardioprotection by ATP-sensitive K+ channels involves high-energy phosphate preservation.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Glyburide; Guanidines; Guinea Pigs; Heart; In Vi | 1993 |
Preconditioning in cardiomyocytes protects by attenuating oxidant stress at reperfusion.
Topics: Animals; Anti-Arrhythmia Agents; Cell Death; Cells, Cultured; Chick Embryo; Decanoic Acids; Hydrogen | 2000 |
Potassium channel openers: are they effective as pretreatment or additives to cardioplegia?
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Circulation; Female; Magne | 2000 |
Ischemic but not pharmacological preconditioning requires protein synthesis.
Topics: Action Potentials; Animals; Blood Flow Velocity; Blood Pressure; Coronary Vessels; Cycloheximide; Da | 2000 |
Effect of adenosine triphosphate-sensitive potassium channel openers on lung preservation.
Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Glyburide; Hypertension, Pulmonary; Lung; P | 2002 |