pinacidil has been researched along with Pulmonary Fibrosis in 1 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We previously reported that the endogenous cystathionine gamma-lyase (CSE)/hydrogen sulfide (H(2)S) pathway is implicated in the pathogenesis of bleomycin-induced pulmonary fibrosis in rats, but the exact cellular mechanisms are not well characterized." | 3.76 | Hydrogen sulfide attenuates epithelial-mesenchymal transition of human alveolar epithelial cells. ( Fang, LP; Lin, Q; Liu, XM; Tang, CS, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fang, LP | 1 |
| Lin, Q | 1 |
| Tang, CS | 1 |
| Liu, XM | 1 |
1 other study available for pinacidil and Pulmonary Fibrosis
| Article | Year |
|---|---|
Hydrogen sulfide attenuates epithelial-mesenchymal transition of human alveolar epithelial cells.
Topics: Benzodioxoles; Cadherins; Cell Line, Tumor; Cell Transdifferentiation; Cystathionine gamma-Lyase; Dr | 2010 |