pinacidil has been researched along with Myocardial Ischemia in 47 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "It is not clear whether activation of ATP-sensitive potassium channels (K(ATP)) with pinacidil in advance of ischemia and reperfusion promotes or suppresses arrhythmias." | 7.73 | Pretreatment with pinacidil promotes arrhythmias in an isolated tissue model of cardiac ischemia and reperfusion. ( Ferrier, GR; Howlett, SE, 2005) |
| " In the present study, we investigated the effects of the administration of non-hypotensive doses of ATP-sensitive K+ channel (KATP) openers (nicorandil and 3-pyridyl pinacidil), a specific mitochondrial KATP channel blocker (5-hydroxydecanoate) and a specific sarcolemmal KATP channel blocker (HMR 1883; 1-[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]sulfonyl-3- methylthiourea) prior to and during coronary occlusion, as well as prior to and during post-ischemic reperfusion, on survival rate, ischemia-induced and reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 7.72 | Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion. ( Das, B; Sarkar, C, 2003) |
| "It is not clear whether activation of ATP-sensitive potassium channels (K(ATP)) with pinacidil in advance of ischemia and reperfusion promotes or suppresses arrhythmias." | 3.73 | Pretreatment with pinacidil promotes arrhythmias in an isolated tissue model of cardiac ischemia and reperfusion. ( Ferrier, GR; Howlett, SE, 2005) |
| " In the present study, we investigated the effects of the administration of non-hypotensive doses of ATP-sensitive K+ channel (KATP) openers (nicorandil and 3-pyridyl pinacidil), a specific mitochondrial KATP channel blocker (5-hydroxydecanoate) and a specific sarcolemmal KATP channel blocker (HMR 1883; 1-[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]sulfonyl-3- methylthiourea) prior to and during coronary occlusion, as well as prior to and during post-ischemic reperfusion, on survival rate, ischemia-induced and reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 3.72 | Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion. ( Das, B; Sarkar, C, 2003) |
| "We previously demonstrated that pinacidil does not affect Na(+)(i) accumulation, cellular energy depletion, or acidosis during myocardial ischemia, but dramatically improves the cationic/energetic status during reperfusion." | 3.72 | Early reperfusion levels of Na(+) and Ca(2+) are strongly associated with postischemic functional recovery but are disassociated from K(ATP) channel-induced cardioprotection. ( Digerness, SB; Guo, LL; Pike, MM; Takayama, E, 2004) |
| "Glibenclamide (10 μM) terminated these arrhythmias and restored APDs to control values." | 1.37 | Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts. ( Ambrosi, CM; Chang, R; Efimov, IR; Fedorov, VV; Glukhov, AV; Janks, D; Kostecki, G; Moazami, N; Nichols, CG; Schuessler, RB, 2011) |
| "Pinacidil solutions have been shown to have significant cardioprotective effects." | 1.32 | Donor heart preservation with pinacidil: the role of the mitochondrial K ATP channel. ( Damiano, RJ; Diodato, MD; Gaynor, SL; Lawton, JS; Prasad, SM; Shah, NR, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 25 (53.19) | 18.2507 |
| 2000's | 21 (44.68) | 29.6817 |
| 2010's | 1 (2.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fedorov, VV | 1 |
| Glukhov, AV | 1 |
| Ambrosi, CM | 1 |
| Kostecki, G | 1 |
| Chang, R | 1 |
| Janks, D | 1 |
| Schuessler, RB | 1 |
| Moazami, N | 1 |
| Nichols, CG | 1 |
| Efimov, IR | 1 |
| Kupriyanov, VV | 1 |
| Xiang, B | 1 |
| Sun, J | 1 |
| Jilkina, O | 1 |
| Legtenberg, RJ | 2 |
| Rongen, GA | 1 |
| Houston, RJ | 2 |
| Oeseburg, B | 2 |
| Smits, P | 2 |
| Ikizler, M | 1 |
| Dernek, S | 1 |
| Sevin, B | 1 |
| Maxey, TS | 1 |
| Kural, T | 1 |
| Fischbach, PS | 1 |
| Barrett, TD | 1 |
| Reed, NJ | 1 |
| Lucchesi, BR | 3 |
| Das, B | 1 |
| Sarkar, C | 1 |
| Wang, J | 1 |
| Zhou, X | 1 |
| Zhao, Y | 1 |
| Tang, H | 1 |
| Hu, Y | 1 |
| Zhu, HF | 1 |
| Dong, JW | 1 |
| Zhu, WZ | 1 |
| Ding, HL | 1 |
| Zhou, ZN | 1 |
| Lindhardt, TB | 1 |
| Gadsbøll, N | 1 |
| Kelbaek, H | 1 |
| Saunamäki, K | 1 |
| Madsen, JK | 1 |
| Clemmensen, P | 1 |
| Hesse, B | 1 |
| Haunsø, S | 1 |
| Takayama, E | 1 |
| Guo, LL | 2 |
| Digerness, SB | 1 |
| Pike, MM | 2 |
| Diodato, MD | 1 |
| Shah, NR | 1 |
| Prasad, SM | 1 |
| Gaynor, SL | 1 |
| Lawton, JS | 3 |
| Damiano, RJ | 5 |
| Er, F | 1 |
| Michels, G | 1 |
| Gassanov, N | 1 |
| Rivero, F | 1 |
| Hoppe, UC | 1 |
| Ferrier, GR | 1 |
| Howlett, SE | 1 |
| Nishizawa, K | 1 |
| Wolkowicz, PE | 1 |
| Yamagishi, T | 1 |
| Trénor, B | 1 |
| Ferrero, JM | 1 |
| Rodríguez, B | 1 |
| Montilla, F | 1 |
| Wu, S | 1 |
| Hayashi, H | 1 |
| Lin, SF | 1 |
| Chen, PS | 1 |
| Jerome, SN | 1 |
| Akimitsu, T | 1 |
| Gute, DC | 1 |
| Korthuis, RJ | 1 |
| Hoffman, BF | 2 |
| Ren, XL | 2 |
| Grover, GJ | 4 |
| D'Alonzo, AJ | 1 |
| Darbenzio, RB | 1 |
| Hess, TA | 1 |
| Sewter, JC | 1 |
| Sleph, PG | 1 |
| Black, SC | 1 |
| Walsh, RS | 1 |
| Tsuchida, A | 1 |
| Daly, JJ | 1 |
| Thornton, JD | 2 |
| Cohen, MV | 1 |
| Downey, JM | 4 |
| Van Wagoner, DR | 1 |
| Lamorgese, M | 1 |
| Cavero, I | 1 |
| Premmereur, J | 1 |
| McPherson, CD | 1 |
| Pierce, GN | 1 |
| Cole, WC | 1 |
| Nakaya, H | 1 |
| Thornton, CS | 1 |
| Sterling, DL | 1 |
| Kubota, I | 1 |
| Yamaki, M | 1 |
| Shibata, T | 1 |
| Ikeno, E | 1 |
| Hosoya, Y | 1 |
| Tomoike, H | 1 |
| Armstrong, SC | 1 |
| Liu, GS | 2 |
| Ganote, CE | 1 |
| Liu, Y | 1 |
| Gao, WD | 1 |
| O'Rourke, B | 1 |
| Marban, E | 1 |
| Harrington, GC | 1 |
| Allen, CT | 1 |
| Hsia, PW | 2 |
| Sellke, FW | 1 |
| Wang, SY | 1 |
| Stamler, A | 1 |
| Lopez, JJ | 1 |
| Li, J | 2 |
| Simons, M | 1 |
| Kanda, A | 1 |
| Watanabe, I | 1 |
| Williams, ML | 1 |
| Engle, CL | 1 |
| Li, S | 1 |
| Koch, GG | 1 |
| Gettes, LS | 1 |
| Critz, SD | 1 |
| Chujo, M | 1 |
| McClain, LC | 1 |
| Maier, GW | 1 |
| Jayawant, M | 1 |
| Stephenson, ER | 1 |
| Liang, BT | 1 |
| Tanhehco, EJ | 1 |
| Yasojima, K | 1 |
| McGeer, PL | 1 |
| Washington, RA | 1 |
| Kilgore, KS | 1 |
| Homeister, JW | 1 |
| Vanden Hoek, T | 1 |
| Becker, LB | 1 |
| Shao, ZH | 1 |
| Li, CQ | 1 |
| Schumacker, PT | 1 |
| Ghosh, S | 1 |
| Standen, NB | 1 |
| Galiñanes, M | 1 |
| Feng, J | 1 |
| Li, H | 1 |
| Rosenkranz, ER | 1 |
| Hoenicke, EM | 1 |
| Lin, R | 1 |
| Zhu, X | 1 |
| Zhang, Z | 1 |
| Kang, M | 1 |
| Xia, Q | 1 |
3 reviews available for pinacidil and Myocardial Ischemia
| Article | Year |
|---|---|
Protective effects of ATP-sensitive potassium-channel openers in experimental myocardial ischemia.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dihydropyridines; Disea | 1994 |
[Potential role of ATP-sensitive K+ channels in ischemia- and reperfusion-induced arrhythmias].
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; G | 1993 |
Pharmacology of ATP-sensitive potassium channel (KATP) openers in models of myocardial ischemia and reperfusion.
Topics: Animals; ATP-Binding Cassette Transporters; Benzopyrans; Cromakalim; Guanidines; Humans; Ischemic Pr | 1997 |
1 trial available for pinacidil and Myocardial Ischemia
| Article | Year |
|---|---|
Pharmacological modulation of the ATP sensitive potassium channels during repeated coronary occlusions: no effect on myocardial ischaemia or function.
Topics: Adenosine Triphosphate; Angina Pectoris; Anti-Arrhythmia Agents; Balloon Occlusion; Coronary Stenosi | 2004 |
43 other studies available for pinacidil and Myocardial Ischemia
| Article | Year |
|---|---|
Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts.
Topics: Action Potentials; Adolescent; Adult; Arrhythmias, Cardiac; Coronary Vessels; Diazoxide; Female; Gen | 2011 |
The effects of drugs modulating K(+) transport on Rb(+) uptake and distribution in pig hearts following regional ischemia: (87)Rb MRI study.
Topics: Animals; Bumetanide; Glyburide; In Vitro Techniques; Magnetic Resonance Imaging; Myocardial Infarcti | 2002 |
The role of myocardial KATP-channel blockade in the protective effects of glibenclamide against ischaemia in the rat heart.
Topics: Animals; Coronary Circulation; Diazoxide; Drug Interactions; Glyburide; Male; Myocardial Ischemia; P | 2002 |
Improved myocardial function with the addition of pinacidil to custadiol.
Topics: Animals; Blood Pressure; Coronary Circulation; Creatine Kinase; Glucose; Heart; Hypothermia, Induced | 2002 |
SNC-80-induced preconditioning: selective activation of the mitochondrial adenosine triphosphate-gated potassium channel.
Topics: Adenosine Triphosphate; Animals; Benzamides; Female; Heart; In Vitro Techniques; Ion Channel Gating; | 2003 |
Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion.
Topics: Animals; Anti-Arrhythmia Agents; Antioxidants; Arrhythmias, Cardiac; Blood Pressure; Decanoic Acids; | 2003 |
Myocardial protection of immature rabbits: polarizing versus depolarizing.
Topics: Aging; Animals; Bicarbonates; Body Water; Calcium Chloride; Cardiotonic Agents; Coronary Circulation | 2003 |
ATP-dependent potassium channels involved in the cardiac protection induced by intermittent hypoxia against ischemia/reperfusion injury.
Topics: Animals; Calcium; Decanoic Acids; Glyburide; Heart Ventricles; Hemodynamics; Hydroxy Acids; Hypoxia; | 2003 |
Pinacidil-induced opening, like glibenclamide-induced closure of cardiac KATP channels, protects cardiac function against ischemia in isolated, working, erythrocyte perfused rat hearts.
Topics: Animals; Glyburide; Heart; In Vitro Techniques; Ion Channel Gating; Male; Myocardial Ischemia; Pinac | 2003 |
Early reperfusion levels of Na(+) and Ca(2+) are strongly associated with postischemic functional recovery but are disassociated from K(ATP) channel-induced cardioprotection.
Topics: Animals; Calcium; Chlorides; Heart Ventricles; In Vitro Techniques; Membrane Proteins; Myocardial Is | 2004 |
Donor heart preservation with pinacidil: the role of the mitochondrial K ATP channel.
Topics: Adenosine; Allopurinol; Animals; Benzamides; Cardiotonic Agents; Coronary Circulation; Decanoic Acid | 2004 |
Testosterone induces cytoprotection by activating ATP-sensitive K+ channels in the cardiac mitochondrial inner membrane.
Topics: Adenosine Triphosphate; Androgen Receptor Antagonists; Androstenedione; Animals; Biological Transpor | 2004 |
Pretreatment with pinacidil promotes arrhythmias in an isolated tissue model of cardiac ischemia and reperfusion.
Topics: Animals; Arrhythmias, Cardiac; Disease Models, Animal; Guinea Pigs; Heart Ventricles; In Vitro Techn | 2005 |
Fasudil prevents KATP channel-induced improvement in postischemic functional recovery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Heart; In Vitro Techniques; Magnetic Resonan | 2005 |
Effects of pinacidil on reentrant arrhythmias generated during acute regional ischemia: a simulation study.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Computer Simulation; Heart | 2005 |
Action potential duration and QT interval during pinacidil infusion in isolated rabbit hearts.
Topics: Action Potentials; Animals; Calcium; Electrocardiography; Heart; In Vitro Techniques; Myocardial Isc | 2005 |
Ischemic preconditioning attenuates capillary no-reflow induced by prolonged ischemia and reperfusion.
Topics: Adenosine Triphosphate; Animals; Capillaries; Dogs; Female; Glyburide; Guanidines; Male; Muscle, Ske | 1995 |
Reversibility of electrophysiological abnormalities in subacute ischemia.
Topics: Action Potentials; Animals; Dogs; Female; Guanidines; Male; Membrane Potentials; Myocardial Ischemia | 1994 |
Effect of potassium on the action of the KATP modulators cromakalim, pinacidil, or glibenclamide on arrhythmias in isolated perfused rat heart subjected to regional ischaemia.
Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; Glyburide; Guanidines; Heart; Heart Rate; My | 1994 |
Potassium channel openers are likely to be proarrhythmic in the diseased human heart.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Death, Sudden, Cardiac; Dogs; Guanidines; Heart; H | 1994 |
Ketamine-xylazine anaesthesia permits a KATP channel antagonist to attenuate preconditioning in rabbit myocardium.
Topics: Animals; Glyburide; Guanidines; Ketamine; Myocardial Infarction; Myocardial Ischemia; Myocardium; Pi | 1994 |
Ischemia potentiates the mechanosensitive modulation of atrial ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Animals; Guanidines; Heart Atria; Ion Channel Gating; Mechanoreceptors; Myoc | 1994 |
Reversibility of electrophysiologic abnormalities of subendocardial Purkinje fibers induced by ischemia.
Topics: Adenosine Triphosphate; Animals; Diastole; Dogs; Electrophysiology; Endocardium; Female; Guanidines; | 1994 |
ATP sensitive potassium channel openers are of potential benefit in ischaemic heart disease.
Topics: Benzopyrans; Cromakalim; Dihydropyridines; Guanidines; Humans; Myocardial Ischemia; Myocardium; Niac | 1994 |
Ischemic cardioprotection by ATP-sensitive K+ channels involves high-energy phosphate preservation.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Glyburide; Guanidines; Guinea Pigs; Heart; In Vi | 1993 |
An explanation for the reported observation that ATP dependent potassium channel openers fail to mimic preconditioning.
Topics: Adenosine Triphosphate; Animals; Dogs; Guanidines; Ion Channel Gating; Myocardial Infarction; Myocar | 1993 |
Blockade of ATP-sensitive potassium channels increases infarct size but does not prevent preconditioning in rabbit hearts.
Topics: Animals; Female; Glyburide; Guanidines; Male; Myocardial Infarction; Myocardial Ischemia; Pinacidil; | 1993 |
Role of ATP-sensitive K+ channel on ECG ST segment elevation during a bout of myocardial ischemia. A study on epicardial mapping in dogs.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Dogs; Electrocardiography; Glyburide; Guanidines | 1993 |
Potassium channels and preconditioning of isolated rabbit cardiomyocytes: effects of glyburide and pinacidil.
Topics: Analysis of Variance; Animals; Cells, Cultured; Glyburide; Guanidines; Heart; Hypoglycemic Agents; K | 1995 |
Synergistic modulation of ATP-sensitive K+ currents by protein kinase C and adenosine. Implications for ischemic preconditioning.
Topics: Adenosine; Adenosine Triphosphate; Animals; Cells, Cultured; Drug Synergism; Enzyme Activation; Guan | 1996 |
Myocardial protection with pinacidil cardioplegia in the blood-perfused heart.
Topics: Animals; Blood; Blood Pressure; Cardiac Volume; Cardioplegic Solutions; Coronary Circulation; Dose-R | 1996 |
Enhanced microvascular relaxations to VEGF and bFGF in chronically ischemic porcine myocardium.
Topics: Adenosine Diphosphate; Animals; Chronic Disease; Coronary Circulation; Endothelial Growth Factors; F | 1996 |
Unanticipated lessening of the rise in extracellular potassium during ischemia by pinacidil.
Topics: Adenosine Triphosphate; Animals; Drug Evaluation, Preclinical; Female; Guanidines; Ion Channel Gatin | 1997 |
Pinacidil but not nicorandil opens ATP-sensitive K+ channels and protects against simulated ischemia in rabbit myocytes.
Topics: Adenosine Triphosphate; Animals; Cell Death; Disease Models, Animal; Electrophysiology; Female; Guan | 1997 |
Myocardial oxygen consumption in the rabbit heart after ischemia: hyperpolarized arrest with pinacidil versus depolarized hyperkalemic arrest.
Topics: Animals; Coronary Circulation; Diastole; Female; Guanidines; Heart Arrest, Induced; Hyperkalemia; Ma | 1997 |
Advantages of continuous hyperpolarized arrest with pinacidil over St. Thomas' Hospital solution during prolonged ischemia.
Topics: Animals; Arrhythmias, Cardiac; Bicarbonates; Body Water; Calcium Chloride; Cardioplegic Solutions; C | 1998 |
Protein kinase C-dependent activation of KATP channel enhances adenosine-induced cardioprotection.
Topics: Adenosine; Animals; Cells, Cultured; Chick Embryo; Enzyme Activation; Glyburide; Ischemic Preconditi | 1998 |
Preconditioning reduces tissue complement gene expression in the rabbit isolated heart.
Topics: Animals; Complement System Proteins; DNA Primers; Gene Expression Regulation; Glyburide; In Vitro Te | 1999 |
Preconditioning in cardiomyocytes protects by attenuating oxidant stress at reperfusion.
Topics: Animals; Anti-Arrhythmia Agents; Cell Death; Cells, Cultured; Chick Embryo; Decanoic Acids; Hydrogen | 2000 |
Evidence for mitochondrial K ATP channels as effectors of human myocardial preconditioning.
Topics: Analysis of Variance; Cell Membrane; Decanoic Acids; Diazoxide; Dose-Response Relationship, Drug; Gl | 2000 |
Pinacidil pretreatment extends ischemia tolerance of neonatal rabbit hearts.
Topics: Animals; Animals, Newborn; Cardioplegic Solutions; Coronary Circulation; Diastole; Heart Arrest, Ind | 2000 |
Superior 12-hour heart preservation with pinacidil hyperpolarizing solution compared to University of Wisconsin solution.
Topics: Animals; Heart Transplantation; Hemodynamics; Myocardial Ischemia; Organ Preservation; Organ Preserv | 2001 |
Myocardial protection of immature rabbits with an ATP-sensitive K+ channel opener pinacidil.
Topics: Animals; Coronary Circulation; Diastole; Female; Male; Myocardial Ischemia; Myocardial Reperfusion I | 2001 |