pinacidil has been researched along with Myocardial Infarction in 23 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "We assessed whether pravastatin attenuates cardiac sympathetic reinnervation after myocardial infarction through the activation of ATP-sensitive K(+) (K(ATP)) channels." | 3.74 | Effect of pravastatin on sympathetic reinnervation in postinfarcted rats. ( Chang, NC; Lee, TM; Lin, MS, 2007) |
| "Male Wistar rats after induction of myocardial infarction were randomized to either vehicle, agonists of K(ATP) channels nicorandil and pinacidil, an antagonist of K(ATP) channels glibenclamide, or a combination of nicorandil and glibenclamide or pinacidil and glibenclamide for 4 weeks." | 3.74 | Effect of ATP-sensitive potassium channel agonists on ventricular remodeling in healed rat infarcts. ( Chang, NC; Lee, TM; Lin, MS, 2008) |
| "Treatment with pinacidil decreased APD (26%) in co-cultures with sMI-Fb." | 1.39 | Fibroblast KATP currents modulate myocyte electrophysiology in infarcted hearts. ( Benamer, N; Coetzee, WA; Mahoney, VM; Morley, GE; Steinhardt, MJ; Vasquez, C, 2013) |
| " The chronic use of mitochondrial K(ATP) channel agonists after infarction may attenuate the arrhythmogenic response to programmed electrical stimulation." | 1.35 | Effect of ATP-sensitive potassium channel agonists on sympathetic hyperinnervation in postinfarcted rat hearts. ( Chang, NC; Chen, CC; Kang, CS; Lee, TM; Lin, CC, 2009) |
| "Myocardial infarction was produced in dogs by ligation of the left anterior descending coronary artery." | 1.31 | Effects of pinacidil on electrophysiological properties of epicardial border zone of healing canine infarcts: possible effects of K(ATP) channel activation. ( Coromilas, J; Costeas, C; Deruyter, B; Dillon, SM; Peters, NS; Wit, AL, 2002) |
| "Cromakalim pretreatment (both when given throughout the experiment and when not present in the reperfusion buffer) resulted in significant improvements in the reperfusion function." | 1.28 | The protective effects of cromakalim and pinacidil on reperfusion function and infarct size in isolated perfused rat hearts and anesthetized dogs. ( Dzwonczyk, S; Grover, GJ; Parham, CS; Sleph, PG, 1990) |
| "Pinacidil was titrated to decrease mean aortic pressure 25 mm Hg, which resulted in an increase in heart rate (HR), cardiac output (CO), and left ventricular (LV) dP/dt and LVdP/dt/P." | 1.28 | Effects of pinacidil on myocardial blood flow and infarct size after acute left anterior descending coronary artery occlusion and reperfusion in awake dogs with and without a coexisting left circumflex coronary artery stenosis. ( Hood, WB; Liang, CS; Sakamoto, S; Stone, CK, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.70) | 18.7374 |
| 1990's | 10 (43.48) | 18.2507 |
| 2000's | 10 (43.48) | 29.6817 |
| 2010's | 1 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Benamer, N | 1 |
| Vasquez, C | 1 |
| Mahoney, VM | 1 |
| Steinhardt, MJ | 1 |
| Coetzee, WA | 1 |
| Morley, GE | 1 |
| Kang, CS | 1 |
| Chen, CC | 1 |
| Lin, CC | 1 |
| Chang, NC | 3 |
| Lee, TM | 3 |
| Strutyns'kyĭ, RB | 2 |
| Neshcheret, OP | 2 |
| Tumanovs'ka, LV | 1 |
| Rovenets', RA | 2 |
| Moĭbenko, OO | 2 |
| Kotsiuruba, AV | 1 |
| Shysh, AM | 1 |
| Kupriyanov, VV | 1 |
| Xiang, B | 1 |
| Sun, J | 1 |
| Jilkina, O | 1 |
| Fischbach, PS | 1 |
| Barrett, TD | 1 |
| Reed, NJ | 1 |
| Lucchesi, BR | 2 |
| Lin, MS | 2 |
| Smallwood, JK | 1 |
| Schelm, JA | 1 |
| Bemis, KG | 1 |
| Simpson, PJ | 1 |
| Grover, GJ | 3 |
| Black, SC | 1 |
| Walsh, RS | 1 |
| Tsuchida, A | 2 |
| Daly, JJ | 1 |
| Thornton, JD | 2 |
| Cohen, MV | 1 |
| Downey, JM | 2 |
| Ito, M | 1 |
| Pride, HP | 1 |
| Zipes, DP | 1 |
| Ren, XL | 1 |
| Hoffman, BF | 1 |
| Thornton, CS | 1 |
| Sterling, DL | 1 |
| Leprán, I | 1 |
| Baczkó, I | 1 |
| Varró, A | 1 |
| Papp, JG | 1 |
| Matsuyama, N | 1 |
| Leavens, JE | 1 |
| McKinnon, D | 1 |
| Gaudette, GR | 1 |
| Aksehirli, TO | 1 |
| Krukenkamp, IB | 1 |
| Tanno, M | 1 |
| Miura, T | 1 |
| Miki, T | 1 |
| Nishino, Y | 1 |
| Ohnuma, Y | 1 |
| Shimamoto, K | 1 |
| Coromilas, J | 1 |
| Costeas, C | 1 |
| Deruyter, B | 1 |
| Dillon, SM | 1 |
| Peters, NS | 1 |
| Wit, AL | 1 |
| Dzwonczyk, S | 1 |
| Parham, CS | 1 |
| Sleph, PG | 1 |
| Sakamoto, S | 2 |
| Liang, CS | 2 |
| Stone, CK | 2 |
| Hood, WB | 2 |
| Imai, N | 1 |
1 review available for pinacidil and Myocardial Infarction
| Article | Year |
|---|---|
Protective effects of ATP-sensitive potassium-channel openers in experimental myocardial ischemia.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dihydropyridines; Disea | 1994 |
22 other studies available for pinacidil and Myocardial Infarction
| Article | Year |
|---|---|
Fibroblast KATP currents modulate myocyte electrophysiology in infarcted hearts.
Topics: Action Potentials; Animals; ATP-Binding Cassette Transporters; Fibroblasts; Glyburide; Heart Ventric | 2013 |
Effect of ATP-sensitive potassium channel agonists on sympathetic hyperinnervation in postinfarcted rat hearts.
Topics: Animals; Arrhythmias, Cardiac; Echocardiography; Endothelin-1; Glyburide; Heart; Hypoglycemic Agents | 2009 |
[Cardioprotective effects of flokalin in experiments in vivo: influence on hemodynamic and myocardial lesions in ischemia-reperfusion].
Topics: Animals; Blood Pressure; Cardiac Output; Cardiotonic Agents; Disease Models, Animal; Dogs; Heart Rat | 2009 |
[Cardioprotective effects of activation of ATP-sensitive potassium channels in experiments in vivo: influence on blood biochemical parameters following ischemia-reperfusion of the myocardium].
Topics: Animals; Antioxidants; Cardiotonic Agents; Disease Models, Animal; Dogs; Free Radicals; Hemodynamics | 2009 |
The effects of drugs modulating K(+) transport on Rb(+) uptake and distribution in pig hearts following regional ischemia: (87)Rb MRI study.
Topics: Animals; Bumetanide; Glyburide; In Vitro Techniques; Magnetic Resonance Imaging; Myocardial Infarcti | 2002 |
SNC-80-induced preconditioning: selective activation of the mitochondrial adenosine triphosphate-gated potassium channel.
Topics: Adenosine Triphosphate; Animals; Benzamides; Female; Heart; In Vitro Techniques; Ion Channel Gating; | 2003 |
Effect of pravastatin on sympathetic reinnervation in postinfarcted rats.
Topics: Animals; Blotting, Western; Cardiac Pacing, Artificial; Coronary Vessels; Disease Models, Animal; GA | 2007 |
Effect of ATP-sensitive potassium channel agonists on ventricular remodeling in healed rat infarcts.
Topics: Animals; Glyburide; Hemodynamics; Hypertrophy, Left Ventricular; Immunohistochemistry; KATP Channels | 2008 |
Effect of activation of ATP-dependent potassium channels with (-)-pinacidil and (-)-3-pyridyl pinacidil on infarct size in a canine model of ischemia-reperfusion injury.
Topics: Animals; Coronary Circulation; Dogs; Dose-Response Relationship, Drug; Guanidines; Hemodynamics; Mal | 1993 |
Potassium channel openers are likely to be proarrhythmic in the diseased human heart.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Death, Sudden, Cardiac; Dogs; Guanidines; Heart; H | 1994 |
Ketamine-xylazine anaesthesia permits a KATP channel antagonist to attenuate preconditioning in rabbit myocardium.
Topics: Animals; Glyburide; Guanidines; Ketamine; Myocardial Infarction; Myocardial Ischemia; Myocardium; Pi | 1994 |
Glibenclamide enhances but pinacidil reduces attenuation in sympathetic responsiveness after acute coronary artery occlusion.
Topics: Acute Disease; Animals; Arterial Occlusive Diseases; Coronary Vessels; Denervation; Dogs; Dose-Respo | 1994 |
Reversibility of electrophysiologic abnormalities of subendocardial Purkinje fibers induced by ischemia.
Topics: Adenosine Triphosphate; Animals; Diastole; Dogs; Electrophysiology; Endocardium; Female; Guanidines; | 1994 |
An explanation for the reported observation that ATP dependent potassium channel openers fail to mimic preconditioning.
Topics: Adenosine Triphosphate; Animals; Dogs; Guanidines; Ion Channel Gating; Myocardial Infarction; Myocar | 1993 |
Blockade of ATP-sensitive potassium channels increases infarct size but does not prevent preconditioning in rabbit hearts.
Topics: Animals; Female; Glyburide; Guanidines; Male; Myocardial Infarction; Myocardial Ischemia; Pinacidil; | 1993 |
ATP-sensitive potassium channel modulators: both pinacidil and glibenclamide produce antiarrhythmic activity during acute myocardial infarction in conscious rats.
Topics: Adenosine Triphosphate; Animals; Glyburide; Guanidines; Kinetics; Male; Myocardial Infarction; Pinac | 1996 |
Ischemic but not pharmacological preconditioning requires protein synthesis.
Topics: Action Potentials; Animals; Blood Flow Velocity; Blood Pressure; Coronary Vessels; Cycloheximide; Da | 2000 |
Contribution of both the sarcolemmal K(ATP) and mitochondrial K(ATP) channels to infarct size limitation by K(ATP) channel openers: differences from preconditioning in the role of sarcolemmal K(ATP) channels.
Topics: Analysis of Variance; Animals; Hemodynamics; Male; Mitochondria; Myocardial Infarction; Pinacidil; P | 2001 |
Effects of pinacidil on electrophysiological properties of epicardial border zone of healing canine infarcts: possible effects of K(ATP) channel activation.
Topics: Animals; Blood Pressure; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Electric St | 2002 |
The protective effects of cromakalim and pinacidil on reperfusion function and infarct size in isolated perfused rat hearts and anesthetized dogs.
Topics: Animals; Benzopyrans; Blood Pressure; Cromakalim; Dogs; Female; Guanidines; In Vitro Techniques; L-L | 1990 |
Effects of pinacidil on myocardial blood flow and infarct size after acute left anterior descending coronary artery occlusion and reperfusion in awake dogs with and without a coexisting left circumflex coronary artery stenosis.
Topics: Animals; Blood Pressure; Cardiac Output; Coronary Circulation; Dogs; Guanidines; Heart Rate; Myocard | 1989 |
Comparative effects of nitroprusside and pinacidil on myocardial blood flow and infarct size in awake dogs with acute myocardial infarction.
Topics: Animals; Consciousness; Coronary Circulation; Coronary Vessels; Dogs; Ferricyanides; Guanidines; Myo | 1988 |