pinacidil has been researched along with Muscle Relaxation in 74 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| " As part of our efforts directed toward identifying novel, bladder-selective potassium channel openers (KCOs) targeted for urge urinary incontinence (UUI), we found that bioisosteric replacement of the N-cyanoguanidine moiety of pinacidil (1, Figure 1) with a diaminocyclobutenedione template afforded squaric acid analogue 2, the prototype of a novel series of K(ATP) channel openers with unique selectivity for bladder smooth muscle in vivo." | 3.70 | Design and SAR of novel potassium channel openers targeted for urge urinary incontinence. 1. N-Cyanoguanidine bioisosteres possessing in vivo bladder selectivity. ( Antane, MM; Antane, SA; Argentieri, TM; Butera, JA; Freeden, C; Graceffa, RF; Hirth, BH; Jenkins, D; Lennox, JR; Matelan, E; Norton, NW; Quagliato, D; Sheldon, JH; Spinelli, W; Warga, D; Wojdan, A; Woods, M, 2000) |
| " Spontaneous detrusor muscle contractions were unaffected by glibenclamide (K(ATP) channel blocker) but were reduced when pinacidil (K(ATP) channel opener) concentrations exceeded 10(-5) M." | 3.70 | K(ATP) channels mediate the beta(2)-adrenoceptor agonist-induced relaxation of rat detrusor muscle. ( Elliott, RA; Hudman, D; Norman, RI, 2000) |
| "Vasorelaxant responses to the potassium channel opening drug, pinacidil, were obtained on preparations of pulmonary artery and aorta taken from rats with pulmonary hypertension (induced by chronic hypoxia or monocrotaline) and pre-contracted either submaximally with endothelin-1 (ET-1), PGF2 alpha, U46619 (thromboxane-mimetic) or noradrenaline (NA), or with 80 mM K+." | 3.69 | Pinacidil-induced relaxation in pulmonary arteries isolated from pulmonary hypertensive and normotensive rats and pre-contracted with different spasmogens. ( Kay, CS; O'Donnell, SR; Wanstall, JC, 1994) |
| "3,5-Di-substituted phenylcyanoguanidine derivatives with halogen, cyano and/or nitro groups at the 3- and 5-positions of the benzene ring exhibited very strong smooth muscle relaxation activity in vitro, as compared to pinacidil." | 3.69 | Synthesis and structure-activity relationships of novel phenylcyanoguanidine derivatives as potassium channel openers. ( Goto, K; Ikeda, S; Morita, T; Nishimura, N; Sukamoto, T; Yoshiizumi, K; Yoshino, K, 1996) |
| "Obesity was induced by 24 weeks of high-fat diet feeding in male Sprague-Dawley rats." | 1.35 | Altered ATP-sensitive potassium channels may underscore obesity-triggered increase in blood pressure. ( Cao, YX; Fan, LH; Hu, Z; Huo, JH; Ma, AQ; Tian, HY, 2008) |
| "Adenosine (10 microM) was used as other contractile agent for comparison." | 1.35 | Contribution of RhoA kinase and protein kinase C to weak relaxant effect of pinacidil on carbachol-induced contractions in sensitized guinea-pig trachealis. ( Gok, S; Izanli-Paksoy, A; Vural, K, 2009) |
| "5 microM) had no significant effect on relaxation dose-response curves (DRCs) to ACh, NTG or NO." | 1.29 | Role of calcium-activated K+ channels in vasodilation induced by nitroglycerine, acetylcholine and nitric oxide. ( Khan, SA; Mathews, WR; Meisheri, KD, 1993) |
| "Nifedipine was far more potent than (+/-)-cic in this respect." | 1.29 | Comparison of in vitro effects of cicletanine, its enantiomers and major metabolite on rat thoracic aorta. ( Mikkelsen, EO; Poulsen, SH; Sehested, J, 1993) |
| "Charybdotoxin (ChTX) is a potent blocker of the high-conductance Ca(++)-activated K+ channel in smooth muscle and produces a concentration-dependent contraction of guinea pig trachea." | 1.28 | Selective inhibition of relaxation of guinea-pig trachea by charybdotoxin, a potent Ca(++)-activated K+ channel inhibitor. ( Charette, L; Garcia, ML; Jones, TR; Kaczorowski, GJ, 1990) |
| "Pinacidil was less effective preventing (anti-spasmogenic) than reversing (spasmolytic) contractions to endothelin on either tissue type." | 1.28 | Pinacidil antagonism of endothelin-induced contractions of smooth muscle in the lungs: differences between tracheal and pulmonary artery preparations. ( O'Donnell, SR; Wanstall, JC; Zeng, XP, 1990) |
| "Cromakalim was three to four times more potent than pinacidil." | 1.28 | K(+)-channel openers for relaxation of isolated penile erectile tissue from rabbit. ( Andersson, KE; Fovaeus, M; Hedlund, H; Holmquist, F, 1990) |
| "Pretreatment with pinacidil caused a parallel shift of the tracheal histamine C/E curve to the right, whereas the maximal response to histamine was markedly depressed in the pulmonary artery." | 1.28 | A comparison of the relaxant effects of pinacidil in guinea-pig trachea, aorta and pulmonary artery. ( Mellemkjaer, S; Nielsen, CB; Nielsen-Kudsk, JE; Siggaard, C, 1989) |
| "Pinacidil does not produce vasodilation via an indirect effect mediated by adenosine, prostaglandin, or endothelial-derived relaxant factor (EDRF) release." | 1.27 | Pinacidil-induced vascular relaxation: comparison to other vasodilators and to classical mechanisms of vasodilation. ( Cohen, ML; Kurz, KD, 1988) |
| "Hydralazine was effective at similar concentrations on these three types of contraction." | 1.27 | Relaxant effects of pinacidil, nicorandil, hydralazine and nifedipine as studied in the porcine coronary artery and guinea-pig taenia coli. ( Imai, S; Matsui, K; Ogawa, Y, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (12.16) | 18.7374 |
| 1990's | 41 (55.41) | 18.2507 |
| 2000's | 19 (25.68) | 29.6817 |
| 2010's | 5 (6.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Buckle, DR | 2 |
| Arch, JR | 2 |
| Fenwick, AE | 1 |
| Houge-Frydrych, CS | 1 |
| Pinto, IL | 1 |
| Smith, DG | 1 |
| Taylor, SG | 2 |
| Tedder, JM | 1 |
| Atwal, KS | 2 |
| Grover, GJ | 1 |
| Lodge, NJ | 1 |
| Normandin, DE | 1 |
| Traeger, SC | 1 |
| Sleph, PG | 1 |
| Cohen, RB | 1 |
| Bryson, CC | 1 |
| Dickinson, KE | 1 |
| Butera, JA | 1 |
| Antane, MM | 1 |
| Antane, SA | 1 |
| Argentieri, TM | 1 |
| Freeden, C | 1 |
| Graceffa, RF | 1 |
| Hirth, BH | 1 |
| Jenkins, D | 1 |
| Lennox, JR | 1 |
| Matelan, E | 1 |
| Norton, NW | 1 |
| Quagliato, D | 1 |
| Sheldon, JH | 1 |
| Spinelli, W | 1 |
| Warga, D | 1 |
| Wojdan, A | 1 |
| Woods, M | 1 |
| de Tullio, P | 4 |
| Becker, B | 1 |
| Boverie, S | 2 |
| Dabrowski, M | 1 |
| Wahl, P | 2 |
| Antoine, MH | 3 |
| Somers, F | 1 |
| Sebille, S | 1 |
| Ouedraogo, R | 1 |
| Hansen, JB | 3 |
| Lebrun, P | 7 |
| Pirotte, B | 4 |
| Tagmose, TM | 2 |
| Schou, SC | 1 |
| Mogensen, JP | 2 |
| Nielsen, FE | 2 |
| Arkhammar, PO | 1 |
| Hansen, BS | 1 |
| Worsaae, A | 2 |
| Boonen, HC | 2 |
| Gündüz, MG | 3 |
| Sevim Oztürk, G | 1 |
| Vural, IM | 1 |
| Simşek, R | 3 |
| Sarioğlu, Y | 3 |
| Safak, C | 3 |
| Khelili, S | 2 |
| Florence, X | 1 |
| Bouhadja, M | 1 |
| Abdelaziz, S | 1 |
| Mechouch, N | 1 |
| Mohamed, Y | 1 |
| Michaux, C | 1 |
| Kihal, N | 1 |
| Yekhlef, M | 1 |
| Işli, F | 1 |
| El-Khouly, A | 1 |
| Yıldırım, S | 1 |
| Öztürk Fincan, GS | 1 |
| Öztürk Yıldırım, S | 1 |
| Butcher, RJ | 1 |
| Fitzgerald, R | 1 |
| DeSantiago, B | 1 |
| Lee, DY | 1 |
| Yang, G | 1 |
| Kim, JY | 1 |
| Foster, DB | 1 |
| Chan-Li, Y | 1 |
| Horton, MR | 1 |
| Panettieri, RA | 1 |
| Wang, R | 1 |
| An, SS | 1 |
| Philyppov, IB | 1 |
| Golub, AА | 1 |
| Boldyriev, OI | 1 |
| Shtefan, NL | 1 |
| Totska, K | 1 |
| Voitychuk, OI | 1 |
| Shuba, YM | 1 |
| Fan, LH | 1 |
| Tian, HY | 1 |
| Ma, AQ | 1 |
| Hu, Z | 1 |
| Huo, JH | 1 |
| Cao, YX | 1 |
| Oztürk, GS | 1 |
| Vural, M | 1 |
| Gok, S | 1 |
| Izanli-Paksoy, A | 1 |
| Vural, K | 1 |
| Zaragoza, F | 1 |
| Jensen, AF | 1 |
| Glavind-Kristensen, M | 1 |
| Matchkov, V | 1 |
| Hansen, VB | 1 |
| Forman, A | 1 |
| Nilsson, H | 1 |
| Aalkjaer, C | 2 |
| Lymarenko, IV | 1 |
| Khanam, R | 1 |
| Pillai, KK | 1 |
| Bagcivan, I | 1 |
| Kaya, T | 1 |
| Yildirim, MK | 1 |
| Turan, M | 1 |
| Aishima, M | 1 |
| Tomoda, T | 1 |
| Yunoki, T | 1 |
| Nakano, T | 1 |
| Seki, N | 1 |
| Yonemitsu, Y | 1 |
| Sueishi, K | 1 |
| Naito, S | 1 |
| Ito, Y | 1 |
| Teramoto, N | 1 |
| Khan, SA | 2 |
| Mathews, WR | 1 |
| Meisheri, KD | 2 |
| Wanstall, JC | 3 |
| Kay, CS | 2 |
| O'Donnell, SR | 3 |
| Mehta, AA | 1 |
| Dave, KC | 1 |
| Goyal, RK | 1 |
| Cai, B | 1 |
| Hao, Q | 1 |
| Greenberg, SS | 1 |
| deBoisblanc, B | 1 |
| Gillott, D | 1 |
| Goharderakhshan, R | 1 |
| Summer, WR | 1 |
| Hyman, A | 1 |
| Lippton, H | 1 |
| Nielsen, CB | 4 |
| Kalsner, S | 2 |
| Norman, NR | 1 |
| Toombs, CF | 1 |
| Buchanan, LV | 1 |
| Cimini, MG | 1 |
| Gibson, JK | 1 |
| Shebuski, RJ | 1 |
| Mikkelsen, EO | 1 |
| Sehested, J | 1 |
| Poulsen, SH | 1 |
| Bowring, NE | 1 |
| Foster, KA | 1 |
| Taylor, JF | 1 |
| Shaw, DJ | 1 |
| Song, P | 1 |
| Rocchi, D | 1 |
| Lazzarotti, M | 1 |
| Crimi, E | 1 |
| Rehder, K | 1 |
| Brusasco, V | 1 |
| Yoshiizumi, K | 2 |
| Ikeda, S | 2 |
| Goto, K | 1 |
| Morita, T | 1 |
| Nishimura, N | 2 |
| Sukamoto, T | 1 |
| Yoshino, K | 2 |
| Gladis-Villanueva, MM | 1 |
| Usera, F | 1 |
| Toro, MJ | 1 |
| Gojkoviíc Bukarica, L | 1 |
| Kazić, T | 1 |
| Sajić, Z | 1 |
| Djukanović, B | 1 |
| Panić, G | 1 |
| Perić, M | 1 |
| Bojić, M | 1 |
| Wilson, K | 1 |
| Cole, PH | 1 |
| Matar, K | 1 |
| Khan, RN | 1 |
| Morrison, JJ | 1 |
| Smith, SK | 1 |
| Ashford, ML | 1 |
| Kwan, YW | 1 |
| To, KW | 1 |
| Lau, WM | 1 |
| Tsang, SH | 1 |
| Ishioka, N | 1 |
| Bukoski, RD | 1 |
| Tabrizchi, R | 1 |
| Dick, JM | 2 |
| Van Geldre, LA | 1 |
| Timmermans, JP | 1 |
| Lefebvre, RA | 3 |
| Hudman, D | 1 |
| Elliott, RA | 1 |
| Norman, RI | 1 |
| Chen, SJ | 1 |
| Wu, CC | 1 |
| Yang, SN | 1 |
| Lin, CI | 1 |
| Yen, MH | 1 |
| Shieh, CC | 1 |
| Feng, J | 1 |
| Buckner, SA | 1 |
| Brioni, JD | 1 |
| Coghlan, MJ | 1 |
| Sullivan, JP | 1 |
| Gopalakrishnan, M | 1 |
| Van Molle, W | 1 |
| Libert, C | 1 |
| Holzmann, S | 1 |
| Kukovetz, WR | 1 |
| Braida, C | 1 |
| Pöch, G | 1 |
| Berry, JL | 1 |
| Small, RC | 1 |
| Foster, RW | 1 |
| Lawson, K | 1 |
| Barras, M | 1 |
| Zazzi-Sudriez, E | 1 |
| Martin, DJ | 1 |
| Armstrong, JM | 1 |
| Hicks, PE | 1 |
| Horacek, J | 1 |
| Nielsen-Kudsk, JE | 6 |
| Mellemkjaer, S | 3 |
| Bang, L | 3 |
| Kashiwabara, T | 1 |
| Nakajima, S | 1 |
| Izawa, T | 1 |
| Fukushima, H | 1 |
| Nishikori, K | 1 |
| Jones, TR | 1 |
| Charette, L | 1 |
| Garcia, ML | 1 |
| Kaczorowski, GJ | 1 |
| Steinberg, MI | 2 |
| Wiest, SA | 1 |
| Zimmerman, KM | 1 |
| Ertel, PJ | 1 |
| Bemis, KG | 1 |
| Robertson, DW | 1 |
| Brønsgaard, AM | 1 |
| Masuzawa, K | 1 |
| Matsuda, T | 1 |
| Asano, M | 1 |
| Fang, ZY | 1 |
| Herchuelz, A | 1 |
| Hermann, M | 1 |
| Berkenboom, G | 1 |
| Fontaine, J | 2 |
| Yanagisawa, T | 1 |
| Teshigawara, T | 1 |
| Taira, N | 1 |
| Zeng, XP | 1 |
| Siggaard, C | 2 |
| Holmquist, F | 1 |
| Andersson, KE | 1 |
| Fovaeus, M | 1 |
| Hedlund, H | 1 |
| Ertel, P | 1 |
| Smallwood, JK | 1 |
| Wyss, V | 1 |
| Zimmerman, K | 1 |
| Cohen, ML | 1 |
| Kurz, KD | 1 |
| Eltze, M | 1 |
| Wilson, C | 1 |
| Coldwell, MC | 1 |
| Howlett, DR | 1 |
| Cooper, SM | 1 |
| Hamilton, TC | 1 |
| Matsui, K | 1 |
| Ogawa, Y | 1 |
| Imai, S | 1 |
| Videbaek, LM | 1 |
| Mulvany, MJ | 1 |
| Akbarali, HI | 1 |
| Bieger, D | 1 |
| Ohia, SE | 1 |
| Triggle, CR | 1 |
1 review available for pinacidil and Muscle Relaxation
| Article | Year |
|---|---|
Pharmacology and structure-activity relationships for KATP modulators: tissue-selective KATP openers.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Cardiovasc | 1994 |
73 other studies available for pinacidil and Muscle Relaxation
| Article | Year |
|---|---|
Relaxant activity of 4-amido-3,4-dihydro-2H-1-benzopyran-3-ols and 4-amido-2H-1-benzopyrans on guinea pig isolated trachealis.
Topics: Amides; Animals; Benzopyrans; Bronchodilator Agents; Chemical Phenomena; Chemistry; Cromakalim; Guin | 1990 |
Binding of ATP-sensitive potassium channel (KATP) openers to cardiac membranes: correlation of binding affinities with cardioprotective and smooth muscle relaxing potencies.
Topics: Animals; ATP-Binding Cassette Transporters; Cardiotonic Agents; Dogs; KATP Channels; Muscle Relaxati | 1998 |
Design and SAR of novel potassium channel openers targeted for urge urinary incontinence. 1. N-Cyanoguanidine bioisosteres possessing in vivo bladder selectivity.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Cyclobutanes; Drug Design; Drug Evaluation, Preclin | 2000 |
Toward tissue-selective pancreatic B-cells KATP channel openers belonging to 3-alkylamino-7-halo-4H-1,2,4-benzothiadiazine 1,1-dioxides.
Topics: Adenosine Triphosphate; Animals; Aorta; Benzothiadiazines; Diazoxide; Female; Glucose; In Vitro Tech | 2003 |
Arylcyanoguanidines as activators of Kir6.2/SUR1K ATP channels and inhibitors of insulin release.
Topics: Animals; Aorta; ATP-Binding Cassette Transporters; Cell Line; Female; Glucose; Guanidines; Humans; I | 2004 |
Evaluation of myorelaxant activity of 7-substituted hexahydroquinoline derivatives in isolated rabbit gastric fundus.
Topics: Animals; Drug Evaluation, Preclinical; Gastric Fundus; In Vitro Techniques; Muscle Relaxation; Muscl | 2008 |
Synthesis and activity on rat aorta rings and rat pancreatic beta-cells of ring-opened analogues of benzopyran-type potassium channel activators.
Topics: Animals; Aorta; Benzopyrans; Chromans; Cromakalim; In Vitro Techniques; Insulin; Insulin Antagonists | 2008 |
Impact of the nature of the substituent at the 3-position of 4H-1,2,4-benzothiadiazine 1,1-dioxides on their opening activity toward ATP-sensitive potassium channels.
Topics: Animals; Aorta; Benzothiadiazines; Diazoxide; Female; Hydrogen Bonding; Hydrogen-Ion Concentration; | 2011 |
Synthesis and pharmacological activity of N-(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)-4H-1,2,4-benzothiadiazine-3-carboxamides 1,1-dioxides on rat uterus, rat aorta and rat pancreatic β-cells.
Topics: Animals; Aorta; Benzothiadiazines; Chemistry Techniques, Synthetic; Female; In Vitro Techniques; Ins | 2012 |
Microwave-assisted synthesis and myorelaxant activity of 9-indolyl-1,8-acridinedione derivatives.
Topics: Acridines; Animals; Crystallography, X-Ray; Microwaves; Molecular Docking Simulation; Muscle Relaxat | 2014 |
H2S relaxes isolated human airway smooth muscle cells via the sarcolemmal K(ATP) channel.
Topics: Bronchi; Bronchodilator Agents; Cells, Cultured; Cystathionine gamma-Lyase; Glyburide; Humans; Hydro | 2014 |
Myorelaxant action of fluorine-containing pinacidil analog, flocalin, in bladder smooth muscle is mediated by inhibition of L-type calcium channels rather than activation of KATP channels.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Electric Stimulation; Guinea Pigs; In V | 2016 |
Altered ATP-sensitive potassium channels may underscore obesity-triggered increase in blood pressure.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Body Weight; Dietary Fats; Electr | 2008 |
Synthesis of 2-methyl-4-aryl-4,6,7,8-tetrahydro-5(1H)-quinolone derivatives and their effects on potassium channels.
Topics: Animals; In Vitro Techniques; Indicators and Reagents; Magnetic Resonance Spectroscopy; Muscle Relax | 2008 |
Contribution of RhoA kinase and protein kinase C to weak relaxant effect of pinacidil on carbachol-induced contractions in sensitized guinea-pig trachealis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Animals; Benzophenanthridines; Bronchodila | 2009 |
Synthesis and biological activity of 3,3-diamino-sulfonylacrylonitriles as novel inhibitors of glucose induced insulin secretion from beta cells.
Topics: Acrylonitrile; Animals; Crystallography, X-Ray; Diazoxide; Diuretics; Female; Glucose; Hydrogen Bond | 2003 |
KATP-channel-induced vasodilation is modulated by the Na,K-pump activity in rabbit coronary small arteries.
Topics: Animals; Arteries; ATP-Binding Cassette Transporters; Cardiotonic Agents; Coronary Vessels; Cromakal | 2004 |
[The comparative study of the effect of new fluorine-containing guanidine-derivate compounds and pinacidil on contractile function of the urinary bladder in vitro].
Topics: Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Female; Guanidine; Hydrocarbons, | 2005 |
Involvement of potassium channels in hypoglycemic effect of sertraline.
Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glucose; Hyperglycemia; | 2006 |
Investigation of the relaxant effects of pinacidil and cromakalim on the sheep sphincter of Oddi.
Topics: Animals; Cromakalim; Glyburide; In Vitro Techniques; Male; Muscle Relaxation; Parasympatholytics; Pi | 2006 |
Actions of ZD0947, a novel ATP-sensitive K+ channel opener, on membrane currents in human detrusor myocytes.
Topics: ATP-Binding Cassette Transporters; Carbachol; Diazoxide; Dihydropyridines; Dose-Response Relationshi | 2006 |
Role of calcium-activated K+ channels in vasodilation induced by nitroglycerine, acetylcholine and nitric oxide.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Calcium; Charybdotoxin; Colforsin; Drug Interactions | 1993 |
Pinacidil-induced relaxation in pulmonary arteries isolated from pulmonary hypertensive and normotensive rats and pre-contracted with different spasmogens.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Guanidines; Hypertension, Pulmonary; Hypoxia; In | 1994 |
Involvement of K+ channels in the relaxant responses to various agonists in estrogen primed rat uterus.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Dose-Response Relationship, Drug; Epinephrine; Estrogens; | 1995 |
Differential effects of pinacidil and cromakalim on vascular relaxation and sympathetic neurotransmission.
Topics: Animals; Benzopyrans; Cattle; Cromakalim; Dogs; Electric Stimulation; Female; Guanidines; In Vitro T | 1994 |
Contraction induced either by iso-osmolar or hyper-osmolar potassium-rich solutions influences relaxant responses to pinacidil and verapamil in rat isolated aorta.
Topics: Animals; Aorta, Thoracic; Female; Guanidines; In Vitro Techniques; Kinetics; Male; Muscle Contractio | 1993 |
Propranolol antagonizes coronary artery relaxation by a potassium channel opener.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Biological Transport; Cattle; Colfor | 1994 |
Comparative effects of the potassium channel openers cromakalim and pinacidil and the cromakalim analog U-89232 on isolated vascular and cardiac tissue.
Topics: Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Female; Glyburide; Guanidines; M | 1994 |
Comparison of in vitro effects of cicletanine, its enantiomers and major metabolite on rat thoracic aorta.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Calcium; Calcium Channels; Catecholamines; Guanid | 1993 |
Relaxant effects of the potassium channel activators BRL 38227 and pinacidil on guinea-pig and human airway smooth muscle, and blockade of their effects by glibenclamide and BRL 31660.
Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Bronchi; Cromakalim; Female; Glyburide; Guanidines; Gu | 1993 |
Hypoxic relaxation in functionally intact cattle coronary artery segments involves K+ ATP channels.
Topics: Adenosine; Adenosine Triphosphate; Animals; Arteries; Calcium; Calcium Channel Blockers; Cattle; Cor | 1995 |
Postjunctional effect of pinacidil on contractility of isolated bovine trachealis.
Topics: Acetylcholine; Animals; Cattle; Cell Membrane; Dose-Response Relationship, Drug; Electric Stimulatio | 1996 |
Synthesis and structure-activity relationships of novel phenylcyanoguanidine derivatives as potassium channel openers.
Topics: Animals; Blood Pressure; Glyburide; Guanidines; Guinea Pigs; Heart Rate; Hypoglycemic Agents; Ileum; | 1996 |
Denervation-induced supersensitivity to forskolin and pinacidil is not related to changes in the adenylate cyclase transduction pathway in the rabbit femoral artery.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylate Cyclase Toxin; Adenylyl | 1997 |
Synthesis and structure-activity relationships of thienylcyanoguanidine derivatives as potassium channel openers.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cecum; Dogs; Female; Guanidines; Guinea Pigs; Inje | 1997 |
The effects of levcromakalim and pinacidil on the human internal mammary artery.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Apamin; Charybdotoxin; Coronary Artery Bypass; Coronary Dis | 1997 |
Evaluation of bosentan, pinacidil and nitroprusside on human pulmonary arteries: comparison with rat pulmonary arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aged; Animals; Antihypertensive | 1997 |
Activation of large-conductance potassium channels in pregnant human myometrium by pinacidil.
Topics: Calcium; Charybdotoxin; Electric Conductivity; Female; Glyburide; Guanidines; Humans; Muscle Relaxat | 1998 |
Comparison of the vascular relaxant effects of ATP-dependent K+ channel openers on aorta and pulmonary artery isolated from spontaneously hypertensive and Wistar-Kyoto rats.
Topics: Adenosine Triphosphate; Aminoquinolines; Animals; Aorta, Thoracic; Apamin; Benzopyrans; Charybdotoxi | 1999 |
A role for N-arachidonylethanolamine (anandamide) as the mediator of sensory nerve-dependent Ca2+-induced relaxation.
Topics: Animals; Arachidonic Acids; Calcium Signaling; Cannabinoids; Endocannabinoids; In Vitro Techniques; | 1999 |
Influence of increase in osmotic pressure with sucrose on relaxation and cyclonucleotides levels in isolated rat aorta.
Topics: Adrenergic beta-Agonists; Animals; Aorta, Thoracic; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response | 1999 |
Investigation of the interaction between nitric oxide and vasoactive intestinal polypeptide in the guinea-pig gastric fundus.
Topics: Adenine; Adrenergic beta-Agonists; Animals; Atrial Natriuretic Factor; Carbachol; Colforsin; Cyclic | 2000 |
K(ATP) channels mediate the beta(2)-adrenoceptor agonist-induced relaxation of rat detrusor muscle.
Topics: Adenosine Triphosphate; Adrenergic beta-Agonists; Animals; Clenbuterol; Colforsin; Cyclic AMP; Cycli | 2000 |
Abnormal activation of K(+) channels in aortic smooth muscle of rats with endotoxic shock: electrophysiological and functional evidence.
Topics: Animals; Aorta; Apamin; Benzimidazoles; Charybdotoxin; Drug Interactions; Enzyme Inhibitors; Glyburi | 2000 |
Functional implication of spare ATP-sensitive K(+) channels in bladder smooth muscle cells.
Topics: Acetylcholine; Amides; Animals; Benzophenones; Drug Interactions; Electrophysiology; Guanidines; Gui | 2001 |
Antisense knockdown of inducible nitric oxide synthase inhibits the relaxant effect of VIP in isolated smooth muscle cells of the mouse gastric fundus.
Topics: Amidines; Animals; Arginine; Benzylamines; Carbachol; Cell Size; DNA, Antisense; Enzyme Inhibitors; | 2001 |
Pharmacological interaction experiments differentiate between glibenclamide-sensitive K+ channels and cyclic GMP as components of vasodilation by nicorandil.
Topics: Animals; Benzopyrans; Cattle; Coronary Vessels; Cromakalim; Cyclic GMP; Drug Interactions; Glyburide | 1992 |
Tracheal relaxation induced by potassium channel opening drugs: its antagonism by adrenergic neurone blocking agents.
Topics: Adrenergic Antagonists; Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Female; | 1992 |
Differential effects of endothelin-1 on the vasorelaxant properties of benzopyran and non-benzopyran potassium channel openers.
Topics: Animals; Aorta; Benzopyrans; Cromakalim; Cyclopentanes; Dihydropyridines; Dose-Response Relationship | 1992 |
Relaxant effects of BRL 38227 and pinacidil on the rat gastric fundus.
Topics: Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Female; Gastric Fundus; Glyburid | 1992 |
Influence of osmolarity of solutions used for K+ contraction on relaxant responses to pinacidil, verapamil, theophylline and terbutaline in isolated airway smooth muscle.
Topics: Animals; Guanidines; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle | 1992 |
Smooth muscle relaxation and inhibition of responses to pinacidil and cromakalim induced by phentolamine in guinea-pig isolated trachea.
Topics: Animals; Benzopyrans; Carbachol; Cromakalim; Dinoprost; Female; Guanidines; Guinea Pigs; Histamine; | 1992 |
Characteristics of KRN2391, a novel vasodilator, compared with those of cromakalim, pinacidil and nifedipine in rat aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Guanidines; Gua | 1991 |
Selective inhibition of relaxation of guinea-pig trachea by charybdotoxin, a potent Ca(++)-activated K+ channel inhibitor.
Topics: Aminophylline; Animals; Benzopyrans; Calcium; Carbachol; Charybdotoxin; Cromakalim; Dose-Response Re | 1990 |
Effects of pinacidil and other cyanoguanidine derivatives on guinea-pig isolated trachea, aorta and pulmonary artery.
Topics: Animals; Aorta; Dinoprost; Guanidines; Guinea Pigs; Histamine; Muscle Relaxation; Muscle, Smooth, Va | 1991 |
Chiral recognition of pinacidil and its 3-pyridyl isomer by canine cardiac and smooth muscle: antagonism by sulfonylureas.
Topics: Adenosine Triphosphate; Animals; Dogs; Dose-Response Relationship, Drug; Female; Glipizide; Glyburid | 1991 |
Glibenclamide blocks the relaxant action of pinacidil and cromakalim in airway smooth muscle.
Topics: Animals; Benzopyrans; Cromakalim; Female; Glyburide; Guanidines; Guinea Pigs; Histamine; In Vitro Te | 1990 |
Evidence that pinacidil may promote the opening of ATP-sensitive K+ channels yet inhibit the opening of Ca2(+)-activated K+ channels in K(+)-contracted canine mesenteric artery.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Dogs; Female; Glyburide; Guanidin | 1990 |
Hypoglycemic sulfonylureas antagonize the effects of cromakalim and pinacidil on 86Rb fluxes and contractile activity in the rat aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Glyburide; Guanidines; Hypoglycemic Agents; In Vi | 1990 |
Cytoplasmic calcium and the relaxation of canine coronary arterial smooth muscle produced by cromakalim, pinacidil and nicorandil.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Coronary Vessels; Cromakalim; Cytoplasm; Dogs | 1990 |
Pinacidil antagonism of endothelin-induced contractions of smooth muscle in the lungs: differences between tracheal and pulmonary artery preparations.
Topics: Animals; Endothelins; Female; Guanidines; Guinea Pigs; In Vitro Techniques; Lung; Male; Muscle Contr | 1990 |
Differential relaxant responses to pinacidil of smooth muscle preparations contracted by a high concentration of potassium in isoosmolar and hyperosmolar solutions.
Topics: Animals; Aorta, Thoracic; Female; Guanidines; Guinea Pigs; Male; Muscle Contraction; Muscle Relaxati | 1990 |
Relaxation response to pinacidil and diazoxide in the mouse isolated distal colon.
Topics: Animals; Colon; Diazoxide; Dose-Response Relationship, Drug; Guanidines; Mice; Muscle Contraction; M | 1990 |
K(+)-channel openers for relaxation of isolated penile erectile tissue from rabbit.
Topics: Animals; Benzopyrans; Cromakalim; Electric Stimulation; Guanidines; In Vitro Techniques; Male; Muscl | 1990 |
The role of potassium channels in vascular relaxation. Proceedings of a symposium on pinacidil. Indianapolis, Indiana, June 25, 1987.
Topics: Animals; Guanidines; Humans; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Pinaci | 1988 |
The relation between vascular relaxant and cardiac electrophysiological effects of pinacidil.
Topics: Action Potentials; Adrenergic alpha-Agonists; Animals; Azepines; Cats; Dogs; Electrophysiology; Fema | 1988 |
Pinacidil-induced vascular relaxation: comparison to other vasodilators and to classical mechanisms of vasodilation.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Guanidines; In Vitro Techniques; Male; Muscle Rela | 1988 |
Glibenclamide is a competitive antagonist of cromakalim, pinacidil and RP 49356 in guinea-pig pulmonary artery.
Topics: Animals; Benzopyrans; Cromakalim; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Male; Met | 1989 |
A comparison of the relaxant effects of pinacidil in guinea-pig trachea, aorta and pulmonary artery.
Topics: Animals; Aorta, Thoracic; Dinoprost; Female; Guanidines; Guinea Pigs; Histamine; In Vitro Techniques | 1989 |
Comparative effects of K+ channel blockade on the vasorelaxant activity of cromakalim, pinacidil and nicorandil.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Benzopyrans; Cardiovascular Agents; Cromakalim; Guanidines | 1988 |
Relaxant effects of pinacidil, nicorandil, hydralazine and nifedipine as studied in the porcine coronary artery and guinea-pig taenia coli.
Topics: Animals; Caffeine; Colon; Coronary Vessels; Female; Guanidines; Guinea Pigs; Hydralazine; In Vitro T | 1986 |
Pinacidil opens K+-selective channels causing hyperpolarization and relaxation of noradrenaline contractions in rat mesenteric resistance vessels.
Topics: Animals; Guanidines; In Vitro Techniques; Male; Membrane Potentials; Muscle Relaxation; Muscle, Smoo | 1988 |
Similarity of relaxations evoked by BRL 34915, pinacidil and field-stimulation in rat oesophageal tunica muscularis mucosae.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Electric Stimulation; Esophagus; Guanidin | 1988 |