pinacidil has been researched along with Muscle Contraction in 92 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin was tested in two experimental groups, one of which underwent common bile duct ligation for 2 days and another that was later de-ligated for 2 days." | 5.35 | Protective effect of melatonin on Ca2+ homeostasis and contractility in acute cholecystitis. ( Camello, PJ; Gomez-Pinilla, PJ; Pozo, MJ, 2008) |
| "Pinacidil is a new antihypertensive, direct vasodilator drug which has been classified as a K+ channel opener." | 5.27 | Effects of pinacidil on guinea-pig airway smooth muscle contracted by asthma mediators. ( Mellemkjaer, S; Nielsen, CB; Nielsen-Kudsk, JE; Siggaard, C, 1988) |
| "In this study we have evaluated the cough reflex inhibiting potential and modulation of ASM reactivity in vitro, by K+ATP opener-pinacidil in guinea pig and cats." | 3.75 | The influence of animal species on the relationship between ATP-sensitive potassium ion channels and defense reflexes of the airways. ( Franova, S; Sutovska, M; Sutovsky, J, 2009) |
| " As part of our efforts directed toward identifying novel, bladder-selective potassium channel openers (KCOs) targeted for urge urinary incontinence (UUI), we found that bioisosteric replacement of the N-cyanoguanidine moiety of pinacidil (1, Figure 1) with a diaminocyclobutenedione template afforded squaric acid analogue 2, the prototype of a novel series of K(ATP) channel openers with unique selectivity for bladder smooth muscle in vivo." | 3.70 | Design and SAR of novel potassium channel openers targeted for urge urinary incontinence. 1. N-Cyanoguanidine bioisosteres possessing in vivo bladder selectivity. ( Antane, MM; Antane, SA; Argentieri, TM; Butera, JA; Freeden, C; Graceffa, RF; Hirth, BH; Jenkins, D; Lennox, JR; Matelan, E; Norton, NW; Quagliato, D; Sheldon, JH; Spinelli, W; Warga, D; Wojdan, A; Woods, M, 2000) |
| " Spontaneous detrusor muscle contractions were unaffected by glibenclamide (K(ATP) channel blocker) but were reduced when pinacidil (K(ATP) channel opener) concentrations exceeded 10(-5) M." | 3.70 | K(ATP) channels mediate the beta(2)-adrenoceptor agonist-induced relaxation of rat detrusor muscle. ( Elliott, RA; Hudman, D; Norman, RI, 2000) |
| "Vasorelaxant responses to the potassium channel opening drug, pinacidil, were obtained on preparations of pulmonary artery and aorta taken from rats with pulmonary hypertension (induced by chronic hypoxia or monocrotaline) and pre-contracted either submaximally with endothelin-1 (ET-1), PGF2 alpha, U46619 (thromboxane-mimetic) or noradrenaline (NA), or with 80 mM K+." | 3.69 | Pinacidil-induced relaxation in pulmonary arteries isolated from pulmonary hypertensive and normotensive rats and pre-contracted with different spasmogens. ( Kay, CS; O'Donnell, SR; Wanstall, JC, 1994) |
| "Pinacidil is an effective vasodilator classified as a K+ channel opener." | 2.37 | Effects of pinacidil on bladder muscle. ( Andersson, KE; Andersson, PO; Fovaeus, M; Hedlund, H; Malmgren, A; Sjögren, C, 1988) |
| "Caffeine is known to inhibit cyclic nucleotide phosphodiesterases (PDEs), leading to an increase in cytosolic cAMP and stimulation of downstream cAMP-dependent mechanisms." | 1.37 | Inhibitory effect of caffeine on pacemaker activity in the oviduct is mediated by cAMP-regulated conductances. ( Britton, F; Dixon, R; Hwang, S; Sanders, K; Ward, S, 2011) |
| "Adenosine (10 microM) was used as other contractile agent for comparison." | 1.35 | Contribution of RhoA kinase and protein kinase C to weak relaxant effect of pinacidil on carbachol-induced contractions in sensitized guinea-pig trachealis. ( Gok, S; Izanli-Paksoy, A; Vural, K, 2009) |
| "Minoxidil did not inhibit the contractions at both examined concentrations except for a very small effect at 1 Hz." | 1.35 | Inhibitory effects of different ATP-sensitive potassium channel openers on electrically generated and carbachol-induced contractions of porcine and human detrusor muscle. ( Badawi, JK; Bross, S; Ding, A, 2008) |
| "Melatonin was tested in two experimental groups, one of which underwent common bile duct ligation for 2 days and another that was later de-ligated for 2 days." | 1.35 | Protective effect of melatonin on Ca2+ homeostasis and contractility in acute cholecystitis. ( Camello, PJ; Gomez-Pinilla, PJ; Pozo, MJ, 2008) |
| "Levcromakalim and aprikalim were more effective as relaxant than as antispasmodic drugs." | 1.29 | Effects of three K+ channel openers on airways and pulmonary circulation in the isolated guinea-pig lung. ( Advenier, C; Dumas, JP; Dumas, M; Giudicelli, JF, 1993) |
| "Pretreatment with pinacidil (10(-6) to 10(-4) M) caused concentration-dependent inhibition of the contractile response to hypoxia." | 1.29 | Inhibition of hypoxic coronary vasoconstriction by pinacidil. ( O'Rourke, ST, 1996) |
| "(1) Pinacidil is an effective inhibitor of hyperreflexia in the in vivo rabbit model." | 1.28 | Effect of pinacidil on spontaneous and evoked contractile activity. ( Hayes, L; Levin, RM; Wein, AJ; Zhao, Y, 1992) |
| "Pinacidil is thought to cause vasodilatation by opening K+ channels and consequent hyperpolarization." | 1.28 | Effect of pinacidil on ion permeability in resting and contracted resistance vessels. ( Aalkjaer, C; Hughes, AD; Mulvany, MJ; Videbaek, LM, 1990) |
| "Pinacidil was less effective preventing (anti-spasmogenic) than reversing (spasmolytic) contractions to endothelin on either tissue type." | 1.28 | Pinacidil antagonism of endothelin-induced contractions of smooth muscle in the lungs: differences between tracheal and pulmonary artery preparations. ( O'Donnell, SR; Wanstall, JC; Zeng, XP, 1990) |
| "Cromakalim was three to four times more potent than pinacidil." | 1.28 | K(+)-channel openers for relaxation of isolated penile erectile tissue from rabbit. ( Andersson, KE; Fovaeus, M; Hedlund, H; Holmquist, F, 1990) |
| "Pretreatment with pinacidil caused a parallel shift of the tracheal histamine C/E curve to the right, whereas the maximal response to histamine was markedly depressed in the pulmonary artery." | 1.28 | A comparison of the relaxant effects of pinacidil in guinea-pig trachea, aorta and pulmonary artery. ( Mellemkjaer, S; Nielsen, CB; Nielsen-Kudsk, JE; Siggaard, C, 1989) |
| "Pinacidil is a recently developed antihypertensive agent classified as a K+ channel opener, and is believed to depress smooth muscle activity by this action." | 1.28 | The action of pinacidil in the isolated human bladder. ( Andersson, KE; Fovaeus, M; Hedlund, H, 1989) |
| "Pinacidil is a new antihypertensive, direct vasodilator drug which has been classified as a K+ channel opener." | 1.27 | Effects of pinacidil on guinea-pig airway smooth muscle contracted by asthma mediators. ( Mellemkjaer, S; Nielsen, CB; Nielsen-Kudsk, JE; Siggaard, C, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (17.39) | 18.7374 |
| 1990's | 50 (54.35) | 18.2507 |
| 2000's | 22 (23.91) | 29.6817 |
| 2010's | 4 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Manley, PW | 1 |
| Quast, U | 1 |
| Eda, M | 1 |
| Takemoto, T | 1 |
| Ono, S | 1 |
| Okada, T | 1 |
| Kosaka, K | 1 |
| Gohda, M | 1 |
| Matzno, S | 1 |
| Nakamura, N | 1 |
| Fukaya, C | 1 |
| Butera, JA | 1 |
| Antane, MM | 1 |
| Antane, SA | 1 |
| Argentieri, TM | 1 |
| Freeden, C | 1 |
| Graceffa, RF | 1 |
| Hirth, BH | 1 |
| Jenkins, D | 1 |
| Lennox, JR | 1 |
| Matelan, E | 1 |
| Norton, NW | 1 |
| Quagliato, D | 1 |
| Sheldon, JH | 1 |
| Spinelli, W | 1 |
| Warga, D | 1 |
| Wojdan, A | 1 |
| Woods, M | 1 |
| Pirotte, B | 3 |
| Ouedraogo, R | 2 |
| de Tullio, P | 3 |
| Khelili, S | 1 |
| Somers, F | 2 |
| Boverie, S | 2 |
| Dupont, L | 2 |
| Fontaine, J | 4 |
| Damas, J | 2 |
| Lebrun, P | 5 |
| Antoine, MH | 2 |
| Becker, B | 1 |
| Rigo, B | 1 |
| Delarge, J | 1 |
| Michaux, C | 1 |
| Shimbo, T | 1 |
| Adachi, T | 1 |
| Fujisawa, S | 1 |
| Hongoh, M | 1 |
| Ohba, T | 1 |
| Ono, K | 1 |
| Gok, S | 1 |
| Izanli-Paksoy, A | 1 |
| Vural, K | 1 |
| Sutovska, M | 1 |
| Franova, S | 1 |
| Sutovsky, J | 1 |
| Oger, S | 1 |
| Behr-Roussel, D | 1 |
| Gorny, D | 1 |
| Bernabé, J | 1 |
| Comperat, E | 1 |
| Chartier-Kastler, E | 1 |
| Denys, P | 1 |
| Giuliano, F | 1 |
| Dixon, R | 1 |
| Hwang, S | 1 |
| Britton, F | 1 |
| Sanders, K | 1 |
| Ward, S | 1 |
| Tsang, SY | 1 |
| Yao, X | 1 |
| Wong, CM | 1 |
| Au, CL | 1 |
| Chen, ZY | 1 |
| Huang, Y | 2 |
| Kito, Y | 1 |
| Suzuki, H | 1 |
| Thompson, R | 1 |
| Doggrell, S | 1 |
| Hoberg, JO | 1 |
| Gong, B | 1 |
| Legault, D | 1 |
| Miki, T | 1 |
| Seino, S | 1 |
| Renaud, JM | 2 |
| Glavind-Kristensen, M | 1 |
| Matchkov, V | 1 |
| Hansen, VB | 1 |
| Forman, A | 1 |
| Nilsson, H | 1 |
| Aalkjaer, C | 3 |
| Pinna, C | 1 |
| Sanvito, P | 1 |
| Bolego, C | 1 |
| Cignarella, A | 1 |
| Puglisi, L | 1 |
| Vijayakumar, C | 1 |
| Kathirvel, K | 1 |
| Sardar, KK | 1 |
| Parija, SC | 1 |
| Broch-Lips, M | 1 |
| Overgaard, K | 1 |
| Praetorius, HA | 1 |
| Nielsen, OB | 1 |
| Novakovic, R | 1 |
| Milovanovic, S | 1 |
| Protic, D | 1 |
| Djokic, J | 1 |
| Heinle, H | 1 |
| Gojkovic-Bukarica, L | 1 |
| Shen, J | 1 |
| Yip, S | 1 |
| Wang, Z | 1 |
| Wang, W | 1 |
| Xing, D | 1 |
| Du, L | 1 |
| Badawi, JK | 1 |
| Ding, A | 1 |
| Bross, S | 1 |
| Gomez-Pinilla, PJ | 1 |
| Camello, PJ | 1 |
| Pozo, MJ | 1 |
| Abrahams, Z | 1 |
| Sutter, MC | 1 |
| Nielsen-Kudsk, JE | 6 |
| Mellemkjaer, S | 5 |
| Thirstrup, S | 1 |
| Wanstall, JC | 3 |
| Kay, CS | 1 |
| O'Donnell, SR | 3 |
| Zhang, H | 2 |
| Bolton, TB | 1 |
| Duncker, DJ | 1 |
| van Zon, NS | 1 |
| Pavek, TJ | 1 |
| Herrlinger, SK | 1 |
| Bache, RJ | 1 |
| Cai, B | 1 |
| Hao, Q | 1 |
| Greenberg, SS | 1 |
| deBoisblanc, B | 1 |
| Gillott, D | 1 |
| Goharderakhshan, R | 1 |
| Summer, WR | 1 |
| Hyman, A | 1 |
| Lippton, H | 1 |
| Ryman, T | 2 |
| Petersson, J | 3 |
| Andersson, KE | 7 |
| Brandt, L | 2 |
| Högestätt, ED | 3 |
| Nielsen, CB | 5 |
| Dumas, M | 1 |
| Dumas, JP | 1 |
| Advenier, C | 1 |
| Giudicelli, JF | 1 |
| Weselcouch, EO | 1 |
| Sargent, C | 1 |
| Wilde, MW | 1 |
| Smith, MA | 1 |
| O'Rourke, ST | 1 |
| Wickenden, AD | 1 |
| Prior, H | 1 |
| Kelly, E | 1 |
| Russell, K | 1 |
| Poucher, SM | 1 |
| Kumar, P | 1 |
| Bülow, A | 1 |
| Song, P | 1 |
| Rocchi, D | 1 |
| Lazzarotti, M | 1 |
| Crimi, E | 1 |
| Rehder, K | 1 |
| Brusasco, V | 1 |
| Lakhe, M | 1 |
| Furukawa, Y | 1 |
| Yonezawa, T | 1 |
| Nagashima, Y | 1 |
| Chiba, S | 1 |
| Rácz, D | 2 |
| Zillikens, S | 2 |
| Forstreuter, P | 2 |
| Nagykáldi, Z | 2 |
| Magyar, K | 2 |
| Török, TL | 1 |
| Ma, L | 1 |
| Yu, Z | 1 |
| Xiao, S | 1 |
| Thadani, U | 1 |
| Robinson, CP | 1 |
| Patterson, E | 1 |
| Levin, RM | 2 |
| Leggett, R | 1 |
| Whitbeck, C | 1 |
| Horan, P | 1 |
| Lau, CW | 1 |
| Moon, DG | 1 |
| Byun, HS | 1 |
| Kim, JJ | 1 |
| Yuan, YM | 1 |
| Xu, DY | 1 |
| Hu, GY | 1 |
| Török, T | 1 |
| Matar, W | 2 |
| Nosek, TM | 1 |
| Wong, D | 1 |
| Renaud, J | 1 |
| Hudman, D | 1 |
| Elliott, RA | 1 |
| Norman, RI | 1 |
| Matsuda, N | 1 |
| Sellke, FW | 1 |
| Long, W | 1 |
| Zhang, L | 1 |
| Longo, LD | 1 |
| Lunde, JA | 1 |
| Jasmin, BJ | 1 |
| Stockbridge, N | 1 |
| Weir, B | 1 |
| Vollrath, B | 1 |
| Cook, D | 1 |
| Hayes, L | 1 |
| Zhao, Y | 1 |
| Wein, AJ | 1 |
| Duty, S | 2 |
| Weston, AH | 3 |
| Taylor, SG | 2 |
| Arch, JR | 1 |
| Bond, J | 1 |
| Buckle, DR | 1 |
| Shaw, DJ | 1 |
| Taylor, JF | 1 |
| Ward, JS | 1 |
| Bang, L | 1 |
| Lundbeck, F | 1 |
| Sjögren, C | 3 |
| Leurs, R | 1 |
| Brozius, MM | 1 |
| Smit, MJ | 1 |
| Bast, A | 1 |
| Timmerman, H | 1 |
| Videbaek, LM | 2 |
| Hughes, AD | 1 |
| Mulvany, MJ | 2 |
| Satoh, K | 1 |
| Yamada, H | 1 |
| Taira, N | 2 |
| Lydrup, ML | 2 |
| Hellstrand, P | 1 |
| Itoh, T | 1 |
| Suzuki, S | 1 |
| Kuriyama, H | 1 |
| Masuzawa, K | 1 |
| Matsuda, T | 1 |
| Asano, M | 1 |
| McPherson, GA | 1 |
| Angus, JA | 1 |
| Fang, ZY | 1 |
| Herchuelz, A | 1 |
| Hermann, M | 1 |
| Berkenboom, G | 1 |
| Yanagisawa, T | 1 |
| Teshigawara, T | 1 |
| Zeng, XP | 2 |
| Siggaard, C | 3 |
| Anabuki, J | 1 |
| Hori, M | 1 |
| Ozaki, H | 1 |
| Kato, I | 1 |
| Karaki, H | 1 |
| Malmgren, A | 2 |
| Andersson, PO | 2 |
| Fovaeus, M | 4 |
| Holmquist, F | 2 |
| Hedlund, H | 4 |
| Southerton, JS | 2 |
| Bray, KM | 2 |
| Newgreen, DT | 2 |
| Hermsmeyer, RK | 1 |
| Steinberg, MI | 1 |
| Ertel, P | 1 |
| Smallwood, JK | 1 |
| Wyss, V | 1 |
| Zimmerman, K | 1 |
| Eltze, M | 1 |
| Nakajima, S | 1 |
| Kurokawa, K | 1 |
| Imamura, N | 1 |
| Ueda, M | 1 |
| Secrest, RJ | 1 |
| Schoepp, DD | 1 |
| Cohen, ML | 1 |
| Nedergaard, OA | 1 |
| Wilson, C | 1 |
| Cooper, SM | 1 |
| McHarg, AD | 1 |
1 review available for pinacidil and Muscle Contraction
| Article | Year |
|---|---|
Effects of pinacidil on bladder muscle.
Topics: Animals; Antihypertensive Agents; Guanidines; Humans; Muscle Contraction; Muscle, Smooth; Pinacidil; | 1988 |
91 other studies available for pinacidil and Muscle Contraction
| Article | Year |
|---|---|
Structure-activity studies of potassium channel opening in pinacidil-type cyanoguanidines, nitroethenediamines, thioureas, and ureas.
Topics: Animals; Diamines; Guanidines; Ion Channel Gating; Male; Molecular Conformation; Molecular Structure | 1992 |
Novel potassium-channel openers: preparation and pharmacological evaluation of racemic and optically active N-(6-amino-3-pyridyl)-N'-bicycloalkyl-N"-cyanoguanidine derivatives.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Bridged Bicyclo Compounds; Chromatography, | 1994 |
Design and SAR of novel potassium channel openers targeted for urge urinary incontinence. 1. N-Cyanoguanidine bioisosteres possessing in vivo bladder selectivity.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Cyclobutanes; Drug Design; Drug Evaluation, Preclin | 2000 |
3-Alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides structurally related to diazoxide and pinacidil as potassium channel openers acting on vascular smooth muscle cells: design, synthesis, and pharmacological evaluation.
Topics: Animals; Aorta; Cyclic S-Oxides; Diazoxide; Drug Design; Female; Guinea Pigs; Ileum; In Vitro Techni | 2000 |
Original 2-alkylamino-6-halogenoquinazolin-4(3H)-ones and K(ATP) channel activity.
Topics: Adenosine Triphosphate; Animals; Aorta; Calcium; Crystallography, X-Ray; Female; Glyburide; Guinea P | 2001 |
Impact of the nature of the substituent at the 3-position of 4H-1,2,4-benzothiadiazine 1,1-dioxides on their opening activity toward ATP-sensitive potassium channels.
Topics: Animals; Aorta; Benzothiadiazines; Diazoxide; Female; Hydrogen Bonding; Hydrogen-Ion Concentration; | 2011 |
In vitro effect of nicorandil on the carbachol-induced contraction of the lower esophageal sphincter of the rat.
Topics: Animals; Carbachol; Diazoxide; Dose-Response Relationship, Drug; Esophageal Sphincter, Lower; Glybur | 2016 |
Contribution of RhoA kinase and protein kinase C to weak relaxant effect of pinacidil on carbachol-induced contractions in sensitized guinea-pig trachealis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Animals; Benzophenanthridines; Bronchodila | 2009 |
The influence of animal species on the relationship between ATP-sensitive potassium ion channels and defense reflexes of the airways.
Topics: Animals; Antitussive Agents; Cats; Citric Acid; Cough; Female; Glyburide; Guinea Pigs; KATP Channels | 2009 |
Effects of potassium channel modulators on myogenic spontaneous phasic contractile activity in human detrusor from neurogenic patients.
Topics: Action Potentials; Adult; Aged; Apamin; Benzimidazoles; Case-Control Studies; Glyburide; Humans; In | 2011 |
Inhibitory effect of caffeine on pacemaker activity in the oviduct is mediated by cAMP-regulated conductances.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; ATP-Binding Cassette Transporters; Biologic | 2011 |
Contribution of Na+ -Ca2+ exchanger to pinacidil-induced relaxation in the rat mesenteric artery.
Topics: Animals; Calcium Channel Blockers; Dose-Response Relationship, Drug; Male; Mesenteric Artery, Superi | 2003 |
Modulation of slow waves by hyperpolarization with potassium channel openers in antral smooth muscle of the guinea-pig stomach.
Topics: Adrenergic alpha-Agonists; Animals; ATP-Binding Cassette Transporters; Biological Clocks; Decanoic A | 2003 |
Potassium channel activators based on the benzopyran substructure: synthesis and activity of the C-8 substituent.
Topics: Animals; Aorta; Benzopyrans; Cromakalim; Epoxy Compounds; In Vitro Techniques; Muscle Contraction; M | 2003 |
KATP channels depress force by reducing action potential amplitude in mouse EDL and soleus muscle.
Topics: Action Potentials; Animals; Mice; Microelectrodes; Muscle Contraction; Muscle Fatigue; Muscle, Skele | 2003 |
KATP-channel-induced vasodilation is modulated by the Na,K-pump activity in rabbit coronary small arteries.
Topics: Animals; Arteries; ATP-Binding Cassette Transporters; Cardiotonic Agents; Coronary Vessels; Cromakal | 2004 |
Effect of the ATP-sensitive potassium channel opener ZM226600 on cystometric parameters in rats with ligature-intact, partial urethral obstruction.
Topics: Adenosine Triphosphate; Amides; Animals; Benzophenones; Blood Pressure; Carbachol; Dose-Response Rel | 2005 |
Effect of KATP channel openers on myogenic and neurogenic responses in goat urinary bladder.
Topics: Acetylcholine; Animals; Atropine; Cholinergic Agents; Cromakalim; Dose-Response Relationship, Drug; | 2007 |
Effects of extracellular HCO3(-) on fatigue, pHi, and K+ efflux in rat skeletal muscles.
Topics: Animals; Bicarbonates; Dose-Response Relationship, Drug; Female; Glyburide; Hydrogen-Ion Concentrati | 2007 |
The effect of potassium channel opener pinacidil on the non-pregnant rat uterus.
Topics: Animals; Electric Stimulation; Female; Glyburide; In Vitro Techniques; Muscle Contraction; Oxytocics | 2007 |
Brazilein-induced contraction of rat arterial smooth muscle involves activation of Ca2+ entry and ROK, ERK pathways.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2008 |
Inhibitory effects of different ATP-sensitive potassium channel openers on electrically generated and carbachol-induced contractions of porcine and human detrusor muscle.
Topics: Aged; Amides; Animals; Benzophenones; Carbachol; Cromakalim; Electric Stimulation; Female; Humans; I | 2008 |
Protective effect of melatonin on Ca2+ homeostasis and contractility in acute cholecystitis.
Topics: Acalculous Cholecystitis; Animals; Caffeine; Calcium; Cholecystitis, Acute; Common Bile Duct; Diseas | 2008 |
Effects of K+ channel openers on the vascular actions of human gamma globulin.
Topics: Animals; Diazoxide; gamma-Globulins; Glyburide; Guanidines; Humans; In Vitro Techniques; Male; Muscl | 1994 |
Inhibition by cromakalim, pinacidil, terbutaline, theophylline and verapamil of non-cholinergic nerve-mediated contractions of guinea-pig isolated bronchi.
Topics: Animals; Benzopyrans; Bronchi; Bronchodilator Agents; Cromakalim; Dose-Response Relationship, Drug; | 1994 |
Pinacidil-induced relaxation in pulmonary arteries isolated from pulmonary hypertensive and normotensive rats and pre-contracted with different spasmogens.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Guanidines; Hypertension, Pulmonary; Hypoxia; In | 1994 |
Activation by intracellular GDP, metabolic inhibition and pinacidil of a glibenclamide-sensitive K-channel in smooth muscle cells of rat mesenteric artery.
Topics: Animals; Deoxyglucose; Electrophysiology; Glyburide; Guanidines; Guanosine Diphosphate; Male; Mesent | 1995 |
Endogenous adenosine mediates coronary vasodilation during exercise after K(ATP)+ channel blockade.
Topics: Adenosine; Animals; Coronary Circulation; Diastole; Dogs; Glyburide; Guanidines; Hemodynamics; Hyper | 1995 |
Differential effects of pinacidil and cromakalim on vascular relaxation and sympathetic neurotransmission.
Topics: Animals; Benzopyrans; Cattle; Cromakalim; Dogs; Electric Stimulation; Female; Guanidines; In Vitro T | 1994 |
Effects of pinacidil on cerebral and mesenteric arteries--influence of the endothelium.
Topics: Adrenergic alpha-Antagonists; Animals; Cerebral Arteries; Endothelium, Vascular; Female; Guanidines; | 1993 |
Contraction induced either by iso-osmolar or hyper-osmolar potassium-rich solutions influences relaxant responses to pinacidil and verapamil in rat isolated aorta.
Topics: Animals; Aorta, Thoracic; Female; Guanidines; In Vitro Techniques; Kinetics; Male; Muscle Contractio | 1993 |
Enhancement of depolarization-induced contractions after endothelium denudation is not related to an impaired production of nitric oxide or prostacyclin in the rabbit basilar artery.
Topics: Animals; Arginine; Basilar Artery; Calcium; Endothelium, Vascular; Epoprostenol; Female; Guanidines; | 1993 |
Effects of three K+ channel openers on airways and pulmonary circulation in the isolated guinea-pig lung.
Topics: Animals; Benzopyrans; Bronchoconstriction; Cromakalim; Dose-Response Relationship, Drug; Guanidines; | 1993 |
ATP-sensitive potassium channels and skeletal muscle function in vitro.
Topics: Animals; Benzopyrans; Cromakalim; Electric Stimulation; Energy Metabolism; Gallamine Triethiodide; G | 1993 |
Inhibition of hypoxic coronary vasoconstriction by pinacidil.
Topics: Animals; Cell Hypoxia; Coronary Vessels; Evaluation Studies as Topic; Guanidines; In Vitro Technique | 1996 |
The effects of pharmacological modulation of KATP on the guinea-pig isolated diaphragm.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diaphragm; Electrophysiology; Glyburide; G | 1996 |
Differentiated effects of vasodilators on myogenic reactivity during partial inhibition of myogenic tone in pressurized skeletal muscle small arteries of the rat.
Topics: Acetylcholine; Animals; Arteries; Calcium Channel Blockers; Diltiazem; Guanidines; In Vitro Techniqu | 1996 |
Postjunctional effect of pinacidil on contractility of isolated bovine trachealis.
Topics: Acetylcholine; Animals; Cattle; Cell Membrane; Dose-Response Relationship, Drug; Electric Stimulatio | 1996 |
Modulation by the endothelium of the inhibitory effects of pinacidil and nimodipine on endothelin-induced contraction in cerebral arteries.
Topics: Animals; Basilar Artery; Calcium; Calcium Channel Blockers; Cerebral Arteries; Endothelin-1; Endothe | 1997 |
Chronotropic and inotropic effects of terikalant on isolated, blood-perfused atrial and ventricular preparations of dogs.
Topics: Acetylcholine; Adenosine; Adrenergic alpha-Agonists; Animals; Anti-Arrhythmia Agents; Atrial Functio | 1997 |
Pre-junctional stimulatory and post-junctional inhibitory effects of pinacidil in the isolated main pulmonary artery of the rabbit under different experimental conditions.
Topics: Animals; Antihypertensive Agents; Dose-Response Relationship, Drug; Guanidines; Muscle Contraction; | 1997 |
Supersensitivity to serotonin- and histamine-induced arterial contraction following ovariectomy.
Topics: Acetylcholine; Adenosine; Animals; Aorta, Thoracic; Coronary Vessels; Dose-Response Relationship, Dr | 1998 |
Correlation of EGTA and calcium-blocking agents on the response of the bladder to in vitro ischemia.
Topics: Animals; Calcium Channel Blockers; Carbachol; Chelating Agents; Diltiazem; Egtazic Acid; Electric St | 1999 |
Differential effects of pinacidil, cromakalim, and NS 1619 on electrically evoked contractions in rat vas deferens.
Topics: Animals; Benzimidazoles; Charybdotoxin; Cromakalim; Electric Stimulation; Glyburide; In Vitro Techni | 1997 |
A KATP-channel opener as a potential treatment modality for erectile dysfunction.
Topics: Animals; Cats; Dose-Response Relationship, Drug; Impotence, Vasculogenic; Male; Muscle Contraction; | 1999 |
Pinacidil suppression on 5-HT3 receptor-mediated contraction of guinea pig ileum in vitro.
Topics: Animals; Carbachol; Guinea Pigs; Ileum; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; | 1998 |
[Pre- and postsynaptic action of the ATP-dependent K+-channel-(K+ATP)-opener pinacidil in rabbit pulmonary artery].
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1999 |
Pinacidil suppresses contractility and preserves energy but glibenclamide has no effect during muscle fatigue.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Energy Metabolism; Glyburide; Hypoglycemic Agent | 2000 |
K(ATP) channels mediate the beta(2)-adrenoceptor agonist-induced relaxation of rat detrusor muscle.
Topics: Adenosine Triphosphate; Adrenergic beta-Agonists; Animals; Clenbuterol; Colforsin; Cyclic AMP; Cycli | 2000 |
Regulation of coronary myoplasmic Ca(2+)-myosin light chain phosphorylation pathway and vasomotor tone: hyperpolarizing versus depolarizing cardioplegia.
Topics: Animals; Arterioles; Calcium; Cardioplegic Solutions; Colforsin; Coronary Vessels; Heart Arrest, Ind | 2000 |
Cerebral artery K(ATP)- and K(Ca)-channel activity and contractility: changes with development.
Topics: 4-Aminopyridine; Animals; Benzimidazoles; Calcium; Fetus; In Vitro Techniques; Middle Cerebral Arter | 2000 |
Denervation enhances the physiological effects of the K(ATP) channel during fatigue in EDL and soleus muscle.
Topics: Adenosine Triphosphate; Animals; Female; Gene Expression; Glyburide; Hypoglycemic Agents; Mice; Mice | 2001 |
Vasodilatation of canine cerebral arteries by nicorandil, pinacidil and lemakalim.
Topics: Animals; Basilar Artery; Benzopyrans; Cerebral Arteries; Cromakalim; Dogs; Female; Glyburide; Guanid | 1992 |
Effect of pinacidil on spontaneous and evoked contractile activity.
Topics: Animals; Bethanechol; Bethanechol Compounds; Blood Pressure; Guanidines; Kinetics; Male; Methoxamine | 1992 |
Characteristics of the contractile response of rabbit aorta produced by cromakalim in calcium-free solution.
Topics: Animals; Aorta; Benzopyrans; Calcium; Colforsin; Cromakalim; Guanidines; Male; Microelectrodes; Mino | 1992 |
The inhibitory effects of cromakalim and its active enantiomer BRL 38227 against various agonists in guinea pig and human airways: comparison with pinacidil and verapamil.
Topics: Animals; Benzopyrans; Bronchi; Bronchial Spasm; Bronchodilator Agents; Carbachol; Cromakalim; Drug I | 1992 |
Influence of osmolarity of solutions used for K+ contraction on relaxant responses to pinacidil, verapamil, theophylline and terbutaline in isolated airway smooth muscle.
Topics: Animals; Guanidines; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle | 1992 |
Smooth muscle relaxation and inhibition of responses to pinacidil and cromakalim induced by phentolamine in guinea-pig isolated trachea.
Topics: Animals; Benzopyrans; Carbachol; Cromakalim; Dinoprost; Female; Guanidines; Guinea Pigs; Histamine; | 1992 |
A pharmacological in vitro study of the mouse urinary bladder at the time of acute change in bladder reservoir function after irradiation.
Topics: Acetylcholine; Animals; Carbachol; Electric Stimulation; Guanidines; In Vitro Techniques; Indomethac | 1992 |
Effects of histamine H1-, H2- and H3-receptor selective drugs on the mechanical activity of guinea-pig small and large intestine.
Topics: Animals; Atropine; Dimaprit; Electric Stimulation; Guanidines; Guinea Pigs; Histamine; In Vitro Tech | 1991 |
Effect of pinacidil on ion permeability in resting and contracted resistance vessels.
Topics: Animals; Calcium; Cell Membrane Permeability; Guanidines; Ion Channels; Male; Mathematics; Membrane | 1990 |
Differential antagonism by glibenclamide of the relaxant effects of cromakalim, pinacidil and nicorandil on canine large coronary arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arteries; Benzopyrans; | 1991 |
Role of K+ channels in spontaneous electrical and mechanical activity of smooth muscle in the guinea-pig mesotubarium.
Topics: 4-Aminopyridine; Animals; Apamin; Electrophysiology; Female; Guanidines; Guinea Pigs; In Vitro Techn | 1991 |
Metabolic correlates to pacemaker activity in the smooth muscle of guinea-pig mesotubarium.
Topics: Adenosine Triphosphate; Animals; Biological Clocks; Biological Transport, Active; Felodipine; Female | 1991 |
Effects of pinacidil on contractile proteins in high K(+)-treated intact, and in beta-escin-treated skinned smooth muscle of the rabbit mesenteric artery.
Topics: Animals; Calcium; Contractile Proteins; Escin; Fura-2; Guanidines; In Vitro Techniques; Male; Mesent | 1991 |
Evidence that pinacidil may promote the opening of ATP-sensitive K+ channels yet inhibit the opening of Ca2(+)-activated K+ channels in K(+)-contracted canine mesenteric artery.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Dogs; Female; Glyburide; Guanidin | 1990 |
Characterization of responses to cromakalim and pinacidil in smooth and cardiac muscle by use of selective antagonists.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Clonidine; Coronary Vessels; Cromakalim; Dogs; Electric Stimu | 1990 |
Hypoglycemic sulfonylureas antagonize the effects of cromakalim and pinacidil on 86Rb fluxes and contractile activity in the rat aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Glyburide; Guanidines; Hypoglycemic Agents; In Vi | 1990 |
Cytoplasmic calcium and the relaxation of canine coronary arterial smooth muscle produced by cromakalim, pinacidil and nicorandil.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Coronary Vessels; Cromakalim; Cytoplasm; Dogs | 1990 |
Pinacidil antagonism of endothelin-induced contractions of smooth muscle in the lungs: differences between tracheal and pulmonary artery preparations.
Topics: Animals; Endothelins; Female; Guanidines; Guinea Pigs; In Vitro Techniques; Lung; Male; Muscle Contr | 1990 |
Differential relaxant responses to pinacidil of smooth muscle preparations contracted by a high concentration of potassium in isoosmolar and hyperosmolar solutions.
Topics: Animals; Aorta, Thoracic; Female; Guanidines; Guinea Pigs; Male; Muscle Contraction; Muscle Relaxati | 1990 |
Mechanisms of pinacidil-induced vasodilatation.
Topics: Animals; Aorta, Thoracic; Guanidines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepineph | 1990 |
Effects of cromakalim (BRL 34915) and pinacidil on normal and hypertrophied rat detrusor in vitro.
Topics: Animals; Benzopyrans; Carbachol; Cromakalim; Dose-Response Relationship, Drug; Electric Stimulation; | 1990 |
Relaxation response to pinacidil and diazoxide in the mouse isolated distal colon.
Topics: Animals; Colon; Diazoxide; Dose-Response Relationship, Drug; Guanidines; Mice; Muscle Contraction; M | 1990 |
Effects of pinacidil on isolated human corpus cavernosum penis.
Topics: Aged; Dose-Response Relationship, Drug; Electric Stimulation; Guanidines; Humans; Male; Middle Aged; | 1990 |
K(+)-channel openers for relaxation of isolated penile erectile tissue from rabbit.
Topics: Animals; Benzopyrans; Cromakalim; Electric Stimulation; Guanidines; In Vitro Techniques; Male; Muscl | 1990 |
The role of potassium channels in vascular relaxation. Proceedings of a symposium on pinacidil. Indianapolis, Indiana, June 25, 1987.
Topics: Animals; Guanidines; Humans; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Pinaci | 1988 |
The mode of action of pinacidil and its analogs P1060 and P1368: results of studies in rat blood vessels.
Topics: Animals; Aorta, Thoracic; Electrophysiology; Guanidines; In Vitro Techniques; Male; Membrane Potenti | 1988 |
Pinacidil actions on ion channels in vascular muscle.
Topics: Animals; Cells, Cultured; Electrophysiology; Guanidines; In Vitro Techniques; Ion Channels; Isometri | 1988 |
Effect of pinacidil on norepinephrine- and potassium-induced contractions and membrane potential in rat and human resistance vessels and in rat aorta.
Topics: Aged; Animals; Aorta, Thoracic; Female; Guanidines; Humans; In Vitro Techniques; Male; Membrane Pote | 1988 |
The relation between vascular relaxant and cardiac electrophysiological effects of pinacidil.
Topics: Action Potentials; Adrenergic alpha-Agonists; Animals; Azepines; Cats; Dogs; Electrophysiology; Fema | 1988 |
Age-dependence of the effects of pinacidil on rat aorta.
Topics: 1-Methyl-3-isobutylxanthine; Aging; Animals; Aorta, Thoracic; Guanidines; In Vitro Techniques; Male; | 1989 |
Glibenclamide is a competitive antagonist of cromakalim, pinacidil and RP 49356 in guinea-pig pulmonary artery.
Topics: Animals; Benzopyrans; Cromakalim; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Male; Met | 1989 |
A study on the hypotensive mechanism of pinacidil: relationship between its vasodilating effect and intracellular Ca2+ levels.
Topics: Animals; Antihypertensive Agents; Calcium; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; | 1989 |
Comparison of contractions to serotonin, carbamylcholine and prostaglandin F2 alpha in rat stomach fundus.
Topics: Animals; Carbachol; Diltiazem; Dinoprost; Gastric Fundus; Guanidines; In Vitro Techniques; Isoproter | 1989 |
Effect of pinacidil on sympathetic neuroeffector transmission in rabbit blood vessels.
Topics: Animals; Aorta, Thoracic; Blood Vessels; Drug Interactions; Electric Stimulation; Female; Guanidines | 1989 |
Effect of cromakalim on contractions in rabbit isolated renal artery in the presence and absence of extracellular Ca2+.
Topics: Animals; Benzopyrans; Caffeine; Calcium; Calcium Channel Blockers; Cromakalim; Guanidines; Guanylate | 1989 |
A comparison of the relaxant effects of pinacidil in guinea-pig trachea, aorta and pulmonary artery.
Topics: Animals; Aorta, Thoracic; Dinoprost; Female; Guanidines; Guinea Pigs; Histamine; In Vitro Techniques | 1989 |
In vitro studies on the mode of action of pinacidil.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Cyclic AMP; Cyclic GMP; Guanidines; Guinea Pigs; | 1988 |
The action of pinacidil in the isolated human bladder.
Topics: Antihypertensive Agents; Depression, Chemical; Female; Guanidines; Humans; In Vitro Techniques; Male | 1989 |
Effects of pinacidil on guinea-pig airway smooth muscle contracted by asthma mediators.
Topics: Animals; Antihypertensive Agents; Asthma; Female; Guanidines; Guinea Pigs; Male; Muscle Contraction; | 1988 |