pinacidil has been researched along with Metabolic Acidosis in 3 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aims of this study were to compare in the rat isolated perfused lung preparation, the dilator actions of nicorandil, pinacidil and nitroglycerin on the hypoxic pulmonary pressure response with or without hypercapnic acidosis and to investigate the possible involvement of K channels and EDRF in these effects." | 3.69 | Comparison of the effects of nicorandil, pinacidil and nitroglycerin on hypoxic and hypercapnic pulmonary vasoconstriction in the isolated perfused lung of rat. ( Advenier, C; Dumas, JP; Dumas, M; Giudicelli, JF; Rochette, L, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lindauer, U | 1 |
| Vogt, J | 1 |
| Schuh-Hofer, S | 1 |
| Dreier, JP | 1 |
| Dirnagl, U | 1 |
| Dumas, M | 1 |
| Dumas, JP | 1 |
| Rochette, L | 1 |
| Advenier, C | 1 |
| Giudicelli, JF | 1 |
| Ishizaka, H | 1 |
| Gudi, SR | 1 |
| Frangos, JA | 1 |
| Kuo, L | 1 |
3 other studies available for pinacidil and Metabolic Acidosis
| Article | Year |
|---|---|
Cerebrovascular vasodilation to extraluminal acidosis occurs via combined activation of ATP-sensitive and Ca2+-activated potassium channels.
Topics: Acidosis; Adenosine Triphosphate; Animals; Benzimidazoles; Cerebrovascular Circulation; Enzyme Inhib | 2003 |
Comparison of the effects of nicorandil, pinacidil and nitroglycerin on hypoxic and hypercapnic pulmonary vasoconstriction in the isolated perfused lung of rat.
Topics: Acidosis; Animals; Guanidines; Hypercapnia; Hypoxia; In Vitro Techniques; Lung; Male; Niacinamide; N | 1996 |
Coronary arteriolar dilation to acidosis: role of ATP-sensitive potassium channels and pertussis toxin-sensitive G proteins.
Topics: Acidosis; Adenosine Triphosphate; Animals; Arterioles; Coronary Vessels; Female; Glyburide; GTP-Bind | 1999 |