pinacidil has been researched along with Liver Cirrhosis in 2 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pinacidil is an investigational vasodilator currently undergoing clinical trials as an antihypertensive agent." | 1.27 | Effect of cirrhosis and debrisoquin phenotype on the disposition and effects of pinacidil. ( Avant, GR; Hamilton, M; Patel, J; Shaheen, O; Wood, AJ, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Blanco-Rivero, J | 1 |
| Márquez-Rodas, I | 1 |
| Sastre, E | 1 |
| Cogolludo, A | 1 |
| Pérez-Vizcaíno, F | 1 |
| del Campo, L | 1 |
| Nava, MP | 1 |
| Balfagón, G | 1 |
| Shaheen, O | 1 |
| Patel, J | 1 |
| Avant, GR | 1 |
| Hamilton, M | 1 |
| Wood, AJ | 1 |
2 other studies available for pinacidil and Liver Cirrhosis
| Article | Year |
|---|---|
Cirrhosis decreases vasoconstrictor response to electrical field stimulation in rat mesenteric artery: role of calcitonin gene-related peptide.
Topics: Animals; ATP-Binding Cassette Transporters; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related | 2011 |
Effect of cirrhosis and debrisoquin phenotype on the disposition and effects of pinacidil.
Topics: Adult; Blood Pressure; Debrisoquin; Drug Interactions; Guanidines; Humans; Isoquinolines; Kinetics; | 1986 |