pinacidil has been researched along with Injury, Myocardial Reperfusion in 33 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to evaluate the cardioprotective effect of pinacidil postconditioning on rat hearts with transient hypoxia and reperfusion." | 7.80 | Effect of pinacidil on rat ventricular myocytes during transient hypoxia and reperfusion. ( Dong, XY; Zhu, F, 2014) |
| "It is not clear whether activation of ATP-sensitive potassium channels (K(ATP)) with pinacidil in advance of ischemia and reperfusion promotes or suppresses arrhythmias." | 7.73 | Pretreatment with pinacidil promotes arrhythmias in an isolated tissue model of cardiac ischemia and reperfusion. ( Ferrier, GR; Howlett, SE, 2005) |
| " In the present study, we investigated the effects of the administration of non-hypotensive doses of ATP-sensitive K+ channel (KATP) openers (nicorandil and 3-pyridyl pinacidil), a specific mitochondrial KATP channel blocker (5-hydroxydecanoate) and a specific sarcolemmal KATP channel blocker (HMR 1883; 1-[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]sulfonyl-3- methylthiourea) prior to and during coronary occlusion, as well as prior to and during post-ischemic reperfusion, on survival rate, ischemia-induced and reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 7.72 | Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion. ( Das, B; Sarkar, C, 2003) |
| "The aim of this study was to evaluate the cardioprotective effect of pinacidil postconditioning on rat hearts with transient hypoxia and reperfusion." | 3.80 | Effect of pinacidil on rat ventricular myocytes during transient hypoxia and reperfusion. ( Dong, XY; Zhu, F, 2014) |
| "the arrhythmia score and the duration of arrhythmias were significantly reduced by HMR 1098, diazoxide, and pinacidil in male rats." | 3.76 | Both mitochondrial KATP channel opening and sarcolemmal KATP channel blockage confer protection against ischemia/reperfusion-induced arrhythmia in anesthetized male rats. ( Bozdogan, O; Gonca, E, 2010) |
| "It is not clear whether activation of ATP-sensitive potassium channels (K(ATP)) with pinacidil in advance of ischemia and reperfusion promotes or suppresses arrhythmias." | 3.73 | Pretreatment with pinacidil promotes arrhythmias in an isolated tissue model of cardiac ischemia and reperfusion. ( Ferrier, GR; Howlett, SE, 2005) |
| " In the present study, we investigated the effects of the administration of non-hypotensive doses of ATP-sensitive K+ channel (KATP) openers (nicorandil and 3-pyridyl pinacidil), a specific mitochondrial KATP channel blocker (5-hydroxydecanoate) and a specific sarcolemmal KATP channel blocker (HMR 1883; 1-[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]sulfonyl-3- methylthiourea) prior to and during coronary occlusion, as well as prior to and during post-ischemic reperfusion, on survival rate, ischemia-induced and reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 3.72 | Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion. ( Das, B; Sarkar, C, 2003) |
| "We investigated the effect of ATP-sensitive K+ channel (KATP) openers (pinacidil and cromakalim), and a KATP blocker (glibenclamide) on reperfusion-induced arrhythmias in pentobarbitone-anaesthetized rats." | 3.69 | KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats. ( Baczkó, I; Leprán, I; Papp, JG, 1997) |
| "Pinacidil-treated hearts had significantly better recovery of left ventricular developed pressure (47 +/- 3." | 1.32 | K(ATP) channel opener protects neonatal rabbit heart better than St. Thomas' solution. ( Feng, J; Li, H; Rosenkranz, ER, 2003) |
| "The pinacidil DRC was shifted to the right by glibenclamide and L-NOARG and to the left by SIN-1 and adenosine." | 1.30 | Inhibitors of nitric oxide synthesis and ischemia/reperfusion attenuate coronary vasodilator response to pinacidil in isolated rat heart. ( Beresewicz, A; Maczewski, M, 1997) |
| "Cromakalim pretreatment (both when given throughout the experiment and when not present in the reperfusion buffer) resulted in significant improvements in the reperfusion function." | 1.28 | The protective effects of cromakalim and pinacidil on reperfusion function and infarct size in isolated perfused rat hearts and anesthetized dogs. ( Dzwonczyk, S; Grover, GJ; Parham, CS; Sleph, PG, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (36.36) | 18.2507 |
| 2000's | 14 (42.42) | 29.6817 |
| 2010's | 7 (21.21) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Strutyns'kyĭ, RB | 7 |
| Kotsiuruba, AV | 2 |
| Rovenets', RA | 5 |
| Strutyns'ka, NA | 1 |
| Iagupols'kyĭ, IuL | 1 |
| Sagach, VF | 1 |
| Moĭbenko, OO | 5 |
| Dong, XY | 1 |
| Zhu, F | 1 |
| Yang, YH | 1 |
| Zhang, Y | 1 |
| Chen, W | 1 |
| Wang, Y | 1 |
| Cao, S | 1 |
| Yu, T | 3 |
| Wang, H | 1 |
| Pyvovar, SM | 1 |
| Tumanovs'ka, LV | 3 |
| Neshcheret, OP | 4 |
| Shysh, AM | 1 |
| Gonca, E | 2 |
| Bozdogan, O | 2 |
| Boĭchuk, TM | 1 |
| Dzhuran, BV | 1 |
| Fu, XY | 1 |
| Liu, XK | 1 |
| Yu, ZH | 1 |
| Kupriyanov, VV | 1 |
| Xiang, B | 1 |
| Sun, J | 1 |
| Jilkina, O | 1 |
| Feng, J | 1 |
| Li, H | 1 |
| Rosenkranz, ER | 1 |
| Hu, Z | 1 |
| Zhang, K | 1 |
| Wang, W | 1 |
| Das, B | 1 |
| Sarkar, C | 1 |
| Miura, T | 1 |
| Miki, T | 1 |
| Ferrier, GR | 1 |
| Howlett, SE | 1 |
| Nebigil, M | 1 |
| Tiryaki, ES | 1 |
| Smallwood, JK | 1 |
| Schelm, JA | 1 |
| Bemis, KG | 1 |
| Simpson, PJ | 1 |
| D'Alonzo, AJ | 2 |
| Darbenzio, RB | 2 |
| Hess, TA | 1 |
| Sewter, JC | 1 |
| Sleph, PG | 2 |
| Grover, GJ | 3 |
| Nakaya, H | 1 |
| Lawton, JS | 1 |
| Sepic, JD | 1 |
| Allen, CT | 1 |
| Hsia, PW | 1 |
| Damiano, RJ | 2 |
| Baczkó, I | 1 |
| Leprán, I | 1 |
| Papp, JG | 1 |
| Maczewski, M | 1 |
| Beresewicz, A | 1 |
| Zhu, JL | 1 |
| Dorso, CR | 1 |
| Jovanović, A | 1 |
| Jovanović, S | 1 |
| Lorenz, E | 1 |
| Terzic, A | 1 |
| Jayawant, AM | 1 |
| Chambers, DJ | 1 |
| Hearse, DJ | 1 |
| Kowaltowski, AJ | 1 |
| Seetharaman, S | 1 |
| Paucek, P | 1 |
| Garlid, KD | 1 |
| Lin, R | 1 |
| Zhu, X | 1 |
| Zhang, Z | 1 |
| Kang, M | 1 |
| Xia, Q | 1 |
| Yu, Z | 1 |
| Liu, X | 1 |
| Yang, S | 1 |
| Ye, Y | 1 |
| Cole, WC | 1 |
| McPherson, CD | 1 |
| Sontag, D | 1 |
| Dzwonczyk, S | 1 |
| Parham, CS | 1 |
3 reviews available for pinacidil and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
ATP-sensitive K+ channel openers: old drugs with new clinical benefits for the heart.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Disease; Diazoxide; Glyburide; Human | 2003 |
[Potential role of ATP-sensitive K+ channels in ischemia- and reperfusion-induced arrhythmias].
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; G | 1993 |
Developments in cardioprotection: "polarized" arrest as an alternative to "depolarized" arrest.
Topics: Adenosine; Animals; Cardioplegic Solutions; Electrocardiography; Heart Arrest, Induced; Humans; Myoc | 1999 |
30 other studies available for pinacidil and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
[Biochemical mechanisms of the cardioprotective effect of the K(ATP) channels opener flocalin (medicinal form) in ischemia-reperfusion of myocardium].
Topics: Animals; Apoptosis; Arginase; Cardiotonic Agents; Dogs; Heart; Heme Oxygenase (Decyclizing); Hydroxy | 2013 |
Effect of pinacidil on rat ventricular myocytes during transient hypoxia and reperfusion.
Topics: Animals; Apoptosis; Heart Ventricles; Hypoxia; Male; Models, Animal; Myocardial Reperfusion; Myocard | 2014 |
Pinacidil-postconditioning is equivalent to ischemic postconditioning in defeating cardiac ischemia-reperfusion injury in rat.
Topics: Animals; Cell Respiration; Coronary Vessels; Hemodynamics; Ischemic Postconditioning; Male; Mitochon | 2016 |
[Cardioprotective effects of flokalin: relative role of activation of sarcolemmal and mitochondrial adenosine triphosphate-dependent potassium channels].
Topics: Animals; Cardiotonic Agents; Decanoic Acids; Guinea Pigs; Hydroxy Acids; In Vitro Techniques; Male; | 2008 |
[Cardioprotective effects of fluorine-containing activator of adenosine triphosphate-dependent potassium channels flokalin].
Topics: Animals; Cardiotonic Agents; Fluorine; Guinea Pigs; Heart; Heart Function Tests; In Vitro Techniques | 2009 |
[Cardioprotective effects of flokalin in experiments in vivo: influence on hemodynamic and myocardial lesions in ischemia-reperfusion].
Topics: Animals; Blood Pressure; Cardiac Output; Cardiotonic Agents; Disease Models, Animal; Dogs; Heart Rat | 2009 |
[Cardioprotective effects of activation of ATP-sensitive potassium channels in experiments in vivo: influence on blood biochemical parameters following ischemia-reperfusion of the myocardium].
Topics: Animals; Antioxidants; Cardiotonic Agents; Disease Models, Animal; Dogs; Free Radicals; Hemodynamics | 2009 |
Both mitochondrial KATP channel opening and sarcolemmal KATP channel blockage confer protection against ischemia/reperfusion-induced arrhythmia in anesthetized male rats.
Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Benzamides; Diazoxid | 2010 |
[Effect of a new activator of adenosine triphosphate-sensitive potassium channels flocalin on the glucose level in blood].
Topics: Administration, Oral; Animals; Blood Glucose; Cardiotonic Agents; Dogs; Dose-Response Relationship, | 2010 |
[Effect of medical form of flocalin on the course of myocardial reperfusion injury].
Topics: Animals; Cardiotonic Agents; Coronary Circulation; Disease Models, Animal; Dogs; Hemodynamics; Ische | 2011 |
Protective effects of pinacidil hyperpolarizing cardioplegia on myocardial ischemia reperfusion injury by mitochondrial KATP channels.
Topics: Animals; Hemodynamics; Membrane Potential, Mitochondrial; Microscopy, Electron, Transmission; Myocar | 2011 |
The effects of drugs modulating K(+) transport on Rb(+) uptake and distribution in pig hearts following regional ischemia: (87)Rb MRI study.
Topics: Animals; Bumetanide; Glyburide; In Vitro Techniques; Magnetic Resonance Imaging; Myocardial Infarcti | 2002 |
K(ATP) channel opener protects neonatal rabbit heart better than St. Thomas' solution.
Topics: Animals; Animals, Newborn; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Circulat | 2003 |
Protective effects of hyperpolarizing cardioplegia with pinacidil on myocardium in rats.
Topics: Animals; Cardioplegic Solutions; Cyclic Nucleotide-Gated Cation Channels; Heart Arrest, Induced; Hyp | 2002 |
Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion.
Topics: Animals; Anti-Arrhythmia Agents; Antioxidants; Arrhythmias, Cardiac; Blood Pressure; Decanoic Acids; | 2003 |
Pretreatment with pinacidil promotes arrhythmias in an isolated tissue model of cardiac ischemia and reperfusion.
Topics: Animals; Arrhythmias, Cardiac; Disease Models, Animal; Guinea Pigs; Heart Ventricles; In Vitro Techn | 2005 |
Effect of thimerosal on arrhythmia induced by coronary ligation: the involvement of ATP-dependent potassium channels.
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Blood Pressure; Coronary Vessels; Electrocard | 2005 |
Effect of activation of ATP-dependent potassium channels with (-)-pinacidil and (-)-3-pyridyl pinacidil on infarct size in a canine model of ischemia-reperfusion injury.
Topics: Animals; Coronary Circulation; Dogs; Dose-Response Relationship, Drug; Guanidines; Hemodynamics; Mal | 1993 |
Effect of potassium on the action of the KATP modulators cromakalim, pinacidil, or glibenclamide on arrhythmias in isolated perfused rat heart subjected to regional ischaemia.
Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; Glyburide; Guanidines; Heart; Heart Rate; My | 1994 |
Myocardial protection with potassium-channel openers is as effective as St. Thomas' solution in the rabbit heart.
Topics: Adenosine Triphosphate; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Ci | 1996 |
KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats.
Topics: Action Potentials; Adenosine Triphosphate; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Ar | 1997 |
Inhibitors of nitric oxide synthesis and ischemia/reperfusion attenuate coronary vasodilator response to pinacidil in isolated rat heart.
Topics: Animals; Coronary Vessels; Glyburide; Guanidines; Heart; In Vitro Techniques; Male; Myocardial Reper | 1997 |
Proarrhythmic effects of pinacidil are partially mediated through enhancement of catecholamine release in isolated perfused guinea-pig hearts.
Topics: Adenosine Triphosphate; Adrenergic Agonists; Adrenergic beta-Antagonists; Animals; Arrhythmias, Card | 1998 |
Recombinant cardiac ATP-sensitive K+ channel subunits confer resistance to chemical hypoxia-reoxygenation injury.
Topics: Adenosine Triphosphate; Animals; Calcium; Cardiovascular Agents; Cell Hypoxia; Cells, Cultured; COS | 1998 |
The superiority of pinacidil over adenosine cardioplegia in blood-perfused isolated hearts.
Topics: Adenosine; Animals; Blood; Cardioplegic Solutions; Female; Glucose; Heart; Male; Membrane Potentials | 1998 |
Bioenergetic consequences of opening the ATP-sensitive K(+) channel of heart mitochondria.
Topics: Adenosine Triphosphate; Animals; Anions; Cell Respiration; Diazoxide; Energy Metabolism; Ion Channel | 2001 |
Myocardial protection of immature rabbits with an ATP-sensitive K+ channel opener pinacidil.
Topics: Animals; Coronary Circulation; Diastole; Female; Male; Myocardial Ischemia; Myocardial Reperfusion I | 2001 |
Myocardial protection with pinacidil induced hyperpolarized arrest during cardiopulmonary bypass.
Topics: Adenine Nucleotides; Alkaline Phosphatase; Animals; Antihypertensive Agents; Cardiopulmonary Bypass; | 2001 |
ATP-regulated K+ channels protect the myocardium against ischemia/reperfusion damage.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Coronary Disease; Glyburide; Guanidines; Guinea | 1991 |
The protective effects of cromakalim and pinacidil on reperfusion function and infarct size in isolated perfused rat hearts and anesthetized dogs.
Topics: Animals; Benzopyrans; Blood Pressure; Cromakalim; Dogs; Female; Guanidines; In Vitro Techniques; L-L | 1990 |