pinacidil has been researched along with Injury, Ischemia-Reperfusion in 12 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate effect of pinacidil, an ATP sensitive potassium channel (K(ATP)) opener, on the neuronal apoptosis and its signaling transduction mechanism following focal cerebral ischemia-reperfusion in rats." | 7.74 | Pinacidil reduces neuronal apoptosis following cerebral ischemia-reperfusion in rats through both mitochondrial and death-receptor signal pathways. ( Liu, YY; Lu, YL; Ma, Y; Song, LC; Zhang, H, 2007) |
| "To investigate effect of pinacidil, an ATP sensitive potassium channel (K(ATP)) opener, on the neuronal apoptosis and its signaling transduction mechanism following focal cerebral ischemia-reperfusion in rats." | 3.74 | Pinacidil reduces neuronal apoptosis following cerebral ischemia-reperfusion in rats through both mitochondrial and death-receptor signal pathways. ( Liu, YY; Lu, YL; Ma, Y; Song, LC; Zhang, H, 2007) |
| "Potassium channel openers with pinacidil can provide pulmonary protection against warm ischemia reperfusion injury." | 3.72 | Warm ischemia lung protection with pinacidil: an ATP regulated potassium channel opener. ( Cohen, NM; Holwitt, DM; Mouria, MM; Pavot, DR; Tang, DG, 2003) |
| "In fact, severe ischemia reperfusion injury can significantly reduce graft survival, even with modern immunosuppressive agents." | 1.35 | Blockade of K(ATP) channels reduces endothelial hyperpolarization and leukocyte recruitment upon reperfusion after hypoxia. ( Chilton, L; Figura, M; Giles, WR; Knight, D; Kubes, P; Liacini, A; Millar, TM; Patel, K; Phan, V; Tibbles, LA; Viskovic, MM, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 9 (75.00) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Figura, M | 1 |
| Chilton, L | 1 |
| Liacini, A | 1 |
| Viskovic, MM | 1 |
| Phan, V | 1 |
| Knight, D | 1 |
| Millar, TM | 1 |
| Patel, K | 1 |
| Kubes, P | 1 |
| Giles, WR | 1 |
| Tibbles, LA | 1 |
| Voitychuk, OI | 1 |
| Strutynskyi, RB | 1 |
| Yagupolskii, LM | 1 |
| Tinker, A | 1 |
| Moibenko, OO | 2 |
| Shuba, YM | 1 |
| Strutyns'kyĭ, RB | 1 |
| Kotsiuruba, AV | 1 |
| Neshcheret, OP | 1 |
| Rovenets', RA | 1 |
| Zhu, HF | 1 |
| Dong, JW | 1 |
| Zhu, WZ | 1 |
| Ding, HL | 1 |
| Zhou, ZN | 1 |
| Tang, DG | 1 |
| Pavot, DR | 1 |
| Mouria, MM | 1 |
| Holwitt, DM | 1 |
| Cohen, NM | 1 |
| Zhang, H | 2 |
| Song, LC | 2 |
| Liu, YY | 1 |
| Ma, Y | 1 |
| Lu, YL | 2 |
| Jia, CH | 1 |
| McPherson, CD | 1 |
| Pierce, GN | 1 |
| Cole, WC | 1 |
| Vanden Hoek, T | 1 |
| Becker, LB | 1 |
| Shao, ZH | 1 |
| Li, CQ | 1 |
| Schumacker, PT | 1 |
| Ducko, CT | 1 |
| Stephenson, ER | 1 |
| Jayawant, AM | 1 |
| Vigilance, DW | 1 |
| Damiano, RJ | 1 |
| Matsuyama, N | 1 |
| Leavens, JE | 1 |
| McKinnon, D | 1 |
| Gaudette, GR | 1 |
| Aksehirli, TO | 1 |
| Krukenkamp, IB | 1 |
| Fukuse, T | 1 |
| Hirata, T | 1 |
| Omasa, M | 1 |
| Wada, H | 1 |
12 other studies available for pinacidil and Injury, Ischemia-Reperfusion
| Article | Year |
|---|---|
Blockade of K(ATP) channels reduces endothelial hyperpolarization and leukocyte recruitment upon reperfusion after hypoxia.
Topics: Animals; Cats; Cell Membrane; Endothelium, Vascular; Gelatin; Glyburide; Humans; Hypoxia; KATP Chann | 2009 |
Sarcolemmal cardiac K(ATP) channels as a target for the cardioprotective effects of the fluorine-containing pinacidil analogue, flocalin.
Topics: Animals; Cardiotonic Agents; Cells, Cultured; Fluorine; Glyburide; Guinea Pigs; Heart; HEK293 Cells; | 2011 |
[The changes of metabolism in myocardium at ischemia-reperfusion and activating of the ATP-sensitive potassium channels].
Topics: Adenosine Triphosphate; Animals; Apoptosis; Arachidonic Acid; Arginase; Arginine; Dogs; Eicosanoids; | 2012 |
ATP-dependent potassium channels involved in the cardiac protection induced by intermittent hypoxia against ischemia/reperfusion injury.
Topics: Animals; Calcium; Decanoic Acids; Glyburide; Heart Ventricles; Hemodynamics; Hydroxy Acids; Hypoxia; | 2003 |
Warm ischemia lung protection with pinacidil: an ATP regulated potassium channel opener.
Topics: Animals; Disease Models, Animal; Female; Graft Rejection; Graft Survival; Lung Transplantation; Male | 2003 |
Pinacidil reduces neuronal apoptosis following cerebral ischemia-reperfusion in rats through both mitochondrial and death-receptor signal pathways.
Topics: Animals; Antihypertensive Agents; Apoptosis; Brain Ischemia; Caspases; Gene Expression Regulation; I | 2007 |
Effects of ATP sensitive potassium channel opener on the mRNA and protein expressions of caspase-12 after cerebral ischemia-reperfusion in rats.
Topics: Animals; Brain Ischemia; Caspase 12; Endoplasmic Reticulum Stress; Infarction, Middle Cerebral Arter | 2008 |
Ischemic cardioprotection by ATP-sensitive K+ channels involves high-energy phosphate preservation.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Glyburide; Guanidines; Guinea Pigs; Heart; In Vi | 1993 |
Preconditioning in cardiomyocytes protects by attenuating oxidant stress at reperfusion.
Topics: Animals; Anti-Arrhythmia Agents; Cell Death; Cells, Cultured; Chick Embryo; Decanoic Acids; Hydrogen | 2000 |
Potassium channel openers: are they effective as pretreatment or additives to cardioplegia?
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Circulation; Female; Magne | 2000 |
Ischemic but not pharmacological preconditioning requires protein synthesis.
Topics: Action Potentials; Animals; Blood Flow Velocity; Blood Pressure; Coronary Vessels; Cycloheximide; Da | 2000 |
Effect of adenosine triphosphate-sensitive potassium channel openers on lung preservation.
Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Glyburide; Hypertension, Pulmonary; Lung; P | 2002 |