pinacidil has been researched along with Hypoxia in 30 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to evaluate the cardioprotective effect of pinacidil postconditioning on rat hearts with transient hypoxia and reperfusion." | 7.80 | Effect of pinacidil on rat ventricular myocytes during transient hypoxia and reperfusion. ( Dong, XY; Zhu, F, 2014) |
| "To investigate the protective and therapeutic effects of pinacidil on hypoxia-induced pulmonary hypertension(HPH) and pulmonary vascular remodeling." | 7.70 | [Laboratory study on protective and therapeutic effects of pinacidil on pulmonary vascular remodeling in rats with hypoxia-induced pulmonary hypertension]. ( He, Z; Liang, G; Zhong, X, 2000) |
| "We studied the electrophysiologic and antifibrillatory effects of the class III agent MS-551 in a rabbit isolated heart model in which ventricular fibrillation (VF) occurs reproducibly under conditions of hypoxia/reoxygenation in the presence of the ATP-dependent potassium channel opener, pinacidil." | 7.69 | Antiarrhythmic agent, MS-551, protects against pinacidil + hypoxia-induced ventricular fibrillation in Langendorff-perfused rabbit isolated heart. ( Black, SC; Chi, L; Friedrichs, GS; Lucchesi, BR; Manley, PJ, 1994) |
| "The potassium channel opening drug, pinacidil, has been examined in isolated perfused lungs taken from rats with hypoxic pulmonary hypertension (housed in 10% oxygen for 7 days) and control rats." | 7.69 | Vasorelaxation by pinacidil in isolated perfused lungs is enhanced in rats with hypoxic pulmonary hypertension but is dependent on the constrictor. ( Wanstall, JC, 1995) |
| " We have used an isolated buffer-perfused preparation of the rabbit ear to investigate the effects of hypoxia and inhibition of endothelium-derived relaxing factor (EDRF) synthesis on the vasodilator responses to the potassium channel opener, levcromakalim (the active (-)-enantiomer of cromakalim)." | 7.68 | Modulation of vasodilatation to levcromakalim by hypoxia and EDRF in the rabbit isolated ear: a comparison with pinacidil, sodium nitroprusside and verapamil. ( Griffith, TM; Randall, MD, 1993) |
| " The present study was performed to determine whether beraprost, a new stable analogue of prostacyclin, may exert beneficial effects on the transmembrane action potentials during normoxia and hypoxia-reoxygenation in isolated right ventricular muscles of the guinea-pig." | 7.68 | Effects of beraprost on the transmembrane potentials of guinea-pig ventricular muscles during normoxia and hypoxia-reoxygenation. ( Nishio, S; Shigenobu, K; Ueno, Y, 1993) |
| "The aim of this study was to evaluate the cardioprotective effect of pinacidil postconditioning on rat hearts with transient hypoxia and reperfusion." | 3.80 | Effect of pinacidil on rat ventricular myocytes during transient hypoxia and reperfusion. ( Dong, XY; Zhu, F, 2014) |
| "To determine if doxapram stimulates the carotid body through the same mechanism as hypoxia, we compared the effects of doxapram and hypoxia on isolated-perfused carotid bodies in rabbits." | 3.73 | Doxapram stimulates the carotid body via a different mechanism than hypoxic chemotransduction. ( Kikuchi, K; Nakano, H; Ohsaki, Y; Osanai, S; Takahashi, T, 2005) |
| " In arteries with endothelium and contracted with phenylephrine, hypoxia, evoked by exchanging 5% CO2 in air for CO2 in N2, caused a transient contraction followed by a sustained contraction." | 3.73 | Glibenclamide reveals role for endothelin in hypoxia-induced vasoconstriction in rat intrapulmonary arteries. ( Andersen, CU; Laursen, BE; López-Valverde, V; Mulvany, MJ; Simonsen, U, 2005) |
| "To investigate the protective and therapeutic effects of pinacidil on hypoxia-induced pulmonary hypertension(HPH) and pulmonary vascular remodeling." | 3.70 | [Laboratory study on protective and therapeutic effects of pinacidil on pulmonary vascular remodeling in rats with hypoxia-induced pulmonary hypertension]. ( He, Z; Liang, G; Zhong, X, 2000) |
| "We studied the electrophysiologic and antifibrillatory effects of the class III agent MS-551 in a rabbit isolated heart model in which ventricular fibrillation (VF) occurs reproducibly under conditions of hypoxia/reoxygenation in the presence of the ATP-dependent potassium channel opener, pinacidil." | 3.69 | Antiarrhythmic agent, MS-551, protects against pinacidil + hypoxia-induced ventricular fibrillation in Langendorff-perfused rabbit isolated heart. ( Black, SC; Chi, L; Friedrichs, GS; Lucchesi, BR; Manley, PJ, 1994) |
| "Vasorelaxant responses to the potassium channel opening drug, pinacidil, were obtained on preparations of pulmonary artery and aorta taken from rats with pulmonary hypertension (induced by chronic hypoxia or monocrotaline) and pre-contracted either submaximally with endothelin-1 (ET-1), PGF2 alpha, U46619 (thromboxane-mimetic) or noradrenaline (NA), or with 80 mM K+." | 3.69 | Pinacidil-induced relaxation in pulmonary arteries isolated from pulmonary hypertensive and normotensive rats and pre-contracted with different spasmogens. ( Kay, CS; O'Donnell, SR; Wanstall, JC, 1994) |
| " The aims of this study were to compare in the rat isolated perfused lung preparation, the dilator actions of nicorandil, pinacidil and nitroglycerin on the hypoxic pulmonary pressure response with or without hypercapnic acidosis and to investigate the possible involvement of K channels and EDRF in these effects." | 3.69 | Comparison of the effects of nicorandil, pinacidil and nitroglycerin on hypoxic and hypercapnic pulmonary vasoconstriction in the isolated perfused lung of rat. ( Advenier, C; Dumas, JP; Dumas, M; Giudicelli, JF; Rochette, L, 1996) |
| "The potassium channel opening drug, pinacidil, has been examined in isolated perfused lungs taken from rats with hypoxic pulmonary hypertension (housed in 10% oxygen for 7 days) and control rats." | 3.69 | Vasorelaxation by pinacidil in isolated perfused lungs is enhanced in rats with hypoxic pulmonary hypertension but is dependent on the constrictor. ( Wanstall, JC, 1995) |
| " We have used an isolated buffer-perfused preparation of the rabbit ear to investigate the effects of hypoxia and inhibition of endothelium-derived relaxing factor (EDRF) synthesis on the vasodilator responses to the potassium channel opener, levcromakalim (the active (-)-enantiomer of cromakalim)." | 3.68 | Modulation of vasodilatation to levcromakalim by hypoxia and EDRF in the rabbit isolated ear: a comparison with pinacidil, sodium nitroprusside and verapamil. ( Griffith, TM; Randall, MD, 1993) |
| " The present study was performed to determine whether beraprost, a new stable analogue of prostacyclin, may exert beneficial effects on the transmembrane action potentials during normoxia and hypoxia-reoxygenation in isolated right ventricular muscles of the guinea-pig." | 3.68 | Effects of beraprost on the transmembrane potentials of guinea-pig ventricular muscles during normoxia and hypoxia-reoxygenation. ( Nishio, S; Shigenobu, K; Ueno, Y, 1993) |
| " In order to determine whether activation of adenosine triphosphate (ATP)-sensitive K+ channels exclusively explains the hypoxia- and ischaemia-induced action potential shortening, effects of tolbutamide and glibenclamide on changes in action potential duration (APD) during hypoxia, metabolic blockade or experimental ischaemia were examined in guinea-pig and canine isolated myocardium by standard microelectrode techniques." | 3.68 | Effects of ATP-sensitive K+ channel blockers on the action potential shortening in hypoxic and ischaemic myocardium. ( Kanno, M; Nakaya, H; Takeda, Y; Tohse, N, 1991) |
| "In fact, severe ischemia reperfusion injury can significantly reduce graft survival, even with modern immunosuppressive agents." | 1.35 | Blockade of K(ATP) channels reduces endothelial hyperpolarization and leukocyte recruitment upon reperfusion after hypoxia. ( Chilton, L; Figura, M; Giles, WR; Knight, D; Kubes, P; Liacini, A; Millar, TM; Patel, K; Phan, V; Tibbles, LA; Viskovic, MM, 2009) |
| "Pinacidil pretreatment induced VF (12 of 14; p = 0." | 1.32 | Risk of ventricular proarrhythmia with selective opening of the myocardial sarcolemmal versus mitochondrial ATP-gated potassium channel. ( Barrett, TD; Fischbach, PS; Lucchesi, BR; White, A, 2004) |
| "The suppression during anoxia (PO2 = 0 mmHg) was approximately 35% (voltage step from -60 to +30 mV) and was due to a combination of several factors: (i) suppression of a cadmium-sensitive, Ca2+-dependent K+ current, IK(CaO2); (ii) suppression of a Ca2+-insensitive, delayed rectifier type K+ current, IK(VO2); (iii) activation of a glibenclamide- (and Ca2+)-sensitive current, IK(ATP)." | 1.30 | Anoxia differentially modulates multiple K+ currents and depolarizes neonatal rat adrenal chromaffin cells. ( Nurse, CA; Thompson, RJ, 1998) |
| "Pretreatment with pinacidil (10(-4) M) or lemakalim (10(-5) M) inhibited the pressor response to hypoxia, but did not inhibit the response to angiotensin II." | 1.28 | [Effect of potassium channel openers on hypoxic pulmonary vasoconstriction]. ( Akiba, Y; Matsumoto, H; Nakano, H; Onodera, S; Osanai, S; Tobise, K, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (50.00) | 18.2507 |
| 2000's | 9 (30.00) | 29.6817 |
| 2010's | 6 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yu, L | 1 |
| Li, W | 1 |
| Park, BM | 1 |
| Lee, GJ | 1 |
| Kim, SH | 1 |
| Dong, XY | 1 |
| Zhu, F | 1 |
| Hozhenko, AI | 1 |
| Filipets', ND | 1 |
| Kojima, A | 1 |
| Matsumoto, A | 1 |
| Nishida, H | 1 |
| Reien, Y | 1 |
| Iwata, K | 1 |
| Shirayama, T | 1 |
| Yabe-Nishimura, C | 1 |
| Nakaya, H | 2 |
| Figura, M | 1 |
| Chilton, L | 1 |
| Liacini, A | 1 |
| Viskovic, MM | 1 |
| Phan, V | 1 |
| Knight, D | 1 |
| Millar, TM | 1 |
| Patel, K | 1 |
| Kubes, P | 1 |
| Giles, WR | 1 |
| Tibbles, LA | 1 |
| Adebiyi, A | 1 |
| McNally, EM | 1 |
| Jaggar, JH | 1 |
| Lin, YK | 1 |
| Lai, MS | 1 |
| Chen, YC | 1 |
| Cheng, CC | 1 |
| Huang, JH | 1 |
| Chen, SA | 1 |
| Chen, YJ | 1 |
| Lin, CI | 1 |
| Zhu, HF | 1 |
| Dong, JW | 1 |
| Zhu, WZ | 1 |
| Ding, HL | 1 |
| Zhou, ZN | 1 |
| Fischbach, PS | 1 |
| White, A | 1 |
| Barrett, TD | 1 |
| Lucchesi, BR | 2 |
| Takahashi, T | 1 |
| Osanai, S | 2 |
| Nakano, H | 2 |
| Ohsaki, Y | 1 |
| Kikuchi, K | 1 |
| López-Valverde, V | 1 |
| Andersen, CU | 1 |
| Laursen, BE | 1 |
| Mulvany, MJ | 1 |
| Simonsen, U | 1 |
| Friedrichs, GS | 1 |
| Chi, L | 1 |
| Black, SC | 1 |
| Manley, PJ | 1 |
| Wanstall, JC | 2 |
| Kay, CS | 1 |
| O'Donnell, SR | 1 |
| Pastoris, O | 1 |
| Dossena, M | 1 |
| Foppa, P | 1 |
| Arnaboldi, R | 1 |
| Gorini, A | 1 |
| Villa, RF | 1 |
| Benzi, G | 1 |
| Dumas, JP | 2 |
| Dumas, M | 2 |
| Sgro, C | 1 |
| Advenier, C | 2 |
| Giudicelli, JF | 2 |
| Randall, MD | 2 |
| Ujiie, H | 1 |
| Griffith, TM | 2 |
| Eddahibi, S | 1 |
| Springall, D | 1 |
| Mannan, M | 1 |
| Carville, C | 1 |
| Chabrier, PE | 1 |
| Levame, M | 1 |
| Raffestin, B | 1 |
| Polak, J | 1 |
| Adnot, S | 1 |
| Ueno, Y | 1 |
| Shigenobu, K | 1 |
| Nishio, S | 1 |
| Kalsner, S | 1 |
| Rochette, L | 1 |
| Thompson, RJ | 1 |
| Nurse, CA | 1 |
| Jovanovic, S | 1 |
| Jovanovic, A | 1 |
| Honchar, OO | 1 |
| Rozova, KV | 1 |
| Seredenko, MM | 1 |
| Zhong, X | 1 |
| Liang, G | 1 |
| He, Z | 1 |
| Han, J | 1 |
| Kim, N | 1 |
| Joo, H | 1 |
| Kim, E | 1 |
| Matsumoto, H | 1 |
| Akiba, Y | 1 |
| Tobise, K | 1 |
| Onodera, S | 1 |
| Antoine, MH | 1 |
| Herchuelz, A | 1 |
| Lebrun, P | 1 |
| Takeda, Y | 1 |
| Tohse, N | 1 |
| Kanno, M | 1 |
30 other studies available for pinacidil and Hypoxia
| Article | Year |
|---|---|
Hypoxia augments NaHS-induced ANP secretion via KATP channel, HIF-1α and PPAR-γ pathway.
Topics: 2-Methoxyestradiol; Anilides; Animals; Atrial Natriuretic Factor; Bosentan; Gene Expression Regulati | 2019 |
Effect of pinacidil on rat ventricular myocytes during transient hypoxia and reperfusion.
Topics: Animals; Apoptosis; Heart Ventricles; Hypoxia; Male; Models, Animal; Myocardial Reperfusion; Myocard | 2014 |
[The functional state of the kidneys after adenosine triphosphate-sensitive potassium channels activation in experimental acute hypoxia].
Topics: Acute Disease; Animals; Disease Models, Animal; Hypoxia; Ion Channel Gating; KATP Channels; Kidney; | 2014 |
A protective role of Nox1/NADPH oxidase in a mouse model with hypoxia-induced bradycardia.
Topics: Action Potentials; Animals; Bradycardia; Calcium Channel Blockers; Disease Models, Animal; Electroca | 2015 |
Blockade of K(ATP) channels reduces endothelial hyperpolarization and leukocyte recruitment upon reperfusion after hypoxia.
Topics: Animals; Cats; Cell Membrane; Endothelium, Vascular; Gelatin; Glyburide; Humans; Hypoxia; KATP Chann | 2009 |
Vasodilation induced by oxygen/glucose deprivation is attenuated in cerebral arteries of SUR2 null mice.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Blotting, Western; Cerebral Arte | 2011 |
Hypoxia and reoxygenation modulate the arrhythmogenic activity of the pulmonary vein and atrium.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Atrial Fibrillation; Blotting, Western; Chloramphe | 2012 |
ATP-dependent potassium channels involved in the cardiac protection induced by intermittent hypoxia against ischemia/reperfusion injury.
Topics: Animals; Calcium; Decanoic Acids; Glyburide; Heart Ventricles; Hemodynamics; Hydroxy Acids; Hypoxia; | 2003 |
Risk of ventricular proarrhythmia with selective opening of the myocardial sarcolemmal versus mitochondrial ATP-gated potassium channel.
Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Heart; Hypoxia; Imidazoles; Male; Membrane Proteins; Mit | 2004 |
Doxapram stimulates the carotid body via a different mechanism than hypoxic chemotransduction.
Topics: Anesthetics, Inhalation; Animals; Benzimidazoles; Carotid Body; Carotid Sinus; Cromakalim; Dose-Resp | 2005 |
Glibenclamide reveals role for endothelin in hypoxia-induced vasoconstriction in rat intrapulmonary arteries.
Topics: Animals; Anti-Arrhythmia Agents; Carboxylic Acids; Dose-Response Relationship, Drug; Endothelin Rece | 2005 |
Antiarrhythmic agent, MS-551, protects against pinacidil + hypoxia-induced ventricular fibrillation in Langendorff-perfused rabbit isolated heart.
Topics: Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Dogs; Guanidines; Heart; Heart Atria; Hypox | 1994 |
Pinacidil-induced relaxation in pulmonary arteries isolated from pulmonary hypertensive and normotensive rats and pre-contracted with different spasmogens.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Guanidines; Hypertension, Pulmonary; Hypoxia; In | 1994 |
Modifications by chronic intermittent hypoxia and drug treatment on skeletal muscle metabolism.
Topics: Adenine Nucleotides; Almitrine; Animals; Chronic Disease; Energy Metabolism; Glycogen; Glycolysis; G | 1995 |
Effects of two K+ channel openers, aprikalim and pinacidil, on hypoxic pulmonary vasoconstriction.
Topics: Animals; Antihypertensive Agents; Arginine; Guanidines; Hypoxia; Muscle, Smooth, Vascular; NG-Nitroa | 1994 |
Modulation of vasodilatation to levcromakalim by adenosine analogues in the rabbit ear: an explanation for hypoxic augmentation.
Topics: Adenosine; Animals; Arginine; Benzopyrans; Blood Pressure; Cromakalim; Drug Synergism; Ear, External | 1994 |
Dilator effect of endothelins in pulmonary circulation: changes associated with chronic hypoxia.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arginine; Autoradiograp | 1993 |
Modulation of vasodilatation to levcromakalim by hypoxia and EDRF in the rabbit isolated ear: a comparison with pinacidil, sodium nitroprusside and verapamil.
Topics: Acetylcholine; Animals; Arginine; Benzopyrans; Cromakalim; Ear, External; Guanidines; Hypoxia; In Vi | 1993 |
Effects of beraprost on the transmembrane potentials of guinea-pig ventricular muscles during normoxia and hypoxia-reoxygenation.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Epoprostenol; Guanidines; Guinea Pigs; Heart; He | 1993 |
Hypoxic relaxation in functionally intact cattle coronary artery segments involves K+ ATP channels.
Topics: Adenosine; Adenosine Triphosphate; Animals; Arteries; Calcium; Calcium Channel Blockers; Cattle; Cor | 1995 |
Comparison of the effects of nicorandil, pinacidil and nitroglycerin on hypoxic and hypercapnic pulmonary vasoconstriction in the isolated perfused lung of rat.
Topics: Acidosis; Animals; Guanidines; Hypercapnia; Hypoxia; In Vitro Techniques; Lung; Male; Niacinamide; N | 1996 |
Vasorelaxation by pinacidil in isolated perfused lungs is enhanced in rats with hypoxic pulmonary hypertension but is dependent on the constrictor.
Topics: Animals; Guanidines; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Male; Perfusion; Pinacid | 1995 |
Anoxia differentially modulates multiple K+ currents and depolarizes neonatal rat adrenal chromaffin cells.
Topics: Animals; Animals, Newborn; Chromaffin Cells; Electric Stimulation; Electrophysiology; Glyburide; Hyp | 1998 |
Pinacidil prevents membrane depolarisation and intracellular Ca2+ loading in single cardiomyocytes exposed to severe metabolic stress.
Topics: Animals; Calcium; Cell Membrane; Dinitrophenols; Guinea Pigs; Hypoxia; Kinetics; Membrane Potentials | 2001 |
[Effect of potassium channel openers on lysosomal function and morphology during acute hypoxic hypoxia].
Topics: Acid Phosphatase; Acute Disease; Animals; Cathepsin D; Disease Models, Animal; Heart; Hypoxia; Lung; | 2001 |
[Laboratory study on protective and therapeutic effects of pinacidil on pulmonary vascular remodeling in rats with hypoxia-induced pulmonary hypertension].
Topics: Animals; Antihypertensive Agents; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Righ | 2000 |
Ketamine abolishes ischemic preconditioning through inhibition of K(ATP) channels in rabbit hearts.
Topics: Animals; Cell Separation; Cytoprotection; Diazoxide; Heart; Hypoxia; In Vitro Techniques; Ischemic P | 2002 |
[Effect of potassium channel openers on hypoxic pulmonary vasoconstriction].
Topics: Angiotensin II; Animals; Benzopyrans; Cromakalim; Guanidines; Hypoxia; In Vitro Techniques; Pinacidi | 1992 |
Anoxia and glucose-sensitive 86Rb outflow from rat portal vein.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diazoxide; Glucose; Guanidines; Hypoxia; P | 1992 |
Effects of ATP-sensitive K+ channel blockers on the action potential shortening in hypoxic and ischaemic myocardium.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Disease; Dogs; Fe | 1991 |