pinacidil has been researched along with Hypertension, Pulmonary in 7 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
Hypertension, Pulmonary: Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the protective and therapeutic effects of pinacidil on hypoxia-induced pulmonary hypertension(HPH) and pulmonary vascular remodeling." | 7.70 | [Laboratory study on protective and therapeutic effects of pinacidil on pulmonary vascular remodeling in rats with hypoxia-induced pulmonary hypertension]. ( He, Z; Liang, G; Zhong, X, 2000) |
| "The potassium channel opening drug, pinacidil, has been examined in isolated perfused lungs taken from rats with hypoxic pulmonary hypertension (housed in 10% oxygen for 7 days) and control rats." | 7.69 | Vasorelaxation by pinacidil in isolated perfused lungs is enhanced in rats with hypoxic pulmonary hypertension but is dependent on the constrictor. ( Wanstall, JC, 1995) |
| "To investigate the protective and therapeutic effects of pinacidil on hypoxia-induced pulmonary hypertension(HPH) and pulmonary vascular remodeling." | 3.70 | [Laboratory study on protective and therapeutic effects of pinacidil on pulmonary vascular remodeling in rats with hypoxia-induced pulmonary hypertension]. ( He, Z; Liang, G; Zhong, X, 2000) |
| "Vasorelaxant responses to the potassium channel opening drug, pinacidil, were obtained on preparations of pulmonary artery and aorta taken from rats with pulmonary hypertension (induced by chronic hypoxia or monocrotaline) and pre-contracted either submaximally with endothelin-1 (ET-1), PGF2 alpha, U46619 (thromboxane-mimetic) or noradrenaline (NA), or with 80 mM K+." | 3.69 | Pinacidil-induced relaxation in pulmonary arteries isolated from pulmonary hypertensive and normotensive rats and pre-contracted with different spasmogens. ( Kay, CS; O'Donnell, SR; Wanstall, JC, 1994) |
| "The potassium channel opening drug, pinacidil, has been examined in isolated perfused lungs taken from rats with hypoxic pulmonary hypertension (housed in 10% oxygen for 7 days) and control rats." | 3.69 | Vasorelaxation by pinacidil in isolated perfused lungs is enhanced in rats with hypoxic pulmonary hypertension but is dependent on the constrictor. ( Wanstall, JC, 1995) |
| "The drugs that are currently used to treat pulmonary hypertension (PH) lack the ability to inhibit or reverse the pulmonary vascular remodeling that occurs during the course of the disease." | 1.38 | Combined effects of the ATP-sensitive potassium channel opener pinacidil and simvastatin on pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary arterial hypertension. ( Jiang, L; Liu, H; Zhou, T, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yu, L | 1 |
| Li, W | 1 |
| Park, BM | 1 |
| Lee, GJ | 1 |
| Kim, SH | 1 |
| Jiang, L | 1 |
| Zhou, T | 1 |
| Liu, H | 1 |
| de Buys Roessingh, AS | 1 |
| de Lagausie, P | 1 |
| Barbet, JP | 1 |
| Mercier, JC | 1 |
| Aigrain, Y | 1 |
| Dinh-Xuan, AT | 1 |
| Wanstall, JC | 2 |
| Kay, CS | 1 |
| O'Donnell, SR | 1 |
| Zhong, X | 1 |
| Liang, G | 1 |
| He, Z | 1 |
| Fukuse, T | 1 |
| Hirata, T | 1 |
| Omasa, M | 1 |
| Wada, H | 1 |
7 other studies available for pinacidil and Hypertension, Pulmonary
| Article | Year |
|---|---|
Hypoxia augments NaHS-induced ANP secretion via KATP channel, HIF-1α and PPAR-γ pathway.
Topics: 2-Methoxyestradiol; Anilides; Animals; Atrial Natriuretic Factor; Bosentan; Gene Expression Regulati | 2019 |
Combined effects of the ATP-sensitive potassium channel opener pinacidil and simvastatin on pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary arterial hypertension.
Topics: Actins; Animals; Arterioles; Blood Vessels; Cell Proliferation; Hydroxymethylglutaryl-CoA Reductase | 2012 |
Role of ATP-dependent potassium channels in pulmonary vascular tone of fetal lambs with congenital diaphragmatic hernia.
Topics: Adenosine Triphosphate; Animals; Female; Glyburide; Hernia, Diaphragmatic; Hernias, Diaphragmatic, C | 2006 |
Pinacidil-induced relaxation in pulmonary arteries isolated from pulmonary hypertensive and normotensive rats and pre-contracted with different spasmogens.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Guanidines; Hypertension, Pulmonary; Hypoxia; In | 1994 |
Vasorelaxation by pinacidil in isolated perfused lungs is enhanced in rats with hypoxic pulmonary hypertension but is dependent on the constrictor.
Topics: Animals; Guanidines; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Male; Perfusion; Pinacid | 1995 |
[Laboratory study on protective and therapeutic effects of pinacidil on pulmonary vascular remodeling in rats with hypoxia-induced pulmonary hypertension].
Topics: Animals; Antihypertensive Agents; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Righ | 2000 |
Effect of adenosine triphosphate-sensitive potassium channel openers on lung preservation.
Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Glyburide; Hypertension, Pulmonary; Lung; P | 2002 |