Page last updated: 2024-11-02

pinacidil and Hyperkalemia

pinacidil has been researched along with Hyperkalemia in 5 studies

Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)

Hyperkalemia: Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinically by electrocardiographic abnormalities (elevated T waves and depressed P waves, and eventually by atrial asystole). In severe cases, weakness and flaccid paralysis may occur. (Dorland, 27th ed)

Research Excerpts

ExcerptRelevanceReference
"Diazoxide did not increase sarcolemmal adenosine triphosphate-sensitive potassium current in wild-type myocytes, although they demonstrated significant swelling during exposure to cardioplegia that was prevented by diazoxide."1.36Diazoxide maintenance of myocyte volume and contractility during stress: evidence for a non-sarcolemmal K(ATP) channel location. ( Al-Dadah, AS; Lawton, JS; Maffit, SK; Nichols, CG; Schuessler, RB; Sellitto, AD; Zhang, H, 2010)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (40.00)18.2507
2000's2 (40.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sellitto, AD1
Maffit, SK1
Al-Dadah, AS1
Zhang, H1
Schuessler, RB1
Nichols, CG1
Lawton, JS2
Wang, J1
Zhou, X1
Zhao, Y1
Tang, H1
Hu, Y1
Hsia, PW1
McClain, LC1
Maier, GW1
Damiano, RJ1
Tang, T1
Dong, C1
Duffield, R1
Ho, AK1
Yu, T1
Yu, Z1
Liu, X1
Yang, S1
Ye, Y1

Other Studies

5 other studies available for pinacidil and Hyperkalemia

ArticleYear
Diazoxide maintenance of myocyte volume and contractility during stress: evidence for a non-sarcolemmal K(ATP) channel location.
    The Journal of thoracic and cardiovascular surgery, 2010, Volume: 140, Issue:5

    Topics: Animals; ATP-Binding Cassette Transporters; Cardioplegic Solutions; Cardiotonic Agents; Cell Size; D

2010
Myocardial protection of immature rabbits: polarizing versus depolarizing.
    The Journal of surgical research, 2003, May-01, Volume: 111, Issue:1

    Topics: Aging; Animals; Bicarbonates; Body Water; Calcium Chloride; Cardiotonic Agents; Coronary Circulation

2003
Myocardial oxygen consumption in the rabbit heart after ischemia: hyperpolarized arrest with pinacidil versus depolarized hyperkalemic arrest.
    Circulation, 1997, Nov-04, Volume: 96, Issue:9 Suppl

    Topics: Animals; Coronary Circulation; Diastole; Female; Guanidines; Heart Arrest, Induced; Hyperkalemia; Ma

1997
Protection of cardiomyocytes by pinacidil during metabolic inhibition and hyperkalemia.
    European journal of pharmacology, 1999, Jul-02, Volume: 376, Issue:1-2

    Topics: Adenosine Triphosphate; Animals; Bepridil; Calcium; Calcium Channel Blockers; Cells, Cultured; Chick

1999
Myocardial protection with pinacidil induced hyperpolarized arrest during cardiopulmonary bypass.
    Chinese medical journal, 2001, Volume: 114, Issue:12

    Topics: Adenine Nucleotides; Alkaline Phosphatase; Animals; Antihypertensive Agents; Cardiopulmonary Bypass;

2001