Page last updated: 2024-11-02

pinacidil and Hypercapnia

pinacidil has been researched along with Hypercapnia in 3 studies

Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)

Hypercapnia: A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.

Research Excerpts

ExcerptRelevanceReference
"Posthypothermic rapid rewarming caused cerebral vascular abnormalities, including a diminished response to acetylcholine, hypercapnia, pinacidil, and SNP."3.72Uncomplicated rapid posthypothermic rewarming alters cerebrovascular responsiveness. ( Kontos, HA; Povlishock, JT; Suehiro, E; Ueda, Y; Wei, EP, 2004)
" The aims of this study were to compare in the rat isolated perfused lung preparation, the dilator actions of nicorandil, pinacidil and nitroglycerin on the hypoxic pulmonary pressure response with or without hypercapnic acidosis and to investigate the possible involvement of K channels and EDRF in these effects."3.69Comparison of the effects of nicorandil, pinacidil and nitroglycerin on hypoxic and hypercapnic pulmonary vasoconstriction in the isolated perfused lung of rat. ( Advenier, C; Dumas, JP; Dumas, M; Giudicelli, JF; Rochette, L, 1996)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's2 (66.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ueda, Y1
Suehiro, E1
Wei, EP2
Kontos, HA2
Povlishock, JT1
Dumas, M1
Dumas, JP1
Rochette, L1
Advenier, C1
Giudicelli, JF1
Rosenblum, WI1

Other Studies

3 other studies available for pinacidil and Hypercapnia

ArticleYear
Uncomplicated rapid posthypothermic rewarming alters cerebrovascular responsiveness.
    Stroke, 2004, Volume: 35, Issue:2

    Topics: Acetylcholine; Animals; Carbon Dioxide; Cerebrovascular Circulation; Disease Models, Animal; Hyperca

2004
Comparison of the effects of nicorandil, pinacidil and nitroglycerin on hypoxic and hypercapnic pulmonary vasoconstriction in the isolated perfused lung of rat.
    British journal of pharmacology, 1996, Volume: 117, Issue:4

    Topics: Acidosis; Animals; Guanidines; Hypercapnia; Hypoxia; In Vitro Techniques; Lung; Male; Niacinamide; N

1996
Evidence for a K(ATP) ion channel link in the inhibition of hypercapnic dilation of pial arterioles by 7-nitroindazole and tetrodotoxin.
    European journal of pharmacology, 2001, Apr-13, Volume: 417, Issue:3

    Topics: Animals; Arginine; Arterioles; Carbon Dioxide; Cromakalim; Hypercapnia; Indazoles; Ion Channel Gatin

2001